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The map label for this gene is ypdF [H]

Identifier: 218690528

GI number: 218690528

Start: 2780289

End: 2781374

Strand: Reverse

Name: ypdF [H]

Synonym: ECED1_2832

Alternate gene names: 218690528

Gene position: 2781374-2780289 (Counterclockwise)

Preceding gene: 218690529

Following gene: 218690527

Centisome position: 53.39

GC content: 57.18

Gene sequence:

>1086_bases
ATGACATTACTCGCTTCGCTGCGTGACTGGCTTAAGGCACAACAACTGGATGCGGTGCTTCTCTCCTCACGGCAGAACAA
ACAGCCGCATCTGGGGATCTCCACCGGATCAGGTTATGTGGTGATTAGCCGTGAAAGTGCGCACATTCTGGTGGATTCGC
GCTATTACGCGGATGTAGAAGCCCGCACGCAAGGTTACCAGCTGCATTTGCTCGACGCGATGCACACGCTTGCCACCATC
GTCAGACAAATCATTGCCGATGAGCAGTTGCAAACACTCGGTTTTGAAGGCCAGCAGGTGAGTTGGGAAACCGCGCACCG
CTGGCAGTCCGAACTCAATGCGAAACTGGTGAGCGCCACGCCGGATGTGCTGCGGCAAATCAAAACGCCAGAAGAGGTGG
AGAAAATCCGCCTTGCCTGCGGGATTGCCGATCGTGGCGCAGAGCATATTCGCCGCTTTATTCAGGCGGGAATGAGCGAA
TGCGAGATAGCCGCTGAACTGGAGTGGTTTATGCGCCGGCAGGGCGCAGAAAAAGCCTCTTTTGACACCATTGTCGCCAG
CGGCTGGCGTGGGGCGCTGCCGCACGGCAAAGCCAGCGACAAGATTGTTACAGCGGGCGAGTTTGTCACTCTCGATTTCG
GTGCGCTCTATCAGGGCTACTGCTCTGATATGACGCGCACCTTGCTGGTGAATGGCGAAGGGGTGAGCGCCGAATCTCAC
CCGCTGTTTAACGTCTATCAGATAGTCCTGCAGGCACAGCTCGCGGCAATCTCTGTAATTCGCCCCGGCGTGCGCTGCCA
GCAGGTTGACGATGCCGCGCGCCGCGTGATTACCGAGGCCGGTTATGGCAAGTTTTTCGGCCATAACACCGGTCATGCTA
TCGGTATTGAAGTCCATGAAGAGCCGCGTTTTTCACCGCGGGACACCACGACGCTACAGCCAGGTATGTTACTGACCGTG
GAGCCAGGGATTTATTTGCCAGGGCAAGGGGGCGTGCGCATCGAAGATGTCGTGCTGGTCACCCCGCAAGGCGCAGAAGT
GCTCTACGCCATGCCGAAAACAGTGTTGCTCACGGGAGAGGCATAA

Upstream 100 bases:

>100_bases
GGGGGCAGTCATAACTGCGCTGATGGTGGTGTTCCTGCGTCTGATGATGTTCCGTAAAGGCAAATTGTTAATCGATAGCC
TGTAAGAAGGAAAAATCCAG

Downstream 100 bases:

>100_bases
TGGATTTATCGCTCTTAAAAGCGTTGAGCGAGGCAGATGCGATCGCCTCCTCAGAACAGGAAGTACGGCAGATCCTACGG
GAAGAAGCGGATCGCCTGCA

Product: aminopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYYADVEARTQGYQLHLLDAMHTLATI
VRQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSE
CEIAAELEWFMRRQGAEKASFDTIVASGWRGALPHGKASDKIVTAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
PLFNVYQIVLQAQLAAISVIRPGVRCQQVDDAARRVITEAGYGKFFGHNTGHAIGIEVHEEPRFSPRDTTTLQPGMLLTV
EPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA

Sequences:

>Translated_361_residues
MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYYADVEARTQGYQLHLLDAMHTLATI
VRQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSE
CEIAAELEWFMRRQGAEKASFDTIVASGWRGALPHGKASDKIVTAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
PLFNVYQIVLQAQLAAISVIRPGVRCQQVDDAARRVITEAGYGKFFGHNTGHAIGIEVHEEPRFSPRDTTTLQPGMLLTV
EPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA
>Mature_360_residues
TLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYYADVEARTQGYQLHLLDAMHTLATIV
RQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEC
EIAAELEWFMRRQGAEKASFDTIVASGWRGALPHGKASDKIVTAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHP
LFNVYQIVLQAQLAAISVIRPGVRCQQVDDAARRVITEAGYGKFFGHNTGHAIGIEVHEEPRFSPRDTTTLQPGMLLTVE
PGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA

Specific function: Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is al

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24 family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=254, Percent_Identity=30.3149606299213, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI149589008, Length=307, Percent_Identity=28.0130293159609, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI260593665, Length=307, Percent_Identity=28.0130293159609, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI260593663, Length=244, Percent_Identity=29.5081967213115, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI264681563, Length=199, Percent_Identity=32.1608040201005, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI93141226, Length=173, Percent_Identity=32.9479768786127, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI264681565, Length=196, Percent_Identity=30.6122448979592, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788728, Length=361, Percent_Identity=95.8448753462604, Blast_Score=709, Evalue=0.0,
Organism=Escherichia coli, GI1789275, Length=254, Percent_Identity=30.7086614173228, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1786364, Length=207, Percent_Identity=25.6038647342995, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790282, Length=300, Percent_Identity=26.3333333333333, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508215, Length=312, Percent_Identity=27.5641025641026, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71989583, Length=250, Percent_Identity=26, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321118, Length=285, Percent_Identity=27.3684210526316, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320922, Length=240, Percent_Identity=24.1666666666667, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323273, Length=253, Percent_Identity=24.901185770751, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19920384, Length=261, Percent_Identity=28.3524904214559, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357079, Length=294, Percent_Identity=28.2312925170068, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI17137632, Length=172, Percent_Identity=33.7209302325581, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39706; Mature: 39575

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYYADVE
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCEEEEECCEEECCH
ARTQGYQLHLLDAMHTLATIVRQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSAT
HCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHCCEEECCC
PDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSECEIAAELEWFMRRQGAEKAS
HHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
FDTIVASGWRGALPHGKASDKIVTAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
HHHHHCCCCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHHHHHCEEEEEECCCCCCCCCC
PLFNVYQIVLQAQLAAISVIRPGVRCQQVDDAARRVITEAGYGKFFGHNTGHAIGIEVHE
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEC
EPRFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGE
CCCCCCCCCCEECCCEEEEECCCEEECCCCCCEEEEEEEECCCCCEEEEECCCEEEEECC
A
C
>Mature Secondary Structure 
TLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYYADVE
CHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCEEEEECCEEECCH
ARTQGYQLHLLDAMHTLATIVRQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSAT
HCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHCCEEECCC
PDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSECEIAAELEWFMRRQGAEKAS
HHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
FDTIVASGWRGALPHGKASDKIVTAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
HHHHHCCCCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHHHHHCEEEEEECCCCCCCCCC
PLFNVYQIVLQAQLAAISVIRPGVRCQQVDDAARRVITEAGYGKFFGHNTGHAIGIEVHE
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEC
EPRFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGE
CCCCCCCCCCEECCCEEEEECCCEEECCCCCCEEEEEEEECCCCCEEEEECCCEEEEECC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]