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The map label for this gene is fhuD [H]

Identifier: 218691329

GI number: 218691329

Start: 3614152

End: 3615162

Strand: Reverse

Name: fhuD [H]

Synonym: ECED1_3690

Alternate gene names: 218691329

Gene position: 3615162-3614152 (Counterclockwise)

Preceding gene: 218691330

Following gene: 218691328

Centisome position: 69.39

GC content: 48.86

Gene sequence:

>1011_bases
TTGGTGGACCATTTTTTTTGCTACTGCTCTGGCAGCGCAGGAACAGTTTTTAACGGGAGTTATATGCGTTTATTTTTTTC
TCTGCTGATACTGTTGTCATTTTTTTCCCGTGCAACAGAACCTGTTCAGGTATTTACTGATGATTTAGGGCGCAAAGTCA
CTGTTCCTGCTCATCCAAAGAGAATTGTCTCTTTACACGATCTTGATATCACTATTCCTCTGATTGAGCTCGGTGTACCT
CCTGTCGCCAGCCACGGGCGAACTCGGCCTGACGGTAGCCATTTCATTCGATCTGGCGCGTTATTGACAGGTGTCGACTT
TGATAATTCATCGATCGCCTTTATTGGTACCGCTGATATTGATATTGAAGCGATTGTGGCGGCAAAGCCTGACCTGATCA
TCACAGAACCGACCCGTAATACGCCCATTGAACAACTTGAAAAAATTGCGCCCACGGTGAGCATTGATCATCTCAAAGGG
GGTGCGCCAGAAATCTATCGCAAGCTGGCAGAACTTACAGGAACGCAGTCGCAGCTGGCGATACTTGAACGCCGCTATCA
GGCACAAATCAATGCGCTGAAGGCGACGCTGGACAGCCAAAAAATAACGGTATCGGTGATTCAGGCAAACCAGGGAAAAA
TTAATGTGATGCATAGCTATCATTCGCTGGGGCGGGTATTACGCGATGCTGGTTTTCGTTTTCCGCCGCTGATTGAGAGC
ATTCCTGAAGGTGGGCGAATGGATGTGAGCGCGGAGCGTTTACCTGAACTGGATGCCGATTTTGTTTTTGCAACCTGGCG
CGGTGACACCGGTGGTAAACCTCAGGATGAGCTGGCAGCAATGGAAAAAGTCATGCCGGGATGGTGTCAGTTTCTGACTG
CCTGTCGTTCCGGGCGTTATGTGCTGATTTCTCGTGAAGAGGCAATTTCTAACTCCTTTGCATCTCTGGGGCTGATGGCT
GCGCAGATACAATCACAAATTGCAGGGCGACCTCTACCGGAGGCTAAATGA

Upstream 100 bases:

>100_bases
AGCGCGGTATCGGGGGCGTTGTTAGTTATTCTGGCGGATAGCATTGGTCGTTTGGCTTTTTTGCCTTTGCAACTGCCTGC
CGGAATCATTATCTCACTGA

Downstream 100 bases:

>100_bases
TCCAGAAAGATAAAGCGCGGGTTGATATTTTTGGTGAGCGTTTTCACACTCGCGCGAGTCAGTTAACGCCTGGGTTAAGA
GCTGTCGCCAGCTACATTAA

Product: putative iron compound-binding protein of ABC transporter family

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MVDHFFCYCSGSAGTVFNGSYMRLFFSLLILLSFFSRATEPVQVFTDDLGRKVTVPAHPKRIVSLHDLDITIPLIELGVP
PVASHGRTRPDGSHFIRSGALLTGVDFDNSSIAFIGTADIDIEAIVAAKPDLIITEPTRNTPIEQLEKIAPTVSIDHLKG
GAPEIYRKLAELTGTQSQLAILERRYQAQINALKATLDSQKITVSVIQANQGKINVMHSYHSLGRVLRDAGFRFPPLIES
IPEGGRMDVSAERLPELDADFVFATWRGDTGGKPQDELAAMEKVMPGWCQFLTACRSGRYVLISREEAISNSFASLGLMA
AQIQSQIAGRPLPEAK

Sequences:

>Translated_336_residues
MVDHFFCYCSGSAGTVFNGSYMRLFFSLLILLSFFSRATEPVQVFTDDLGRKVTVPAHPKRIVSLHDLDITIPLIELGVP
PVASHGRTRPDGSHFIRSGALLTGVDFDNSSIAFIGTADIDIEAIVAAKPDLIITEPTRNTPIEQLEKIAPTVSIDHLKG
GAPEIYRKLAELTGTQSQLAILERRYQAQINALKATLDSQKITVSVIQANQGKINVMHSYHSLGRVLRDAGFRFPPLIES
IPEGGRMDVSAERLPELDADFVFATWRGDTGGKPQDELAAMEKVMPGWCQFLTACRSGRYVLISREEAISNSFASLGLMA
AQIQSQIAGRPLPEAK
>Mature_336_residues
MVDHFFCYCSGSAGTVFNGSYMRLFFSLLILLSFFSRATEPVQVFTDDLGRKVTVPAHPKRIVSLHDLDITIPLIELGVP
PVASHGRTRPDGSHFIRSGALLTGVDFDNSSIAFIGTADIDIEAIVAAKPDLIITEPTRNTPIEQLEKIAPTVSIDHLKG
GAPEIYRKLAELTGTQSQLAILERRYQAQINALKATLDSQKITVSVIQANQGKINVMHSYHSLGRVLRDAGFRFPPLIES
IPEGGRMDVSAERLPELDADFVFATWRGDTGGKPQDELAAMEKVMPGWCQFLTACRSGRYVLISREEAISNSFASLGLMA
AQIQSQIAGRPLPEAK

Specific function: Part of the ABC transporter complex fhuCBGD involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of ferrichrome and coprogen [H]

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 36751; Mature: 36751

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDHFFCYCSGSAGTVFNGSYMRLFFSLLILLSFFSRATEPVQVFTDDLGRKVTVPAHPK
CCCEEEEEEECCCCCEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEECCCCCC
RIVSLHDLDITIPLIELGVPPVASHGRTRPDGSHFIRSGALLTGVDFDNSSIAFIGTADI
CEEEEECCEEEEEHHCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCCEEEEEECCC
DIEAIVAAKPDLIITEPTRNTPIEQLEKIAPTVSIDHLKGGAPEIYRKLAELTGTQSQLA
CEEEEEECCCCEEEECCCCCCCHHHHHHHCCCEEECCCCCCCHHHHHHHHHHCCCHHHHH
ILERRYQAQINALKATLDSQKITVSVIQANQGKINVMHSYHSLGRVLRDAGFRFPPLIES
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEHHHHHHHHHHHHCCCCCCHHHHH
IPEGGRMDVSAERLPELDADFVFATWRGDTGGKPQDELAAMEKVMPGWCQFLTACRSGRY
CCCCCCCCCCHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHCCCCE
VLISREEAISNSFASLGLMAAQIQSQIAGRPLPEAK
EEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVDHFFCYCSGSAGTVFNGSYMRLFFSLLILLSFFSRATEPVQVFTDDLGRKVTVPAHPK
CCCEEEEEEECCCCCEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEECCCCCC
RIVSLHDLDITIPLIELGVPPVASHGRTRPDGSHFIRSGALLTGVDFDNSSIAFIGTADI
CEEEEECCEEEEEHHCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCCEEEEEECCC
DIEAIVAAKPDLIITEPTRNTPIEQLEKIAPTVSIDHLKGGAPEIYRKLAELTGTQSQLA
CEEEEEECCCCEEEECCCCCCCHHHHHHHCCCEEECCCCCCCHHHHHHHHHHCCCHHHHH
ILERRYQAQINALKATLDSQKITVSVIQANQGKINVMHSYHSLGRVLRDAGFRFPPLIES
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEHHHHHHHHHHHHCCCCCCHHHHH
IPEGGRMDVSAERLPELDADFVFATWRGDTGGKPQDELAAMEKVMPGWCQFLTACRSGRY
CCCCCCCCCCHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHCCCCE
VLISREEAISNSFASLGLMAAQIQSQIAGRPLPEAK
EEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8388528; 9639930; 9384377 [H]