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The map label for this gene is adrB

Identifier: 218695377

GI number: 218695377

Start: 2048834

End: 2050432

Strand: Direct

Name: adrB

Synonym: EC55989_1988

Alternate gene names: 218695377

Gene position: 2048834-2050432 (Clockwise)

Preceding gene: 218695376

Following gene: 218695379

Centisome position: 39.75

GC content: 50.53

Gene sequence:

>1599_bases
ATGCAAAAAGCACAACGGATCATTAAAACCTATCGCCGTAATCGAATGATTGTTTGTACGATTTGCGCACTCGTTACGCT
CGCTTCGACCCTGAGCGTGCGATTTATTTCACAGCGTAACTTAAATCAACAACGGGTAGTACAATTCGCCAATCACGCTG
TAGAGGAATTAGATAAAGTACTGCTTCCCCTACAGGCAGGTAGCGAAGTCTTGCTTCCGCTGATTGGTCTGCCCTGCTCT
GTCGCCCATTTGCCATTACGTAAACAGGCGGCAAAACTCCAAACTGTGCGATCCATTGGCCTGGTGCAAGACGGCACACT
CTATTGCTCCAGCATTTTTGGTTATCGCAATGTGCCCGTCGTGGACATTCTGGCTGAACTTCCTGCACCGCAACCACTTT
TACGCCTGACGATCGACCGTGCCCTGATTAAAGGCAGTCCGGTTTTGATTCAATGGACGCCTGCAGCGGGCAGTAGCAAT
GCTGGGGTCATGGAGATGATTAACATCGACTTACTGACGGCAATGCTCCTTGAGCCACAACTGCCGCAAATCAGTAGCGC
CAGCCTGACGGTGGACAAACGGCATTTGCTCTATGGTAATGGGCTGGTAGATTCCCTTCCGCAACCTGAAGACAATGAAA
ACTATCAGGTTTCTTCGCAACGCTTTCCTTTTACCATTAACGTTAATGGTCCGGGGGCTACGGCGCTGGCATGGCACTAT
CTTCCAACACAATTACCGCTGGCGGTGCTGCTAAGTTTACTGGTGGGCTACATCGCCTGGCTGGCGACCGCTTACCGGAT
GAGCTTTTCCCGCGAAATCAATCTGGGCCTGGCGCAACATGAGTTCGAATTGTTCTGTCAGCCTTTGCTTAATGCGCGCA
GCCAGCAATGTATTGGTGTAGAGATTTTGCTGCGCTGGAACAATCCGCGTCAGGGCTGGATTTCACCGGATGTGTTTATT
CCTATCGCGGAAGAACATCATTTAATTGTGCCACTGACCCGCTATGTGATGGCAGAAACCATTCGTCAGCGCCATGTTTT
CCCGATGAGTAGTCAGTTTCATGTTGGCATTAACGTCGCACCCAGCCATTTTCGCCGTGGTGTGCTGATAAAAGATCTCA
ATCAGTACTGGTTTAGCGCTCACCCGATTCAGCAACTGATCCTCGAAATCACCGAACGCGATGCCTTACTGGATGTTGAT
TATCGGATTGCCCGCGAGCTACATCGTAAAAACGTCAAACTGGCGATTGATGACTTCGGCACCGGCAACAGTTCATTTTC
CTGGCTTGAAACATTACGTCCTGACGTGCTGAAAATTGATAAGTCATTTACCGCAGCTATAGGTTCTGACGCGGTTAACT
CGACGGTGACCGATATCATCATCGCGCTGGGGCAAAGACTGAATATTGAACTGGTGGCGGAGGGCGTGGAAACGCAAGAA
CAGGCGAAGTATTTGCGCCGTCATGGCGTGCATATTTTGCAAGGGTATTTGTACGCACAGCCGATGCCGCTACGTGATTT
TCCCAAATGGCTGGCGGGCAGCCAACCGCCGCCCGCCCGGCATAATGGACATATCACGCCCATTATGCCGTTACGTTAA

Upstream 100 bases:

>100_bases
GGCGAATTTATACCCGCTTTCTCGTCTGCTGTAATATTCCCCACTACACTTCCACTGTTGCGTCAGGCGTTTGTCGCCAT
ACGCTTACAGGGTGGCCCGC

Downstream 100 bases:

