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The map label for this gene is pgm [H]

Identifier: 218688495

GI number: 218688495

Start: 692762

End: 694402

Strand: Direct

Name: pgm [H]

Synonym: ECED1_0670

Alternate gene names: 218688495

Gene position: 692762-694402 (Clockwise)

Preceding gene: 218688494

Following gene: 218688503

Centisome position: 13.3

GC content: 54.6

Gene sequence:

>1641_bases
ATGGCAATCCACAATCGTGCAGGCCAACCTGCACAACAGAGTGATTTGATTAACGTCGCCCAACTGACGGCGCAATATTA
TGTACTGAAACCAGAAGCAGGGAATGCGGAGCACGCGGTGAAATTCGGTACTTCCGGTCACCGTGGCAGTGCAGCGCGCC
ACAGCTTTAACGAGCCGCACATTCTGGCGATCGCTCAGGCAATTGCTGAAGAACGTGCGAAAAACGGCATCACTGGCCCT
TGCTATGTGGGTAAAGATACTCACGCCCTGTCCGAGCCTGCGTTCATTTCCGTACTGGAAGTGCTGGCAGCGAACGGCGT
TGATGTCATTGTGCAGGAAAACAATGGCTTCACTCCGACACCTGCCATTTCCAATGCCATTCTGGTTCACAATAAAAAAG
GTGGCCCGCTGGCAGACGGTATCGTGATTACACCGTCCCATAACCCGCCGGAAGATGGTGGTATCAAGTACAATCCGCCA
AATGGTGGCCCGGCTGATACCAACGTCACTAAAGTGGTGGAAGACAGAGCCAACGCACTGCTGGCTGATGGCCTGAAAGG
CGTGAAGCGTATCTCCCTCGACGAAGCGATGGCATCCGGTCATGTGAAAGAGCAGGATCTGGTGCAGCCGTTTGTGGAAG
GGCTGGCCGATATCGTTGATATGGCGGCGATTCAGAAAGCGGGCCTGACGCTGGGCGTTGATCCGCTGGGTGGTTCCGGT
ATCGAATACTGGAAGCGCATTGGCGAGTATTACAACCTCAACCTGACCATCGTTAACGATCAGGTCGATCAAACCTTCCG
CTTTATGCACCTCGATAAAGACGGTGCGATCCGTATGGACTGCTCCTCCGAGTGTGCGATGGCGGGCCTGCTGGCACTGC
GTGATAAGTTCGATCTGGCGTTTGCTAACGACCCGGATTATGACCGTCACGGTATCGTCACTCCGGCAGGTTTGATGAAT
CCGAACCACTACCTGGCGGTGGCGATCAACTACCTGTTCCAGCATCGTCCGCAGTGGGGCAAAGATGTTGCTGTCGGTAA
AACGCTGGTTTCATCTGCGATGATCGACCGTGTGGTCAATGATTTGGGCCGTAAGCTGGTAGAAGTACCGGTAGGTTTCA
AATGGTTTGTTGATGGTTTGTTCGATGGCAGCTTCGGCTTTGGCGGCGAAGAGAGTGCAGGCGCTTCCTTCCTGCGTTTC
GACGGCACGCCGTGGTCCACCGATAAAGACGGCATCATTATGTGTCTGCTGGCGGCGGAAATCACCGCTGTCACCGGTAA
GAACCCGCAGGAACACTATAACGAACTGGCAAAACGCTTTGGTGCGCCGAGCTATAACCGTTTGCAGGCAGCAGCGACTT
CCGCACAAAAAGCGGCGTTGTCTAAGCTGTCTCCGGAAATGGTGAGCGCCAGCACCCTGGCAGGTGACCCGATCACCGCG
CGTCTGACGGCGGCACCGGGTAATGGCGCTTCTATCGGCGGTCTGAAAGTGATGACTGACAACGGCTGGTTCGCCGCGCG
TCCGTCAGGCACGGAAGACGCATATAAGATCTACTGCGAAAGCTTCCTTGGTGAAGAACATCGCAAGCAGATTGAGAAAG
AAGCGGTTGAGATTGTTAGCGAAGTTCTGAAAAACGCGTAA

Upstream 100 bases:

>100_bases
AGCATGATCGAACACATCATGCAGTCGATGCAATTCCCGGCGGAATTGATTGAGAAGGTTTGCGGAACTATCTAAAACGT
TGCAGACAAAGGACAAAGCA

Downstream 100 bases:

>100_bases
ACATATCAAATAAGAAAAAGGGCGGTCGGAAGATCGCCCTTTTTTGCTTTGCTTAATTAACCGTGTTTATTTTTCAGTTC
AAAGCGTGGTGAGACCAGAC

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPHILAIAQAIAEERAKNGITGP
CYVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPTPAISNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPP
NGGPADTNVTKVVEDRANALLADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSG
IEYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLAFANDPDYDRHGIVTPAGLMN
PNHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVNDLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRF
DGTPWSTDKDGIIMCLLAAEITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITA
RLTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVSEVLKNA

Sequences:

>Translated_546_residues
MAIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPHILAIAQAIAEERAKNGITGP
CYVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPTPAISNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPP
NGGPADTNVTKVVEDRANALLADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSG
IEYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLAFANDPDYDRHGIVTPAGLMN
PNHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVNDLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRF
DGTPWSTDKDGIIMCLLAAEITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITA
RLTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVSEVLKNA
>Mature_545_residues
AIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPHILAIAQAIAEERAKNGITGPC
YVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPTPAISNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPPN
GGPADTNVTKVVEDRANALLADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSGI
EYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLAFANDPDYDRHGIVTPAGLMNP
NHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVNDLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRFD
GTPWSTDKDGIIMCLLAAEITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITAR
LTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVSEVLKNA

Specific function: This enzyme participates in both the breakdown and synthesis of glucose [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI290463102, Length=447, Percent_Identity=26.1744966442953, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI133922562, Length=420, Percent_Identity=24.7619047619048, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI21361621, Length=399, Percent_Identity=26.8170426065163, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786904, Length=546, Percent_Identity=99.8168498168498, Blast_Score=1126, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17535441, Length=567, Percent_Identity=25.9259259259259, Blast_Score=86, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6323752, Length=561, Percent_Identity=26.2032085561497, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322722, Length=532, Percent_Identity=27.2556390977444, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI17864244, Length=488, Percent_Identity=28.2786885245902, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005852 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 58375; Mature: 58244

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPH
CCCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCCCCCCEEEECCCCCCCCHHHCCCCCCH
ILAIAQAIAEERAKNGITGPCYVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPT
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCC
PAISNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPPNGGPADTNVTKVVEDRANAL
CCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
LADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCH
IEYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLA
HHHHHHHCHHEEEEEEEECCCHHHHEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCEE
FANDPDYDRHGIVTPAGLMNPNHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVN
ECCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
DLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRFDGTPWSTDKDGIIMCLLAAE
HHHHHHHHCCCCCEEHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEHHH
ITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITA
HHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEE
RLTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVS
EEEECCCCCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHH
EVLKNA
HHHHCC
>Mature Secondary Structure 
AIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPH
CCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCCCCCCEEEECCCCCCCCHHHCCCCCCH
ILAIAQAIAEERAKNGITGPCYVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPT
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCC
PAISNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPPNGGPADTNVTKVVEDRANAL
CCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
LADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCH
IEYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLA
HHHHHHHCHHEEEEEEEECCCHHHHEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCEE
FANDPDYDRHGIVTPAGLMNPNHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVN
ECCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
DLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRFDGTPWSTDKDGIIMCLLAAE
HHHHHHHHCCCCCEEHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEHHH
ITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITA
HHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEE
RLTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVS
EEEECCCCCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHH
EVLKNA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8083177; 8905232; 9278503; 8011018 [H]