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The map label for this gene is tcpE [H]

Identifier: 218691159

GI number: 218691159

Start: 3438685

End: 3439851

Strand: Direct

Name: tcpE [H]

Synonym: ECED1_3508

Alternate gene names: 218691159

Gene position: 3438685-3439851 (Clockwise)

Preceding gene: 218691158

Following gene: 218691160

Centisome position: 66.01

GC content: 50.47

Gene sequence:

>1167_bases
TTGATCCGCTGGCGGCCCATTACATCTCTCCCGTCGATGAGGACAGCTATACGCTGCTGCACTGATATGAAATATCTGGA
AAAACTCCACAGTACCGACATCGAGCTGACAGCACTGACCGTCTGGATAGCCAGAAAAACCTTTGCCCTGAACCGGGTGG
AGTTCTACGAAGCCCTGGGCGGCATGATACGTGACGGAACGCCGTCCCTGCGTGCCCTCGAATTTCTCTGCGAGATCGAA
ACCGATTTTGGTGAAAAGAAAGGCACATCCGGCATGTATTTTCTGGCAAAAGAATGCATCGCGTCCATCAAAGCCAGCGG
CATGTTATCCGGTGCCCTGTTCACCTGGGTGCCACCGGAGGAAGCCACGTTAATCAGAAACGGGGAAGAGCGCGGGAATA
TTGCCGACGCCCTTTTCCAGGTGGCCAGAACCGTTAAAGCCCGGCGGGAAATGACATCCAGCCTCATTGCCGTCTGCCTC
TATCCCCTTCTGCTGCTTTCACTCTGTGTGGTGAACATGTACAACGCCCATACCCGTATCATTCCCATCGTCAGTGCGTT
TGCCACGGAAGATAAATGGTCATTCCAGATGAAAGTGCTGGCCGGCATGTCGGAATTTATCATCGGGTACGGACTCTGGC
TCTGCGGGGCCATTATCGCCCTGACGGTTCTGATCCGTTTTTCCTTCAGCAGGTACACCGGCCCCGGCCGGAGGATGCTG
GACAGGGTACCACCCTGGTCACTGTATCAGACCTTACACGGAGTGAATTATCTGTTCAGTATTTCATCCATGCTGCAGAT
TAATATTCCGCTTTCGCAGGCACTGCTCAGAATGGAAAAAGGGGCAGAAAAGAATAAATGGTTAAAGGAGAGAATTCAGG
CAATACGAAAACATGTGTTATCCGGTCAGAATCTGGCCACGGCAATGCGAAATTCCGGTTACGATTTTCCGTCCAGAGTA
TGCATCAATAAACTGCTCCTGAATTCCGAAAGGGAGGATAATGTGGCAGCCATGGCGGTCTATGCCGACCAGTGGCTGGA
AGAGGCAAAAAAACGGGTAAAACGCAGCGGATTAATTATTACCGGTATATCAGGAGGTTTTGTCTTCTTTTTTATTCTTA
ACATGATATCTGCCATCTACAGTATCAGCGACATGCTGAAACAATAA

Upstream 100 bases:

>100_bases
CGGGAAAAGGGGCGTATCGAGGCCAGAACCTACTGGCACCGGGAACTGGGCGGAATGACCCGTAATCAGCATCTGCTGGG
AAAAATCAACAGCGGACAGG

Downstream 100 bases:

>100_bases
CCCCCACCATACAGAATATTTCTGAAACATCCCATAAACCAGGAGTGATATATGAACTTCAGAGCACGTCTTTTTTATTA
TTTTTCTTTAAAAAAAGAAG

Product: membrane protein

Products: NA

Alternate protein names: TCP pilus biosynthesis protein tcpE [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MIRWRPITSLPSMRTAIRCCTDMKYLEKLHSTDIELTALTVWIARKTFALNRVEFYEALGGMIRDGTPSLRALEFLCEIE
TDFGEKKGTSGMYFLAKECIASIKASGMLSGALFTWVPPEEATLIRNGEERGNIADALFQVARTVKARREMTSSLIAVCL
YPLLLLSLCVVNMYNAHTRIIPIVSAFATEDKWSFQMKVLAGMSEFIIGYGLWLCGAIIALTVLIRFSFSRYTGPGRRML
DRVPPWSLYQTLHGVNYLFSISSMLQINIPLSQALLRMEKGAEKNKWLKERIQAIRKHVLSGQNLATAMRNSGYDFPSRV
CINKLLLNSEREDNVAAMAVYADQWLEEAKKRVKRSGLIITGISGGFVFFFILNMISAIYSISDMLKQ

Sequences:

>Translated_388_residues
MIRWRPITSLPSMRTAIRCCTDMKYLEKLHSTDIELTALTVWIARKTFALNRVEFYEALGGMIRDGTPSLRALEFLCEIE
TDFGEKKGTSGMYFLAKECIASIKASGMLSGALFTWVPPEEATLIRNGEERGNIADALFQVARTVKARREMTSSLIAVCL
YPLLLLSLCVVNMYNAHTRIIPIVSAFATEDKWSFQMKVLAGMSEFIIGYGLWLCGAIIALTVLIRFSFSRYTGPGRRML
DRVPPWSLYQTLHGVNYLFSISSMLQINIPLSQALLRMEKGAEKNKWLKERIQAIRKHVLSGQNLATAMRNSGYDFPSRV
CINKLLLNSEREDNVAAMAVYADQWLEEAKKRVKRSGLIITGISGGFVFFFILNMISAIYSISDMLKQ
>Mature_388_residues
MIRWRPITSLPSMRTAIRCCTDMKYLEKLHSTDIELTALTVWIARKTFALNRVEFYEALGGMIRDGTPSLRALEFLCEIE
TDFGEKKGTSGMYFLAKECIASIKASGMLSGALFTWVPPEEATLIRNGEERGNIADALFQVARTVKARREMTSSLIAVCL
YPLLLLSLCVVNMYNAHTRIIPIVSAFATEDKWSFQMKVLAGMSEFIIGYGLWLCGAIIALTVLIRFSFSRYTGPGRRML
DRVPPWSLYQTLHGVNYLFSISSMLQINIPLSQALLRMEKGAEKNKWLKERIQAIRKHVLSGQNLATAMRNSGYDFPSRV
CINKLLLNSEREDNVAAMAVYADQWLEEAKKRVKRSGLIITGISGGFVFFFILNMISAIYSISDMLKQ

Specific function: Probably involved in cholera toxin receptor (GM1) interaction in order to bring the cells within close proximity of the ganglioside for efficient toxin delivery [H]

COG id: COG1459

COG function: function code NU; Type II secretory pathway, component PulF

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP F family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018076
- InterPro:   IPR001992 [H]

Pfam domain/function: PF00482 GSPII_F [H]

EC number: NA

Molecular weight: Translated: 43812; Mature: 43812

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRWRPITSLPSMRTAIRCCTDMKYLEKLHSTDIELTALTVWIARKTFALNRVEFYEALG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GMIRDGTPSLRALEFLCEIETDFGEKKGTSGMYFLAKECIASIKASGMLSGALFTWVPPE
CHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCC
EATLIRNGEERGNIADALFQVARTVKARREMTSSLIAVCLYPLLLLSLCVVNMYNAHTRI
CHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
IPIVSAFATEDKWSFQMKVLAGMSEFIIGYGLWLCGAIIALTVLIRFSFSRYTGPGRRML
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
DRVPPWSLYQTLHGVNYLFSISSMLQINIPLSQALLRMEKGAEKNKWLKERIQAIRKHVL
HCCCCHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
SGQNLATAMRNSGYDFPSRVCINKLLLNSEREDNVAAMAVYADQWLEEAKKRVKRSGLII
CCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEE
TGISGGFVFFFILNMISAIYSISDMLKQ
EECCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRWRPITSLPSMRTAIRCCTDMKYLEKLHSTDIELTALTVWIARKTFALNRVEFYEALG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GMIRDGTPSLRALEFLCEIETDFGEKKGTSGMYFLAKECIASIKASGMLSGALFTWVPPE
CHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCC
EATLIRNGEERGNIADALFQVARTVKARREMTSSLIAVCLYPLLLLSLCVVNMYNAHTRI
CHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
IPIVSAFATEDKWSFQMKVLAGMSEFIIGYGLWLCGAIIALTVLIRFSFSRYTGPGRRML
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
DRVPPWSLYQTLHGVNYLFSISSMLQINIPLSQALLRMEKGAEKNKWLKERIQAIRKHVL
HCCCCHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
SGQNLATAMRNSGYDFPSRVCINKLLLNSEREDNVAAMAVYADQWLEEAKKRVKRSGLII
CCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEE
TGISGGFVFFFILNMISAIYSISDMLKQ
EECCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11179381 [H]