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The map label for this gene is csrD [H]

Identifier: 218691535

GI number: 218691535

Start: 3833644

End: 3835584

Strand: Reverse

Name: csrD [H]

Synonym: ECED1_3903

Alternate gene names: 218691535

Gene position: 3835584-3833644 (Counterclockwise)

Preceding gene: 218691540

Following gene: 218691533

Centisome position: 73.63

GC content: 50.23

Gene sequence:

>1941_bases
ATGAGATTAACGACGAAATTTTCGGCCTTTGTCACGCTGCTCACCGGGTTAACAATTTTTGTGACTTTGCTGGGCTGTTC
GCTAAGTTTCTACAACGCCATTCAGTATAAGTTTAGTCATCGTGTTCAGGCGGTGGCGACGGCGATTGATACCCACCTAG
TGTCGAATGACTTCAGCACATTAAGGCCACAAATTACCGAATTAATGATGTCGGCAGATATCGTTCGTGTAGACCTGCTC
CATGGTGATAAGCAGGTTTATACCCTGGCCAGAAATGGTAGTTATCGTCCGGTTGGCACCAACGATCTGTTTCGTGAACT
GAGCGTTCCGTTGATAAAGCATCCGGGGATGTCGCTGCGTCTGGTTTATCAGGATCCGATGGGCAACTATTTCCATTCTT
TAATGACTACCGCGCCGCTCACGGGGGCGATTGGCTTTATCATTCTTATGCTCTTCCTGGCGGTACGCTGGTTACAACGG
CAACTTGCCGGGCAAGAATTGCTGGAAACCCGGGCTACTCGTATCTTAAACGGTGAGCGTGGCTCTAATGTGTTGGGAAC
CATCTATGAATGGCCGCCCAGAACCAGCAGTGCGCTGGATACGCTGCTTTGTGAAATTCAGAACGCACGCGAACAACACA
GCCGTCTTGATACGCTGATCCGCTCTTATGCCGCCCAGGACATGAAAACCGGCCTCAATAACCGACTCTTTTTCGATAAT
CAGTTAGCAACGTTACTGGAAGATCAAGAGAAAGTAGGTACCCACGGGATCGTGATGATGATTCGTCTGCCGGATTTCAA
TATGTTGAGTGATACCTGGGGGCACAGCCAGGTTGAAGAACAGTTCTTCTCTCTGACGAATCTGCTATCGACATTTATGA
TGCGCTACCCTGGCGCACTGCTGGCGCGTTACCACCGCAGTGATTTTGCTGCGCTGTTACCGCACCGGACGTTAAAAGAG
GCAGAGAGCATCGCCAGTCAGTTAATCAAAGCCGTCGATACCTTGCCGAACAATAAAATGCTCGATCGCGACGATATGAT
CCACATTGGTATCTGTGCCTGGCGTAGTGGTCAGGATACCGAGCAGGTAATGGAACATGCAGAGTCTGCCACGCGTAATG
CGGGATTGCAGGGCGGCAATAGCTGGGCTATTTACGATGACTCGTTGCCTGAAAAAGGACGCGGTAATGTTCGCTGGCGT
ACGCTTATCGAGCAAATGCTCAGTCGCGGCGGCCCGCGCCTTTATCAAAAACCGGCGGTTACTCGCGAAGGCCGGGTTTA
TCATCGTGAACTCATGTGCCGCATTTTCGATGGTAATGAAGAGGTTAGCTCGGCAGAGTATATGCCGATGGTCTTGCAGT
TTGGTTTATCGGAAGAGTATGACCGCCTGCAAATCAGCCGTCTTATTCCACTATTGCGTTACTGGCCAGAGGAAAATCTG
GCGATTCAGGTTACCGTTGAGTCGCTGATTCGCCCGCGTTTTCAGCGTTGGCTGCGCGATACGTTAATGCAATGTGAAAA
ATCGCAACGAAGACACATAATTATTGAACTTGCAGAGGCCGATGTTGGTCAACATATCAGTCGCTTACAACCTGTTATTC
GTTTAGTGAATGCTTTAGGGGTACGGGTAGCCGTCAACCAGGCTGGTTTGACGCTGGTAAGCACCAGTTGGATCAAAGAA
CTTAATGTTGAGTTACTCAAGCTCCATCCGGGGCTGGTCAGAAACATTGAGAAGCGAACGGAGAACCAACTGCTGGTTCA
AAGCCTGGTGGAAGCCTGCTCCGGGACCAGCACCCAGGTTTACGCCACCGGCGTGCGTTCGCGAAGCGAGTGGCAGACCC
TGATTCAGCGCGGTGTTACAGGTGGGCAAGGGGATTTTTTCGCGTCCTCACAGCCACTTGATACTAACGTGAAAAAATAT
TCACAAAGATACTCGGTTTAA

Upstream 100 bases:

>100_bases
CTCGCTAATGGAAAAGCAAAGCCGATGAAGCGCAATAAATTGCGAGATAAATCTGATTTGCTAGTATGCCCGCTTCCTCA
CTATCGGAGTTAACACAAGG

Downstream 100 bases:

>100_bases
CCTGCCGTTTAATCCGTTTTCACGTAGAATAACGCGCGCTGCGTCTCATGGGAGTGTGCTTGTCTGCTCGCCAGATTGTT
GCAGCACATATGCAGATGAA

Product: regulatory protein CsrD

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSTLRPQITELMMSADIVRVDLL
HGDKQVYTLARNGSYRPVGTNDLFRELSVPLIKHPGMSLRLVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQR
QLAGQELLETRATRILNGERGSNVLGTIYEWPPRTSSALDTLLCEIQNAREQHSRLDTLIRSYAAQDMKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFSLTNLLSTFMMRYPGALLARYHRSDFAALLPHRTLKE
AESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDTEQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWR
TLIEQMLSRGGPRLYQKPAVTREGRVYHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRRHIIIELAEADVGQHISRLQPVIRLVNALGVRVAVNQAGLTLVSTSWIKE
LNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQVYATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKY
SQRYSV

Sequences:

>Translated_646_residues
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSTLRPQITELMMSADIVRVDLL
HGDKQVYTLARNGSYRPVGTNDLFRELSVPLIKHPGMSLRLVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQR
QLAGQELLETRATRILNGERGSNVLGTIYEWPPRTSSALDTLLCEIQNAREQHSRLDTLIRSYAAQDMKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFSLTNLLSTFMMRYPGALLARYHRSDFAALLPHRTLKE
AESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDTEQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWR
TLIEQMLSRGGPRLYQKPAVTREGRVYHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRRHIIIELAEADVGQHISRLQPVIRLVNALGVRVAVNQAGLTLVSTSWIKE
LNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQVYATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKY
SQRYSV
>Mature_646_residues
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSTLRPQITELMMSADIVRVDLL
HGDKQVYTLARNGSYRPVGTNDLFRELSVPLIKHPGMSLRLVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQR
QLAGQELLETRATRILNGERGSNVLGTIYEWPPRTSSALDTLLCEIQNAREQHSRLDTLIRSYAAQDMKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFSLTNLLSTFMMRYPGALLARYHRSDFAALLPHRTLKE
AESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDTEQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWR
TLIEQMLSRGGPRLYQKPAVTREGRVYHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRRHIIIELAEADVGQHISRLQPVIRLVNALGVRVAVNQAGLTLVSTSWIKE
LNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQVYATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKY
SQRYSV

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=646, Percent_Identity=98.1424148606811, Blast_Score=1312, Evalue=0.0,
Organism=Escherichia coli, GI1787541, Length=455, Percent_Identity=21.7582417582418, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788849, Length=236, Percent_Identity=23.3050847457627, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787410, Length=121, Percent_Identity=26.4462809917355, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082096, Length=237, Percent_Identity=23.6286919831224, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 73456; Mature: 73456

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGTNDLFRELSVPLIKHPGMSLR
HHHHHHHHHHHHHHHEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHCCCHHCCCCCEEE
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
EEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GSNVLGTIYEWPPRTSSALDTLLCEIQNAREQHSRLDTLIRSYAAQDMKTGLNNRLFFDN
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECH
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFSLTNLLSTFMMRYPGAL
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
LARYHRSDFAALLPHRTLKEAESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCH
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
HHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
TREGRVYHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRRHIIIELAEADVGQHISRLQPVIRLVNALG
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCHHHHHHHHHHHHHHHHHHHC
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
CEEEECCCCCEEHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
EEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGTNDLFRELSVPLIKHPGMSLR
HHHHHHHHHHHHHHHEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHCCCHHCCCCCEEE
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
EEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GSNVLGTIYEWPPRTSSALDTLLCEIQNAREQHSRLDTLIRSYAAQDMKTGLNNRLFFDN
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECH
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFSLTNLLSTFMMRYPGAL
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
LARYHRSDFAALLPHRTLKEAESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCH
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
HHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
TREGRVYHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRRHIIIELAEADVGQHISRLQPVIRLVNALG
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCHHHHHHHHHHHHHHHHHHHC
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
CEEEECCCCCEEHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
EEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]