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The map label for this gene is ubiH [H]

Identifier: 218691031

GI number: 218691031

Start: 3316831

End: 3318009

Strand: Reverse

Name: ubiH [H]

Synonym: ECED1_3366

Alternate gene names: 218691031

Gene position: 3318009-3316831 (Counterclockwise)

Preceding gene: 218691032

Following gene: 218691030

Centisome position: 63.69

GC content: 59.8

Gene sequence:

>1179_bases
ATGAGCGTAATCATCGTCGGTGGCGGCATGGCGGGCGCGACGCTGGCGCTGGCTATTTCCCGGTTAAGTCACGGGGCGCT
GCCAGTACATTTGATTGAAGCGACCGCGCCAGAGTCACATGCGCATCCGGGCTTTGATGGACGAGCTATTGCGCTGGCGG
CGGGTACCTGTCAGCAACTGGCGCGCATCGGCGTCTGGCAATCTCTGGCTGATTGCGCAACTGCCATCACCACCGTGCAT
GTCAGCGATCGTGGTCACGCTGGATTTGTCACCCTCGCCGCAGAAGATTACCAACTGGCGGCGCTGGGGCAGGTTGTTGA
GTTGCACAATGTCGGGCAACGGCTGTTTGCATTGCTGCGCAAAGCACCTGGCGTAACGCTGCATTGCCCTGATCGTGTTG
CTAACGTTTGCCGTACTCAGAGTCACGTTGAAGTGACGCTGGAGAGCGGCGAGATGCTGACGGGCTGCGTGCTGGTAGCC
GCTGATGGCACCCATTCAGCGTTAGCCACTGTGTGCGGCGTTGACTGGCAGCAGGAGCCTTACGAACAACTGGCCGTGAT
TGCCAACGTTGCGACTTCCGTTGCGCACGAAGGCCGCGCTTTTGAACGTTTTACGCAACATGGCCCGCTGGCGATGTTGC
CGATGTCTGACGGACGCTGTTCGCTAGTCTGGTGTCATCCACTGGAACGGCGCGAAGAGCTGCTGTCGTGGAGTGACGAG
AAGTTTTGCCGTGAGCTCCAGTCTGCCTTTGGCTGGCGACTGGGGCAAATTACCCACGCCGGTAAACGCAGTGCTTACCC
GCTGGCGTTAACCCGCGCCGCCAGACCTATTACCCATCGTACCGTGCTGGTGGGCAATGCGGCGCAAACTCTGCACCCGA
TTGCCGGGCAAGGGTTCAACCTCGGTATGCGTGATGTCATGAGCCTTGCAGAAACCCTGACTCAGGCGCAGGAGCGCGGA
GAAGACATGGGTGATTACGGCGTATTGTGCCGTTATCAGCAGCGTCGACAGAGCGATCGCGAAGCAACCATCGGCGTCAC
GGACAGCCTTGTACATCTTTTTGCCAACCGTTGGACCCCGCTGGTTGTCGGGCGCAACATCGGGCTGATGACGATGGAAT
TATTTACCCCGGCACGCGATGTGCTGGCGCAGCGCACCCTCGGTTGGGTGGCGCGTTGA

Upstream 100 bases:

>100_bases
ACGATATTGTGATTACCGAAACCGGTAATGAAAACCTCACCGCCAGCGTGGTGAAAAAGCCGGAAGAAATCGAAGCGTTG
ATGGCAGCTGCGAGAAAGCA

Downstream 100 bases:

>100_bases
AGGCGGTTTTAAGGAATAAACAATGCAAAGTGTTGATGTAGCCATTGTTGGTGGCGGCATGGTGGGGCTGGCGGTTGCCT
GCGGCTTACAGGGGAGCGGC

Product: 2-octaprenyl-6-methoxyphenyl hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSVIIVGGGMAGATLALAISRLSHGALPVHLIEATAPESHAHPGFDGRAIALAAGTCQQLARIGVWQSLADCATAITTVH
VSDRGHAGFVTLAAEDYQLAALGQVVELHNVGQRLFALLRKAPGVTLHCPDRVANVCRTQSHVEVTLESGEMLTGCVLVA
ADGTHSALATVCGVDWQQEPYEQLAVIANVATSVAHEGRAFERFTQHGPLAMLPMSDGRCSLVWCHPLERREELLSWSDE
KFCRELQSAFGWRLGQITHAGKRSAYPLALTRAARPITHRTVLVGNAAQTLHPIAGQGFNLGMRDVMSLAETLTQAQERG
EDMGDYGVLCRYQQRRQSDREATIGVTDSLVHLFANRWTPLVVGRNIGLMTMELFTPARDVLAQRTLGWVAR

Sequences:

>Translated_392_residues
MSVIIVGGGMAGATLALAISRLSHGALPVHLIEATAPESHAHPGFDGRAIALAAGTCQQLARIGVWQSLADCATAITTVH
VSDRGHAGFVTLAAEDYQLAALGQVVELHNVGQRLFALLRKAPGVTLHCPDRVANVCRTQSHVEVTLESGEMLTGCVLVA
ADGTHSALATVCGVDWQQEPYEQLAVIANVATSVAHEGRAFERFTQHGPLAMLPMSDGRCSLVWCHPLERREELLSWSDE
KFCRELQSAFGWRLGQITHAGKRSAYPLALTRAARPITHRTVLVGNAAQTLHPIAGQGFNLGMRDVMSLAETLTQAQERG
EDMGDYGVLCRYQQRRQSDREATIGVTDSLVHLFANRWTPLVVGRNIGLMTMELFTPARDVLAQRTLGWVAR
>Mature_391_residues
SVIIVGGGMAGATLALAISRLSHGALPVHLIEATAPESHAHPGFDGRAIALAAGTCQQLARIGVWQSLADCATAITTVHV
SDRGHAGFVTLAAEDYQLAALGQVVELHNVGQRLFALLRKAPGVTLHCPDRVANVCRTQSHVEVTLESGEMLTGCVLVAA
DGTHSALATVCGVDWQQEPYEQLAVIANVATSVAHEGRAFERFTQHGPLAMLPMSDGRCSLVWCHPLERREELLSWSDEK
FCRELQSAFGWRLGQITHAGKRSAYPLALTRAARPITHRTVLVGNAAQTLHPIAGQGFNLGMRDVMSLAETLTQAQERGE
DMGDYGVLCRYQQRRQSDREATIGVTDSLVHLFANRWTPLVVGRNIGLMTMELFTPARDVLAQRTLGWVAR

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=386, Percent_Identity=28.7564766839378, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI32967307, Length=374, Percent_Identity=29.6791443850267, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1789274, Length=392, Percent_Identity=97.7040816326531, Blast_Score=778, Evalue=0.0,
Organism=Escherichia coli, GI1786883, Length=372, Percent_Identity=32.258064516129, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789273, Length=393, Percent_Identity=30.0254452926209, Blast_Score=161, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI25146631, Length=426, Percent_Identity=26.056338028169, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321694, Length=453, Percent_Identity=24.7240618101545, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI19920760, Length=420, Percent_Identity=23.8095238095238, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 42399; Mature: 42268

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIIVGGGMAGATLALAISRLSHGALPVHLIEATAPESHAHPGFDGRAIALAAGTCQQL
CEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHH
ARIGVWQSLADCATAITTVHVSDRGHAGFVTLAAEDYQLAALGQVVELHNVGQRLFALLR
HHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
KAPGVTLHCPDRVANVCRTQSHVEVTLESGEMLTGCVLVAADGTHSALATVCGVDWQQEP
HCCCCEEECCHHHHHHHCCCCCEEEEEECCCEEEEEEEEEECCCHHHHHHHHCCCCCCCH
YEQLAVIANVATSVAHEGRAFERFTQHGPLAMLPMSDGRCSLVWCHPLERREELLSWSDE
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCCEEEEEECCHHHHHHHHCCCHH
KFCRELQSAFGWRLGQITHAGKRSAYPLALTRAARPITHRTVLVGNAAQTLHPIAGQGFN
HHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHCCCCCCEEEEECCCHHHHCCCCCCCCC
LGMRDVMSLAETLTQAQERGEDMGDYGVLCRYQQRRQSDREATIGVTDSLVHLFANRWTP
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHCCCCCCEECCHHHHHHHHHHCCCCE
LVVGRNIGLMTMELFTPARDVLAQRTLGWVAR
EEEECCCCEEEHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVIIVGGGMAGATLALAISRLSHGALPVHLIEATAPESHAHPGFDGRAIALAAGTCQQL
EEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHH
ARIGVWQSLADCATAITTVHVSDRGHAGFVTLAAEDYQLAALGQVVELHNVGQRLFALLR
HHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
KAPGVTLHCPDRVANVCRTQSHVEVTLESGEMLTGCVLVAADGTHSALATVCGVDWQQEP
HCCCCEEECCHHHHHHHCCCCCEEEEEECCCEEEEEEEEEECCCHHHHHHHHCCCCCCCH
YEQLAVIANVATSVAHEGRAFERFTQHGPLAMLPMSDGRCSLVWCHPLERREELLSWSDE
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCCEEEEEECCHHHHHHHHCCCHH
KFCRELQSAFGWRLGQITHAGKRSAYPLALTRAARPITHRTVLVGNAAQTLHPIAGQGFN
HHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHCCCCCCEEEEECCCHHHHCCCCCCCCC
LGMRDVMSLAETLTQAQERGEDMGDYGVLCRYQQRRQSDREATIGVTDSLVHLFANRWTP
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHCCCCCCEECCHHHHHHHHHHCCCCE
LVVGRNIGLMTMELFTPARDVLAQRTLGWVAR
EEEECCCCEEEHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]