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The map label for this gene is emrK [H]

Identifier: 218690511

GI number: 218690511

Start: 2756919

End: 2758082

Strand: Reverse

Name: emrK [H]

Synonym: ECED1_2815

Alternate gene names: 218690511

Gene position: 2758082-2756919 (Counterclockwise)

Preceding gene: 218690514

Following gene: 218690510

Centisome position: 52.94

GC content: 41.58

Gene sequence:

>1164_bases
GTGGAACAGGTTAATTCAAATAAAAAACATTCTGACAGAAGAAAGTATTTTGCTTTGTTAGCGGTAGTTTTATTTATTGC
GTTTTCAGGTGCCTATGCCTATTGGTCAATGGAATTAAAAGACATGATTAGTACAGATGACGCCTATGTCACGGGAAATG
CAGATCCAATTTCTGCACAAGTCTCAGGCAGTGTCACTGTCGTTAATCATAAAGATACGAACTACGTTCGACAAGGTGAC
ATTTTAGTTTCACTGGATAAAACTGATGCCACTATCGCACTCAATAAAGCTAAAAATAATCTGGCAAATATTGTTCGGCA
AACGAATAAACTATACTTACAGGATAAACAATACAGTGCCGAAGTCGCTTCAGCACGTATTCAGTATCAACAATCTTTAG
AAGATTATAACCGTCGTGTGCCTTTAGCGAAGCAAGGGGTTATTTCAAAAGAAGCGCTGGAGCATACCAAAGATACGTTA
ATAAGTAGCAAAGCGGCATTGAATGCTGCTATCCAGGCTTATAAAGCGAATAAAGCTTTAGTAATGAACACACCATTAAA
CCGTCAGCCACAAGTCATTGAAGCTGCAGATGCAACCAAAGAAGCCTGGTTGGCGCTTAAACGTACGGATATTAAGAGTC
CGGTTACCGGTTATATTGCCCAGAGAAGTGTTCAGGTCGGCGAAACAGTGAGTCCCGGACAATCACTAATGGCTGTCGTA
CCGGCGCGTCAAATGTGGGTTAATGCCAACTTTAAAGAAACACAACTCACGGATGTACGGATTGGTCAATCGGTCAATAT
TATCAGCGATCTTTATGGTGAAAATGTTGTGTTTCATGGTCGGGTGACAGGGATCAATATGGGAACCGGCAATGCGTTCT
CCTTATTACCTGCACAAAATGCGACAGGGAACTGGATCAAAATCGTTCAGCGTGTACCGGTTGAAGTTTCTCTGGATCCA
AAAGAACTCATGGAACACCCTTTGCGCATTGGTTTATCGATGACTGCTACTATTGATACGAAGAATGAAGACATTGCCGA
GATGCCCGATCTGGCTTCAACCGTGACGTCCATGCCTGCTTATACCAGTAAGGCTTTAGTTATCGATACCAGTCCGATAG
AAAAAGAAATTAGCAACATTATTTCGCATAATGGACAACTTTAA

Upstream 100 bases:

>100_bases
CCTGGGATAATGTGCAAAACATGCACTGTGTTTGATATGAGGAATGAATACTCTTTTCATTCAATTCATAAATTTCATCT
ATGCGAAATGAGAGATAATA

Downstream 100 bases:

>100_bases
TGGCAATCACTAAATCAACTCCTGCACCATTAACCGGTGGGACGTTATGGTGCGTCACTATTGCATTGTCATTAGCGACG
TTTATGCAAATGTTGGATTC

Product: EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MEQVNSNKKHSDRRKYFALLAVVLFIAFSGAYAYWSMELKDMISTDDAYVTGNADPISAQVSGSVTVVNHKDTNYVRQGD
ILVSLDKTDATIALNKAKNNLANIVRQTNKLYLQDKQYSAEVASARIQYQQSLEDYNRRVPLAKQGVISKEALEHTKDTL
ISSKAALNAAIQAYKANKALVMNTPLNRQPQVIEAADATKEAWLALKRTDIKSPVTGYIAQRSVQVGETVSPGQSLMAVV
PARQMWVNANFKETQLTDVRIGQSVNIISDLYGENVVFHGRVTGINMGTGNAFSLLPAQNATGNWIKIVQRVPVEVSLDP
KELMEHPLRIGLSMTATIDTKNEDIAEMPDLASTVTSMPAYTSKALVIDTSPIEKEISNIISHNGQL

Sequences:

