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The map label for this gene is aidB [H]

Identifier: 218551457

GI number: 218551457

Start: 4347618

End: 4349261

Strand: Direct

Name: aidB [H]

Synonym: EFER_4240

Alternate gene names: 218551457

Gene position: 4347618-4349261 (Clockwise)

Preceding gene: 218551456

Following gene: 218551460

Centisome position: 94.75

GC content: 49.88

Gene sequence:

>1644_bases
TTGATGGAGGGAGACATAGTGCACTGGCAAACTCACACTATATTCAATCAACCTGCACCGTTGAATAACAGTAATTTGTA
TTTGTCTGATAGCGCGCTTTGCGAAGCCGTAAACCGTGAAGGTGCAGCCTGGGATAACGAGTTGCTTGCCAGTATTGGCC
AGCAACTGGGGACCGCAGAATCTCTGGAGCTTGGGCGGCTGGCGAATATCTATCCGCCAGAGCTGCTGCGCTACGATGCT
CAGGGGAGACGGTTAGATGATGTCCGTTTTCACCCTGCCTGGCATTTACTGATGCAGGGATTATGTGCAAATCGGGTACA
TAATCTTGCATGGGAAGAAGATGCCAGAGTCGGATCATTTGTGGTGCGGGCTGCCCGCTTCATTATTCACGCCCAGGTTG
AAGCCGGGACGCTTTGCCCTATTACTATGACCTTTGCCGCCACACCTTTGTTGTTAGAGTTATTACCCGCGCCGTTTCAG
GACTGGAAAACACCATTATTAAGTGATCGCTATGATTCTCATCTTTTGCCCGGAGGGCAGAAGCGAGGGCTGCTTATCGG
CATGGGAATGACTGAAAAGCAGGGTGGGTCAGATGTATTGAGCAACACAACTCAGGCCGAACGTCTGGAGGATGGCTCGT
ATCGATTAGTGGGACATAAGTGGTTCTTTTCTGTGCCACAAAGTGATGCACATCTGGTGTTGGCACAGACGAAAGGTGGA
CTTTCTTGTTTCTTCTTGCCGCGTTTTTTACCTGATGGTCAACGCAATGCCATTCGTCTTGAGCGGCTGAAAGATAAGTT
GGGCAATCGTTCTAACGCCAGCTGCGAAGTGGAATTTCAAGATGCGATTGGCTGGCTGGTGGGCAATGAGGGGGAAGGTG
TTCGCTATATTCTTAAAATGGGCGGTATGACACGCTTCGATTGTGCATTAGGTAGCCATGCCATGATGCGCCGAGCTTTT
TCACTGGCTATTTATCATGCTCATCAGCGACAAGTTTTCGGTAAACCTTTGATTGAACAACCACTCATGCGCAATGTCCT
CTGCAGGATGGCATTGCAACTTGAAGGGCAAACTTCTCTGCTCTTCCGTTTGGCGCGGGCGTGGGATCGACGTACCGATG
AAAAAGAAGTGCTTTGGGCGCGTTTATTTACTCCAGCGGCAAAATTTGCAGTGTGCAAAGCAGGAATACCTTTTGTGGCA
GAAGCAATGGAAGTGTTGGGGGGAATTGGTTATTGCGAAGACAGTGAGTTGCCCCGACTTTATCGGGAAATGCCAGTAAA
CAGCATCTGGGAAGGGTCTGGTAACATCATGTGCCTGGATGTACTGCGCGTTTTAAGTAAGCAACCAGGCGTCTATGATC
TACTAACGGATGCTTTTGCTCAGGTTAAAGGCCAGGACCGGCATTTTGATCGGGCAGTCAGACGTTTCCAGCAGCTGCTG
CGCAAACCATCTGAAGAGCAAGGGCGGGAGATCACCCTACAACTTTTCATTTTAGGCTGTGGAGCACAAATGTTACGCCA
TGCTTCGCCGCCCATTGCTGAAAACTGGTGTCAGTTGATGTTAGGTCATCGTCGGGGTGTTCGGATAAGCGAACAAGTTC
AGAATGATTTGTTGCTACGGGCGACGGGAGGCGTTTGCCTGTAG

