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The map label for this gene is mhpR [H]

Identifier: 218688217

GI number: 218688217

Start: 394715

End: 395629

Strand: Reverse

Name: mhpR [H]

Synonym: ECED1_0374

Alternate gene names: 218688217

Gene position: 395629-394715 (Counterclockwise)

Preceding gene: 218688226

Following gene: 218688216

Centisome position: 7.59

GC content: 53.88

Gene sequence:

>915_bases
GTGTTTTCGGCTACAATCAAAACATGCCCGAATGTGCACCAGGTGCACAACGTTGTTTTAACTATAGAAATGTCAATTAA
TATGCAGAACAATGAGCAGACGGAATACAAAACCGTGCGCGGCTTAACCCGCGGTCTAATGTTATTAAATATGTTAAGTA
AACTTGATGGCGGTGCCAGCGTCGGGCTGCTGGCGGAACTCAGCGGCCTGCATCGCACCACTGTGCGGCGACTGCTGGAG
ACGCTGCAGGAAGAGGGATATGTCCGGCGTAGTCCCTCCGATGATAGTTTCCGTTTGACCATCAAAGTGCGGCAATTAAG
CGAAGGATTTCGTGACGAACAGTGGATTTCTGCACTGGCGGCCCCACTGCTGGGCGATCTGTTGCGCGAAGTGGTATGGC
CGACAGATGTGTCCACCCTGGATGTTGATGCAATGGTGGTACGCGAAACCACCCATCGTTTCAGCCGCTTATCTTTTCAC
CGGGCAATGGTCGGGCGACGGTTACCGCTTCTGAAAACCGCCTCGGGCCTGACCTGGCTGGCCTTTTGCCCGGAACAAGA
ACGCAAGGAATTAATCGAGATGTTAGCCTCCCGCCCCGGTGATGACTATCAACTGGCACGGGAACCGTTAAATCTGGAAG
CCATTCTGGCGCGCGCGCGCAAAGAGGGGTACGGACAGAACTACCGCGGCTGGGATCAAGAAGAAAAGATCGCCTCTATT
GCCGTACCGCTGCGCAGTGAACAACGGGTGATTGGCTGTCTGAATCTGGTGTATATGGCGAGCGCAATGACCATTGAACA
GGCAGCGGAAAAGCATCTTCCGGCGCTACAACGGGTGGCAAAACAGATCGAAGAAGGGGTTGAATCGCAGGCTATTCTGG
TAGCGGGAAGGCGAAGCGGCGTGCATTTACGCTGA

Upstream 100 bases:

>100_bases
CACGACTCGGACAAAATGCCGTTGCGCGCACAGTACAGCGCAACTTATTTTGTTAAAAACATGTAAATGATTTTTTTATT
GTGCGCTCAGTATAGGAAGG

Downstream 100 bases:

>100_bases
CACCATCGAATGGCGCAAAACCTTTCGTGGTATGGCATGATAGCGCCCGGAAGAGAGTCAATTCAGGGTGGTGAATGTGA
AACCAGTAACGCTATACGAT

Product: DNA-binding transcriptional activator MhpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLLNMLSKLDGGASVGLLAELSGLHRTTVRRLLE
TLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFH
RAMVGRRLPLLKTASGLTWLAFCPEQERKELIEMLASRPGDDYQLAREPLNLEAILARARKEGYGQNYRGWDQEEKIASI
AVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVESQAILVAGRRSGVHLR

Sequences:

>Translated_304_residues
MFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLLNMLSKLDGGASVGLLAELSGLHRTTVRRLLE
TLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFH
RAMVGRRLPLLKTASGLTWLAFCPEQERKELIEMLASRPGDDYQLAREPLNLEAILARARKEGYGQNYRGWDQEEKIASI
AVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVESQAILVAGRRSGVHLR
>Mature_304_residues
MFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLLNMLSKLDGGASVGLLAELSGLHRTTVRRLLE
TLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFH
RAMVGRRLPLLKTASGLTWLAFCPEQERKELIEMLASRPGDDYQLAREPLNLEAILARARKEGYGQNYRGWDQEEKIASI
AVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVESQAILVAGRRSGVHLR

Specific function: Activator of the mhpRABCDEF operon coding for components of the 3-hydroxyphenylpropionate degradation pathway [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI145693096, Length=277, Percent_Identity=98.5559566787004, Blast_Score=556, Evalue=1e-160,
Organism=Escherichia coli, GI1789999, Length=143, Percent_Identity=32.8671328671329, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786468, Length=226, Percent_Identity=26.9911504424779, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082359, Length=205, Percent_Identity=28.780487804878, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 34273; Mature: 34273

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLLNMLSKLDGGAS
CCCCCCCCCCCHHHHCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALA
HHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEEEHHHHCCCCHHHHHHHHH
APLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPLLKTASGLTWL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEE
AFCPEQERKELIEMLASRPGDDYQLAREPLNLEAILARARKEGYGQNYRGWDQEEKIASI
EECCCHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
AVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVESQAILVAGRRSG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCC
VHLR
CCCC
>Mature Secondary Structure
MFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLLNMLSKLDGGAS
CCCCCCCCCCCHHHHCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALA
HHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEEEHHHHCCCCHHHHHHHHH
APLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPLLKTASGLTWL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEE
AFCPEQERKELIEMLASRPGDDYQLAREPLNLEAILARARKEGYGQNYRGWDQEEKIASI
EECCCHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
AVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVESQAILVAGRRSG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCC
VHLR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]