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The map label for this gene is gmr

Identifier: 218694861

GI number: 218694861

Start: 1486482

End: 1488467

Strand: Reverse

Name: gmr

Synonym: EC55989_1447

Alternate gene names: 218694861

Gene position: 1488467-1486482 (Counterclockwise)

Preceding gene: 218694862

Following gene: 218694860

Centisome position: 28.88

GC content: 48.54

Gene sequence:

>1986_bases
ATGAAAACCGTTAGGGAGTCCACAACGTTGTACAACTTTCTCGGATCGCACAATCCATACTGGCGGTTGACGGAAAGCAG
CGATGTTTTGCGCTTTTCTACCACCGAAACCACAGAACCTGATCGTACTTTGCAGTTATCTGCCGAACAGGCTGCTCGCA
TCAGGGAAATGACGGTCATCACCTCCAGCCTGATGATGAGTCTGACCGTCGATGAGAGCGATCTTTCTGTGCATCTGGTA
GGACGAAAAATCAATAAACGGGAATGGGCTGGCAACGCGTCTGCATGGCATGACACACCGGCAGTTGCTCGTGATTTATC
ACACGGGCTTTCCTTTGCTGAGCAGGTAGTTTCTGAAGCACATTCCGCAATAGTGATTCTCGACAGCCGGGGGAATATCC
AACGCTTCAATCGGTTATGTGAAGATTACACTGGGTTGAAAGAACACGACGTCATTGGCCAAAGCGTGTTTAAACTGTTT
ATGAGCCGTCGTGAAGCTGCGGCATCCAGGCGCAATAACCGTGTATTTTTTCGAAGCGGCAATGCATATGAAGTCGAACT
GTGGATACCAACACGTAAAGGCCAGCGGCTGTTTCTGTTTCGCAATAAATTTGTCCACAGCGGCAGTGGCAAAAACGAGA
TTTTTTTAATCTGTTCCGGCACCGACATTACCGAAGAGCGCCGCGCTCAGGAGCGACTGCGTATTCTGGCAAATACCGAC
AGTATCACCGGACTGCCGAATCGTAACGCAATGCAGGATTTAATCGATCACGCTATTAATCATGCAGATAACAATAAAGT
TGGGGTTGTGTATCTTGATTTGGATAATTTCAAAAAGGTCAACGACGCCTATGGGCATTTGTTTGGTGACCAGTTATTAC
GCGACGTGTCATTGGCTATTTTAAGCTGTCTCGAACATGACCAGGTGTTGGCGCGTCCAGGTGGCGATGAGTTTCTGGTA
CTGGCATCCAACACCTCACAAAGCGCGCTGGAAGCAATGGCATCACGAATTTTGACCCGCTTACGGCTCCCCTTTCGCAT
TGGTTTAATTGAAGTTTATACCAGCTGTTCAGTAGGTATTGCACTCTCTCCCGAACATGGTTCAGACAGCACGGCTATTA
TTCGTCACGCCGACACAGCAATGTACACAGCGAAGGAAGGCGGACGAGGACAATTTTGCGTTTTTACCCCAGAAATGAAT
CAACGGGTATTTGAATATCTCTGGCTGGATACCAACTTGCGTAAAGCACTGGAAAACGATCAGTTGGTTATTCACTATCA
ACCGAAAATCACCTGGCGTGGCGAAGTGCGCAGTCTGGAAGCACTAGTACGTTGGCAGTCACCTGAACGTGGGTTGATTC
CACCGTTGGACTTCATTTCCTACGCCGAAGAGTCAGGGCTAATTGTGCCTTTAGGCCGTTGGGTGATTCTCGATGTCGTA
CGCCAGGTGGCGAAGTGGCGGGATAAAGGTATTAACCTGCGAGTGGCGGTAAATATTTCTGCACGTCAGCTCGCCGATCA
AACCATTTTCACCGCCCTGAAACAGGTTCTCCAGGAACTCAATTTTGAATACTGCCCTATAGATGTTGAACTGACAGAGA
GTTGTCTGATTGAGAATGATGAACTGGCACTGTCTGTTATTCAACAATTTAGCCAACTAGGTGCGCAAGTGCATCTGGAT
GATTTTGGTACCGGCTACTCTTCACTTTCGCAACTGGCGCGCTTTCCGATCGATGCCATCAAACTTGACCAGGTTTTTGT
TCGAGATATTCACAAACAACCTGTCTCGCAGTCACTGGTCCGGGCGATCGTCGCTGTGGCCCAGGCATTGAATCTTCAGG
TGATCGCCGAAGGTGTAGAGAGTGCAAAGGAAGATGCTTTTTTAACCAAGAACGGGATCAATGAGCGGCAAGGATTTTTG
TTTGCCAAACCGATGCCCGCCGTCGCCTTCGAACGCTGGTATAAACGCTATCTGAAGCGCGCATAA

Upstream 100 bases:

>100_bases
TATAAAAAAACAATGCGTTTAGCCGCCGTTAATTTCATGTAAGTCATGTTGTTCCTTTTATTTAACCGCGGACTCCGCAG
TTAACCGGAGGATATGCATC

Downstream 100 bases:

>100_bases
GTAGATGAATATATATACTTAGCGCTATATCCCGTCATTATATATCGTATTCCTGGATGATAATTAGCCGTTGCTGTTAA
ACACTTCTCTTTTAGCGGCA

Product: RNase II stability modulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 661; Mature: 661

Protein sequence:

>661_residues
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVITSSLMMSLTVDESDLSVHLV
GRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEAHSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLF
MSRREAAASRRNNRVFFRSGNAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLV
LASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGIALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMN
QRVFEYLWLDTNLRKALENDQLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENDELALSVIQQFSQLGAQVHLD
DFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFL
FAKPMPAVAFERWYKRYLKRA

Sequences:

>Translated_661_residues
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVITSSLMMSLTVDESDLSVHLV
GRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEAHSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLF
MSRREAAASRRNNRVFFRSGNAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLV
LASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGIALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMN
QRVFEYLWLDTNLRKALENDQLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENDELALSVIQQFSQLGAQVHLD
DFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFL
FAKPMPAVAFERWYKRYLKRA
>Mature_661_residues
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVITSSLMMSLTVDESDLSVHLV
GRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEAHSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLF
MSRREAAASRRNNRVFFRSGNAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLV
LASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGIALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMN
QRVFEYLWLDTNLRKALENDQLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENDELALSVIQQFSQLGAQVHLD
DFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFL
FAKPMPAVAFERWYKRYLKRA

Specific function: Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antag

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=661, Percent_Identity=99.8487140695915, Blast_Score=1361, Evalue=0.0,
Organism=Escherichia coli, GI87081921, Length=439, Percent_Identity=33.9407744874715, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI226510982, Length=428, Percent_Identity=31.7757009345794, Blast_Score=193, Evalue=4e-50,
Organism=Escherichia coli, GI1788502, Length=246, Percent_Identity=30.4878048780488, Blast_Score=140, Evalue=3e-34,
Organism=Escherichia coli, GI1790496, Length=249, Percent_Identity=32.5301204819277, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI87081743, Length=247, Percent_Identity=30.3643724696356, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081845, Length=237, Percent_Identity=34.1772151898734, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1787055, Length=294, Percent_Identity=30.2721088435374, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786507, Length=256, Percent_Identity=30.078125, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1788849, Length=439, Percent_Identity=26.4236902050114, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI87081980, Length=259, Percent_Identity=30.5019305019305, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1788381, Length=550, Percent_Identity=23.6363636363636, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI87082096, Length=427, Percent_Identity=25.5269320843091, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87081977, Length=177, Percent_Identity=32.2033898305085, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787816, Length=171, Percent_Identity=32.7485380116959, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1787262, Length=162, Percent_Identity=33.9506172839506, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786584, Length=179, Percent_Identity=31.8435754189944, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693134, Length=157, Percent_Identity=33.1210191082803, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI87081881, Length=200, Percent_Identity=29, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1788956, Length=152, Percent_Identity=35.5263157894737, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787410, Length=129, Percent_Identity=37.2093023255814, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1789650, Length=437, Percent_Identity=21.5102974828375, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI87082007, Length=172, Percent_Identity=33.7209302325581, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR000014
- InterPro:   IPR013767 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00989 PAS [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 74719; Mature: 74719

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50112 PAS ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
CCCCHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCEEEECHHHHHHHHHHHHH
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HHHHHEEEEECCCCCEEEEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
CCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
NAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
CEEEEEEEEECCCCCEEEEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHEEECCC
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
CCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
HHHHCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEE
ALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
EECCCCCCCCCEEEEECCCCEEEECCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHCCC
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
CEEEEECCCEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEECHHHHHHHHH
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
HHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHCCCC
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHH
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHC
A
C
>Mature Secondary Structure
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
CCCCHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCEEEECHHHHHHHHHHHHH
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HHHHHEEEEECCCCCEEEEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
CCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
NAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
CEEEEEEEEECCCCCEEEEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHEEECCC
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
CCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
HHHHCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEE
ALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
EECCCCCCCCCEEEEECCCCEEEECCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHCCC
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
CEEEEECCCEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEECHHHHHHHHH
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
HHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHCCCC
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHH
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]