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The map label for this gene is cycA [H]

Identifier: 218551485

GI number: 218551485

Start: 4371725

End: 4373137

Strand: Direct

Name: cycA [H]

Synonym: EFER_4268

Alternate gene names: 218551485

Gene position: 4371725-4373137 (Clockwise)

Preceding gene: 218551484

Following gene: 218551489

Centisome position: 95.27

GC content: 50.04

Gene sequence:

>1413_bases
ATGGTAGATCAGGTAAAAGTCGTTGCCGAAGAACAGGCTCCGGCTGAACAGTCGCTACGGCGCAATCTCACAAACCGACA
TATCCAGCTTATTGCCATTGGTGGGGCCATTGGTACGGGGCTGTTTATGGGTTCCGGTAAAACAATCAGTCTTGCCGGAC
CGTCGATCATCTTCGTTTATATGATCATCGGTTTTATGCTCTTTTTCGTGATGCGGGCAATGGGGGAATTGCTGCTTTCG
AATCTGGAATACAAATCTTTTAGTGACTTCGCTTCCGATCTACTGGGGCCGTGGGCAGGGTATTTTACTGGCTGGACCTA
CTGGTTCTGTTGGGTAGTAACCGGGATGGCAGATGTCGTTGCCATTACCGCATATGCGCAATTCTGGTTCCCTGGGCTTT
CTGACTGGGTTGCTTCGTTATCCGTGATCATTCTATTACTGGTTCTAAACCTCGCCACGGTAAAAATGTTCGGTGAGATG
GAGTTCTGGTTTGCGATGATCAAAATTGTCGCCATCGTGTCACTGATTGTTGTCGGTTTGATCATGGTGATGATGCACTT
CCAGTCACCGACTGGCGTGGAAGCATCATTCACGCATTTGTGGAATGATGGCGGCTGGTTCCCGAAAGGCTTAAGCGGCT
TCTTTGCTGGATTCCAGATAGCGGTTTTCGCTTTCGTGGGAATTGAGCTGGTCGGTACAACAGCTGCGGAAACCAAAGAT
CCGGAGAAATCACTGCCGCGCGCAATTAACTCCATTCCAATTCGCATCATTATGTTCTATGTGTTTGCGCTGATTGTGAT
CATGTCTGTAACACCGTGGAGCTCCGTTGTTGCTGAGAAAAGCCCGTTCGTTGAACTGTTTGTATTGGTGGGGCTGCCTG
CTGCCGCAAGCGTGATTAACTTTGTGGTGCTGACGTCTGCGGCCTCTTCCGCTAACAGCGGCGTCTTCTCTACCAGTCGT
ATGCTGTTTGGTCTGGCACAGGAAGGTGTGGCGCCGAAAGCGTTTGCTAAACTCTCTAAGCGCGCCGTACCAGCGAAAGG
GCTGACCTTCTCTTGTATCTGTCTGCTTGGCGGCGTGGTGATGTTGTATGTGAATCCAAGTGTAATTGGCGCGTTCACGA
TGATCACGACTGTTTCCGCGATTCTGTTTATGTTCGTCTGGACGATTATCCTTTGCTCGTACCTGGTGTATCGCAAACAG
CGTCCGCACCTGCATGAGAAATCAATCTACAAGATGCCGCTCGGTAAGCTGATGTGCTGGGTATGTATGGCGTTCTTTGT
GTTCGTGATCGTGCTGCTGACACTGGAAGATGACACTCGCCAGGCGCTGATAGTTACCCCGTTATGGTTTATCTTGTTGG
GGCTGGGCTGGTTATTTATTGGTAAGAAGCGGACTGCTGAACTGCGGAAGTAA

Upstream 100 bases:

>100_bases
TTACCTAATATCGATGAGTCCCGATACAGATTCGTCGTATCATAGACGTACAAAAGGCCGCAGAGCCTGAACAACACAGA
CAGGTACAGGAAGAAAAAAC

Downstream 100 bases:

>100_bases
CGGCTTTCTCATGCTGGATGGCGCAATGCCATCCAGCTTTTAGATCACTCACCCGCCAGCGCGCGCGGGAATAGTACATT
GTTTTCCAGACTGATGTGCT

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MVDQVKVVAEEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEM
EFWFAMIKIVAIVSLIVVGLIMVMMHFQSPTGVEASFTHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVAEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQ
RPHLHEKSIYKMPLGKLMCWVCMAFFVFVIVLLTLEDDTRQALIVTPLWFILLGLGWLFIGKKRTAELRK

Sequences:

>Translated_470_residues
MVDQVKVVAEEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEM
EFWFAMIKIVAIVSLIVVGLIMVMMHFQSPTGVEASFTHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVAEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQ
RPHLHEKSIYKMPLGKLMCWVCMAFFVFVIVLLTLEDDTRQALIVTPLWFILLGLGWLFIGKKRTAELRK
>Mature_470_residues
MVDQVKVVAEEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEM
EFWFAMIKIVAIVSLIVVGLIMVMMHFQSPTGVEASFTHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVAEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQ
RPHLHEKSIYKMPLGKLMCWVCMAFFVFVIVLLTLEDDTRQALIVTPLWFILLGLGWLFIGKKRTAELRK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=358, Percent_Identity=22.3463687150838, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI258645169, Length=147, Percent_Identity=29.9319727891156, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI181337167, Length=340, Percent_Identity=21.7647058823529, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI115648063, Length=369, Percent_Identity=24.6612466124661, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI115648022, Length=369, Percent_Identity=24.6612466124661, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1790653, Length=470, Percent_Identity=97.0212765957447, Blast_Score=922, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=461, Percent_Identity=40.7809110629067, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI1786602, Length=454, Percent_Identity=41.6299559471366, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1786789, Length=453, Percent_Identity=37.7483443708609, Blast_Score=334, Evalue=6e-93,
Organism=Escherichia coli, GI48994972, Length=462, Percent_Identity=38.3116883116883, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI87081915, Length=459, Percent_Identity=37.2549019607843, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI87081708, Length=474, Percent_Identity=32.2784810126582, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1788480, Length=422, Percent_Identity=34.8341232227488, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1789017, Length=440, Percent_Identity=30.2272727272727, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI2367353, Length=328, Percent_Identity=23.780487804878, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI87082023, Length=351, Percent_Identity=20.5128205128205, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=378, Percent_Identity=24.3386243386243, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531343, Length=449, Percent_Identity=22.271714922049, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=449, Percent_Identity=33.4075723830735, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6324924, Length=426, Percent_Identity=31.4553990610329, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6320772, Length=447, Percent_Identity=29.7539149888143, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6322892, Length=421, Percent_Identity=30.166270783848, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=416, Percent_Identity=31.0096153846154, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321629, Length=421, Percent_Identity=28.2660332541568, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324059, Length=459, Percent_Identity=29.1938997821351, Blast_Score=153, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6320717, Length=414, Percent_Identity=26.3285024154589, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6324553, Length=391, Percent_Identity=27.8772378516624, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=438, Percent_Identity=26.027397260274, Blast_Score=146, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6319824, Length=399, Percent_Identity=26.3157894736842, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=404, Percent_Identity=25, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=402, Percent_Identity=26.3681592039801, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6321053, Length=410, Percent_Identity=26.3414634146341, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319608, Length=416, Percent_Identity=25.9615384615385, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322967, Length=421, Percent_Identity=28.0285035629454, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=419, Percent_Identity=27.2076372315036, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320364, Length=488, Percent_Identity=24.3852459016393, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24666159, Length=358, Percent_Identity=21.2290502793296, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221512776, Length=358, Percent_Identity=21.2290502793296, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161077963, Length=208, Percent_Identity=25.4807692307692, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51823; Mature: 51823

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDQVKVVAEEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEMEFWFAMIKIVAIVSLIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMVMMHFQSPTGVEASFTHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVAEKSPFVELFVLVGLPAAASVIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQRPHLHEKSIYKMPLGKLMCW
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHH
VCMAFFVFVIVLLTLEDDTRQALIVTPLWFILLGLGWLFIGKKRTAELRK
HHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MVDQVKVVAEEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEMEFWFAMIKIVAIVSLIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMVMMHFQSPTGVEASFTHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVAEKSPFVELFVLVGLPAAASVIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQRPHLHEKSIYKMPLGKLMCW
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHH
VCMAFFVFVIVLLTLEDDTRQALIVTPLWFILLGLGWLFIGKKRTAELRK
HHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]