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The map label for this gene is agaI [H]

Identifier: 218691437

GI number: 218691437

Start: 3734342

End: 3735109

Strand: Direct

Name: agaI [H]

Synonym: ECED1_3805

Alternate gene names: 218691437

Gene position: 3734342-3735109 (Clockwise)

Preceding gene: 218691436

Following gene: 218691439

Centisome position: 71.68

GC content: 50.0

Gene sequence:

>768_bases
ATGGAACGAGGCACCGCGTCTGGCGGTGCCTCTTTACTTAAGGAATTTCATCCTGTGCAAACCCTTCAACAAGTTGAAAA
CTATACGGCATTAAGTGAACGTGCCAGCGAATATTTATTGGCCGAGATCCGTCGCAAACCGGATGCCGTGATTTGCCTGG
CGACCGGAGCCACGCCATTACTGACGTATCATTATCTGGTAGAAAAAATCCACCAGCAGCAGGTTGATGTCAGCCATCTC
ACCTTCGTGAAGCTCGACGAATGGGTGGATCTGCCATTAACGATGCCTGGTACCTGCGAAACTTTCCTTCAACAGCATAT
CGTGCAGCCGCTGGGGCTACGTGAAGACCAGCTCATCAGCTTTCACTCCGAAGAGATAAATGAGACAGAGTGCGAACGGG
TAACGAACCTGATTGCGCGCAAAGGCGGTCTGGACTTATGCGTTCTCGGATTGGGGAAAAACGGTCATCTTGGGCTGAAC
GAACCGGGAGAAAGCCTGCAACCGGCCTGCCATATCAGTCAACTTGATGCCAGAACACAGCAACATGAGATGTTAAAAAC
CGCGGACCGTCCCGTGACTCGTGGGATCACCTTAGGCCTGAAGGATATTCTCAATGCCCGCGAAGTTTTGTTACTGGTGA
CTGGCGAAGGAAAACAGGATGCGACAAAACGTTTTCTCACGGCTAAAGTCTCTACCGCTATCCCGGCTTCATTTTTATGG
CTGCATAACTATTTCACATGCATGATTGATGAGATGTGTCGTCGTTAA

Upstream 100 bases:

>100_bases
GATGTATTACTTCCTGCGGGTGAAAAAAGCGCATCCGGTGCTGTTAATCGGCGTGACGTTTGTTCTTTCTATTGTTTGTT
CTGCATTCGGCATTTTGTAA

Downstream 100 bases:

>100_bases
CTCGCCTGCTACAGGCGTTGCAACGCTATTCCTGCTGCGACGCCTGTAATCACTCTCCCTGCTGCTCCAGCGCATACTTA
TACAGCGCATTTTTCTTCAC

Product: galactosamine-6-phosphate isomerase

Products: D-Tagatose 6-Phosphate; NH3. [C]

Alternate protein names: Galactosamine-6-phosphate deaminase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MERGTASGGASLLKEFHPVQTLQQVENYTALSERASEYLLAEIRRKPDAVICLATGATPLLTYHYLVEKIHQQQVDVSHL
TFVKLDEWVDLPLTMPGTCETFLQQHIVQPLGLREDQLISFHSEEINETECERVTNLIARKGGLDLCVLGLGKNGHLGLN
EPGESLQPACHISQLDARTQQHEMLKTADRPVTRGITLGLKDILNAREVLLLVTGEGKQDATKRFLTAKVSTAIPASFLW
LHNYFTCMIDEMCRR

Sequences:

>Translated_255_residues
MERGTASGGASLLKEFHPVQTLQQVENYTALSERASEYLLAEIRRKPDAVICLATGATPLLTYHYLVEKIHQQQVDVSHL
TFVKLDEWVDLPLTMPGTCETFLQQHIVQPLGLREDQLISFHSEEINETECERVTNLIARKGGLDLCVLGLGKNGHLGLN
EPGESLQPACHISQLDARTQQHEMLKTADRPVTRGITLGLKDILNAREVLLLVTGEGKQDATKRFLTAKVSTAIPASFLW
LHNYFTCMIDEMCRR
>Mature_255_residues
MERGTASGGASLLKEFHPVQTLQQVENYTALSERASEYLLAEIRRKPDAVICLATGATPLLTYHYLVEKIHQQQVDVSHL
TFVKLDEWVDLPLTMPGTCETFLQQHIVQPLGLREDQLISFHSEEINETECERVTNLIARKGGLDLCVLGLGKNGHLGLN
EPGESLQPACHISQLDARTQQHEMLKTADRPVTRGITLGLKDILNAREVLLLVTGEGKQDATKRFLTAKVSTAIPASFLW
LHNYFTCMIDEMCRR

Specific function: N-acetylgalactosamine utilization. [C]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI13027378, Length=210, Percent_Identity=27.1428571428571, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI19923881, Length=221, Percent_Identity=26.6968325791855, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1789530, Length=250, Percent_Identity=95.2, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1786893, Length=244, Percent_Identity=28.2786885245902, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI48994958, Length=227, Percent_Identity=27.7533039647577, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17554876, Length=234, Percent_Identity=28.6324786324786, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24581960, Length=207, Percent_Identity=25.1207729468599, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI19920764, Length=207, Percent_Identity=25.1207729468599, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: 5.3.1.- [C]

Molecular weight: Translated: 28543; Mature: 28543

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERGTASGGASLLKEFHPVQTLQQVENYTALSERASEYLLAEIRRKPDAVICLATGATPL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHH
LTYHYLVEKIHQQQVDVSHLTFVKLDEWVDLPLTMPGTCETFLQQHIVQPLGLREDQLIS
HHHHHHHHHHHHHHCCHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
FHSEEINETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHISQLDARTQ
HHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QHEMLKTADRPVTRGITLGLKDILNAREVLLLVTGEGKQDATKRFLTAKVSTAIPASFLW
HHHHHHHCCCCHHHHHHCCHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHH
LHNYFTCMIDEMCRR
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MERGTASGGASLLKEFHPVQTLQQVENYTALSERASEYLLAEIRRKPDAVICLATGATPL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHH
LTYHYLVEKIHQQQVDVSHLTFVKLDEWVDLPLTMPGTCETFLQQHIVQPLGLREDQLIS
HHHHHHHHHHHHHHCCHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
FHSEEINETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHISQLDARTQ
HHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QHEMLKTADRPVTRGITLGLKDILNAREVLLLVTGEGKQDATKRFLTAKVSTAIPASFLW
HHHHHHHCCCCHHHHHHCCHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHH
LHNYFTCMIDEMCRR
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Galactosamine 6-Phosphate; H2O [C]

Specific reaction: D-Galactosamine 6-Phosphate + H2O = D-Tagatose 6-Phosphate + NH3. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10931310; 9278503; 8932697 [H]