>Translated_387_residues
MEQVNSNKKHSDRRKYFALLAVVLFIAFSGAYAYWSMELKDMISTDDAYVTGNADPISAQVSGSVTVVNHKDTNYVRQGD
ILVSLDKTDATIALNKAKNNLANIVRQTNKLYLQDKQYSAEVASARIQYQQSLEDYNRRVPLAKQGVISKEALEHTKDTL
ISSKAALNAAIQAYKANKALVMNTPLNRQPQVIEAADATKEAWLALKRTDIKSPVTGYIAQRSVQVGETVSPGQSLMAVV
PARQMWVNANFKETQLTDVRIGQSVNIISDLYGENVVFHGRVTGINMGTGNAFSLLPAQNATGNWIKIVQRVPVEVSLDP
KELMEHPLRIGLSMTATIDTKNEDIAEMPDLASTVTSMPAYTSKALVIDTSPIEKEISNIISHNGQL
>Mature_387_residues
MEQVNSNKKHSDRRKYFALLAVVLFIAFSGAYAYWSMELKDMISTDDAYVTGNADPISAQVSGSVTVVNHKDTNYVRQGD
ILVSLDKTDATIALNKAKNNLANIVRQTNKLYLQDKQYSAEVASARIQYQQSLEDYNRRVPLAKQGVISKEALEHTKDTL
ISSKAALNAAIQAYKANKALVMNTPLNRQPQVIEAADATKEAWLALKRTDIKSPVTGYIAQRSVQVGETVSPGQSLMAVV
PARQMWVNANFKETQLTDVRIGQSVNIISDLYGENVVFHGRVTGINMGTGNAFSLLPAQNATGNWIKIVQRVPVEVSLDP
KELMEHPLRIGLSMTATIDTKNEDIAEMPDLASTVTSMPAYTSKALVIDTSPIEKEISNIISHNGQL

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=387, Percent_Identity=98.1912144702842, Blast_Score=785, Evalue=0.0,
Organism=Escherichia coli, GI1789041, Length=378, Percent_Identity=49.4708994708995, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1790519, Length=312, Percent_Identity=28.2051282051282, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081951, Length=311, Percent_Identity=27.3311897106109, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789637, Length=310, Percent_Identity=26.1290322580645, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1790024, Length=238, Percent_Identity=22.2689075630252, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42526; Mature: 42526

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQVNSNKKHSDRRKYFALLAVVLFIAFSGAYAYWSMELKDMISTDDAYVTGNADPISAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCEEEECCCCCCEEE
VSGSVTVVNHKDTNYVRQGDILVSLDKTDATIALNKAKNNLANIVRQTNKLYLQDKQYSA
ECCEEEEEECCCCCEEEECCEEEEECCCCCEEEEEHHHHHHHHHHHHHCCEEEECCHHHH
EVASARIQYQQSLEDYNRRVPLAKQGVISKEALEHTKDTLISSKAALNAAIQAYKANKAL
HHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VMNTPLNRQPQVIEAADATKEAWLALKRTDIKSPVTGYIAQRSVQVGETVSPGQSLMAVV
EEECCCCCCCCEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHEEEE
PARQMWVNANFKETQLTDVRIGQSVNIISDLYGENVVFHGRVTGINMGTGNAFSLLPAQN
CCHHEEECCCCCCCEEEEEECCCCCHHHHHHCCCCEEEEEEEEEEECCCCCEEEEEECCC
ATGNWIKIVQRVPVEVSLDPKELMEHPLRIGLSMTATIDTKNEDIAEMPDLASTVTSMPA
CCCHHHHHHHHCCEEEECCHHHHHHHHHHCCCEEEEEEECCCCCHHHCCHHHHHHHHCCC
YTSKALVIDTSPIEKEISNIISHNGQL
CCCCEEEEECCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEQVNSNKKHSDRRKYFALLAVVLFIAFSGAYAYWSMELKDMISTDDAYVTGNADPISAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCEEEECCCCCCEEE
VSGSVTVVNHKDTNYVRQGDILVSLDKTDATIALNKAKNNLANIVRQTNKLYLQDKQYSA
ECCEEEEEECCCCCEEEECCEEEEECCCCCEEEEEHHHHHHHHHHHHHCCEEEECCHHHH
EVASARIQYQQSLEDYNRRVPLAKQGVISKEALEHTKDTLISSKAALNAAIQAYKANKAL
HHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VMNTPLNRQPQVIEAADATKEAWLALKRTDIKSPVTGYIAQRSVQVGETVSPGQSLMAVV
EEECCCCCCCCEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHEEEE
PARQMWVNANFKETQLTDVRIGQSVNIISDLYGENVVFHGRVTGINMGTGNAFSLLPAQN
CCHHEEECCCCCCCEEEEEECCCCCHHHHHHCCCCEEEEEEEEEEECCCCCEEEEEECCC
ATGNWIKIVQRVPVEVSLDPKELMEHPLRIGLSMTATIDTKNEDIAEMPDLASTVTSMPA
CCCHHHHHHHHCCEEEECCHHHHHHHHHHCCCEEEEEEECCCCCHHHCCHHHHHHHHCCC
YTSKALVIDTSPIEKEISNIISHNGQL
CCCCEEEEECCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]