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The map label for this gene is rutG

Identifier: 218694542

GI number: 218694542

Start: 1176944

End: 1178272

Strand: Reverse

Name: rutG

Synonym: EC55989_1117

Alternate gene names: 218694542

Gene position: 1178272-1176944 (Counterclockwise)

Preceding gene: 218694543

Following gene: 218694539

Centisome position: 22.86

GC content: 54.25

Gene sequence:

>1329_bases
ATGGCAATGTTCGGTTTTCCTCACTGGCAGTTAAAATCGACCTCTACAGAGAGCGGCGTGGTCGCGCCGGATGAACGATT
GCCGTTTGCTCAGACGGCAGTAATGGGCGTTCAACACGCGGTGGCGATGTTTGGCGCGACGGTGTTAATGCCGATTCTGA
TGGGGCTGGATCCCAATCTTTCCATTTTAATGTCGGGGATCGGCACGTTACTGTTTTTCTTTATTACCGGCGGGCGCGTC
CCCAGTTATCTCGGCTCCAGCGCGGCTTTTGTCGGCGTGGTGATCGCCGCGACGGGCTTTAACGGTCAGGGCATTAACCC
GAATATCAGCATTGCGCTGGGCGGGATTATCGCCTGTGGGCTGGTTTATACCGTCATTGGCCTGGTGGTGATGAAAATCG
GTACGCGCTGGATTGAACGACTGATGCCGCCGGTGGTGACGGGTGCGGTGGTGATGGCGATTGGCCTGAACTTAGCGCCT
ATCGCAGTGAAAAGTGTATCGGCTTCGGCCTTTGATAGCTGGATGGCGGTAATGACGGTGCTGTGTATTGGGCTGGTGGC
GGTGTTTACCCGTGGCATGATCCAGCGGTTATTGATTCTCGTAGGATTAATTGTCGCCTGTCTGCTGTATGGCGTGATGA
CCAACGTTTTAGGGCTGGGAAAAGCCGTCGATTTTACTCTCGTCAGCCATGCTGCCTGGTTCGGTCTGCCACATTTTTCC
ACTCCTGCTTTTAATGGTCAGGCAATGATGCTGATTGCGCCCGTGGCGGTGATTCTGGTGGCGGAAAACTTAGGTCATCT
CAAGGCAGTCGCCGGGATGACCGGACGCAATATGGACCCGTATATGGGGCGGGCATTCGTCGGTGATGGGCTGGCGACGA
TGCTTTCTGGTTCTGTCGGTGGCAGCGGCGTAACCACCTACGCCGAGAATATCGGTGTAATGGCCGTGACAAAAGTCTAC
TCGACGCTGGTGTTTGTCGCTGCTGCCGTCATCGCCATGCTGTTGGGCTTTTCACCGAAATTTGGCGCGCTGATTCATAC
CATTCCGGCCGCGGTGATTGGTGGTGCATCAATTGTTGTGTTCGGGCTGATTGCCGTCGCAGGCGCAAGGATATGGGTAC
AAAACCGTGTCGATTTAAGCCAGAACGGTAATTTGATTATGGTCGCAGTAACCTTAGTGCTGGGCGCGGGTGATTTTGCT
CTCACGCTGGGCGGTTTTACGTTGGGAGGGATTGGTACAGCAACCTTTGGCGCGATTTTACTCAATGCGTTGTTAAGCAG
AAAGTTGGTTGACGTTCCACCGCCAGAAGTTGTTCATCAGGAGCCATAA

Upstream 100 bases:

>100_bases
CGATTCATCGTCACACCACACCCTACGGGCTGGTGTGGTTCGATCGCAGTTATCACGCGCTGATGCGCCCTGCTTGTTAA
CCTCCTTAAGGAGACTGCTG

Downstream 100 bases:

>100_bases
ACAGAAAACCGCCGGGATTACCGGCGGTGATGACTTTTTGACGAGCCTAAGAAAAAAATGCATTCGTCATTGATTAGCCC
GGCTAGTTGTCGCTTTTGCC

Product: pyrimidine transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MAMFGFPHWQLKSTSTESGVVAPDERLPFAQTAVMGVQHAVAMFGATVLMPILMGLDPNLSILMSGIGTLLFFFITGGRV
PSYLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACGLVYTVIGLVVMKIGTRWIERLMPPVVTGAVVMAIGLNLAP
IAVKSVSASAFDSWMAVMTVLCIGLVAVFTRGMIQRLLILVGLIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFS
TPAFNGQAMMLIAPVAVILVAENLGHLKAVAGMTGRNMDPYMGRAFVGDGLATMLSGSVGGSGVTTYAENIGVMAVTKVY
STLVFVAAAVIAMLLGFSPKFGALIHTIPAAVIGGASIVVFGLIAVAGARIWVQNRVDLSQNGNLIMVAVTLVLGAGDFA
LTLGGFTLGGIGTATFGAILLNALLSRKLVDVPPPEVVHQEP

Sequences:

>Translated_442_residues
MAMFGFPHWQLKSTSTESGVVAPDERLPFAQTAVMGVQHAVAMFGATVLMPILMGLDPNLSILMSGIGTLLFFFITGGRV
PSYLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACGLVYTVIGLVVMKIGTRWIERLMPPVVTGAVVMAIGLNLAP
IAVKSVSASAFDSWMAVMTVLCIGLVAVFTRGMIQRLLILVGLIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFS
TPAFNGQAMMLIAPVAVILVAENLGHLKAVAGMTGRNMDPYMGRAFVGDGLATMLSGSVGGSGVTTYAENIGVMAVTKVY
STLVFVAAAVIAMLLGFSPKFGALIHTIPAAVIGGASIVVFGLIAVAGARIWVQNRVDLSQNGNLIMVAVTLVLGAGDFA
LTLGGFTLGGIGTATFGAILLNALLSRKLVDVPPPEVVHQEP
>Mature_441_residues
AMFGFPHWQLKSTSTESGVVAPDERLPFAQTAVMGVQHAVAMFGATVLMPILMGLDPNLSILMSGIGTLLFFFITGGRVP
SYLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACGLVYTVIGLVVMKIGTRWIERLMPPVVTGAVVMAIGLNLAPI
AVKSVSASAFDSWMAVMTVLCIGLVAVFTRGMIQRLLILVGLIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFST
PAFNGQAMMLIAPVAVILVAENLGHLKAVAGMTGRNMDPYMGRAFVGDGLATMLSGSVGGSGVTTYAENIGVMAVTKVYS
TLVFVAAAVIAMLLGFSPKFGALIHTIPAAVIGGASIVVFGLIAVAGARIWVQNRVDLSQNGNLIMVAVTLVLGAGDFAL
TLGGFTLGGIGTATFGAILLNALLSRKLVDVPPPEVVHQEP

Specific function: May function as a proton-driven pyrimidine uptake system

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily

Homologues:

Organism=Escherichia coli, GI87081818, Length=442, Percent_Identity=100, Blast_Score=863, Evalue=0.0,
Organism=Escherichia coli, GI1788843, Length=425, Percent_Identity=36.9411764705882, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI87082181, Length=457, Percent_Identity=25.8205689277899, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI87082178, Length=407, Percent_Identity=27.027027027027, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71993493, Length=174, Percent_Identity=35.0574712643678, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17542260, Length=174, Percent_Identity=35.0574712643678, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17542262, Length=176, Percent_Identity=30.6818181818182, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=181, Percent_Identity=29.8342541436464, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=175, Percent_Identity=29.1428571428571, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356175, Length=176, Percent_Identity=30.6818181818182, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUTG_ECOLI (P75892)

Other databases:

- EMBL:   U00096
- EMBL:   AP009048
- PIR:   D64842
- RefSeq:   AP_001637.1
- RefSeq:   NP_415526.4
- ProteinModelPortal:   P75892
- STRING:   P75892
- EnsemblBacteria:   EBESCT00000004789
- EnsemblBacteria:   EBESCT00000015631
- GeneID:   946589
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW5137
- KEGG:   eco:b1006
- EchoBASE:   EB3613
- EcoGene:   EG13853
- eggNOG:   COG2233
- GeneTree:   EBGT00050000009612
- HOGENOM:   HBG470187
- OMA:   WLAMPNF
- ProtClustDB:   CLSK879920
- BioCyc:   EcoCyc:B1006-MONOMER
- Genevestigator:   P75892
- InterPro:   IPR019918
- InterPro:   IPR006042
- InterPro:   IPR006043
- PANTHER:   PTHR11119:SF3
- PANTHER:   PTHR11119
- TIGRFAMs:   TIGR00801
- TIGRFAMs:   TIGR03616

Pfam domain/function: PF00860 Xan_ur_permease

EC number: NA

Molecular weight: Translated: 45558; Mature: 45427

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x169fb994)-; HASH(0x1886c9d4)-; HASH(0x185f4f54)-; HASH(0x15b0495c)-; HASH(0x1615c6c0)-; HASH(0x18dc82bc)-; HASH(0x18db9628)-; HASH(0x18dccf08)-; HASH(0x1683a7e4)-; HASH(0x18dac6d4)-; HASH(0x1683a82c)-; HASH(0x1615c798)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
AMFGFPHWQLKSTSTESGVVAPDERLPFAQTAVMGVQHAVAMFGATVLMPILMGLDPNL
CCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SILMSGIGTLLFFFITGGRVPSYLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACG
HHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHEEEECCCCCCCCCCCEEHHHHHHHHH
LVYTVIGLVVMKIGTRWIERLMPPVVTGAVVMAIGLNLAPIAVKSVSASAFDSWMAVMTV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LCIGLVAVFTRGMIQRLLILVGLIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
TPAFNGQAMMLIAPVAVILVAENLGHLKAVAGMTGRNMDPYMGRAFVGDGLATMLSGSVG
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHCHHHHCCCHHHHHCCCCC
GSGVTTYAENIGVMAVTKVYSTLVFVAAAVIAMLLGFSPKFGALIHTIPAAVIGGASIVV
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHH
FGLIAVAGARIWVQNRVDLSQNGNLIMVAVTLVLGAGDFALTLGGFTLGGIGTATFGAIL
HHHHHHHHHHEEEECCCCCCCCCCEEEEEHHHHHCCCCCEEEECCEEECCHHHHHHHHHH
LNALLSRKLVDVPPPEVVHQEP
HHHHHHCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503