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The map label for this gene is hyuA [H]

Identifier: 218690999

GI number: 218690999

Start: 3275720

End: 3277105

Strand: Direct

Name: hyuA [H]

Synonym: ECED1_3333

Alternate gene names: 218690999

Gene position: 3275720-3277105 (Clockwise)

Preceding gene: 218690998

Following gene: 218691000

Centisome position: 62.88

GC content: 52.96

Gene sequence:

>1386_bases
ATGCGCGTATTGATAAAAAACGGCATTGTTGTTAATGCAGATGGACAGGCGAAGCAGGATTTGCTGATTGAAAGCGGGAT
TGTTCGCCAGTTGGGTACCGATATTTCGCCGCAACTCCCTTGCGAAGAAATTGATGCCTCTGGCTGTTACGTTTTCCCTG
GCGGCGTGGATGTCCATACGCATTTCAATATTGATGTCGGCATCGCGCGCAGTTGTGATGATTTTTTTACCGGTACCCGC
GCTGCTGCGTGTGGCGGTACAACAACCATTATTGACCATATGGGATTTGGCCCAAATGGCTGCCGGTTACGCCATCAACT
GGAAGTTTATCGCGGTTATGCCGCCCACAAAGCGGTCATCGACTACAGCTTTCACGGTGTCATTCAACATATTAATCACG
CTATCCTCGACGAAATTCCGATGATGGTTGAGGAAGGACTGAGCAGTTTTAAACTCTATTTAACCTATCAATATAAACTC
AACGATGATGAAGTGTTGCAGGCATTACGCCGCTTGCATGAGTCCGGCGCGCTGACCACCGTACACCCGGAAAATGACGC
AGCTATCGCCAGCAAGCGGGCGGAGTTTATCGCCGCAGGGTTAACCGCGCCGCGTTATCATGCTTTGAGTCGACCTCTGG
AATGCGAAGCGGAAGCCATCGCCCGCATGATTAACCTGGCACAAATTGCCGGTAACGCCCCGCTCTATATCGTGCACCTG
TCTAACGGCTTAGGTCTGGATTATCTGCGTCTTGCCCGTGCGAACCACCAGCCAGTCTGGGTTGAAACCTGCCCACAATA
TCTCCTGTTGGACGAACGCAGTTACGATACAGAAGATGGCATGAAGTTCATTCTTAGCCCACCGCTGCGTAACGTACGCG
AGCAGGACAAACTGTGGTGTGGCATCAGCGATGGTGCGATTGACGTGGTGGCAACCGATCACTGCACCTTCTCGATGGCC
CAGCGCCAGCAAATTTCTAAAGGCGATTTCAGCCGCTGCCCAAATGGCTTACCCGGTGTGGAGAACCGCATGCAACTGCT
GTTCTCCAGTGGCGTGATGACGGGACGTATCTCACCGGAGCGTTTTGTTGAGTTAACCAGTGCAATGCCCGCCAGGCTGT
TTGGCCTGTGGCCGCAAAAAGGGATATTAGCGCCCGGTTCCGATGGTGACGTGGTGATTATCGACCCACGTCAGAGCCAA
CAAATTCAGCATCGCCATCTCCACGACAACGCTGACTACTCGCCATGGGAGGGGTTTACCTGTCAGGGCGCGATTGTCAG
AACCTTATCCCGTGGTGAAACGATTTTCTGCGACGGCACCTTTACAGGCAAAGCCGGGCGAGGTCGTTTCCTGCGACGCA
AACCGTTTGTCCCTCCCGTGCTCTAA

Upstream 100 bases:

>100_bases
CCGCTATGTACGCTGCAATCCCATTAAGCTGGCTGGCAACCGAATAATTACTCTTCACTTATTCCCCCTCCGGTTTACCG
GAGGGTTTTTGGAGTTTGCT

Downstream 100 bases:

>100_bases
CCACTGCCAGGGATCTATACACAATCAAGAATGATGAGTGAGGAAAAATGAGTAAGAAAATTGTTCTCGCCCTGGGCGGG
AATGCGCTGGGCGATGACCT

Product: phenylhydantoinase

Products: NA

Alternate protein names: Hydantoin-utilizing enzyme hyuA [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MRVLIKNGIVVNADGQAKQDLLIESGIVRQLGTDISPQLPCEEIDASGCYVFPGGVDVHTHFNIDVGIARSCDDFFTGTR
AAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAHKAVIDYSFHGVIQHINHAILDEIPMMVEEGLSSFKLYLTYQYKL
NDDEVLQALRRLHESGALTTVHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLYIVHL
SNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNVREQDKLWCGISDGAIDVVATDHCTFSMA
QRQQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGRISPERFVELTSAMPARLFGLWPQKGILAPGSDGDVVIIDPRQSQ
QIQHRHLHDNADYSPWEGFTCQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL

Sequences:

>Translated_461_residues
MRVLIKNGIVVNADGQAKQDLLIESGIVRQLGTDISPQLPCEEIDASGCYVFPGGVDVHTHFNIDVGIARSCDDFFTGTR
AAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAHKAVIDYSFHGVIQHINHAILDEIPMMVEEGLSSFKLYLTYQYKL
NDDEVLQALRRLHESGALTTVHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLYIVHL
SNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNVREQDKLWCGISDGAIDVVATDHCTFSMA
QRQQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGRISPERFVELTSAMPARLFGLWPQKGILAPGSDGDVVIIDPRQSQ
QIQHRHLHDNADYSPWEGFTCQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL
>Mature_461_residues
MRVLIKNGIVVNADGQAKQDLLIESGIVRQLGTDISPQLPCEEIDASGCYVFPGGVDVHTHFNIDVGIARSCDDFFTGTR
AAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAHKAVIDYSFHGVIQHINHAILDEIPMMVEEGLSSFKLYLTYQYKL
NDDEVLQALRRLHESGALTTVHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLYIVHL
SNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNVREQDKLWCGISDGAIDVVATDHCTFSMA
QRQQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGRISPERFVELTSAMPARLFGLWPQKGILAPGSDGDVVIIDPRQSQ
QIQHRHLHDNADYSPWEGFTCQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=466, Percent_Identity=36.9098712446352, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI4503377, Length=462, Percent_Identity=35.2813852813853, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI4503379, Length=462, Percent_Identity=34.8484848484849, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI4503051, Length=462, Percent_Identity=35.2813852813853, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI62422571, Length=462, Percent_Identity=35.2813852813853, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI19923821, Length=463, Percent_Identity=34.1252699784017, Blast_Score=265, Evalue=9e-71,
Organism=Homo sapiens, GI190194363, Length=462, Percent_Identity=33.982683982684, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI18105007, Length=405, Percent_Identity=23.9506172839506, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI87082175, Length=461, Percent_Identity=98.0477223427332, Blast_Score=941, Evalue=0.0,
Organism=Escherichia coli, GI1786722, Length=444, Percent_Identity=30.1801801801802, Blast_Score=171, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI71989490, Length=467, Percent_Identity=35.7601713062098, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17539558, Length=463, Percent_Identity=35.4211663066955, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI86575075, Length=473, Percent_Identity=28.3298097251586, Blast_Score=166, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI193204318, Length=459, Percent_Identity=24.1830065359477, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=423, Percent_Identity=27.8959810874704, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI221377917, Length=478, Percent_Identity=36.8200836820084, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI17137462, Length=468, Percent_Identity=35.8974358974359, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24644287, Length=310, Percent_Identity=36.7741935483871, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24644289, Length=235, Percent_Identity=39.1489361702128, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24642586, Length=408, Percent_Identity=25.4901960784314, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI18859883, Length=457, Percent_Identity=24.507658643326, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.-.-.- [C]

Molecular weight: Translated: 50971; Mature: 50971

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIKNGIVVNADGQAKQDLLIESGIVRQLGTDISPQLPCEEIDASGCYVFPGGVDVHT
CEEEEECCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEECCCEEEEE
HFNIDVGIARSCDDFFTGTRAAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAHKAVI
EEEEEEECCCCCHHHHCCCCHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHCHHHHHEEE
DYSFHGVIQHINHAILDEIPMMVEEGLSSFKLYLTYQYKLNDDEVLQALRRLHESGALTT
EHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHCCCEEE
VHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLYIVHL
ECCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEC
SNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNVREQDKLWC
CCCCCHHHHHHHHCCCCEEEHCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHHCCEEE
GISDGAIDVVATDHCTFSMAQRQQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGRISPE
EECCCEEEEEEECCCHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHCCCEEECCCHH
RFVELTSAMPARLFGLWPQKGILAPGSDGDVVIIDPRQSQQIQHRHLHDNADYSPWEGFT
HHHHHHHCCHHHHHCCCCCCCEECCCCCCCEEEECCCCCHHHHHHHCCCCCCCCCCCCEE
CQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL
ECHHHHHHHCCCCEEEECCEECCCCCCCCCEECCCCCCCCC
>Mature Secondary Structure
MRVLIKNGIVVNADGQAKQDLLIESGIVRQLGTDISPQLPCEEIDASGCYVFPGGVDVHT
CEEEEECCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEECCCEEEEE
HFNIDVGIARSCDDFFTGTRAAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAHKAVI
EEEEEEECCCCCHHHHCCCCHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHCHHHHHEEE
DYSFHGVIQHINHAILDEIPMMVEEGLSSFKLYLTYQYKLNDDEVLQALRRLHESGALTT
EHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHCCCEEE
VHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLYIVHL
ECCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEC
SNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNVREQDKLWC
CCCCCHHHHHHHHCCCCEEEHCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHHCCEEE
GISDGAIDVVATDHCTFSMAQRQQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGRISPE
EECCCEEEEEEECCCHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHCCCEEECCCHH
RFVELTSAMPARLFGLWPQKGILAPGSDGDVVIIDPRQSQQIQHRHLHDNADYSPWEGFT
HHHHHHHCCHHHHHCCCCCCCEECCCCCCCEEEECCCCCHHHHHHHCCCCCCCCCCCCEE
CQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL
ECHHHHHHHCCCCEEEECCEECCCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA