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The map label for this gene is hemE

Identifier: 218697705

GI number: 218697705

Start: 4587575

End: 4588639

Strand: Direct

Name: hemE

Synonym: EC55989_4482

Alternate gene names: 218697705

Gene position: 4587575-4588639 (Clockwise)

Preceding gene: 218697704

Following gene: 218697706

Centisome position: 89.0

GC content: 56.34

Gene sequence:

>1065_bases
ATGACCGAACTTAAAAACGATCGTTATCTGCGGGCGCTGCTGCGCCAGCCCGTTGATGTCACTCCAGTATGGATGATGCG
CCAGGCGGGTCGCTATCTACCGGAATATAAAGCCACGCGCGCCCAGGCGGGCGATTTTATGTCGCTGTGCAAAAACGCCG
AGCTGGCGTGCGAAGTGACTTTGCAACCGCTGCGTCGCTACCCGCTGGATGCGGCGATCCTCTTTTCCGATATCCTCACC
GTGCCGGACGCGATGGGGTTAGGGCTCTATTTTGAAGCCGGAGAAGGTCCGCGTTTTACCTCGCCAGTCACCTGCAAAGC
CGACGTCGATAAACTGCCAATTCCGGACCCGGAAGATGAGCTGGGTTACGTGATGAACGCGGTGCGTACCATTCGTCGCG
AACTGAAAGGCGAAGTGCCGCTGATTGGTTTTTCCGGCAGCCCGTGGACGCTGGCGACCTACATGGTGGAAGGCGGCAGC
AGCAAAGCCTTCACCGTGATCAAAAAAATGATGTATGCCGATCCGCAGGCGCTGCACGCTCTGCTCGATAAACTGGCGAA
AAGCGTCACTTTGTATCTGAATGCGCAGATTAAAGCCGGTGCTCAGGCAGTGATGATTTTCGACACCTGGGGCGGCGTGC
TTACCGGGCGCGATTATCAACAGTTCTCGCTCTATTACATGCATAAAATTGTTGATGGTTTAGTGCGTGAAAACGACGGT
CGCCGCGTACCGGTCACGCTGTTTACCAAAGGCGGCGGACAGTGGCTGGAAGCCATGGCAGAAACCGGTTGCGATGCGCT
GGGCCTCGACTGGACAACGGACATCGCCGATGCGCGCCGCCGTGTGGGCAATAAAGTCGCGTTGCAGGGTAATATGGATC
CGTCGATGCTGTACGCGCCGCCTGCCCGCATTGAAGAAGAAGTAGCGACTATACTTGCAGGTTTCGGTCACGGCGAAGGT
CATGTCTTTAACCTTGGTCACGGCATTCATCAGGATGTGCCGCCAGAACATGCTGGCGTGTTCGTGGAGGCAGTGCATCG
ACTGTCTGAACAGTATCACCGCTAA

Upstream 100 bases:

>100_bases
CACCGTAGCGCGCCGTCTGATAGAAGATACGGTGGCGATGTGTCGGGCAGAGTATGAGTGATGATACACTGACCGCCTGA
CGCACTAAGGAACAGCCAAA

Downstream 100 bases:

>100_bases
GGAGTGATTATGGATCTCGCGTCATTACGCGCTCAACAAATCGAACTGGCTTCTTCTGTGATCCGCGAGGATCGACTCGA
TAAAGATCCACCGGATCTGA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILT
VPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLVRENDG
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPPARIEEEVATILAGFGHGEG
HVFNLGHGIHQDVPPEHAGVFVEAVHRLSEQYHR

Sequences:

>Translated_354_residues
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILT
VPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLVRENDG
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPPARIEEEVATILAGFGHGEG
HVFNLGHGIHQDVPPEHAGVFVEAVHRLSEQYHR
>Mature_353_residues
TELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILTV
PDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSS
KAFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLVRENDGR
RVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPPARIEEEVATILAGFGHGEGH
VFNLGHGIHQDVPPEHAGVFVEAVHRLSEQYHR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=353, Percent_Identity=48.1586402266289, Blast_Score=314, Evalue=6e-86,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=99.7175141242938, Blast_Score=732, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320252, Length=356, Percent_Identity=38.2022471910112, Blast_Score=261, Evalue=2e-70,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=42.6512968299712, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=42.6512968299712, Blast_Score=285, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39235; Mature: 39103

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCHHHHHHHCCCCEEEEEE
LQPLRRYPLDAAILFSDILTVPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDE
HHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCCHH
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHA
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLVRENDG
HHHHHHHHEEEEEEEEECCCCEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAP
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEECC
PARIEEEVATILAGFGHGEGHVFNLGHGIHQDVPPEHAGVFVEAVHRLSEQYHR
CHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCHHHHHHHCCCCEEEEEE
LQPLRRYPLDAAILFSDILTVPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDE
HHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCCHH
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHA
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLVRENDG
HHHHHHHHEEEEEEEEECCCCEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAP
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEECC
PARIEEEVATILAGFGHGEGHVFNLGHGIHQDVPPEHAGVFVEAVHRLSEQYHR
CHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA