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The map label for this gene is cytR

Identifier: 218697648

GI number: 218697648

Start: 4505185

End: 4506210

Strand: Reverse

Name: cytR

Synonym: EC55989_4412

Alternate gene names: 218697648

Gene position: 4506210-4505185 (Counterclockwise)

Preceding gene: 218697649

Following gene: 218697647

Centisome position: 87.42

GC content: 51.75

Gene sequence:

>1026_bases
GTGAAAGCGAAGAAGCAGGAAACTGCCGCGACCATGAAAGACGTTGCCCTCAAGGCAAAAGTCTCTACAGCGACTGTCTC
CCGAGCATTAATGAATCCCGATAAAGTCTCCCAGGCCACCCGTAATCGGGTTGAAAAAGCGGCCCGGGAAGTGGGTTATT
TACCGCAGCCTATGGGGCGCAACGTCAAGCGTAATGAATCCCGCACCATTCTGGTGATTGTCCCGGATATCTGCGATCCC
TTCTTTAGCGAAATTATTCGCGGTATCGAAGTTACGGCGGCAAATCACGGATATCTGGTGCTGATTGGCGACTGTGCGCA
TCAAAATCAGCAGGAAAAAACCTTTATCGATTTGATCATCACCAAGCAAATTGATGGCATGTTGCTGCTGGGTTCAAGGC
TGCCGTTTGATGCCAGCATTGAGGAACAGCGTAATCTGCCGCCGATGGTGATGGCGAACGAATTCGCACCGGAACTGGAG
CTACCTACAGTTCATATCGACAATCTGACCGCCGCATTTGATGCAGTAAATTATTTATATGAGCAAGGGCATAAACGGAT
TGGCTGTATAGCCGGTCCCGAAGAGATGCCACTGTGTCACTACCGCCTGCAAGGCTATGTTCAGGCGCTGCATCGCTGCG
GCATTATGGTTGATCCGCAATACATCGCCCGTGGCGACTTCACCTTCGAAGCCGGAAGCAAAGCGATGCAGCAGCTGCTT
GATCTTCCACAACCGCCTACTGCTGTCTTCTGCCATAGCGATGTGATGGCGCTCGGCGCACTTTCTCAGGCAAAACGCCA
GGGGCTGAAAGTCCCGGAAGACCTTTCCATAATCGGTTTTGATAACATCGACCTGACGCAATTTTGTGATCCGCCGCTGA
CAACCATCGCGCAGCCGCGTTACGAAATCGGTCGGGAAGCTATGCTGTTATTGCTTGATCAAATGCAGGGGCAACACGTT
GGCAGTGGCTCTCGTTTAATGGACTGCGAACTTATCATCCGGGGATCAACACGCGCGTTACCTTAA

Upstream 100 bases:

>100_bases
AAAATTCTGTAACCGTTTTCACGCGCTATCTGCTAAAAATGTTGCCGATGTGAAGTAAACATGGATGTAGTACGCCTGAC
GTGCCAGGCGAGGAGTGAGT

Downstream 100 bases:

>100_bases
AGTAAACCTTTAAGACTGCCGTGACTGGTCAAAGGCCCGCCGCTTAAGTAACATGGCGGGCTGACGAACGAATAAATACA
GCGAAACGATAGTGGCACAA

Product: DNA-binding transcriptional regulator CytR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKAKKQETAATMKDVALKAKVSTATVSRALMNPDKVSQATRNRVEKAAREVGYLPQPMGRNVKRNESRTILVIVPDICDP
FFSEIIRGIEVTAANHGYLVLIGDCAHQNQQEKTFIDLIITKQIDGMLLLGSRLPFDASIEEQRNLPPMVMANEFAPELE
LPTVHIDNLTAAFDAVNYLYEQGHKRIGCIAGPEEMPLCHYRLQGYVQALHRCGIMVDPQYIARGDFTFEAGSKAMQQLL
DLPQPPTAVFCHSDVMALGALSQAKRQGLKVPEDLSIIGFDNIDLTQFCDPPLTTIAQPRYEIGREAMLLLLDQMQGQHV
GSGSRLMDCELIIRGSTRALP

Sequences:

