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The map label for this gene is uxaB [H]

Identifier: 218689415

GI number: 218689415

Start: 1638417

End: 1639904

Strand: Reverse

Name: uxaB [H]

Synonym: ECED1_1653

Alternate gene names: 218689415

Gene position: 1639904-1638417 (Counterclockwise)

Preceding gene: 218689416

Following gene: 218689414

Centisome position: 31.48

GC content: 51.95

Gene sequence:

>1488_bases
GTGGCAGTCGCCATGGATAATGCAATTTTAGAAAACATCTTGCGGCAAGTTCGTCGCGATTTTCCCGGTGCACAGTATCC
AGAACGTATCATTCAGTTTGGTGAAGGTAACTTCCTGCGCGCCTTTGTTGACTGGCAAATCGATCTCCTGAATGAGCACA
CCGATCTGAATTCTGGCGTGGTCGTTGTTCGTCCGATTGAAACTTCATTCCCGCCGTCACTGAGCACGCAGGATGGTCTG
TATACCACCATTATCCGTGGCCTGAATGAGAAGGGTGAAGCGGTCAGCGACGCGCGTCTGATTCGCTCGGTTAATCGTGA
AATCAGCGTCTACAGTGAATACGATGAATTCCTGAAACTGGCTCACAACCCGGAAATGCGCTTTGTTTTCTCTAACACCA
CCGAAGCGGGTATCAGCTACCATGCGGGCGATAAATTCGATGACGCGCCAGCGGTAAGTTATCCGGCAAAACTGACCCGT
CTGCTGTTCGAACGTTTTAGCCATTTCAACGGTGCGCTGGATAAAGGTTGGATCATCATCCCGTGTGAGTTGATTGACTA
TAATGGCGACGCGTTGCGTGAACTGGTGCTGCGCTATGCGCAAGAGTGGGCACTGCCAGAAGCATTTATTCAATGGCTGG
ATCAGGCTAACAGCTTCTGTTCTACGCTGGTGGACCGTATCGTTACCGGTTATCCGCGTGATGAAGTGGCTAAACTGGAA
GAAGAACTGGGCTACCACGATGGTTTCCTCGACACCGCTGAACACTTTTACCTGTTTGTGATTCAGGGGCCGAAATCCTT
AGCGACTGAACTTCGTCTGGACAAATATCCGCTCAACGTGCTGATCGTTGACGATATTAAACCGTATAAAGAACGCAAAG
TGGCAATCCTCAACGGTGCGCACACCGCGCTGGTGCCGGTGGCGTTCCAGGCAGGGCTGGATACCGTAGGTGAAGCGATG
AACGATGCTGAAATTTGCGCATTCGTTGAAAAAGCCATCTACGAAGAAATTATTCCGGTACTGGATTTGCCACGCGATGA
GCTGGAGTCTTTCGCCAGTGCAGTCACCGGACGTTTCCGTAACCCGTACATCAAGCATCAACTGCTGTCTATCGCGCTCA
ACGGTATGACCAAGTTCCGCACACGCATCCTGCCGCAGCTGCTGGCAGGGCAGAAGGCAAACGGCACACTTCCGGCGCGC
CTTACTTTCGCATTAGCGGCATTGATTGCGTTCTATCGCGGTGAGCGTAATGGAGAAACATATCCGGTACAGGACGATGC
ACACTGGCTGGAACGTTATCAGCAACTCTGGAGCCAGTATCGTGACCGTGTTATCGGGACCCAGGAACTGGTAGCGATTG
TGTTGGCAGAAAAAGACCACTGGGAGCAGGACCTGACGCAAGTGCCTGGTCTGGTCGAGCAGGTTGCTAATGACCTGGAT
GCGATTCTCGAAAAAGGGATGCGCGAAGCTGTACGCCCGTTGTGCTAA

Upstream 100 bases:

>100_bases
CTGTAATATTCAGACGGTATGGAAAGACCGGGTCTGACGCTATATATTCAGCTCTGATATACTCGCAGGTCTTTTCAGAC
CTGCGGTCCAGGAGTAGAAA

Downstream 100 bases:

>100_bases
TACTCTGAACCCGGTTTCGACCGGGTTTCTTATTTCACTATATTAGTTACAACATCCTATGCGTCTTTATCATTAACAGG
TGCCACATGCAGCACCTGTT

Product: altronate oxidoreductase

Products: NA

Alternate protein names: Tagaturonate dehydrogenase; Tagaturonate reductase [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MAVAMDNAILENILRQVRRDFPGAQYPERIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGVVVVRPIETSFPPSLSTQDGL
YTTIIRGLNEKGEAVSDARLIRSVNREISVYSEYDEFLKLAHNPEMRFVFSNTTEAGISYHAGDKFDDAPAVSYPAKLTR
LLFERFSHFNGALDKGWIIIPCELIDYNGDALRELVLRYAQEWALPEAFIQWLDQANSFCSTLVDRIVTGYPRDEVAKLE
EELGYHDGFLDTAEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAGLDTVGEAM
NDAEICAFVEKAIYEEIIPVLDLPRDELESFASAVTGRFRNPYIKHQLLSIALNGMTKFRTRILPQLLAGQKANGTLPAR
LTFALAALIAFYRGERNGETYPVQDDAHWLERYQQLWSQYRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLD
AILEKGMREAVRPLC

Sequences:

>Translated_495_residues
MAVAMDNAILENILRQVRRDFPGAQYPERIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGVVVVRPIETSFPPSLSTQDGL
YTTIIRGLNEKGEAVSDARLIRSVNREISVYSEYDEFLKLAHNPEMRFVFSNTTEAGISYHAGDKFDDAPAVSYPAKLTR
LLFERFSHFNGALDKGWIIIPCELIDYNGDALRELVLRYAQEWALPEAFIQWLDQANSFCSTLVDRIVTGYPRDEVAKLE
EELGYHDGFLDTAEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAGLDTVGEAM
NDAEICAFVEKAIYEEIIPVLDLPRDELESFASAVTGRFRNPYIKHQLLSIALNGMTKFRTRILPQLLAGQKANGTLPAR
LTFALAALIAFYRGERNGETYPVQDDAHWLERYQQLWSQYRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLD
AILEKGMREAVRPLC
>Mature_494_residues
AVAMDNAILENILRQVRRDFPGAQYPERIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGVVVVRPIETSFPPSLSTQDGLY
TTIIRGLNEKGEAVSDARLIRSVNREISVYSEYDEFLKLAHNPEMRFVFSNTTEAGISYHAGDKFDDAPAVSYPAKLTRL
LFERFSHFNGALDKGWIIIPCELIDYNGDALRELVLRYAQEWALPEAFIQWLDQANSFCSTLVDRIVTGYPRDEVAKLEE
ELGYHDGFLDTAEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAGLDTVGEAMN
DAEICAFVEKAIYEEIIPVLDLPRDELESFASAVTGRFRNPYIKHQLLSIALNGMTKFRTRILPQLLAGQKANGTLPARL
TFALAALIAFYRGERNGETYPVQDDAHWLERYQQLWSQYRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLDA
ILEKGMREAVRPLC

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxaB subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994885, Length=478, Percent_Identity=99.7907949790795, Blast_Score=984, Evalue=0.0,
Organism=Escherichia coli, GI1787823, Length=368, Percent_Identity=27.1739130434783, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1790779, Length=513, Percent_Identity=25.1461988304094, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788497, Length=482, Percent_Identity=22.1991701244813, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324401, Length=436, Percent_Identity=22.9357798165138, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320765, Length=436, Percent_Identity=22.9357798165138, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.58 [H]

Molecular weight: Translated: 56130; Mature: 55999

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVAMDNAILENILRQVRRDFPGAQYPERIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGV
CCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCCCCE
VVVRPIETSFPPSLSTQDGLYTTIIRGLNEKGEAVSDARLIRSVNREISVYSEYDEFLKL
EEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHNPEMRFVFSNTTEAGISYHAGDKFDDAPAVSYPAKLTRLLFERFSHFNGALDKGWIII
HCCCCEEEEECCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEE
PCELIDYNGDALRELVLRYAQEWALPEAFIQWLDQANSFCSTLVDRIVTGYPRDEVAKLE
EEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EELGYHDGFLDTAEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGA
HHCCCCCCCHHCCCCEEEEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHCEEEEECCC
HTALVPVAFQAGLDTVGEAMNDAEICAFVEKAIYEEIIPVLDLPRDELESFASAVTGRFR
CHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
NPYIKHQLLSIALNGMTKFRTRILPQLLAGQKANGTLPARLTFALAALIAFYRGERNGET
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
YPVQDDAHWLERYQQLWSQYRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLD
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHH
AILEKGMREAVRPLC
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVAMDNAILENILRQVRRDFPGAQYPERIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGV
CEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCCCCE
VVVRPIETSFPPSLSTQDGLYTTIIRGLNEKGEAVSDARLIRSVNREISVYSEYDEFLKL
EEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHNPEMRFVFSNTTEAGISYHAGDKFDDAPAVSYPAKLTRLLFERFSHFNGALDKGWIII
HCCCCEEEEECCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEE
PCELIDYNGDALRELVLRYAQEWALPEAFIQWLDQANSFCSTLVDRIVTGYPRDEVAKLE
EEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EELGYHDGFLDTAEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGA
HHCCCCCCCHHCCCCEEEEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHCEEEEECCC
HTALVPVAFQAGLDTVGEAMNDAEICAFVEKAIYEEIIPVLDLPRDELESFASAVTGRFR
CHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
NPYIKHQLLSIALNGMTKFRTRILPQLLAGQKANGTLPARLTFALAALIAFYRGERNGET
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
YPVQDDAHWLERYQQLWSQYRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLD
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHH
AILEKGMREAVRPLC
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA