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The map label for this gene is lpxH

Identifier: 218698889

GI number: 218698889

Start: 519680

End: 520402

Strand: Reverse

Name: lpxH

Synonym: ECIAI39_0487

Alternate gene names: 218698889

Gene position: 520402-519680 (Counterclockwise)

Preceding gene: 218698890

Following gene: 218698888

Centisome position: 10.14

GC content: 53.8

Gene sequence:

>723_bases
GTGGCGACACTCTTTATTGCAGATCTTCATCTCTGCGCGGAAGAACCGGCGATCACCGCCGGTTTTCTGCGTTTTTTAGC
GAGGGAAGCCCGCAAGGCCGACGCGCTGTATATTCTTGGCGATCTGTTTGAAGCGTGGATTGGCGACGACGATCCCAACC
CACTCCATCGCCAGATGGCGGCAGCGATCAAAGCGGTGTCCGATTCCGGTGTTCCCTGTTATTTCATTCATGGCAACCGT
GATTTTCTGCTCGGCAAACGCTTTGCCCGTGAAAGCGGCATGACGTTATTGCCGGAAGAAAAGGTGCTCGAACTTTATGG
TCGCCGGGTATTGATTATGCATGGCGACACGCTGTGCACCGATGACATCGGTTATCAGGCTTTTCGCGCCAAAGTCCACA
AGCCGTGGCTGCAAACGCTATTCCTCGCCCTGCCGTTGTTTGTGCGCAAACGCATTGCCGCGCGAATGCGAGCGAACAGC
AAAGAAGCCAACAGCAGTAAATCGCTGGCGATCATGGACGTTAACCAAAACGCGGTGGTCAGTGCGATGGAAAAACATCA
GGTGCAATGGCTGATTCACGGGCATACCCATCGCCCGGCGGTACATGAACTTATCGCCAACCAGCAACCTGCTTTTCGCG
TAGTACTGGGTGCCTGGCATACGGAAGGTTCGATGGTGAAAGTCACGGCGGATGACGTTGAGCTGATTCATTTTCCGTTT
TAA

Upstream 100 bases:

>100_bases
TAGACAAAATCAAAGGTGTTGCAACCGGTCGTAGCGGTATGCACCAGGACGTGCCAAAAGAAGACGTTATCATTGAAAGC
GTGACCGTTAGCGAGTAATC

Downstream 100 bases:

>100_bases
AAAACCCACAACTTTGCTGATTTCACAGCCACGCAACCGTTTTCCTTGCTCTCTTTCCGTGCTATTCTCTGTGCCCTCTA
AAGCCGAGAGTTGTGCACCA

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MATLFIADLHLCAEEPAITAGFLRFLAREARKADALYILGDLFEAWIGDDDPNPLHRQMAAAIKAVSDSGVPCYFIHGNR
DFLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCTDDIGYQAFRAKVHKPWLQTLFLALPLFVRKRIAARMRANS
KEANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF

Sequences:

>Translated_240_residues
MATLFIADLHLCAEEPAITAGFLRFLAREARKADALYILGDLFEAWIGDDDPNPLHRQMAAAIKAVSDSGVPCYFIHGNR
DFLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCTDDIGYQAFRAKVHKPWLQTLFLALPLFVRKRIAARMRANS
KEANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF
>Mature_239_residues
ATLFIADLHLCAEEPAITAGFLRFLAREARKADALYILGDLFEAWIGDDDPNPLHRQMAAAIKAVSDSGVPCYFIHGNRD
FLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCTDDIGYQAFRAKVHKPWLQTLFLALPLFVRKRIAARMRANSK
EANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=240, Percent_Identity=98.3333333333333, Blast_Score=489, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: 3.6.1.-

Molecular weight: Translated: 27008; Mature: 26876

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLFIADLHLCAEEPAITAGFLRFLAREARKADALYILGDLFEAWIGDDDPNPLHRQMA
CCEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCCCHHHHHHH
AAIKAVSDSGVPCYFIHGNRDFLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCT
HHHHHHCCCCCEEEEEECCCCEEHHHHHHHHCCCEECCHHHHHHHHCCEEEEEECCEEEC
DDIGYQAFRAKVHKPWLQTLFLALPLFVRKRIAARMRANSKEANSSKSLAIMDVNQNAVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHH
SAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF
HHHHHHCEEEEEECCCCCHHHHHHHCCCCCCEEEEEEEEECCCCEEEEECCCEEEEEECC
>Mature Secondary Structure 
ATLFIADLHLCAEEPAITAGFLRFLAREARKADALYILGDLFEAWIGDDDPNPLHRQMA
CEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCCCHHHHHHH
AAIKAVSDSGVPCYFIHGNRDFLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCT
HHHHHHCCCCCEEEEEECCCCEEHHHHHHHHCCCEECCHHHHHHHHCCEEEEEECCEEEC
DDIGYQAFRAKVHKPWLQTLFLALPLFVRKRIAARMRANSKEANSSKSLAIMDVNQNAVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHH
SAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF
HHHHHHCEEEEEECCCCCHHHHHHHCCCCCCEEEEEEEEECCCCEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA