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The map label for this gene is uhpA [H]

Identifier: 218691961

GI number: 218691961

Start: 4290704

End: 4291294

Strand: Reverse

Name: uhpA [H]

Synonym: ECED1_4364

Alternate gene names: 218691961

Gene position: 4291294-4290704 (Counterclockwise)

Preceding gene: 218691963

Following gene: 218691960

Centisome position: 82.37

GC content: 58.71

Gene sequence:

>591_bases
ATGATCACCGTTGCCCTTATAGACGATCACCTTATCGTCCGCTCCGGCTTTGCGCAGCTGCTGGGGCTGGAACCTGATTT
GCAGGTAGTTGCCGAGTTTGGTTCGGGGCGCGAGGCGCTGGCGGGGCTGCCGGGGCGCGGTGTGCTGGTGTGTATTTGCG
ATATCTCCATGCCTGATATCTCCGGTCTGGAGCTTCTAAGCCAGCTGCCGAAAGGCATGGCGACAATTATGCTCTCCGTT
CATGACAGTCCGGCGCTGGTTGAGCAGGCGCTTAACGCGGGGGCGCGCGGCTTTCTCTCCAAACGCTGTAGCCCGGATGA
ACTCATTGCTGCGGTGCATACGGTTGCCACGGGCGGCTGTTATCTGACGCCGGATATTGCCATTAAACTGGCATCCGGTC
GCCAGGACCCGCTAACCAAACGCGAACGCCAGGTGGCGGAAAAACTGGCGCAAGGAATGGCGGTGAAAGAGATTGCTGCC
GAACTGGGCTTGTCACCGAAAACGGTACATGTCCATCGCGCCAACCTGATGGAAAAACTGGGCGTCAGTAACGACGTTGA
ACTGGCGCGCCGCATGTTTGATGGCTGGTGA

Upstream 100 bases:

>100_bases
GCAACAGGAGCGCAGCTTTTTTCAGTAACCGCTCAAGGCTTGAACAGTGGCGCGCTTATCGTTAAGGTAAGCGCGTTTTA
TTACCCGCCAGGACAAGACC

Downstream 100 bases:

>100_bases
TGAAGACGTTGTTCTCCCGCTTAATTACCGTTATTGCCTGCTTTTTTATCTTCTCTGCCGCATGGTTTTGCCTGTGGAGT
ATCAGCCTGCACCTGGTTGA

Product: DNA-binding transcriptional activator UhpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVLVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Sequences:

>Translated_196_residues
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVLVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW
>Mature_196_residues
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVLVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Specific function: Appears to be the positive activator of uhpT transcription [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=99.4897959183673, Blast_Score=393, Evalue=1e-111,
Organism=Escherichia coli, GI1788222, Length=200, Percent_Identity=36.5, Blast_Score=124, Evalue=3e-30,
Organism=Escherichia coli, GI1788521, Length=194, Percent_Identity=36.0824742268041, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=33.879781420765, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1786747, Length=196, Percent_Identity=29.5918367346939, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1788712, Length=183, Percent_Identity=28.9617486338798, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788546, Length=199, Percent_Identity=30.1507537688442, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 20875; Mature: 20875

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVLVCICDISMPDI
CEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHCCCCCCEEEEEEECCCCCC
SGLELLSQLPKGMATIMLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGC
HHHHHHHHCCCHHHHEEEECCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCE
YLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKL
EECCHHEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEHHHHHHHHHH
GVSNDVELARRMFDGW
CCCCHHHHHHHHHCCC
>Mature Secondary Structure
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVLVCICDISMPDI
CEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHCCCCCCEEEEEEECCCCCC
SGLELLSQLPKGMATIMLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGC
HHHHHHHHCCCHHHHEEEECCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCE
YLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKL
EECCHHEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEHHHHHHHHHH
GVSNDVELARRMFDGW
CCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]