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The map label for this gene is gabP

Identifier: 218696260

GI number: 218696260

Start: 3004942

End: 3006342

Strand: Direct

Name: gabP

Synonym: EC55989_2931

Alternate gene names: 218696260

Gene position: 3004942-3006342 (Clockwise)

Preceding gene: 218696259

Following gene: 218696261

Centisome position: 58.29

GC content: 51.39

Gene sequence:

>1401_bases
ATGGGGCAATCATCGCAACCACATGAGTTAGGCGGCGGGCTGAAGTCACGCCACGTCACCATGTTGTCTATTGCCGGTGT
TATCGGCGCAAGTCTGTTTGTCGGTTCCAGCGTCGCCATCGCCGAAGCGGGCCCGGCGGTATTACTGGCCTATCTGTTCG
CCGGATTACTGGTGGTTATGATTATGCGAATGCTGGCGGAAATGGCGGTTGCCACGCCCGATACCGGTTCGTTTTCCACC
TATGCCGATAAAGCCATTGGCCGCTGGGCGGGTTATACCATCGGCTGGCTGTACTGGTGGTTTTGGGTACTGGTTATCCC
GCTGGAAGCCAACATCGCCGCTATGATCCTGCACTCGTGGGTTCCAGGCATTCCCATCTGGTTATTTTCCCTCGTCATTA
CCCTCGCCTTAACTGGCAGTAATTTATTAAGCGTTAAAAACTACGGCGAATTTGAGTTCTGGCTGGCGCTGTGCAAAGTC
ATCGCTATCCTGGCCTTTATTTTCCTTGGTGCAGTCGCAATTAGCGGTTTTTACCCTTATGCCGAAGTGAGCGGGATCTC
AAGATTGTGGGATAGCGGCGGCTTTATGCCCAACGGCTTCGGTGCGGTATTAAGCGCGATGTTGATCACCATGTTCTCGT
TTATGGGCGCAGAAATTGTCACCATTGCCGCCGCGGAATCCGACACGCCGGAAAAACATATTGTCCGCGCTACCAACTCG
GTTATCTGGCGTATTTCTATCTTCTATTTGTGCTCTATTTTTGTCGTAGTGGCGTTAATACCGTGGAATATGCCGGGGCT
GAAAGCCGTTGGTTCTTATCGCTCGGTTCTGGAATTGCTCAATATTCCCCATGCGAAATTAATCATGGACTGCGTGATAT
TACTTTCCGTAACCAGCTGTCTGAACTCGGCGCTGTATACCGCGTCAAGGATGCTCTACTCCTTAAGCCGTCGCGGTGAT
GCGCCCGCGCTAATGGGCAAAATCAACCGCAGTAAAACCCCGTATGTGGCGGTGTTACTCTCCACCGGAGCGGCATTTTT
AACGGTGGTGGTGAACTATTACGCACCTGCGAAAGTGTTTAAATTCCTGATAGACAGCTCCGGCGCTATCGCCCTGCTGG
TTTATTTAGTCATCGCCGTTTCACAGTTGCGGATGCGCAAAATTCTGCGAGCAGAAGGAAGCGAAATTCGCTTGCGCATG
TGGCTTTATCCCTGGCTCACCTGGCTGGTCATCGGCTTTATTACCTTTGTGTTGGTAGTGATGCTATTCCGTCCGGCGCA
ACAGTTAGAAGTGATCTCCACCGGCTTATTAGCGATAGGGATTATCTGTACCGTGCCAATTATGGCTCGCTGGAAAAAGC
TGGTATTGTGGCAAAAAACACCCGTTCATAATACGCGCTGA

Upstream 100 bases:

>100_bases
CGTTTTTAAGATTTTGTTGACCGTCTCAATTAAACGCGTGACCCGACGCGGGAAATGTCGGGGCGCTCTCCCAAGTGACA
CACTTTCGAGAGGATTCAGG

Downstream 100 bases:

>100_bases
TAATGATCAGGAGTCACACCATGACCATTACGTCTCTGGATGGCTATCGCTGGCTGAAGAACGATATTATTCGCGGTAAT
TTTCAACCGGATGAAAAATT

Product: gamma-aminobutyrate transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MGQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFST
YADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSWVPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKV
IAILAFIFLGAVAISGFYPYAEVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNS
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSCLNSALYTASRMLYSLSRRGD
APALMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRM
WLYPWLTWLVIGFITFVLVVMLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR

Sequences:

>Translated_466_residues
MGQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFST
YADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSWVPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKV
IAILAFIFLGAVAISGFYPYAEVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNS
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSCLNSALYTASRMLYSLSRRGD
APALMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRM
WLYPWLTWLVIGFITFVLVVMLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR
>Mature_465_residues
GQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFSTY
ADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSWVPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVI
AILAFIFLGAVAISGFYPYAEVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNSV
IWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSCLNSALYTASRMLYSLSRRGDA
PALMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRMW
LYPWLTWLVIGFITFVLVVMLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=466, Percent_Identity=99.7854077253219, Blast_Score=928, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=433, Percent_Identity=36.7205542725173, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1786789, Length=431, Percent_Identity=36.8909512761021, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI48994972, Length=464, Percent_Identity=32.9741379310345, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87081708, Length=438, Percent_Identity=35.3881278538813, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1788480, Length=392, Percent_Identity=34.1836734693878, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=33.3333333333333, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1786602, Length=431, Percent_Identity=33.4106728538283, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1790653, Length=447, Percent_Identity=29.9776286353468, Blast_Score=224, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI17532491, Length=364, Percent_Identity=22.5274725274725, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=443, Percent_Identity=30.4740406320542, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324061, Length=443, Percent_Identity=29.5711060948081, Blast_Score=199, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6324059, Length=439, Percent_Identity=29.6127562642369, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=389, Percent_Identity=32.133676092545, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324924, Length=464, Percent_Identity=28.6637931034483, Blast_Score=176, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6324990, Length=421, Percent_Identity=30.8788598574822, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322892, Length=410, Percent_Identity=30.7317073170732, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320717, Length=413, Percent_Identity=29.0556900726392, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6321053, Length=401, Percent_Identity=27.6807980049875, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6319824, Length=408, Percent_Identity=28.1862745098039, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6319543, Length=440, Percent_Identity=26.3636363636364, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321629, Length=400, Percent_Identity=27.5, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320251, Length=408, Percent_Identity=28.4313725490196, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319542, Length=404, Percent_Identity=27.7227722772277, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=404, Percent_Identity=26.2376237623762, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6324981, Length=405, Percent_Identity=29.6296296296296, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=437, Percent_Identity=26.0869565217391, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=480, Percent_Identity=23.125, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24667468, Length=406, Percent_Identity=23.1527093596059, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51095; Mature: 50964

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVM
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
IMRMLAEMAVATPDTGSFSTYADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSW
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIFLGAVAISGFYPY
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AEVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSC
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LNSALYTASRMLYSLSRRGDAPALMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVF
HHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEHHCCHHHHHHHHHHCCHHHHH
KFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRMWLYPWLTWLVIGFITFVLVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
MLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
GQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVM
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
IMRMLAEMAVATPDTGSFSTYADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSW
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIFLGAVAISGFYPY
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AEVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSC
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LNSALYTASRMLYSLSRRGDAPALMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVF
HHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEHHCCHHHHHHHHHHCCHHHHH
KFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRMWLYPWLTWLVIGFITFVLVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
MLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]