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The map label for this gene is helD [C]

Identifier: 218691152

GI number: 218691152

Start: 3429755

End: 3431263

Strand: Reverse

Name: helD [C]

Synonym: ECED1_3500

Alternate gene names: 218691152

Gene position: 3431263-3429755 (Counterclockwise)

Preceding gene: 218691164

Following gene: 218691151

Centisome position: 65.86

GC content: 56.06

Gene sequence:

>1509_bases
ATGCCCCATAAACCGACAGAAGAACAGACGGCAATTATTCACTGGCAGGGGAGGAAGCTTGTTGTTAATGCTTTTGCCGG
TACAGGGAAAACCAGCACACTGGTCAGCTATGCCATGGCCTGCCCGGAAAGCAGGATGCTCTATCTCGCCTATAATCGTG
CGATTCGTGATGAAGCTGAGCGCAGGTTTCCTTTTAACGTTGAATGCAAAACGTCGCATCAGCTGGCGTTTGCCCGCTTC
GGAAGGCATTACCAGAAGCGGCTTGTTCCGGGCTTGTTCGTCACCGATGTGGCAAGAAAACTGAATACCCGATACTGGGC
ACTGGCCCGGGTGGCCATGACAGGGCTGAATCAGTTTATCTGCTCAGCGGATGCAACCCCCGGCAGGCAGCATCTGCCGG
ACAAGGACGAAATGAAAGGCGTTGCTCCGGATGAGGCACTTCGTGCTGTGAGGACGCTCTGGCAGGCCATGAGCGATCCG
GATGGAACGTTTCCGGTCACCCATGACACCTATCTCAAATTGTTTCAGCTCTCCGGACCTGATCTCTCGCGCAGATGGGA
CACCATTCTGTTTGATGAAGCGCAGGATGCGAATCCGGTGACTTCCGCACTTGTGCTGGGACAGCGGTGCAGGATTGTGC
TGGTCGGTGACCGGTATCAGCAGATCTACCGTTTTCGTGGCGCGGATGATGCCCTGTCTCATCCGTCTCTGGCCGGTGCC
GACCGTCTCTGGCTGACACAGAGTTTTCGTTTTGGCCCCGCAGTGGCCGCGATGGCTAATCTGCTGCTGAAACGCGCAGG
GGAAAGTCGGGAGGTGAGCGGCTGCGGTGGTGATGATGAGGTGCTTACCATGCAGGAAATGCGTGAGCGCATGAAGCGTG
GAAAATTTGGGGGACACCGGGCGGTACTGAACCGGACCGTCGCCGGAGTGATTGGCACGGCGCTGATGGCGGCAATGGCG
GGCAGGAAGGTTTACTGGGTCGGGGGCATTGAGGGATACCGAACGGAGGCGCTTGAAGATCTTTACTGGTTCCAGATGGA
TATGCCGGCCCGGATGCACTCTGACCGGTTGCGCAGGGATTACCGGAATTTTGATGAATACCGTCATATTGCGAAGGTGA
CGAAGGATGTGGAAATGAGTCAGTCCATACGACTACTGGAGCTGTGTTTTCCGTTACCCAAAAAACTGGAGCTACTCAGG
GAGCACACAGTCACGAACGAGCGGGAGGCTGATATCACGGTTTCAACGGCGCACCGCAGTAAGGGGCTGGAATGGGAGCG
GGTTGTACTGGGGGATGATTTTCAGGATATCGCTGATCCGTTGATGTCAGAACAGGAGCGCCGGGATGAAACTAACCTGT
TGTATGTGGCGGTGACCCGGGCACGCAGGACGCTGGTACTCAATGAACTCATGCAGCAACTGGCGGAGGAAAAGAGCAGG
ACGAAGGAGAAGACGACGTCCCCGCATCAGCGTGGCACAGAGAAGGCGGTGGAGGGAAAGGATGTTTAA

Upstream 100 bases:

>100_bases
GGCGGTAAAATTTTCTGGTCACCAGGGTAAATTAATGCTGGTCACGGTCGCCTGGCTGAAGGCAGAGTGACCGGAAATTT
CGTCTTTACGGAGGAAAGCC

Downstream 100 bases:

>100_bases
GTTACGGAAGTTTTTTACCTCCGGTTCAGCAGTGGAGATACCCGATGACGGGCGGTCAGTGCCGGGAACACCGGAAGGCT
TTTATGCGCCGCTGACGACA

Product: hypothetical protein

Products: Separated DNA [C]

Alternate protein names: Superfamily I DNA/RNA Helicase-Like Protein; Helicase; Superfamily I DNA/RNA Helicase; Helicase Superfamily Protein I; F-Box Only Protein; I DNA And RNA Helicase Protein; I DNA And RNA Helicase; Superfamily I DNA And RNA Helicase; I DNA/RNA Helicase; UvrD/REP Helicase; UvrD/Rep Family Helicase; Helicase Superfamily I

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MPHKPTEEQTAIIHWQGRKLVVNAFAGTGKTSTLVSYAMACPESRMLYLAYNRAIRDEAERRFPFNVECKTSHQLAFARF
GRHYQKRLVPGLFVTDVARKLNTRYWALARVAMTGLNQFICSADATPGRQHLPDKDEMKGVAPDEALRAVRTLWQAMSDP
DGTFPVTHDTYLKLFQLSGPDLSRRWDTILFDEAQDANPVTSALVLGQRCRIVLVGDRYQQIYRFRGADDALSHPSLAGA
DRLWLTQSFRFGPAVAAMANLLLKRAGESREVSGCGGDDEVLTMQEMRERMKRGKFGGHRAVLNRTVAGVIGTALMAAMA
GRKVYWVGGIEGYRTEALEDLYWFQMDMPARMHSDRLRRDYRNFDEYRHIAKVTKDVEMSQSIRLLELCFPLPKKLELLR
EHTVTNEREADITVSTAHRSKGLEWERVVLGDDFQDIADPLMSEQERRDETNLLYVAVTRARRTLVLNELMQQLAEEKSR
TKEKTTSPHQRGTEKAVEGKDV

Sequences:

>Translated_502_residues
MPHKPTEEQTAIIHWQGRKLVVNAFAGTGKTSTLVSYAMACPESRMLYLAYNRAIRDEAERRFPFNVECKTSHQLAFARF
GRHYQKRLVPGLFVTDVARKLNTRYWALARVAMTGLNQFICSADATPGRQHLPDKDEMKGVAPDEALRAVRTLWQAMSDP
DGTFPVTHDTYLKLFQLSGPDLSRRWDTILFDEAQDANPVTSALVLGQRCRIVLVGDRYQQIYRFRGADDALSHPSLAGA
DRLWLTQSFRFGPAVAAMANLLLKRAGESREVSGCGGDDEVLTMQEMRERMKRGKFGGHRAVLNRTVAGVIGTALMAAMA
GRKVYWVGGIEGYRTEALEDLYWFQMDMPARMHSDRLRRDYRNFDEYRHIAKVTKDVEMSQSIRLLELCFPLPKKLELLR
EHTVTNEREADITVSTAHRSKGLEWERVVLGDDFQDIADPLMSEQERRDETNLLYVAVTRARRTLVLNELMQQLAEEKSR
TKEKTTSPHQRGTEKAVEGKDV
>Mature_501_residues
PHKPTEEQTAIIHWQGRKLVVNAFAGTGKTSTLVSYAMACPESRMLYLAYNRAIRDEAERRFPFNVECKTSHQLAFARFG
RHYQKRLVPGLFVTDVARKLNTRYWALARVAMTGLNQFICSADATPGRQHLPDKDEMKGVAPDEALRAVRTLWQAMSDPD
GTFPVTHDTYLKLFQLSGPDLSRRWDTILFDEAQDANPVTSALVLGQRCRIVLVGDRYQQIYRFRGADDALSHPSLAGAD
RLWLTQSFRFGPAVAAMANLLLKRAGESREVSGCGGDDEVLTMQEMRERMKRGKFGGHRAVLNRTVAGVIGTALMAAMAG
RKVYWVGGIEGYRTEALEDLYWFQMDMPARMHSDRLRRDYRNFDEYRHIAKVTKDVEMSQSIRLLELCFPLPKKLELLRE
HTVTNEREADITVSTAHRSKGLEWERVVLGDDFQDIADPLMSEQERRDETNLLYVAVTRARRTLVLNELMQQLAEEKSRT
KEKTTSPHQRGTEKAVEGKDV

Specific function: Helicase IV Catalyzes The Unwinding Of Duplex DNA In The 3' To 5' Direction With Respect To The Bound Single Strand In A Reaction That Is Dependent Upon The Hydrolysis Of ATP. [C]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI30795119, Length=540, Percent_Identity=30.5555555555556, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI30795117, Length=540, Percent_Identity=30.5555555555556, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.6.1.- [C]

Molecular weight: Translated: 57215; Mature: 57084

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHKPTEEQTAIIHWQGRKLVVNAFAGTGKTSTLVSYAMACPESRMLYLAYNRAIRDEAE
CCCCCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHH
RRFPFNVECKTSHQLAFARFGRHYQKRLVPGLFVTDVARKLNTRYWALARVAMTGLNQFI
HCCCCCEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CSADATPGRQHLPDKDEMKGVAPDEALRAVRTLWQAMSDPDGTFPVTHDTYLKLFQLSGP
HCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEEECCCC
DLSRRWDTILFDEAQDANPVTSALVLGQRCRIVLVGDRYQQIYRFRGADDALSHPSLAGA
CHHHHCCEEEECCCCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCHHCCCCCCCCC
DRLWLTQSFRFGPAVAAMANLLLKRAGESREVSGCGGDDEVLTMQEMRERMKRGKFGGHR
CHHHEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCHH
AVLNRTVAGVIGTALMAAMAGRKVYWVGGIEGYRTEALEDLYWFQMDMPARMHSDRLRRD
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
YRNFDEYRHIAKVTKDVEMSQSIRLLELCFPLPKKLELLREHTVTNEREADITVSTAHRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEECHHC
KGLEWERVVLGDDFQDIADPLMSEQERRDETNLLYVAVTRARRTLVLNELMQQLAEEKSR
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
TKEKTTSPHQRGTEKAVEGKDV
HHHHCCCCHHCCCHHCCCCCCC
>Mature Secondary Structure 
PHKPTEEQTAIIHWQGRKLVVNAFAGTGKTSTLVSYAMACPESRMLYLAYNRAIRDEAE
CCCCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHH
RRFPFNVECKTSHQLAFARFGRHYQKRLVPGLFVTDVARKLNTRYWALARVAMTGLNQFI
HCCCCCEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CSADATPGRQHLPDKDEMKGVAPDEALRAVRTLWQAMSDPDGTFPVTHDTYLKLFQLSGP
HCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEEECCCC
DLSRRWDTILFDEAQDANPVTSALVLGQRCRIVLVGDRYQQIYRFRGADDALSHPSLAGA
CHHHHCCEEEECCCCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCHHCCCCCCCCC
DRLWLTQSFRFGPAVAAMANLLLKRAGESREVSGCGGDDEVLTMQEMRERMKRGKFGGHR
CHHHEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCHH
AVLNRTVAGVIGTALMAAMAGRKVYWVGGIEGYRTEALEDLYWFQMDMPARMHSDRLRRD
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
YRNFDEYRHIAKVTKDVEMSQSIRLLELCFPLPKKLELLREHTVTNEREADITVSTAHRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEECHHC
KGLEWERVVLGDDFQDIADPLMSEQERRDETNLLYVAVTRARRTLVLNELMQQLAEEKSR
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
TKEKTTSPHQRGTEKAVEGKDV
HHHHCCCCHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Duplex DNA; DNA [C]

Specific reaction: Catalyzes the unwinding and separation of duplex DNA in vivo Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA