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The map label for this gene is bisC [H]

Identifier: 218691842

GI number: 218691842

Start: 4156681

End: 4158960

Strand: Reverse

Name: bisC [H]

Synonym: ECED1_4236

Alternate gene names: 218691842

Gene position: 4158960-4156681 (Counterclockwise)

Preceding gene: 218691845

Following gene: 218691839

Centisome position: 79.83

GC content: 54.52

Gene sequence:

>2280_bases
ATGCAGGTTGAAACCGACGGCGAAACCGTGTTTAGCTCGCGTGGCGCGTTAGCCACAGGAATGGAAAACTCCTTGCAGAG
CGCGGTTCGCGACCAGGTTCACAGCAATACGCGGGTGCGATTTCCAATGGTGCGCAAAGGCTTTCTTGCGTCACCGGAAA
ATCCGCAAGGCATTCGTGGGCAGGATGAATTTGTTCGCGTGAGTTGGGATGAGGCGCTGGAGCTTATTCACCATCAACAT
AAACGCATTCGTGAGGCTTATGGCCCGGCATCGATTTTTGCTGGTTCCTACGGCTGGCGTTCAAACGGCGTGCTGCATAA
GGCCTCGACATTATTACAACGCTATATGGCGCTGGCAGGCGGTTATACTGGGCATCTGGGGGATTATTCGACCGGCGCGG
CACAGGCGATCATGCCGTATGTCGTGGGTGGCAGCGAAGTTTATCAACAGCAAACCAGTTGGCCGTTGGTATTGGAACAT
AGCGATGTCGTGGTGCTATGGAGTGCTAATCCACTCAATACGCTGAAAATTGCGTGGAATGCATCCGATGAGCAGGGGCT
TTCTTACTTTTCCGCACTGCGTGACAGCGGGAAAAAGCTGATCTGCATTGATCCAATGCGATCGGAAACCGTCGATTTCT
TTGGCGATAAAATGGAGTGGGTGGCACCGCACATGGGCACCGATGTTGCGCTGATGCTGGGGATCGCCCATACGCTGGTG
GAAAATGGTTGGCACGACGAAGCGTTTCTGGCGCGTTGCACCACCGGTTATGCCGTCTTCGCCTCTTATTTGCTGGGCGA
GAGTGACGGAATAGCGAAAACCGCCGAATGGGCGGCAGGGATTTGTGGGGTTAACGCAGCGAAAATCCGCGAGCTGGCGG
CTCTTTTCCACCAAAATACCACCATGCTGATGGCTGGCTGGGGAATGCAGCGTCAACAGTTTGGTGAGCAAAAACATTGG
ATGATCGTCACGCTGGCGGCAATGTTGGGGCAAATCGGCACACCCGGCGGCGGTTTTGGTCTTTCTTACCATTTTGCCAA
TGGTGGTAACCCCACGCGCCGCGCTGCGGTGCTCTCTTCCATGCAGGGCAGTTTGCCTGGCGGCACCGATGCGGTGGATA
AAATCCCTGTTGCCCGCATTGTTGAAGCACTGGAAAACCCCGGTGGCGCATATCAACATAACGGTATGGACCGACATTTC
CCGGATATTCGTTTTATCTGGTGGGCGGGCGGTGCCAACTTTACTCATCATCAGGATACCAATCGCCTGATCCGTGCCTG
GCAAAAACCGGAGCTGGTGGTGATCTCCGAATGCTTCTGGACGGCTGCGGCGAAACACGCGGATATCGTTCTGCCTGCGA
CCACCTCTTTTGAGCGTAATGATCTCACCATGACCGGTGATTACAGTAATCAGCATCTGGTGCCGATGAAGCAAGTGGTG
CCGCCACGCGATGAAGCGCGTAATGATTTTGATGTTTTTGCCGACTTGAGTGAACGTTGGCAGAAGGGCGGTTATGCACG
TTTTACGGAAGGAAAAAGTGAGCTGCAATGGCTGGAAACGTTTTATAACGTTGCCCGGCAGCGCGGGGCAAGCCAGCAGG
TTGAATTGCCGCCATTTGCTGAGTTCTGGCAAGCCAACCAGTTAATTGAGATGCCGGAAAACCCGGACAGTGAGCGGTTT
ATTCGCTTCGCCGATTTTCGCCGCGATCCGCAGGCGCATCCATTAAAAACCGCCAGCGGTAAGATTGAAATCTTCTCGCA
GCGTATTGCCGATTACGCTTATCCGGATTGCCCGGGGCATCCAATGTGGCTGGCGCCGGACGAATGGCAGGGCAATGCCG
AACCGGAACAGTTGCAGGTACTTTCTGCTCATCCGGCGCATCGTCTGCACAGCCAGCTGAATTACAGTTCTCTGCGCGAA
TTGTACGCGGTGGCAAATCGTGAGCCTGTCACCATTCATCCTGACGATGCCCAGACGCGCGGCATACAAGATGGCGATAC
TGTTCGGCTGTGGAACTCACGCGGGCAAATTCTTGCCGGAGCGGTCATTAGCGAGGGAATTAAACCTGGCGTGATTTGTA
TTCACGAAGGCGCATGGCCAGATCTGGATTTAACCGCTGACGGCATTTGTAAAAACGGCGCAGTGAACGTGCTGACCAAA
GATCTCCCCAGCTCGCGGCTGGGGAATGGCTGTGCGGGTAATACGGCGCTGGCATGGCTGGAAAAATACAACGGTCCGGA
ACTGACACTTACAGCGTTTGAACCACCGGCCAGCTCATAA

Upstream 100 bases:

>100_bases
TAATATTTAACTGCTCAATACATCTAACCTTTCAGGAGTCTTCGGTTTGGCCAACTCATCCTCACGATATTCCGTTCTGA
CTGCCGCCCACTGGGGGCCC

Downstream 100 bases:

>100_bases
TCCAGGTGGGTAGTTGGGTTTCATCCTGCCATGCGCAATCGACAATGTGAAAACCCTGCGCATGGTAGAAATCTATCGCC
GGTTGATTTTTTTGATAAAC

Product: biotin sulfoxide reductase

Products: Biotin. [C]

Alternate protein names: BDS reductase; BSO reductase [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MQVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVRVSWDEALELIHHQH
KRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEH
SDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
ENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAGICGVNAAKIRELAALFHQNTTMLMAGWGMQRQQFGEQKHW
MIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSSMQGSLPGGTDAVDKIPVARIVEALENPGGAYQHNGMDRHF
PDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
PPRDEARNDFDVFADLSERWQKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERF
IRFADFRRDPQAHPLKTASGKIEIFSQRIADYAYPDCPGHPMWLAPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRE
LYAVANREPVTIHPDDAQTRGIQDGDTVRLWNSRGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
DLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS

Sequences:

>Translated_759_residues
MQVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVRVSWDEALELIHHQH
KRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEH
SDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
ENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAGICGVNAAKIRELAALFHQNTTMLMAGWGMQRQQFGEQKHW
MIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSSMQGSLPGGTDAVDKIPVARIVEALENPGGAYQHNGMDRHF
PDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
PPRDEARNDFDVFADLSERWQKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERF
IRFADFRRDPQAHPLKTASGKIEIFSQRIADYAYPDCPGHPMWLAPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRE
LYAVANREPVTIHPDDAQTRGIQDGDTVRLWNSRGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
DLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS
>Mature_759_residues
MQVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVRVSWDEALELIHHQH
KRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEH
SDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
ENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAGICGVNAAKIRELAALFHQNTTMLMAGWGMQRQQFGEQKHW
MIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSSMQGSLPGGTDAVDKIPVARIVEALENPGGAYQHNGMDRHF
PDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
PPRDEARNDFDVFADLSERWQKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERF
IRFADFRRDPQAHPLKTASGKIEIFSQRIADYAYPDCPGHPMWLAPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRE
LYAVANREPVTIHPDDAQTRGIQDGDTVRLWNSRGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
DLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS

Specific function: This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI145693196, Length=759, Percent_Identity=97.6284584980237, Blast_Score=1543, Evalue=0.0,
Organism=Escherichia coli, GI87081994, Length=763, Percent_Identity=64.089121887287, Blast_Score=1050, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=747, Percent_Identity=44.0428380187416, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI87081797, Length=752, Percent_Identity=32.4468085106383, Blast_Score=306, Evalue=3e-84,
Organism=Escherichia coli, GI1787870, Length=753, Percent_Identity=30.5444887118194, Blast_Score=290, Evalue=3e-79,
Organism=Escherichia coli, GI171474008, Length=753, Percent_Identity=30.4116865869854, Blast_Score=277, Evalue=2e-75,
Organism=Escherichia coli, GI3868721, Length=474, Percent_Identity=23.6286919831224, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 83889; Mature: 83889

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRG
CCCCCCCCHHHHCCCCCHHCHHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCC
QDEFVRVSWDEALELIHHQHKRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAG
CCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHC
GYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWN
CCCCCCCCCCCCHHHHHHHHEECCHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEEC
ASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
CCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHH
ENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAGICGVNAAKIRELAALFHQNT
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCC
TMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSS
EEEEECCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHH
MQGSLPGGTDAVDKIPVARIVEALENPGGAYQHNGMDRHFPDIRFIWWAGGANFTHHQDT
HCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHH
NRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
HHHHHHCCCCCEEEEEHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCHHHCC
PPRDEARNDFDVFADLSERWQKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFA
CCHHHCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
EFWQANQLIEMPENPDSERFIRFADFRRDPQAHPLKTASGKIEIFSQRIADYAYPDCPGH
HHHCCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
PMWLAPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDAQTR
CEECCCCCCCCCCCHHHEEEECCCCHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCHHHC
GIQDGDTVRLWNSRGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
CCCCCCEEEEECCCCCEEEHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEC
DLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS
CCCCHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MQVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRG
CCCCCCCCHHHHCCCCCHHCHHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCC
QDEFVRVSWDEALELIHHQHKRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAG
CCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHC
GYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWN
CCCCCCCCCCCCHHHHHHHHEECCHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEEC
ASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
CCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHH
ENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAGICGVNAAKIRELAALFHQNT
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCC
TMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSS
EEEEECCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHH
MQGSLPGGTDAVDKIPVARIVEALENPGGAYQHNGMDRHFPDIRFIWWAGGANFTHHQDT
HCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHH
NRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
HHHHHHCCCCCEEEEEHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCHHHCC
PPRDEARNDFDVFADLSERWQKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFA
CCHHHCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
EFWQANQLIEMPENPDSERFIRFADFRRDPQAHPLKTASGKIEIFSQRIADYAYPDCPGH
HHHCCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
PMWLAPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDAQTR
CEECCCCCCCCCCCHHHEEEECCCCHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCHHHC
GIQDGDTVRLWNSRGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
CCCCCCEEEEECCCCCEEEHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEC
DLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS
CCCCHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: Reduction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2180922; 8041620; 9278503 [H]