Click here to switch to the map view.

The map label for this gene is garR [H]

Identifier: 218691420

GI number: 218691420

Start: 3717617

End: 3718507

Strand: Reverse

Name: garR [H]

Synonym: ECED1_3786

Alternate gene names: 218691420

Gene position: 3718507-3717617 (Counterclockwise)

Preceding gene: 218691421

Following gene: 218691419

Centisome position: 71.38

GC content: 53.31

Gene sequence:

>891_bases
ATGACTATGAAAGTTGGTTTTATTGGCCTGGGGATTATGGGTAAACCAATGAGTAAAAACCTTCTGAAAGCAGGTTACTC
GCTGGTGGTTGCTGACCGTAACCCGTCAGCTATTGCTGACGTGATTGCTGCAGGTGCAGAAACAGCCTCTACGGCTAAAG
CGATCGCTGAACAGTGCGACGTCATCATAACCATGCTGCCAAACTCCCCTCATGTGAAAGAGGTGGCGCTGGGTGAGAAT
GGCATTATTGAAGGCGCGAAGCCAGGTACGGTATTGATCGATATGAGTTCTATCGCACCGCTGGTAAGCCGTGAAATCAG
CGAAGCGCTGAAAGCGAAAGGCATTGATATGCTGGACGCCCCGGTGAGCGGCGGTGAACCGAAAGCCATCGACGGTACGC
TGTCAGTGATGGTGGGCGGCGACAAGGCTATTTTCGACAAATACTATGATTTGATGAAAGCGATGGCGGGTTCCGTGGTG
CATACCGGGGAAATCGGTGCAGGTAACGTCACCAAACTGGCAAATCAGGTCATTGTGGCGCTGAATATTGCTGCGATGTC
AGAAGCGTTAACGCTGGCAACCAAAGCGGGCGTTAACCCGGATCTGGTGTATCAGGCAATTCGCGGTGGGCTGGCGGGCA
GTACCGTGCTGGATGCCAAAGCGCCGATGGTGATGGACCGCAACTTCAAACCGGGCTTCCGTATTGATCTGCATATTAAG
GATCTGGCGAATGCGCTGGATACTTCTCACGGCGTCGGCGCGCAACTGCCGCTCACAGCTGCGGTTATGGAGATGATGCA
GGCACTGCGTGCAGATGGTTTAGGAACGGCGGATCATAGCGCCCTGGCGTGCTACTACGAAAAACTGGCGAAAGTCGAAG
TTACTCGCTAA

Upstream 100 bases:

>100_bases
TGGCTGTCGGCAGCGATCTCGGCATCTTCCGCTCTGCCACTCAGAAACTGGCTGATACCTTTAAAAAATAACCACCACCG
CAACAAGAGAGATGATTGAT

Downstream 100 bases:

>100_bases
TGACGTCGTGCCCGGATGGCGTATTGCAATCCGGGCCTGGAATCCAGGCCGAATAAGAGAAACGCCCTCCGGCGTCATGT
GGTAACAGGCATAGGTATGA

Product: tartronate semialdehyde reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTMKVGFIGLGIMGKPMSKNLLKAGYSLVVADRNPSAIADVIAAGAETASTAKAIAEQCDVIITMLPNSPHVKEVALGEN
GIIEGAKPGTVLIDMSSIAPLVSREISEALKAKGIDMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVV
HTGEIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIK
DLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKVEVTR

Sequences:

>Translated_296_residues
MTMKVGFIGLGIMGKPMSKNLLKAGYSLVVADRNPSAIADVIAAGAETASTAKAIAEQCDVIITMLPNSPHVKEVALGEN
GIIEGAKPGTVLIDMSSIAPLVSREISEALKAKGIDMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVV
HTGEIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIK
DLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKVEVTR
>Mature_295_residues
TMKVGFIGLGIMGKPMSKNLLKAGYSLVVADRNPSAIADVIAAGAETASTAKAIAEQCDVIITMLPNSPHVKEVALGENG
IIEGAKPGTVLIDMSSIAPLVSREISEALKAKGIDMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVH
TGEIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIKD
LANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKVEVTR

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=285, Percent_Identity=35.7894736842105, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=29.0780141843972, Blast_Score=138, Evalue=7e-33,
Organism=Escherichia coli, GI145693186, Length=294, Percent_Identity=99.3197278911565, Blast_Score=583, Evalue=1e-168,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=43.9446366782007, Blast_Score=240, Evalue=8e-65,
Organism=Escherichia coli, GI1790315, Length=280, Percent_Identity=36.4285714285714, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789092, Length=282, Percent_Identity=34.3971631205674, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17557316, Length=275, Percent_Identity=33.0909090909091, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24655230, Length=284, Percent_Identity=32.3943661971831, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19922568, Length=284, Percent_Identity=32.3943661971831, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=25.531914893617, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30646; Mature: 30515

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMKVGFIGLGIMGKPMSKNLLKAGYSLVVADRNPSAIADVIAAGAETASTAKAIAEQCD
CEEEEEEEEECCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCC
VIITMLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLVSREISEALKAKGIDMLDA
EEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEECC
PVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGEIGAGNVTKLANQVIVA
CCCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHE
LNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIK
EHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCEEECCCCCCCCEEEEEHH
DLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKVEVTR
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCC
>Mature Secondary Structure 
TMKVGFIGLGIMGKPMSKNLLKAGYSLVVADRNPSAIADVIAAGAETASTAKAIAEQCD
EEEEEEEEECCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCC
VIITMLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLVSREISEALKAKGIDMLDA
EEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEECC
PVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGEIGAGNVTKLANQVIVA
CCCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHE
LNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIK
EHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCEEECCCCCCCCEEEEEHH
DLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKVEVTR
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]