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The map label for this gene is iucA

Identifier: 218697853

GI number: 218697853

Start: 4761351

End: 4763138

Strand: Reverse

Name: iucA

Synonym: EC55989_4645

Alternate gene names: 218697853

Gene position: 4763138-4761351 (Counterclockwise)

Preceding gene: 218697855

Following gene: 218697852

Centisome position: 92.4

GC content: 53.52

Gene sequence:

>1788_bases
TTGATAATGAGAATCATTATTGACATAATTGTTATTATTTTACTGTGTGGGAGCTGTTTGACTATGACCCTGCCCTCTGA
AAAACCAGCCACAGATGTGGCTGCGCAGTGCTTCCTGAATGCACTGATTCGTGAAACCACAGACTGGAAACTGACAGAAT
ACCCGCCAGACGAATTGATCATCCCGCTGGATGAGCAGAAATCGCTCCATTTCAGAGTGGCTTATTTCTCCCCAACCCAG
CATCACCGCTTTGCATTTCCTGCACGTCTGGTCACGGCATCAGGCAGTTATCCTGTCGACTTTACCACTCTCTCCCGGCT
TATTATTGATAAGCTACGGCATCAACTGTTTCTGCCCGTTCCCCTCTGCGAAACTTTCCACCAGCGCGTGCTGGAAAGCC
ACGCCCATACGCAACAGACAATTGATGCCCGTCATGACTGGACCGCCCTGCGTGAAAAAGCGTTGAATTTTGGCGAAGCT
GAGCAGGCGCTGCTGACAGGACACGCTTTCCACCCTGCGCCTAAGTCTCATGAACCGTTTAACCGGCGGGAGGCTGAACG
CTACCTGCCTGATATGGCACCCCACTTCCCACTGCGGTGGTTTTCGGTGGATAAAACGCAAATCGCCGGTGAAAGTTTGC
ATCTCAACCTTCAACAGCGGCTGACGCGATTTGCCGCAGAGAATGCGCCTCAGTTACTCAACGAATTAAGTGACAACCAA
TGGCTGTTCCCGTTGCACCCGTGGCAGGGGGAATATCTTTTGCAGCAGGGGTGGTGCCAGGCACTTGTTGCTAAAGGGCT
GATTAAAGACTTAGGTGAGGCCGGCACGTCGTGGCTGCCGACCACCTCTTCCCGTTCCCTCTACTGTGCCACCAGCCGCG
ATATGATCAAGTTCTCCCTGAGCGTACGGCTGACCAACTCCATCCGTACTCTGTCCGTGAAAGAAGTGAAGCGTGGGATG
CGCCTGGCACGCCTGGCTCAAACCGACGGCTGGCAGATGCTACAGGTCCGCTTCCCGACTTTCCGGGTAATGCAGGAGGA
TGGCTGGGCCGGGCTGCTCGATCTTAACGGCAACATCATGCAGGAAAGTCTGTTTGCCCTGCGTGAAAATCTGCTGGTGG
ATCAGCCGAAAAGCCAGACCAACGTACTGGTCTCCCTGACTCAGGCCGCACCTGATGGCGGTGATTCGCTGCTGGTTTCG
GCGGTAAAACGCCTGAGCGATCGCCTCGGTATCACTGTGCAACAGGCCGCCCATGCATGGGTCGATGCATACTGTCAGCA
AGTGCTAAAGCCGCTGTTTACGGCTGAAGCGGATTACGGCCTGGTGCTGCTGGCGCATCAGCAAAATATTCTTGTCCAGA
TGCTTGGGGATCTGCCGGTCGGATTTATTTACCGTGACTGTCAGGGCAGCGCTTTTATGCCTCACGCGACAGACTGGCTC
GATTCTATTGGCGAGGCGCAGGCGGAAAATATTTTCACCCATGAGCAGTTGCTGCGCTATTTCCCTTATTACCTGCTGGT
TAACTCCACTTTTGCTGTGACCGCTGCGCTGGGGGCTGCCGGGCTGGACAGCGAATCGAATCTGATGGCTCGTGTACGAG
CATCGCTGGCTGAAGTGCGTGATCAGGTGACTCATAAAACCTGTCTCAACTACGTGCTGGAAAGTCCGTACTGGAACGTA
AAAGGTAACTTTTTCTGTTATCTGAACGATCATAACGAGAACACCATTGTTGACCCTTCGGTGATCTATTTCGATTTCGC
TAACCCGCTGCAGGCTCAGGAGGTCTGA

Upstream 100 bases:

>100_bases
GGGGCGTATCTTCGATCCCAGGGGACATTTTAATGTTTCAACTCCATGTATTAATTGTGTTTATTTGTAAAATTAATTTA
TCTGACAATAACATTTCTTA

Downstream 100 bases:

>100_bases
ATGTCTGAGGCAAACATTATTCACAGCAGATATGGACTGCGCTGTGAAAAACTCGACAAGCCCCTGAATCTTGGCTGGGG
ACTGGACAATAGCGCGGTGT

Product: aerobactin siderophore biosynthesis protein

Products: ADP; phosphate; aerobactin

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MIMRIIIDIIVIILLCGSCLTMTLPSEKPATDVAAQCFLNALIRETTDWKLTEYPPDELIIPLDEQKSLHFRVAYFSPTQ
HHRFAFPARLVTASGSYPVDFTTLSRLIIDKLRHQLFLPVPLCETFHQRVLESHAHTQQTIDARHDWTALREKALNFGEA
EQALLTGHAFHPAPKSHEPFNRREAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQ
WLFPLHPWQGEYLLQQGWCQALVAKGLIKDLGEAGTSWLPTTSSRSLYCATSRDMIKFSLSVRLTNSIRTLSVKEVKRGM
RLARLAQTDGWQMLQVRFPTFRVMQEDGWAGLLDLNGNIMQESLFALRENLLVDQPKSQTNVLVSLTQAAPDGGDSLLVS
AVKRLSDRLGITVQQAAHAWVDAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATDWL
DSIGEAQAENIFTHEQLLRYFPYYLLVNSTFAVTAALGAAGLDSESNLMARVRASLAEVRDQVTHKTCLNYVLESPYWNV
KGNFFCYLNDHNENTIVDPSVIYFDFANPLQAQEV

Sequences:

>Translated_595_residues
MIMRIIIDIIVIILLCGSCLTMTLPSEKPATDVAAQCFLNALIRETTDWKLTEYPPDELIIPLDEQKSLHFRVAYFSPTQ
HHRFAFPARLVTASGSYPVDFTTLSRLIIDKLRHQLFLPVPLCETFHQRVLESHAHTQQTIDARHDWTALREKALNFGEA
EQALLTGHAFHPAPKSHEPFNRREAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQ
WLFPLHPWQGEYLLQQGWCQALVAKGLIKDLGEAGTSWLPTTSSRSLYCATSRDMIKFSLSVRLTNSIRTLSVKEVKRGM
RLARLAQTDGWQMLQVRFPTFRVMQEDGWAGLLDLNGNIMQESLFALRENLLVDQPKSQTNVLVSLTQAAPDGGDSLLVS
AVKRLSDRLGITVQQAAHAWVDAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATDWL
DSIGEAQAENIFTHEQLLRYFPYYLLVNSTFAVTAALGAAGLDSESNLMARVRASLAEVRDQVTHKTCLNYVLESPYWNV
KGNFFCYLNDHNENTIVDPSVIYFDFANPLQAQEV
>Mature_595_residues
MIMRIIIDIIVIILLCGSCLTMTLPSEKPATDVAAQCFLNALIRETTDWKLTEYPPDELIIPLDEQKSLHFRVAYFSPTQ
HHRFAFPARLVTASGSYPVDFTTLSRLIIDKLRHQLFLPVPLCETFHQRVLESHAHTQQTIDARHDWTALREKALNFGEA
EQALLTGHAFHPAPKSHEPFNRREAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQ
WLFPLHPWQGEYLLQQGWCQALVAKGLIKDLGEAGTSWLPTTSSRSLYCATSRDMIKFSLSVRLTNSIRTLSVKEVKRGM
RLARLAQTDGWQMLQVRFPTFRVMQEDGWAGLLDLNGNIMQESLFALRENLLVDQPKSQTNVLVSLTQAAPDGGDSLLVS
AVKRLSDRLGITVQQAAHAWVDAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATDWL
DSIGEAQAENIFTHEQLLRYFPYYLLVNSTFAVTAALGAAGLDSESNLMARVRASLAEVRDQVTHKTCLNYVLESPYWNV
KGNFFCYLNDHNENTIVDPSVIYFDFANPLQAQEV

Specific function: Unknown

COG id: COG4264

COG function: function code Q; Siderophore synthetase component

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iucA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007310
- InterPro:   IPR022770 [H]

Pfam domain/function: PF06276 FhuF; PF04183 IucA_IucC [H]

EC number: 6.3.2.27

Molecular weight: Translated: 67380; Mature: 67380

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMRIIIDIIVIILLCGSCLTMTLPSEKPATDVAAQCFLNALIRETTDWKLTEYPPDELI
CHHHHHHHHHHHHHHHCCHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCEE
IPLDEQKSLHFRVAYFSPTQHHRFAFPARLVTASGSYPVDFTTLSRLIIDKLRHQLFLPV
EECCCCCCEEEEEEEECCCCCCCEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHEECCC
PLCETFHQRVLESHAHTQQTIDARHDWTALREKALNFGEAEQALLTGHAFHPAPKSHEPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCC
NRREAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQ
CHHHHHHHCCCCCCCCCEEEEECCHHHHCCCCEEEEHHHHHHHHHHCCHHHHHHHCCCCC
WLFPLHPWQGEYLLQQGWCQALVAKGLIKDLGEAGTSWLPTTSSRSLYCATSRDMIKFSL
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEE
SVRLTNSIRTLSVKEVKRGMRLARLAQTDGWQMLQVRFPTFRVMQEDGWAGLLDLNGNIM
EEEEECCCCEEEHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEECCCCEEEEECCCCHH
QESLFALRENLLVDQPKSQTNVLVSLTQAAPDGGDSLLVSAVKRLSDRLGITVQQAAHAW
HHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCEEHHHHHHHH
VDAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATDWL
HHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHH
DSIGEAQAENIFTHEQLLRYFPYYLLVNSTFAVTAALGAAGLDSESNLMARVRASLAEVR
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
DQVTHKTCLNYVLESPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLQAQEV
HHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCEEECCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MIMRIIIDIIVIILLCGSCLTMTLPSEKPATDVAAQCFLNALIRETTDWKLTEYPPDELI
CHHHHHHHHHHHHHHHCCHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCEE
IPLDEQKSLHFRVAYFSPTQHHRFAFPARLVTASGSYPVDFTTLSRLIIDKLRHQLFLPV
EECCCCCCEEEEEEEECCCCCCCEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHEECCC
PLCETFHQRVLESHAHTQQTIDARHDWTALREKALNFGEAEQALLTGHAFHPAPKSHEPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCC
NRREAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQ
CHHHHHHHCCCCCCCCCEEEEECCHHHHCCCCEEEEHHHHHHHHHHCCHHHHHHHCCCCC
WLFPLHPWQGEYLLQQGWCQALVAKGLIKDLGEAGTSWLPTTSSRSLYCATSRDMIKFSL
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEE
SVRLTNSIRTLSVKEVKRGMRLARLAQTDGWQMLQVRFPTFRVMQEDGWAGLLDLNGNIM
EEEEECCCCEEEHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEECCCCEEEEECCCCHH
QESLFALRENLLVDQPKSQTNVLVSLTQAAPDGGDSLLVSAVKRLSDRLGITVQQAAHAW
HHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCEEHHHHHHHH
VDAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATDWL
HHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHH
DSIGEAQAENIFTHEQLLRYFPYYLLVNSTFAVTAALGAAGLDSESNLMARVRASLAEVR
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
DQVTHKTCLNYVLESPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLQAQEV
HHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCEEECCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; citrate; N6-acetyl-N6-hydroxylysine

Specific reaction: 4 ATP + citrate + N6-acetyl-N6-hydroxylysine = 4 ADP + 4 phosphate + aerobactin

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8003107 [H]