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The map label for this gene is exbB

Identifier: 218691296

GI number: 218691296

Start: 3582359

End: 3583093

Strand: Reverse

Name: exbB

Synonym: ECED1_3656

Alternate gene names: 218691296

Gene position: 3583093-3582359 (Counterclockwise)

Preceding gene: 218691297

Following gene: 218691295

Centisome position: 68.78

GC content: 52.93

Gene sequence:

>735_bases
GTGGGTAATAATTTAATGCAGACGGACCTCTCCGTCTGGGGTATGTATCAGCACGCCGATATTGTCGTTAAGTGCGTGAT
GATTGGGCTTATTTTGGCCTCCGTAGTCACCTGGGCAATCTTCTTCAGTAAGAGCGTGGAGTTCTTCAATCAGAAGCGTC
GTCTTAAGCGCGAGCAGCAACTGCTGGCTGAAGCGCGTTCCTTAAACCAGGCCAACGATATCGCCGCTGATTTTGGTAGC
AAAAGCTTGAGCCTGCATTTGCTCAATGAAGCGCAGAATGAGCTGGAACTGTCAGAAGGCAGCGACGATAACGAAGGTAT
TAAAGAACGTACCAGCTTCCGTCTGGAGCGTCGGGTCGCCGCAGTAGGTCGTCAAATGGGCCGTGGTAACGGCTATCTGG
CAACCATCGGCGCGATTTCGCCGTTCGTTGGTCTGTTTGGTACGGTCTGGGGCATCATGAACAGCTTTATTGGTATCGCG
CAAACGCAGACCACTAACCTGGCAGTCGTTGCGCCGGGTATTGCAGAAGCTCTGTTAGCAACGGCAATCGGCCTCGTGGC
AGCGATTCCTGCGGTCGTTATCTATAACGTATTTGCACGCCAGATTGGCGGCTTTAAAGCGATGCTGGGTGATGTTGCAG
CGCAGGTATTGTTGCTGCAAAGCCGTGACCTGGATCTGGAAGCCAGCGCCGCTGCGCATCCGGTTCGTGTCGCACAAAAA
TTACGTGCAGGATAA

Upstream 100 bases:

>100_bases
GTACGGCAGTATGCAAATAGTAATGAGAACGACTATCAATTCGACGTCGTTTTGATATTATTATGCACAGATTTTGTGAC
TTGCGTCCTGGAGATACACA

Downstream 100 bases:

>100_bases
TGTCCGATGGCGATGCATCTTAACGAAAACCTCGACGATAACGGCGAAATGCATGATATCAACGTGACGCCGTTTATCGA
CGTGATGTTGGTTTTGCTGA

Product: biopolymer transport protein ExbB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MGNNLMQTDLSVWGMYQHADIVVKCVMIGLILASVVTWAIFFSKSVEFFNQKRRLKREQQLLAEARSLNQANDIAADFGS
KSLSLHLLNEAQNELELSEGSDDNEGIKERTSFRLERRVAAVGRQMGRGNGYLATIGAISPFVGLFGTVWGIMNSFIGIA
QTQTTNLAVVAPGIAEALLATAIGLVAAIPAVVIYNVFARQIGGFKAMLGDVAAQVLLLQSRDLDLEASAAAHPVRVAQK
LRAG

Sequences:

>Translated_244_residues
MGNNLMQTDLSVWGMYQHADIVVKCVMIGLILASVVTWAIFFSKSVEFFNQKRRLKREQQLLAEARSLNQANDIAADFGS
KSLSLHLLNEAQNELELSEGSDDNEGIKERTSFRLERRVAAVGRQMGRGNGYLATIGAISPFVGLFGTVWGIMNSFIGIA
QTQTTNLAVVAPGIAEALLATAIGLVAAIPAVVIYNVFARQIGGFKAMLGDVAAQVLLLQSRDLDLEASAAAHPVRVAQK
LRAG
>Mature_243_residues
GNNLMQTDLSVWGMYQHADIVVKCVMIGLILASVVTWAIFFSKSVEFFNQKRRLKREQQLLAEARSLNQANDIAADFGSK
SLSLHLLNEAQNELELSEGSDDNEGIKERTSFRLERRVAAVGRQMGRGNGYLATIGAISPFVGLFGTVWGIMNSFIGIAQ
TQTTNLAVVAPGIAEALLATAIGLVAAIPAVVIYNVFARQIGGFKAMLGDVAAQVLLLQSRDLDLEASAAAHPVRVAQKL
RAG

Specific function: Involved in the tonB-dependent energy-dependent transport of various receptor-bound substrates. Protects exbD from proteolytic degradation and functionally stabilizes tonB

COG id: COG0811

COG function: function code U; Biopolymer transport proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the exbB/tolQ family

Homologues:

Organism=Escherichia coli, GI1789381, Length=244, Percent_Identity=100, Blast_Score=493, Evalue=1e-141,
Organism=Escherichia coli, GI1786958, Length=205, Percent_Identity=33.1707317073171, Blast_Score=100, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EXBB_ECO57 (P0ABU8)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B85960
- PIR:   B91115
- RefSeq:   NP_289583.1
- RefSeq:   NP_311917.1
- ProteinModelPortal:   P0ABU8
- EnsemblBacteria:   EBESCT00000026998
- EnsemblBacteria:   EBESCT00000058406
- GeneID:   916284
- GeneID:   959561
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4359
- KEGG:   ecs:ECs3890
- GeneTree:   EBGT00050000010126
- HOGENOM:   HBG681852
- OMA:   DDNNGIK
- ProtClustDB:   PRK10414
- BioCyc:   ECOL83334:ECS3890-MONOMER
- InterPro:   IPR002898
- InterPro:   IPR014164
- TIGRFAMs:   TIGR02797

Pfam domain/function: PF01618 MotA_ExbB

EC number: NA

Molecular weight: Translated: 26288; Mature: 26157

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x237cb964)-; HASH(0x242c1b8c)-; HASH(0x229d5280)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNNLMQTDLSVWGMYQHADIVVKCVMIGLILASVVTWAIFFSKSVEFFNQKRRLKREQQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAEARSLNQANDIAADFGSKSLSLHLLNEAQNELELSEGSDDNEGIKERTSFRLERRVA
HHHHHHHCCHHHHHHHHCCCCHHEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AVGRQMGRGNGYLATIGAISPFVGLFGTVWGIMNSFIGIAQTQTTNLAVVAPGIAEALLA
HHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHH
TAIGLVAAIPAVVIYNVFARQIGGFKAMLGDVAAQVLLLQSRDLDLEASAAAHPVRVAQK
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LRAG
HHCH
>Mature Secondary Structure 
GNNLMQTDLSVWGMYQHADIVVKCVMIGLILASVVTWAIFFSKSVEFFNQKRRLKREQQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAEARSLNQANDIAADFGSKSLSLHLLNEAQNELELSEGSDDNEGIKERTSFRLERRVA
HHHHHHHCCHHHHHHHHCCCCHHEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AVGRQMGRGNGYLATIGAISPFVGLFGTVWGIMNSFIGIAQTQTTNLAVVAPGIAEALLA
HHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHH
TAIGLVAAIPAVVIYNVFARQIGGFKAMLGDVAAQVLLLQSRDLDLEASAAAHPVRVAQK
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LRAG
HHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796