>Translated_341_residues
MKAKKQETAATMKDVALKAKVSTATVSRALMNPDKVSQATRNRVEKAAREVGYLPQPMGRNVKRNESRTILVIVPDICDP
FFSEIIRGIEVTAANHGYLVLIGDCAHQNQQEKTFIDLIITKQIDGMLLLGSRLPFDASIEEQRNLPPMVMANEFAPELE
LPTVHIDNLTAAFDAVNYLYEQGHKRIGCIAGPEEMPLCHYRLQGYVQALHRCGIMVDPQYIARGDFTFEAGSKAMQQLL
DLPQPPTAVFCHSDVMALGALSQAKRQGLKVPEDLSIIGFDNIDLTQFCDPPLTTIAQPRYEIGREAMLLLLDQMQGQHV
GSGSRLMDCELIIRGSTRALP
>Mature_341_residues
MKAKKQETAATMKDVALKAKVSTATVSRALMNPDKVSQATRNRVEKAAREVGYLPQPMGRNVKRNESRTILVIVPDICDP
FFSEIIRGIEVTAANHGYLVLIGDCAHQNQQEKTFIDLIITKQIDGMLLLGSRLPFDASIEEQRNLPPMVMANEFAPELE
LPTVHIDNLTAAFDAVNYLYEQGHKRIGCIAGPEEMPLCHYRLQGYVQALHRCGIMVDPQYIARGDFTFEAGSKAMQQLL
DLPQPPTAVFCHSDVMALGALSQAKRQGLKVPEDLSIIGFDNIDLTQFCDPPLTTIAQPRYEIGREAMLLLLDQMQGQHV
GSGSRLMDCELIIRGSTRALP

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=341, Percent_Identity=99.7067448680352, Blast_Score=703, Evalue=0.0,
Organism=Escherichia coli, GI1787948, Length=309, Percent_Identity=37.2168284789644, Blast_Score=217, Evalue=9e-58,
Organism=Escherichia coli, GI1790194, Length=309, Percent_Identity=35.5987055016181, Blast_Score=198, Evalue=3e-52,
Organism=Escherichia coli, GI1789202, Length=291, Percent_Identity=33.6769759450172, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1788474, Length=307, Percent_Identity=35.1791530944625, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1789068, Length=311, Percent_Identity=30.5466237942122, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI48994940, Length=323, Percent_Identity=29.4117647058824, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1787580, Length=316, Percent_Identity=27.5316455696203, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1790715, Length=313, Percent_Identity=27.1565495207668, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786540, Length=335, Percent_Identity=27.7611940298507, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787906, Length=316, Percent_Identity=26.2658227848101, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1789456, Length=340, Percent_Identity=27.0588235294118, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786268, Length=312, Percent_Identity=23.0769230769231, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790689, Length=315, Percent_Identity=25.0793650793651, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37801; Mature: 37801

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAKKQETAATMKDVALKAKVSTATVSRALMNPDKVSQATRNRVEKAAREVGYLPQPMGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NVKRNESRTILVIVPDICDPFFSEIIRGIEVTAANHGYLVLIGDCAHQNQQEKTFIDLII
CCCCCCCCEEEEEECCCCCHHHHHHHCCEEEEECCCCEEEEEECCCCCCCCHHHHEEEEE
TKQIDGMLLLGSRLPFDASIEEQRNLPPMVMANEFAPELELPTVHIDNLTAAFDAVNYLY
ECCCCCEEEECCCCCCCCCCHHHCCCCCEEEECCCCCCCCCCEEEECCHHHHHHHHHHHH
EQGHKRIGCIAGPEEMPLCHYRLQGYVQALHRCGIMVDPQYIARGDFTFEAGSKAMQQLL
HCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEECCHHHHCCCCEEHHHHHHHHHHH
DLPQPPTAVFCHSDVMALGALSQAKRQGLKVPEDLSIIGFDNIDLTQFCDPPLTTIAQPR
CCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCHHHHCCCH
YEIGREAMLLLLDQMQGQHVGSGSRLMDCELIIRGSTRALP
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCC
>Mature Secondary Structure
MKAKKQETAATMKDVALKAKVSTATVSRALMNPDKVSQATRNRVEKAAREVGYLPQPMGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NVKRNESRTILVIVPDICDPFFSEIIRGIEVTAANHGYLVLIGDCAHQNQQEKTFIDLII
CCCCCCCCEEEEEECCCCCHHHHHHHCCEEEEECCCCEEEEEECCCCCCCCHHHHEEEEE
TKQIDGMLLLGSRLPFDASIEEQRNLPPMVMANEFAPELELPTVHIDNLTAAFDAVNYLY
ECCCCCEEEECCCCCCCCCCHHHCCCCCEEEECCCCCCCCCCEEEECCHHHHHHHHHHHH
EQGHKRIGCIAGPEEMPLCHYRLQGYVQALHRCGIMVDPQYIARGDFTFEAGSKAMQQLL
HCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEECCHHHHCCCCEEHHHHHHHHHHH
DLPQPPTAVFCHSDVMALGALSQAKRQGLKVPEDLSIIGFDNIDLTQFCDPPLTTIAQPR
CCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCHHHHCCCH
YEIGREAMLLLLDQMQGQHVGSGSRLMDCELIIRGSTRALP
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]