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The map label for this gene is dipZ [H]

Identifier: 218692474

GI number: 218692474

Start: 4881993

End: 4883690

Strand: Reverse

Name: dipZ [H]

Synonym: ECED1_4924

Alternate gene names: 218692474

Gene position: 4883690-4881993 (Counterclockwise)

Preceding gene: 218692475

Following gene: 218692473

Centisome position: 93.74

GC content: 53.65

Gene sequence:

>1698_bases
ATGGCTCAACGCATCTTTACGCTGATCCTGCTACTTTGCAGCACTTCCGTTTTTGCCGGATTATTCGACGCGCCGGGACG
TTCACAATTTGTCCCCGCGGATCAAGCCTTTGCTTTTGATTTTCAGCAAAATCAACATGATCTGAATCTGACCTGGCAGA
TCAAAGACGGTTACTACCTCTACCGTAAACAGATCCGCATTACGCCGGAACACGCGAAAATTGCTGACGTGCAGCTGCCG
CAAGGCGTCTGGCATGAAGATGAGTTTTACGGCAAAAGCGAGATTTACCGCGATCGGCTGACGCTTCCCGTAACCATCAA
CCAGGCGAGTGCGGGAGCAACGTTAACTGTCACCTACCAGGGCTGTGCTGATGCCGGTTTCTGTTATCCGCCAGAAACCA
AAACCGTTCCGTTAAGCGAAGTGGTCGCTAACAACGAAGCGTCACAGCCTGTGTCTGTTCCGCAGCAAGAGCAGCCCACC
GCGCAATTGCCCTTTTCCGCGCTCTGGGCGTTGTTGATCGGTATTGGTATCGCCTTTACGCCATGCGTGCTGCCAATGTA
CCCACTGATTTCTGGCATCGTGCTGGGCGGTAAACAGCGGCTTTCCACTGCCAGAGCATTGTTGCTGACCTTTATTTATG
TGCAGGGGATGGCGCTGACTTACACGGCGCTGGGTCTGGTGGTTGCCGCCGCAGGGTTACAGTTCCAGGCGGCGCTACAG
CACCCATACGTGCTCATTGGCCTCGCCATCGTCTTTACCTTGCTGGCGATGTCAATGTTTGGCTTGTTTACTCTGCAACT
CCCCTCTTCGCTGCAAACACGTCTCACGCTGATGAGCAATCGCCAACAGGGCGGCTCACCTGGCGGTGTGTTTATTATGG
GGGCGATTGCCGGACTGATCTGTTCACCATGCACCACTGCACCGCTTAGCGCGATTCTGCTGTATATCGCCCAAAGCGGG
AACATGTGGCTGGGCGGCGGCACGCTTTATCTTTATGCGCTGGGCATGGGCCTGCCGCTGATGCTAATTACCGTCTTTGG
TAACCGCTTGCTGCCGAAAAGCGGCCCGTGGATGGAACAAGTCAAAACCGCGTTTGGTTTTGTGATCCTCGCACTGCCGG
TCTTCCTGCTGGAGCGAGTGATTGGTGATATATGGGGATTACGCTTGTGGTCGGCGCTTGGTGTCGCATTCTTTGGCTGG
GCCTTTATCACCAGCCTACAGGCCAAACGCGGCTGGATGCGCGTGGTGCAAATAATCCTGCTGGCAGCGGCATTGGTTAG
CGTGCGCCCACTTCAGGATTGGGCATTTGGTGAAACACATACCGCGCAAACTCAGACGCATCTCAACTTTACACAAATCA
AAACAGTAGATGAGTTAAATCAGGCGCTCGTTGAAGCCAAAGGCAAACCAGTGATGTTAGATCTCTATGCCGACTGGTGC
GTCGCCTGTAAAGAGTTTGAGAAATACACCTTCAGCGACCCGCAGGTGCAAAAAGCGTTAGCAGATACGGTCTTACTTCA
GGCCAACGTCACTGCCAACGACGCACAAGATGTGGCGCTGTTAAAGCATCTTAATGTCCTTGGCCTACCGACAATTCTCT
TTTTTGACGGACAAGGCCAGGAGCATCCACAAGCACGCGTCACGGGCTTTATGGATGCTGAAACCTTCAGCGCACATTTG
CGCGATCGCCAACCGTGA

Upstream 100 bases:

>100_bases
ACCAGCAGGCAATGCTGGAATGCCTGAAGTCTCATCATCCATATCAAACCCCGGAACTTCTGGTTTTACCTGTTACACAC
GGAGACACAGATTACCTCTC

Downstream 100 bases:

>100_bases
ACGACACTTGCAGTGGGAAAGACGGAGGAAAATAGCGTGCAACGTGAAGATGTACTGGGAGAAGCCCTGAAATTATTAGA
ATTACAAGGGATTGCCAACA

Product: thiol:disulfide interchange protein

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MAQRIFTLILLLCSTSVFAGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADVQLP
QGVWHEDEFYGKSEIYRDRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNEASQPVSVPQQEQPT
AQLPFSALWALLIGIGIAFTPCVLPMYPLISGIVLGGKQRLSTARALLLTFIYVQGMALTYTALGLVVAAAGLQFQAALQ
HPYVLIGLAIVFTLLAMSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFIMGAIAGLICSPCTTAPLSAILLYIAQSG
NMWLGGGTLYLYALGMGLPLMLITVFGNRLLPKSGPWMEQVKTAFGFVILALPVFLLERVIGDIWGLRLWSALGVAFFGW
AFITSLQAKRGWMRVVQIILLAAALVSVRPLQDWAFGETHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWC
VACKEFEKYTFSDPQVQKALADTVLLQANVTANDAQDVALLKHLNVLGLPTILFFDGQGQEHPQARVTGFMDAETFSAHL
RDRQP

Sequences:

>Translated_565_residues
MAQRIFTLILLLCSTSVFAGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADVQLP
QGVWHEDEFYGKSEIYRDRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNEASQPVSVPQQEQPT
AQLPFSALWALLIGIGIAFTPCVLPMYPLISGIVLGGKQRLSTARALLLTFIYVQGMALTYTALGLVVAAAGLQFQAALQ
HPYVLIGLAIVFTLLAMSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFIMGAIAGLICSPCTTAPLSAILLYIAQSG
NMWLGGGTLYLYALGMGLPLMLITVFGNRLLPKSGPWMEQVKTAFGFVILALPVFLLERVIGDIWGLRLWSALGVAFFGW
AFITSLQAKRGWMRVVQIILLAAALVSVRPLQDWAFGETHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWC
VACKEFEKYTFSDPQVQKALADTVLLQANVTANDAQDVALLKHLNVLGLPTILFFDGQGQEHPQARVTGFMDAETFSAHL
RDRQP
>Mature_564_residues
AQRIFTLILLLCSTSVFAGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADVQLPQ
GVWHEDEFYGKSEIYRDRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNEASQPVSVPQQEQPTA
QLPFSALWALLIGIGIAFTPCVLPMYPLISGIVLGGKQRLSTARALLLTFIYVQGMALTYTALGLVVAAAGLQFQAALQH
PYVLIGLAIVFTLLAMSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFIMGAIAGLICSPCTTAPLSAILLYIAQSGN
MWLGGGTLYLYALGMGLPLMLITVFGNRLLPKSGPWMEQVKTAFGFVILALPVFLLERVIGDIWGLRLWSALGVAFFGWA
FITSLQAKRGWMRVVQIILLAAALVSVRPLQDWAFGETHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWCV
ACKEFEKYTFSDPQVQKALADTVLLQANVTANDAQDVALLKHLNVLGLPTILFFDGQGQEHPQARVTGFMDAETFSAHLR
DRQP

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm, thereby maintaining the

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=565, Percent_Identity=98.9380530973451, Blast_Score=1142, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 61916; Mature: 61785

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQRIFTLILLLCSTSVFAGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYL
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCCEEE
YRKQIRITPEHAKIADVQLPQGVWHEDEFYGKSEIYRDRLTLPVTINQASAGATLTVTYQ
EEEEEEECCCCCEEEEEECCCCCCCCHHCCCHHHHHHCCEEEEEEEECCCCCCEEEEEEC
GCADAGFCYPPETKTVPLSEVVANNEASQPVSVPQQEQPTAQLPFSALWALLIGIGIAFT
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
PCVLPMYPLISGIVLGGKQRLSTARALLLTFIYVQGMALTYTALGLVVAAAGLQFQAALQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHC
HPYVLIGLAIVFTLLAMSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFIMGAIAGLI
CCHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHH
CSPCTTAPLSAILLYIAQSGNMWLGGGTLYLYALGMGLPLMLITVFGNRLLPKSGPWMEQ
CCCCCCHHHHHHHHHHHCCCCEEECCCHHEEHHHHCCHHHHHHHHHCCCCCCCCCCHHHH
VKTAFGFVILALPVFLLERVIGDIWGLRLWSALGVAFFGWAFITSLQAKRGWMRVVQIIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAALVSVRPLQDWAFGETHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWC
HHHHHHHCCCCHHCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHH
VACKEFEKYTFSDPQVQKALADTVLLQANVTANDAQDVALLKHLNVLGLPTILFFDGQGQ
HHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHCCHHCCCEEEEECCCCC
EHPQARVTGFMDAETFSAHLRDRQP
CCCHHHHEEECCHHHHHHHHCCCCC
>Mature Secondary Structure 
AQRIFTLILLLCSTSVFAGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCCEEE
YRKQIRITPEHAKIADVQLPQGVWHEDEFYGKSEIYRDRLTLPVTINQASAGATLTVTYQ
EEEEEEECCCCCEEEEEECCCCCCCCHHCCCHHHHHHCCEEEEEEEECCCCCCEEEEEEC
GCADAGFCYPPETKTVPLSEVVANNEASQPVSVPQQEQPTAQLPFSALWALLIGIGIAFT
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
PCVLPMYPLISGIVLGGKQRLSTARALLLTFIYVQGMALTYTALGLVVAAAGLQFQAALQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHC
HPYVLIGLAIVFTLLAMSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFIMGAIAGLI
CCHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHH
CSPCTTAPLSAILLYIAQSGNMWLGGGTLYLYALGMGLPLMLITVFGNRLLPKSGPWMEQ
CCCCCCHHHHHHHHHHHCCCCEEECCCHHEEHHHHCCHHHHHHHHHCCCCCCCCCCHHHH
VKTAFGFVILALPVFLLERVIGDIWGLRLWSALGVAFFGWAFITSLQAKRGWMRVVQIIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAALVSVRPLQDWAFGETHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWC
HHHHHHHCCCCHHCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHH
VACKEFEKYTFSDPQVQKALADTVLLQANVTANDAQDVALLKHLNVLGLPTILFFDGQGQ
HHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHCCHHCCCEEEEECCCCC
EHPQARVTGFMDAETFSAHLRDRQP
CCCHHHHEEECCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]