>100_bases
TGCTTACTCATCTTCATCGTGCGCCGGTTGCTCTTTAACAATGCGAACCAGATCAACACGATAATCATTGGCTTCAATGA
TGGTGATATGCAGTGGCCCT

Product: putative cyclic di-GMP phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCS
VAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSN
AGVMEMINIDLLTAMLLEPQLPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQRFPFTINVNGPGATALAWHY
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFI
PIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVD
YRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
QAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR

Sequences:

>Translated_532_residues
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCS
VAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSN
AGVMEMINIDLLTAMLLEPQLPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQRFPFTINVNGPGATALAWHY
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFI
PIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVD
YRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
QAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR
>Mature_532_residues
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCS
VAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSN
AGVMEMINIDLLTAMLLEPQLPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQRFPFTINVNGPGATALAWHY
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFI
PIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVD
YRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
QAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR

Specific function: May serve as a negative regulator of cellulose synthesis (as has been suggested for S.typhimurium); over-expression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surfa

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain

Homologues:

Organism=Escherichia coli, GI87081980, Length=532, Percent_Identity=100, Blast_Score=1089, Evalue=0.0,
Organism=Escherichia coli, GI1788502, Length=520, Percent_Identity=28.8461538461538, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI87081845, Length=531, Percent_Identity=28.060263653484, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1786507, Length=247, Percent_Identity=39.2712550607287, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI1790496, Length=259, Percent_Identity=35.1351351351351, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081921, Length=261, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI87081743, Length=327, Percent_Identity=31.1926605504587, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI226510982, Length=262, Percent_Identity=31.6793893129771, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787541, Length=259, Percent_Identity=30.5019305019305, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788849, Length=239, Percent_Identity=31.3807531380753, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87082096, Length=242, Percent_Identity=29.7520661157025, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1787055, Length=254, Percent_Identity=30.3149606299213, Blast_Score=102, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADRB_ECOLI (P76261)

Other databases:

- EMBL:   U00096
- EMBL:   AP009048
- PIR:   G64942
- RefSeq:   AP_002434.1
- RefSeq:   NP_416329.4
- ProteinModelPortal:   P76261
- SMR:   P76261
- IntAct:   P76261
- STRING:   P76261
- EnsemblBacteria:   EBESCT00000001313
- EnsemblBacteria:   EBESCT00000018063
- GeneID:   946336
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW1804
- KEGG:   eco:b1815
- EchoBASE:   EB3289
- EcoGene:   EG13516
- eggNOG:   COG2200
- GeneTree:   EBGT00050000008780
- HOGENOM:   HBG468612
- OMA:   TDRALIK
- ProtClustDB:   CLSK880219
- BioCyc:   EcoCyc:G6996-MONOMER
- Genevestigator:   P76261
- InterPro:   IPR001633
- SMART:   SM00052

Pfam domain/function: PF00563 EAL

EC number: =3.1.4.52

Molecular weight: Translated: 59712; Mature: 59712

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKV
CCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHH
LLPLQAGSEVLLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPV
HHCCCCCCHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCH
VDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSNAGVMEMINIDLLTAMLLEPQ
HHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCC
LPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQRFPFTINVNGPGATALAWHY
CCCCCCCEEEEECCEEEECCCHHHCCCCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEC
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCCCCCEEE
EILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVA
EEEEEECCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
PSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVDYRIARELHRKNVKLAIDDFG
HHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHCCCEEEEECCC
TGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
CCCCCHHHHHHCCCHHEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHH
QAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR
HHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKV
CCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHH
LLPLQAGSEVLLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPV
HHCCCCCCHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCH
VDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSNAGVMEMINIDLLTAMLLEPQ
HHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCC
LPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQRFPFTINVNGPGATALAWHY
CCCCCCCEEEEECCEEEECCCHHHCCCCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEC
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCCCCCEEE
EILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVA
EEEEEECCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
PSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVDYRIARELHRKNVKLAIDDFG
HHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHCCCEEEEECCC
TGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
CCCCCHHHHHHCCCHHEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHH
QAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR
HHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503