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The map label for this gene is cbl

Identifier: 218695597

GI number: 218695597

Start: 2274629

End: 2275579

Strand: Reverse

Name: cbl

Synonym: EC55989_2222

Alternate gene names: 218695597

Gene position: 2275579-2274629 (Counterclockwise)

Preceding gene: 218695598

Following gene: 218695596

Centisome position: 44.14

GC content: 47.63

Gene sequence:

>951_bases
GTGAATTTCCAACAACTAAAGATAATCCGCGAGGCTGCACGTCAGGATTACAACCTGACAGAGGTTGCGAATATGCTTTT
TACCTCACAGTCCGGCGTCAGCCGTCATATTCGGGAACTGGAGGATGAACTTGGCATCGAAATATTTGTTCGACGAGGTA
AGCGACTGCTGGGCATGACTGAACCGGGCAAAGCATTACTGGTCATTGCAGAACGTATTCTGAATGAAGCCAGTAATGTT
CGTCGGCTTGCAGACCTGTTTACCAACGATACGTCTGGCGTTCTCACTATTGCAACGACGCATACTCAGGCACGTTATAG
TTTGCCAGAGGTCATTAAATCTTTTCGCGAACTTTTCCCGGAGGTTCGGCTCGAGCTAATCCAGGGGACGCCACAGGAAA
TTGCGACGTTGTTGCATAATGGTGAAGCTGATATTGGTATCGCCAGCGAGCGTTTGAGTAATGACCCGCAGCTCGTCGCC
TTCCCGTGGTTTCGTTGGCACCATAGTTTGCTTGTTCCACTCGATCATCCCTTGACGCAAATTACACCATTGACGCTGGA
ATCAATAGCGAAGTGGCCGTTAATCACTTACCGACAGGGGATTACGGGGCGCTCACGTATTGATGACGCATTTGCCCGCA
AAGGTTTGCTGGCAGATATTGTATTAAGTGCGCAGGATTCTGATGTCATTAAAACCTATGTTGCTCTTGGGCTTGGGATC
GGAATAGTTGCCGAACAATCCAGCGGTGAACAAGAGGAAAAGAATTTAATCCGCCTGGATACGCGGCATATTTTTGATGC
TAATACTGTCTGGTTGGGACTGAAGCGAGGACAACTTCAGCGTAACTATGTCTGGCGCTTTCTGGAACTTTGTAATGCAG
GACTTTCAGTTGAGGATATCAAGCGGCAGGTGATGGAAAACAGTGAAGAGGAAATTGATTATCAGATATAG

Upstream 100 bases:

>100_bases
CGTTATATCGGGATGGAATAAGATGCGGGTTTTTATTATTTGTTATGCCGGGCATTAGACTTTAACAATAACGGAAAATC
TGAACTGCCCGGAGTTTACC

Downstream 100 bases:

>100_bases
CAAAAAGCCCGCTATAAAAGCGGGCTTTTCAGAAATTTGGCTCCTCTGACTGGACTCGAACCAGTGACATACGGATTAAC
AGTCCGCCGTTCTACCGACT

Product: transcriptional regulator Cbl

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTSGVLTIATTHTQARYSLPEVIKSFRELFPEVRLELIQGTPQEIATLLHNGEADIGIASERLSNDPQLVA
FPWFRWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
GIVAEQSSGEQEEKNLIRLDTRHIFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI

Sequences:

>Translated_316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTSGVLTIATTHTQARYSLPEVIKSFRELFPEVRLELIQGTPQEIATLLHNGEADIGIASERLSNDPQLVA
FPWFRWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
GIVAEQSSGEQEEKNLIRLDTRHIFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI
>Mature_316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTSGVLTIATTHTQARYSLPEVIKSFRELFPEVRLELIQGTPQEIATLLHNGEADIGIASERLSNDPQLVA
FPWFRWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
GIVAEQSSGEQEEKNLIRLDTRHIFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=316, Percent_Identity=97.4683544303797, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1787530, Length=313, Percent_Identity=41.5335463258786, Blast_Score=257, Evalue=7e-70,
Organism=Escherichia coli, GI1788481, Length=295, Percent_Identity=27.1186440677966, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI157672245, Length=207, Percent_Identity=28.9855072463768, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788887, Length=235, Percent_Identity=27.6595744680851, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790208, Length=249, Percent_Identity=28.1124497991968, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI2367136, Length=245, Percent_Identity=24.0816326530612, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI145693105, Length=232, Percent_Identity=25, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=24.2798353909465, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082132, Length=134, Percent_Identity=35.0746268656716, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081904, Length=208, Percent_Identity=29.3269230769231, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35898; Mature: 35898

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCHHCCCC
EPGKALLVIAERILNEASNVRRLADLFTNDTSGVLTIATTHTQARYSLPEVIKSFRELFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHCCHHHHHHHHHHHHH
EVRLELIQGTPQEIATLLHNGEADIGIASERLSNDPQLVAFPWFRWHHSLLVPLDHPLTQ
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEECHHHHCCCEEEECCCCHHH
ITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
CCCHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCC
GIVAEQSSGEQEEKNLIRLDTRHIFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDI
CEEEECCCCCHHHHHHEEEHHHHEECCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
KRQVMENSEEEIDYQI
HHHHHCCCHHHCCCCC
>Mature Secondary Structure
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCHHCCCC
EPGKALLVIAERILNEASNVRRLADLFTNDTSGVLTIATTHTQARYSLPEVIKSFRELFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHCCHHHHHHHHHHHHH
EVRLELIQGTPQEIATLLHNGEADIGIASERLSNDPQLVAFPWFRWHHSLLVPLDHPLTQ
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEECHHHHCCCEEEECCCCHHH
ITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
CCCHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCC
GIVAEQSSGEQEEKNLIRLDTRHIFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDI
CEEEECCCCCHHHHHHEEEHHHHEECCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
KRQVMENSEEEIDYQI
HHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]