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The map label for this gene is rtcR

Identifier: 218697104

GI number: 218697104

Start: 3893513

End: 3895111

Strand: Direct

Name: rtcR

Synonym: EC55989_3829

Alternate gene names: 218697104

Gene position: 3893513-3895111 (Clockwise)

Preceding gene: 218697101

Following gene: 218697108

Centisome position: 75.53

GC content: 55.91

Gene sequence:

>1599_bases
ATGCGTAAAACAGTGGCTTTTGGCTTTGTCGGTACCGTGCTGGATTATGCCGGACGCGGCAGTCAGCGCTGGTCGAAATG
GCGTCCGACGCTTTGTTTATGCCAGCAAGAATCGTTAGTCATCGATCGGCTGGAATTGTTGCACGACACCCGCTCGCGCT
CGCTATTCGAAACGCTTAAACGCGATATCGCCAGCGTTTCGCCAGAAACAGAAGTCGTGGGCGTTGAGATTGAACTGCAT
AACCCGTGGGATTTCGAAGAGGTTTACGCCTGCCTGCATGATTTCGCCCGTGGTTACGAGTTTCAGCCAGAAAAAGAAGA
CTATTTAATTCACATCACCACCGGCACCCACGTCGCGCAGATTTGCTGGTTTCTGCTGGCGGAAGCGCGTTACCTGCCCG
CCCGGCTGATACAATCTTCACCTCCGCGCAAAAAAGAACAGCCGCGCGGCGCAGGTGAAGTGACGATTATCGATCTCGAT
TTAAGCCGTTATAACGCCATCGCCAGCCGCTTTGCCGAGGAACGCCAGCAAACGCTTGATTTTCTTAAGTCCGGCATTGC
CACGCGTAACCCCCACTTCAACCGCATGATTGAGCAGATCGAAAAAGTGGCGATCAAATCCCGCGCGCCGATTCTGCTTA
ACGGTCCAACCGGCGCGGGCAAGTCATTTCTGGCGCGACGCATCTTCGAGTTAAAACAGGCGCGGCATCAGTTTAGCGGC
GCGTTTGTGGAAGTGAACTGCGCCACCCTGCGCGGCGATACCGCCATGTCGACGCTGTTTGGTCATGTAAAAGGCGCGTT
TACCGGGGCGCGGGAATCTCGTGAAGGTTTATTACGCAGCGCCAACGGCGGAATGTTGTTTCTTGATGAGATTGGCGAAC
TGGGCGCAGACGAACAGGCAATGCTGCTAAAAGCCATTGAAGAGAAAACCTTTTACCCGTTTGGCAGCGATCGCCAGGTG
AGCAGTGATTTTCAGCTTATCGCCGGAACGGTGCGCGATTTGCGCCAGCTGGTTGCCGAAGGCAAATTTCGCGAAGATCT
GTACGCGCGGATCAATCTCTGGACCTTCACCCTGCCGGGTCTACGCCAGCGCCAGGAAGATATTGAACCGAACCTTGATT
ATGAAGTGGAGCGCCACGCCACACTCACTGGCGACAGCGTGCGTTTTAACACCGAAGCGCGGCGCGCCTGGTTGGCTTTT
GCGACCTCTCCCCAGGCAACATGGCGCGGTAACTTTCGCGAACTTTCTGCCAGCGTCACGCGGATGGCCACCTTTGCCAC
TAGCGGACGCATCACTCTGGACGTGGTTGAAGATGAGATAAACCGTCTGCGCTATAACTGGCAGGAGAGCCGCCCCTCCG
CGCTTACGGCGTTGCTGGGCGCAGAGGCAGAAAACATCGACCTTTTTGACAGGCTGCAACTGGAACACGTGATAGCTCTC
TGTCGCCAGGCAAAGTCGCTTTCCGCTGCCGGACGCCTGCTTTTTGATGTTTCGCGCCAGGGCAAAGCCAGCGTCAATGA
CGCGGATCGGCTACGCAAATACCTGGCGCGTTTTGGTCTGACGTGGGAAGCCGTGCAGGATCAGCACAGCTCCAGTTGA

Upstream 100 bases:

>100_bases
TTGTTTTAAAAAAGATTATATCTTTACGTCCGTAAACGGAGATTTTCCACAAAACCAATTCACCGATAATGAAATATCGT
CTTTTATAAGGATATCTAAG

Downstream 100 bases:

>100_bases
ATATGATGGTCCGTCAGCACCTGCATTACGCTTACTGGCGGCGGGGCGTCGGTGTAGACGGCATCTACCATGCTGATGCT
GCCCATATTGACCATCGCGT

Product: sigma 54-dependent transcriptional regulator of rtcBA expression

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MRKTVAFGFVGTVLDYAGRGSQRWSKWRPTLCLCQQESLVIDRLELLHDTRSRSLFETLKRDIASVSPETEVVGVEIELH
NPWDFEEVYACLHDFARGYEFQPEKEDYLIHITTGTHVAQICWFLLAEARYLPARLIQSSPPRKKEQPRGAGEVTIIDLD
LSRYNAIASRFAEERQQTLDFLKSGIATRNPHFNRMIEQIEKVAIKSRAPILLNGPTGAGKSFLARRIFELKQARHQFSG
AFVEVNCATLRGDTAMSTLFGHVKGAFTGARESREGLLRSANGGMLFLDEIGELGADEQAMLLKAIEEKTFYPFGSDRQV
SSDFQLIAGTVRDLRQLVAEGKFREDLYARINLWTFTLPGLRQRQEDIEPNLDYEVERHATLTGDSVRFNTEARRAWLAF
ATSPQATWRGNFRELSASVTRMATFATSGRITLDVVEDEINRLRYNWQESRPSALTALLGAEAENIDLFDRLQLEHVIAL
CRQAKSLSAAGRLLFDVSRQGKASVNDADRLRKYLARFGLTWEAVQDQHSSS

Sequences:

>Translated_532_residues
MRKTVAFGFVGTVLDYAGRGSQRWSKWRPTLCLCQQESLVIDRLELLHDTRSRSLFETLKRDIASVSPETEVVGVEIELH
NPWDFEEVYACLHDFARGYEFQPEKEDYLIHITTGTHVAQICWFLLAEARYLPARLIQSSPPRKKEQPRGAGEVTIIDLD
LSRYNAIASRFAEERQQTLDFLKSGIATRNPHFNRMIEQIEKVAIKSRAPILLNGPTGAGKSFLARRIFELKQARHQFSG
AFVEVNCATLRGDTAMSTLFGHVKGAFTGARESREGLLRSANGGMLFLDEIGELGADEQAMLLKAIEEKTFYPFGSDRQV
SSDFQLIAGTVRDLRQLVAEGKFREDLYARINLWTFTLPGLRQRQEDIEPNLDYEVERHATLTGDSVRFNTEARRAWLAF
ATSPQATWRGNFRELSASVTRMATFATSGRITLDVVEDEINRLRYNWQESRPSALTALLGAEAENIDLFDRLQLEHVIAL
CRQAKSLSAAGRLLFDVSRQGKASVNDADRLRKYLARFGLTWEAVQDQHSSS
>Mature_532_residues
MRKTVAFGFVGTVLDYAGRGSQRWSKWRPTLCLCQQESLVIDRLELLHDTRSRSLFETLKRDIASVSPETEVVGVEIELH
NPWDFEEVYACLHDFARGYEFQPEKEDYLIHITTGTHVAQICWFLLAEARYLPARLIQSSPPRKKEQPRGAGEVTIIDLD
LSRYNAIASRFAEERQQTLDFLKSGIATRNPHFNRMIEQIEKVAIKSRAPILLNGPTGAGKSFLARRIFELKQARHQFSG
AFVEVNCATLRGDTAMSTLFGHVKGAFTGARESREGLLRSANGGMLFLDEIGELGADEQAMLLKAIEEKTFYPFGSDRQV
SSDFQLIAGTVRDLRQLVAEGKFREDLYARINLWTFTLPGLRQRQEDIEPNLDYEVERHATLTGDSVRFNTEARRAWLAF
ATSPQATWRGNFRELSASVTRMATFATSGRITLDVVEDEINRLRYNWQESRPSALTALLGAEAENIDLFDRLQLEHVIAL
CRQAKSLSAAGRLLFDVSRQGKASVNDADRLRKYLARFGLTWEAVQDQHSSS

Specific function: Transcriptional repressor of the rtcAB genes. Interacts with sigma-54 [H]

COG id: COG4650

COG function: function code KT; Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1789828, Length=532, Percent_Identity=98.4962406015038, Blast_Score=1079, Evalue=0.0,
Organism=Escherichia coli, GI1788905, Length=275, Percent_Identity=36, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1788550, Length=252, Percent_Identity=38.0952380952381, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1790437, Length=256, Percent_Identity=39.453125, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1789233, Length=256, Percent_Identity=35.9375, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI87082117, Length=237, Percent_Identity=37.5527426160338, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1789087, Length=287, Percent_Identity=34.4947735191638, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1787583, Length=244, Percent_Identity=36.0655737704918, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87082152, Length=247, Percent_Identity=36.4372469635627, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1790299, Length=241, Percent_Identity=35.6846473029046, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786524, Length=239, Percent_Identity=35.5648535564854, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87081872, Length=254, Percent_Identity=33.0708661417323, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87081858, Length=242, Percent_Identity=29.7520661157025, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR002078
- InterPro:   IPR009715
- InterPro:   IPR017183 [H]

Pfam domain/function: PF06956 RtcR; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 60289; Mature: 60289

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTVAFGFVGTVLDYAGRGSQRWSKWRPTLCLCQQESLVIDRLELLHDTRSRSLFETLK
CCCEEEHHHHHHHHHHCCCCCCHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
RDIASVSPETEVVGVEIELHNPWDFEEVYACLHDFARGYEFQPEKEDYLIHITTGTHVAQ
HHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHH
ICWFLLAEARYLPARLIQSSPPRKKEQPRGAGEVTIIDLDLSRYNAIASRFAEERQQTLD
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
FLKSGIATRNPHFNRMIEQIEKVAIKSRAPILLNGPTGAGKSFLARRIFELKQARHQFSG
HHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
AFVEVNCATLRGDTAMSTLFGHVKGAFTGARESREGLLRSANGGMLFLDEIGELGADEQA
CEEEEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEHHHCCCCCHHH
MLLKAIEEKTFYPFGSDRQVSSDFQLIAGTVRDLRQLVAEGKFREDLYARINLWTFTLPG
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEEEEECCC
LRQRQEDIEPNLDYEVERHATLTGDSVRFNTEARRAWLAFATSPQATWRGNFRELSASVT
HHHHHHCCCCCCCCEECCCEEECCCCEEECHHHHHEEEEEECCCCCHHCCCHHHHHHHHH
RMATFATSGRITLDVVEDEINRLRYNWQESRPSALTALLGAEAENIDLFDRLQLEHVIAL
HHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
CRQAKSLSAAGRLLFDVSRQGKASVNDADRLRKYLARFGLTWEAVQDQHSSS
HHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCC
>Mature Secondary Structure
MRKTVAFGFVGTVLDYAGRGSQRWSKWRPTLCLCQQESLVIDRLELLHDTRSRSLFETLK
CCCEEEHHHHHHHHHHCCCCCCHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
RDIASVSPETEVVGVEIELHNPWDFEEVYACLHDFARGYEFQPEKEDYLIHITTGTHVAQ
HHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHH
ICWFLLAEARYLPARLIQSSPPRKKEQPRGAGEVTIIDLDLSRYNAIASRFAEERQQTLD
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
FLKSGIATRNPHFNRMIEQIEKVAIKSRAPILLNGPTGAGKSFLARRIFELKQARHQFSG
HHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
AFVEVNCATLRGDTAMSTLFGHVKGAFTGARESREGLLRSANGGMLFLDEIGELGADEQA
CEEEEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEHHHCCCCCHHH
MLLKAIEEKTFYPFGSDRQVSSDFQLIAGTVRDLRQLVAEGKFREDLYARINLWTFTLPG
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEEEEECCC
LRQRQEDIEPNLDYEVERHATLTGDSVRFNTEARRAWLAFATSPQATWRGNFRELSASVT
HHHHHHCCCCCCCCEECCCEEECCCCEEECHHHHHEEEEEECCCCCHHCCCHHHHHHHHH
RMATFATSGRITLDVVEDEINRLRYNWQESRPSALTALLGAEAENIDLFDRLQLEHVIAL
HHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
CRQAKSLSAAGRLLFDVSRQGKASVNDADRLRKYLARFGLTWEAVQDQHSSS
HHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 3045764; 7984428; 7920643; 9738023 [H]