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The map label for this gene is idnD [H]

Identifier: 218692653

GI number: 218692653

Start: 5062609

End: 5063640

Strand: Reverse

Name: idnD [H]

Synonym: ECED1_5121

Alternate gene names: 218692653

Gene position: 5063640-5062609 (Counterclockwise)

Preceding gene: 218692655

Following gene: 218692652

Centisome position: 97.2

GC content: 47.09

Gene sequence:

>1032_bases
ATGCAAGTGAAAACACAGTCCTGCGTTGTTGCGGGCAAGAAAACTGTTGCCGTTACCGAGCAGACGATAGATTGGAATAA
TAATGGAACATTAGTACAAATAACCCGAGGTGGAATTTGCGGTTCCGATTTACATTATTATCAGGAAGGAAAAGTAGGTA
ATTTCATGATAAAGGCACCGATGGTGTTAGGTCATGAAGTTATCGGTAAAGTTATTCATAGCGACTCATCAAAATTACAT
GAAGGGCAAACGGTAGCCATTAATCCGTCTAAACCGTGCGGTCACTGCAAATACTGCATTGAACATAACGAGAATCAGTG
TACAGAGATGCGTTTTTTTGGCAGTGCCATGTATTTCCCTCATGTTGATGGTGGCTTTACCCGTTATAAAATGGTCGAAA
CGTCGCAATGTGTCCCTTATCCGGCCAAAGCTGACGAAAAGGTTATAGCTTTTGCCGAACCTTTAGCCGTCGCAATTCAT
GCCGCACATCAGGCCGGCGAGTTACAGGGCAAGCGAGTATTTATTTCTGGTGTTGGGCCCATTGGCTGCCTGATTGTCAG
TGCAGTGAAAACACTGGGGGCCGCGGAAATTGTCTGTGCCGATGTGAGTCCCCGTTCCCTTTCGCTGGGCAAAGAGATGG
GGGCGGATGTGCTCGTAAACCCACAAAACGACGACATGGATCACTGGAAAGCGGAAAAAGGCTATTTCGATGTCAGCTTT
GAAGTGTCCGGTCATCCTTCATCAGTGAATACCTGTCTGGAGGTCACTCGTGCACGCGGCGTAATGGTGCAGGTAGGTAT
GGGAGGCGCGATGGCAGAATTCCCAATGATGACATTGATTGGTAAGGAGATTTCACTCAAAGGCTCTTTCCGTTTTACCA
GCGAATTTAATACCGCAGTGTCATGGCTGGCGAATGGCGTTATTAATCCACTGCCTTTACTGAGTGCTGAATATCCCTTC
ACTGACCTGGAAGAGGCGCTACGTTTCGCCGGTGATAAAACCCAGGCAGCAAAAGTCCAGCTTGTTTTCTAA

Upstream 100 bases:

>100_bases
TAGTAATGTAACAATTTTCTGACGTGATCTTCATCACAAATAATGACAATTAAAACCGCTTAAATGCTTCCGAGGTGTCT
ACCTGACCAGTGAGGAATTT

Downstream 100 bases:

>100_bases
GAGATAAATAAAGGAATAATACAATGAACGATCTATTTTCACTGGCAGGAAAAAATATCTTGATTACCGGTTCAGCACAG
GGCATTGGCTTTTTACTGGC

Product: L-idonate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MQVKTQSCVVAGKKTVAVTEQTIDWNNNGTLVQITRGGICGSDLHYYQEGKVGNFMIKAPMVLGHEVIGKVIHSDSSKLH
EGQTVAINPSKPCGHCKYCIEHNENQCTEMRFFGSAMYFPHVDGGFTRYKMVETSQCVPYPAKADEKVIAFAEPLAVAIH
AAHQAGELQGKRVFISGVGPIGCLIVSAVKTLGAAEIVCADVSPRSLSLGKEMGADVLVNPQNDDMDHWKAEKGYFDVSF
EVSGHPSSVNTCLEVTRARGVMVQVGMGGAMAEFPMMTLIGKEISLKGSFRFTSEFNTAVSWLANGVINPLPLLSAEYPF
TDLEEALRFAGDKTQAAKVQLVF

Sequences:

>Translated_343_residues
MQVKTQSCVVAGKKTVAVTEQTIDWNNNGTLVQITRGGICGSDLHYYQEGKVGNFMIKAPMVLGHEVIGKVIHSDSSKLH
EGQTVAINPSKPCGHCKYCIEHNENQCTEMRFFGSAMYFPHVDGGFTRYKMVETSQCVPYPAKADEKVIAFAEPLAVAIH
AAHQAGELQGKRVFISGVGPIGCLIVSAVKTLGAAEIVCADVSPRSLSLGKEMGADVLVNPQNDDMDHWKAEKGYFDVSF
EVSGHPSSVNTCLEVTRARGVMVQVGMGGAMAEFPMMTLIGKEISLKGSFRFTSEFNTAVSWLANGVINPLPLLSAEYPF
TDLEEALRFAGDKTQAAKVQLVF
>Mature_343_residues
MQVKTQSCVVAGKKTVAVTEQTIDWNNNGTLVQITRGGICGSDLHYYQEGKVGNFMIKAPMVLGHEVIGKVIHSDSSKLH
EGQTVAINPSKPCGHCKYCIEHNENQCTEMRFFGSAMYFPHVDGGFTRYKMVETSQCVPYPAKADEKVIAFAEPLAVAIH
AAHQAGELQGKRVFISGVGPIGCLIVSAVKTLGAAEIVCADVSPRSLSLGKEMGADVLVNPQNDDMDHWKAEKGYFDVSF
EVSGHPSSVNTCLEVTRARGVMVQVGMGGAMAEFPMMTLIGKEISLKGSFRFTSEFNTAVSWLANGVINPLPLLSAEYPF
TDLEEALRFAGDKTQAAKVQLVF

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=307, Percent_Identity=32.5732899022801, Blast_Score=169, Evalue=5e-42,
Organism=Escherichia coli, GI1790718, Length=343, Percent_Identity=98.8338192419825, Blast_Score=711, Evalue=0.0,
Organism=Escherichia coli, GI1788073, Length=308, Percent_Identity=29.5454545454545, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787863, Length=344, Percent_Identity=27.0348837209302, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1790045, Length=321, Percent_Identity=27.1028037383178, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788407, Length=336, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI226510992, Length=305, Percent_Identity=29.1803278688525, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786825, Length=365, Percent_Identity=24.6575342465753, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788075, Length=333, Percent_Identity=25.8258258258258, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87081918, Length=331, Percent_Identity=27.190332326284, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI87082125, Length=256, Percent_Identity=26.953125, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786552, Length=334, Percent_Identity=23.9520958083832, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=324, Percent_Identity=33.9506172839506, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17562878, Length=321, Percent_Identity=34.5794392523364, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319955, Length=312, Percent_Identity=32.3717948717949, Blast_Score=166, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322619, Length=312, Percent_Identity=32.3717948717949, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6323099, Length=340, Percent_Identity=30.8823529411765, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6319258, Length=318, Percent_Identity=26.4150943396226, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319257, Length=314, Percent_Identity=25.796178343949, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=351, Percent_Identity=23.6467236467236, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737897, Length=336, Percent_Identity=30.952380952381, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI17137530, Length=309, Percent_Identity=31.0679611650485, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 37114; Mature: 37114

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVKTQSCVVAGKKTVAVTEQTIDWNNNGTLVQITRGGICGSDLHYYQEGKVGNFMIKAP
CCCCCCEEEEECCEEEEEEEEEEEECCCCCEEEEECCCCCCCCCCEEECCCCCCEEEECC
MVLGHEVIGKVIHSDSSKLHEGQTVAINPSKPCGHCKYCIEHNENQCTEMRFFGSAMYFP
HHHHHHHHHHHHHCCCCHHCCCCEEEECCCCCCCCHHHHHHCCCCCHHHHEEECCEEECC
HVDGGFTRYKMVETSQCVPYPAKADEKVIAFAEPLAVAIHAAHQAGELQGKRVFISGVGP
CCCCCCEEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEEECCCH
IGCLIVSAVKTLGAAEIVCADVSPRSLSLGKEMGADVLVNPQNDDMDHWKAEKGYFDVSF
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCEEECCCCCCHHHHCCCCCEEEEEE
EVSGHPSSVNTCLEVTRARGVMVQVGMGGAMAEFPMMTLIGKEISLKGSFRFTSEFNTAV
EECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHCCHHHHHCCEEEEEEEEEECCHHHHHH
SWLANGVINPLPLLSAEYPFTDLEEALRFAGDKTQAAKVQLVF
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEC
>Mature Secondary Structure
MQVKTQSCVVAGKKTVAVTEQTIDWNNNGTLVQITRGGICGSDLHYYQEGKVGNFMIKAP
CCCCCCEEEEECCEEEEEEEEEEEECCCCCEEEEECCCCCCCCCCEEECCCCCCEEEECC
MVLGHEVIGKVIHSDSSKLHEGQTVAINPSKPCGHCKYCIEHNENQCTEMRFFGSAMYFP
HHHHHHHHHHHHHCCCCHHCCCCEEEECCCCCCCCHHHHHHCCCCCHHHHEEECCEEECC
HVDGGFTRYKMVETSQCVPYPAKADEKVIAFAEPLAVAIHAAHQAGELQGKRVFISGVGP
CCCCCCEEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEEECCCH
IGCLIVSAVKTLGAAEIVCADVSPRSLSLGKEMGADVLVNPQNDDMDHWKAEKGYFDVSF
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCEEECCCCCCHHHHCCCCCEEEEEE
EVSGHPSSVNTCLEVTRARGVMVQVGMGGAMAEFPMMTLIGKEISLKGSFRFTSEFNTAV
EECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHCCHHHHHCCEEEEEEEEEECCHHHHHH
SWLANGVINPLPLLSAEYPFTDLEEALRFAGDKTQAAKVQLVF
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]