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The map label for this gene is uhpB [H]

Identifier: 218691960

GI number: 218691960

Start: 4289202

End: 4290704

Strand: Reverse

Name: uhpB [H]

Synonym: ECED1_4363

Alternate gene names: 218691960

Gene position: 4290704-4289202 (Counterclockwise)

Preceding gene: 218691961

Following gene: 218691959

Centisome position: 82.36

GC content: 56.75

Gene sequence:

>1503_bases
ATGAAGACGTTGTTCTCCCGCTTAATTACCGTTATTGCCTGCTTTTTTATCTTCTCTGCCGCATGGTTTTGCCTGTGGAG
TATCAGCCTGCACCTGGTTGAGCGCCCTGATATGGCGGTACTGTTATTTCCGTTTGGCCTGCGGCTAGGGCTAATGCTGC
AATGCCCGCGCGGATACTGGCCGGTGTTGCTGGGCGCGGAGTGGCTGCTGATTTACTGGTTAACGCAGGCGGTCGGTTTA
ACCCATTTCTCCTTATTGATGATCGGTAGTTTACTGACGTTACTGCCCGTGGCGCTGATCTCGCGCTATCGCCATCAACG
TGACTGGCGCACCTTGCTGTTACAGGGTGCGGCATTAACGGCGGCGGCGTTGTTGCAGTCGCTGCCCTGGCTTTGGCACG
GCAAAGAGTCGTGGAATGCGCTACTGCTGACTTTAACTGGCGGCCTGACGCTGGCCCCGATATGTCTGGTGTTCTGGCAC
TATCTCGCCAATAACACCTGGCTGCCGCTCGGCCCGTCACTGGTTTCTCAACCAATCAACTGGCGTGGGCGGCATCTGGT
CTGGTACTTGCTGCTGTTTGTTATCAGTCTCTGGCTCCAGTTGGGATTGCCGGACGAACTGTCGCGCTTTACGCCATTCT
GTCTGGCGCTGCCGATTATCGCGCTGGCCTGGCACTATGGTTGGCAAGGAGCGCTGATTGCGACATTGATGAACGCCATC
GCGCTGATCGCCAGTCAAACCTGGCGCGATCATCCGGTGGATTTATTGCTCTCGCTGCTGGTGCAAAGTCTGACAGGGTT
GTTATTGGGCGCTGGCATCCAGCGGTTGCGTGAACTTAACCAGTCGCTGCAAAAGGAACTGGCGCGCAATCAGCATCTCG
CTGAACGGTTGCTGGAAACCGAAGAGAGCGTGCGCCGTGATGTGGCACGTGAGCTGCACGATGATATCGGTCAGACCATT
ACTGCTATTCGAACTCAAGCGGGCATTGTCCAGCGGCTCGCGGCGGATAACGCCAGCGTGAAACAGAGCGGGCAGCTCAT
CGAACAGTTGTCGTTGGGCGTTTACGACGCGGTGCGCCGCTTGTTAGGGCGGTTACGTCCGCGCCAGCTGGATGATCTCA
CCCTGGAGCAGGCCATCCGCTCACTGATGCGGGAAATGGAGCTGGAAGGGCGCGGCATTGTCAGTCATCTCGAATGGCGA
ATCGATGAATCAGCGTTAAGCGAAAACCAGCGCGTGACGCTGTTTCGCGTCTGCCAGGAAGGGTTGAACAACATTGTGAA
ACATGCCGATGCCAGCGCGGTCACGCTGCAAGGCTGGCAGCATGATGAGCGGTTAATGCTGGTGATTGAAGACGATGGCA
GCGGTTTACCGCCAGATTCCGGGCAACACGGTTTTGGCCTTACCGGAATGCGCGAGCGCGTAACGGCGCTGGGTGGCACA
TTGACCATTTCCTGTCTGCACGGCACGCGTGTCAGCGTTTCTCTACCTCAACGTTATGTCTAA

Upstream 100 bases:

>100_bases
TGTCACCGAAAACGGTACATGTCCATCGCGCCAACCTGATGGAAAAACTGGGCGTCAGTAACGACGTTGAACTGGCGCGC
CGCATGTTTGATGGCTGGTG

Downstream 100 bases:

>100_bases
GGTTCGATGATGTTGCCGTTTCTGAAAGCGCCTGCCGATGCGCCATTAATGACTGATAAACATGAAATTGATGCCCGCTA
TCGCTACTGGCGTCGGCATA

Product: sensory histidine kinase UhpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MKTLFSRLITVIACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLIYWLTQAVGL
THFSLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGAALTAAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWH
YLANNTWLPLGPSLVSQPINWRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWRDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNQHLAERLLETEESVRRDVARELHDDIGQTI
TAIRTQAGIVQRLAADNASVKQSGQLIEQLSLGVYDAVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWR
IDESALSENQRVTLFRVCQEGLNNIVKHADASAVTLQGWQHDERLMLVIEDDGSGLPPDSGQHGFGLTGMRERVTALGGT
LTISCLHGTRVSVSLPQRYV

Sequences:

>Translated_500_residues
MKTLFSRLITVIACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLIYWLTQAVGL
THFSLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGAALTAAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWH
YLANNTWLPLGPSLVSQPINWRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWRDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNQHLAERLLETEESVRRDVARELHDDIGQTI
TAIRTQAGIVQRLAADNASVKQSGQLIEQLSLGVYDAVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWR
IDESALSENQRVTLFRVCQEGLNNIVKHADASAVTLQGWQHDERLMLVIEDDGSGLPPDSGQHGFGLTGMRERVTALGGT
LTISCLHGTRVSVSLPQRYV
>Mature_500_residues
MKTLFSRLITVIACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLIYWLTQAVGL
THFSLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGAALTAAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWH
YLANNTWLPLGPSLVSQPINWRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWRDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNQHLAERLLETEESVRRDVARELHDDIGQTI
TAIRTQAGIVQRLAADNASVKQSGQLIEQLSLGVYDAVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWR
IDESALSENQRVTLFRVCQEGLNNIVKHADASAVTLQGWQHDERLMLVIEDDGSGLPPDSGQHGFGLTGMRERVTALGGT
LTISCLHGTRVSVSLPQRYV

Specific function: Member of the two-component regulatory system uhpB/uhpA involved in the regulation of the uptake of hexose phosphates. UhpB functions as a membrane-associated protein kinase that phosphorylates uhpA in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=500, Percent_Identity=99, Blast_Score=980, Evalue=0.0,
Organism=Escherichia coli, GI1788812, Length=214, Percent_Identity=33.1775700934579, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787474, Length=219, Percent_Identity=27.3972602739726, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR007895
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; PF05231 MASE1 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56337; Mature: 56337

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLFSRLITVIACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHEECCCCCC
PVLLGAEWLLIYWLTQAVGLTHFSLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGAALT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWHYLANNTWLPLGPSLVSQPIN
HHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCC
WRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALIASQTWRDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNQHLAERLLET
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EESVRRDVARELHDDIGQTITAIRTQAGIVQRLAADNASVKQSGQLIEQLSLGVYDAVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHH
LLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWRIDESALSENQRVTLFRVCQE
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHH
GLNNIVKHADASAVTLQGWQHDERLMLVIEDDGSGLPPDSGQHGFGLTGMRERVTALGGT
HHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
LTISCLHGTRVSVSLPQRYV
EEEEEECCCEEEECCCCCCC
>Mature Secondary Structure
MKTLFSRLITVIACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHEECCCCCC
PVLLGAEWLLIYWLTQAVGLTHFSLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGAALT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWHYLANNTWLPLGPSLVSQPIN
HHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCC
WRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALIASQTWRDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNQHLAERLLET
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EESVRRDVARELHDDIGQTITAIRTQAGIVQRLAADNASVKQSGQLIEQLSLGVYDAVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHH
LLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWRIDESALSENQRVTLFRVCQE
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHH
GLNNIVKHADASAVTLQGWQHDERLMLVIEDDGSGLPPDSGQHGFGLTGMRERVTALGGT
HHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
LTISCLHGTRVSVSLPQRYV
EEEEEECCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3301805; 1569007; 7686882; 9278503 [H]