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The map label for this gene is nadA

Identifier: 218694167

GI number: 218694167

Start: 795940

End: 796983

Strand: Direct

Name: nadA

Synonym: EC55989_0729

Alternate gene names: 218694167

Gene position: 795940-796983 (Clockwise)

Preceding gene: 218694166

Following gene: 218694168

Centisome position: 15.44

GC content: 50.29

Gene sequence:

>1044_bases
ATGAGCGTAATGTTTGATCCAGACACGGCGATTTATCCTTTCCCCCCGAAGCCGACGCCGTTAAGCATTGATGAAAAAGC
GTATTACCGCGAGAAGATAAAACGTCTGCTAAAAGAACGTAATGCGGTGATGGTTGCCCACTACTATACCGATCCCGAAA
TTCAACAACTGGCAGAAGAAACCGGTGGCTGTATTTCTGATTCTCTGGAAATGGCGCGCTTCGGTGCAAAGCATCCCGCT
TCTACTTTGTTAGTCGCTGGGGTGAGATTTATGGGAGAAACCGCCAAAATTCTCAGTCCGGAAAAAACAATTCTGATGCC
GACACTTCAGGCTGAATGTTCACTGGATCTCGGCTGCCCTGTTGAAGAATTTAACGCATTTTGCGATGCCCATCCCGATC
GTACTGTCGTCGTCTACGCCAACACTTCTGCTGCGGTAAAAGCGCGCGCAGATTGGGTGGTAACTTCAAGCATTGCCGTC
GAACTTATTGATCATCTTGATAGTTTGGGTGAAAAAATCATCTGGGCACCCGACAAACATCTGGGGCGTTACGTGCAAAA
ACAGACGGGTGGAGACATTCTATGCTGGCAGGGTGCCTGTATTGTGCATGATGAATTTAAGACTCAGGCGTTAACCCGCT
TGCAAGAAGAATACCCGGATGCTGCCATACTGGTGCATCCAGAATCACCACAAGCTATTGTCGATATGGCGGATGCGGTC
GGTTCCACCAGTCAACTGATCGCTGCTGCGAAAACATTGCCACATCAGCGGCTTATCGTGGCAACCGATCGGGGCATTTT
CTACAAAATGCAGCAGGCAGTGCCAGATAAAGAGTTACTGGAAGCACCAACCGCAGGTGAGGGTGCAACCTGCCGCAGCT
GCGCGCATTGTCCGTGGATGGCCATGAATGGCCTTCAGTCCATCGCAGAGGCATTAGAACAGGAAGGAAGCAATCACGAG
GTTCATGTTGATGAAAGGCTGCGAGAGAGGGCGCTGGTGCCGCTCAATCGTATGCTGGATTTTGCGGCTACACTACGTGG
ATAA

Upstream 100 bases:

>100_bases
TCGACTATCTTGTTTAGCATATAAAACAAATTACACCGATAACAGCGAATATTACGCTAATGTCGGTTTTAACGTTAAGC
CTGTAAAACGAGATGGTAAG

Downstream 100 bases:

>100_bases
CGAATAATAAGGCGTAACGTTACGCTTTGGGGGAAAGATGGATTTTTTTAGTGTGCAGAATATCCTGGTACATATACCAA
TAGGGGCAGGCGGTTATGAT

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSVMFDPDTAIYPFPPKPTPLSIDEKAYYREKIKRLLKERNAVMVAHYYTDPEIQQLAEETGGCISDSLEMARFGAKHPA
STLLVAGVRFMGETAKILSPEKTILMPTLQAECSLDLGCPVEEFNAFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAV
ELIDHLDSLGEKIIWAPDKHLGRYVQKQTGGDILCWQGACIVHDEFKTQALTRLQEEYPDAAILVHPESPQAIVDMADAV
GSTSQLIAAAKTLPHQRLIVATDRGIFYKMQQAVPDKELLEAPTAGEGATCRSCAHCPWMAMNGLQSIAEALEQEGSNHE
VHVDERLRERALVPLNRMLDFAATLRG

Sequences:

>Translated_347_residues
MSVMFDPDTAIYPFPPKPTPLSIDEKAYYREKIKRLLKERNAVMVAHYYTDPEIQQLAEETGGCISDSLEMARFGAKHPA
STLLVAGVRFMGETAKILSPEKTILMPTLQAECSLDLGCPVEEFNAFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAV
ELIDHLDSLGEKIIWAPDKHLGRYVQKQTGGDILCWQGACIVHDEFKTQALTRLQEEYPDAAILVHPESPQAIVDMADAV
GSTSQLIAAAKTLPHQRLIVATDRGIFYKMQQAVPDKELLEAPTAGEGATCRSCAHCPWMAMNGLQSIAEALEQEGSNHE
VHVDERLRERALVPLNRMLDFAATLRG
>Mature_346_residues
SVMFDPDTAIYPFPPKPTPLSIDEKAYYREKIKRLLKERNAVMVAHYYTDPEIQQLAEETGGCISDSLEMARFGAKHPAS
TLLVAGVRFMGETAKILSPEKTILMPTLQAECSLDLGCPVEEFNAFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAVE
LIDHLDSLGEKIIWAPDKHLGRYVQKQTGGDILCWQGACIVHDEFKTQALTRLQEEYPDAAILVHPESPQAIVDMADAVG
STSQLIAAAKTLPHQRLIVATDRGIFYKMQQAVPDKELLEAPTAGEGATCRSCAHCPWMAMNGLQSIAEALEQEGSNHEV
HVDERLRERALVPLNRMLDFAATLRG

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=347, Percent_Identity=99.7118155619597, Blast_Score=720, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_ECO24 (A7ZJC5)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001461904.1
- STRING:   A7ZJC5
- EnsemblBacteria:   EBESCT00000019258
- GeneID:   5587082
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_0777
- eggNOG:   COG0379
- GeneTree:   EBGT00050000011584
- HOGENOM:   HBG291157
- OMA:   IAHPECE
- ProtClustDB:   PRK09375
- BioCyc:   ECOL331111:ECE24377A_0777-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00567
- InterPro:   IPR003473
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 38257; Mature: 38126

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: BINDING 47-47 BINDING 68-68 BINDING 139-139 BINDING 156-156 BINDING 226-226 BINDING 243-243

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVMFDPDTAIYPFPPKPTPLSIDEKAYYREKIKRLLKERNAVMVAHYYTDPEIQQLAEE
CCEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHH
TGGCISDSLEMARFGAKHPASTLLVAGVRFMGETAKILSPEKTILMPTLQAECSLDLGCP
HCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHCCCCCEEEEEECCCCCCCCCCCC
VEEFNAFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAVELIDHLDSLGEKIIWAPDKH
HHHHHHHHCCCCCCEEEEEECCCCEEEECCCEEEHHHHHHHHHHHHHHHCCCEEECCCHH
LGRYVQKQTGGDILCWQGACIVHDEFKTQALTRLQEEYPDAAILVHPESPQAIVDMADAV
HHHHHHHHCCCCEEEECCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHH
GSTSQLIAAAKTLPHQRLIVATDRGIFYKMQQAVPDKELLEAPTAGEGATCRSCAHCPWM
CCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCHHHHCCCCCCCCCCCHHHCCCCHH
AMNGLQSIAEALEQEGSNHEVHVDERLRERALVPLNRMLDFAATLRG
HHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SVMFDPDTAIYPFPPKPTPLSIDEKAYYREKIKRLLKERNAVMVAHYYTDPEIQQLAEE
CEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHH
TGGCISDSLEMARFGAKHPASTLLVAGVRFMGETAKILSPEKTILMPTLQAECSLDLGCP
HCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHCCCCCEEEEEECCCCCCCCCCCC
VEEFNAFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAVELIDHLDSLGEKIIWAPDKH
HHHHHHHHCCCCCCEEEEEECCCCEEEECCCEEEHHHHHHHHHHHHHHHCCCEEECCCHH
LGRYVQKQTGGDILCWQGACIVHDEFKTQALTRLQEEYPDAAILVHPESPQAIVDMADAV
HHHHHHHHCCCCEEEECCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHH
GSTSQLIAAAKTLPHQRLIVATDRGIFYKMQQAVPDKELLEAPTAGEGATCRSCAHCPWM
CCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCHHHHCCCCCCCCCCCHHHCCCCHH
AMNGLQSIAEALEQEGSNHEVHVDERLRERALVPLNRMLDFAATLRG
HHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA