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The map label for this gene is mreD

Identifier: 218696947

GI number: 218696947

Start: 3748016

End: 3748504

Strand: Reverse

Name: mreD

Synonym: EC55989_3661

Alternate gene names: 218696947

Gene position: 3748504-3748016 (Counterclockwise)

Preceding gene: 218696948

Following gene: 218696946

Centisome position: 72.72

GC content: 50.92

Gene sequence:

>489_bases
GTGGCGAGCTATCGTAGCCAGGGACGTTGGGTAATCTGGCTCTCTTTCCTCATTGCGCTGTTGCTGCAAATCATGCCCTG
GCCGGATAACCTGATTGTTTTCCGGCCAAACTGGGTGTTACTCATCTTGTTGTATTGGATCCTGGCCTTGCCTCATCGCG
TAAATGTGGGCACAGGTTTTGTGATGGGTGCCATACTGGATCTGATCAGCGGCTCGACGCTTGGCGTACGCGTATTGGCG
ATGAGCATCATTGCTTACCTGGTGGCGCTGAAATACCAGCTTTTCCGCAACCTCGCATTATGGCAGCAGGCGCTGGTCGT
CATGTTGCTTTCGCTGGTGGTGGATATTATTGTTTTCTGGGCAGAGTTTTTAGTGATTAACGTCTCTTTCAGACCGGAAG
TGTTCTGGAGTAGTGTAGTCAATGGGGTGCTCTGGCCGTGGATTTTCTTGCTGATGCGTAAAGTCCGTCAGCAGTTTGCA
GTGCAATAA

Upstream 100 bases:

>100_bases
CTGCTGCGCCCACACAGCCTGCTGCTAATCGCTCTCCACAAAGGGCTACGCCGCCGCAAAGTGGTGCTCAACCGCCTGCG
CGTGCGCCGGGAGGGCAATA

Downstream 100 bases:

>100_bases
AGGTTTCTATGACTTCTCTGTATTTAGCTTCCGGTTCTCCGCGTCGTCAGGAGTTACTTGCGCAACTTGGCGTGACCTTT
GAACGTATTGTTACGGGCAT

Product: rod shape-determining protein MreD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MASYRSQGRWVIWLSFLIALLLQIMPWPDNLIVFRPNWVLLILLYWILALPHRVNVGTGFVMGAILDLISGSTLGVRVLA
MSIIAYLVALKYQLFRNLALWQQALVVMLLSLVVDIIVFWAEFLVINVSFRPEVFWSSVVNGVLWPWIFLLMRKVRQQFA
VQ

Sequences:

>Translated_162_residues
MASYRSQGRWVIWLSFLIALLLQIMPWPDNLIVFRPNWVLLILLYWILALPHRVNVGTGFVMGAILDLISGSTLGVRVLA
MSIIAYLVALKYQLFRNLALWQQALVVMLLSLVVDIIVFWAEFLVINVSFRPEVFWSSVVNGVLWPWIFLLMRKVRQQFA
VQ
>Mature_161_residues
ASYRSQGRWVIWLSFLIALLLQIMPWPDNLIVFRPNWVLLILLYWILALPHRVNVGTGFVMGAILDLISGSTLGVRVLAM
SIIAYLVALKYQLFRNLALWQQALVVMLLSLVVDIIVFWAEFLVINVSFRPEVFWSSVVNGVLWPWIFLLMRKVRQQFAV
Q

Specific function: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins

COG id: COG2891

COG function: function code M; Cell shape-determining protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mreD family

Homologues:

Organism=Escherichia coli, GI1789647, Length=162, Percent_Identity=100, Blast_Score=310, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRED_ECO57 (P0ABH6)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A91144
- PIR:   D85989
- RefSeq:   NP_289816.1
- RefSeq:   NP_312148.1
- ProteinModelPortal:   P0ABH6
- EnsemblBacteria:   EBESCT00000025357
- EnsemblBacteria:   EBESCT00000057221
- GeneID:   916032
- GeneID:   958683
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4607
- KEGG:   ecs:ECs4121
- GeneTree:   EBGT00050000010670
- HOGENOM:   HBG701138
- OMA:   WIIWLSF
- ProtClustDB:   PRK11060
- BioCyc:   ECOL83334:ECS4121-MONOMER
- InterPro:   IPR007227
- TIGRFAMs:   TIGR03426

Pfam domain/function: PF04093 MreD

EC number: NA

Molecular weight: Translated: 18788; Mature: 18657

Theoretical pI: Translated: 10.98; Mature: 10.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ad37cd0)-; HASH(0x1c8ef458)-; HASH(0x1ca8c368)-; HASH(0x1a9333d8)-; HASH(0x1c9b8c50)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASYRSQGRWVIWLSFLIALLLQIMPWPDNLIVFRPNWVLLILLYWILALPHRVNVGTGF
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCHHH
VMGAILDLISGSTLGVRVLAMSIIAYLVALKYQLFRNLALWQQALVVMLLSLVVDIIVFW
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEFLVINVSFRPEVFWSSVVNGVLWPWIFLLMRKVRQQFAVQ
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
ASYRSQGRWVIWLSFLIALLLQIMPWPDNLIVFRPNWVLLILLYWILALPHRVNVGTGF
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCHHH
VMGAILDLISGSTLGVRVLAMSIIAYLVALKYQLFRNLALWQQALVVMLLSLVVDIIVFW
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEFLVINVSFRPEVFWSSVVNGVLWPWIFLLMRKVRQQFAVQ
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796