Upstream 100 bases:

>100_bases
CTTCACGTTTTGTTCCTCATTACATTTCTGGCTAGGAATGTGTTAGCGATTCCTCTCTGTCATGAATGAATGGCAGTGAC
CATACTTAAGGTTACTGCCA

Downstream 100 bases:

>100_bases
TTTATTGTTCAGCATCGCATCTGGCATTAAGTGCCTGATGCGATGCTGGCAAGGATGTGCAACTATTTGAAAACGTTGCC
TTTGTTTGCCGGATAAGGTG

Product: isovaleryl CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MMEGDIVHWQTHTIFNQPAPLNNSNLYLSDSALCEAVNREGAAWDNELLASIGQQLGTAESLELGRLANIYPPELLRYDA
QGRRLDDVRFHPAWHLLMQGLCANRVHNLAWEEDARVGSFVVRAARFIIHAQVEAGTLCPITMTFAATPLLLELLPAPFQ
DWKTPLLSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVLSNTTQAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTKGG
LSCFFLPRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLVGNEGEGVRYILKMGGMTRFDCALGSHAMMRRAF
SLAIYHAHQRQVFGKPLIEQPLMRNVLCRMALQLEGQTSLLFRLARAWDRRTDEKEVLWARLFTPAAKFAVCKAGIPFVA
EAMEVLGGIGYCEDSELPRLYREMPVNSIWEGSGNIMCLDVLRVLSKQPGVYDLLTDAFAQVKGQDRHFDRAVRRFQQLL
RKPSEEQGREITLQLFILGCGAQMLRHASPPIAENWCQLMLGHRRGVRISEQVQNDLLLRATGGVCL

Sequences:

>Translated_547_residues
MMEGDIVHWQTHTIFNQPAPLNNSNLYLSDSALCEAVNREGAAWDNELLASIGQQLGTAESLELGRLANIYPPELLRYDA
QGRRLDDVRFHPAWHLLMQGLCANRVHNLAWEEDARVGSFVVRAARFIIHAQVEAGTLCPITMTFAATPLLLELLPAPFQ
DWKTPLLSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVLSNTTQAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTKGG
LSCFFLPRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLVGNEGEGVRYILKMGGMTRFDCALGSHAMMRRAF
SLAIYHAHQRQVFGKPLIEQPLMRNVLCRMALQLEGQTSLLFRLARAWDRRTDEKEVLWARLFTPAAKFAVCKAGIPFVA
EAMEVLGGIGYCEDSELPRLYREMPVNSIWEGSGNIMCLDVLRVLSKQPGVYDLLTDAFAQVKGQDRHFDRAVRRFQQLL
RKPSEEQGREITLQLFILGCGAQMLRHASPPIAENWCQLMLGHRRGVRISEQVQNDLLLRATGGVCL
>Mature_547_residues
MMEGDIVHWQTHTIFNQPAPLNNSNLYLSDSALCEAVNREGAAWDNELLASIGQQLGTAESLELGRLANIYPPELLRYDA
QGRRLDDVRFHPAWHLLMQGLCANRVHNLAWEEDARVGSFVVRAARFIIHAQVEAGTLCPITMTFAATPLLLELLPAPFQ
DWKTPLLSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVLSNTTQAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTKGG
LSCFFLPRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLVGNEGEGVRYILKMGGMTRFDCALGSHAMMRRAF
SLAIYHAHQRQVFGKPLIEQPLMRNVLCRMALQLEGQTSLLFRLARAWDRRTDEKEVLWARLFTPAAKFAVCKAGIPFVA
EAMEVLGGIGYCEDSELPRLYREMPVNSIWEGSGNIMCLDVLRVLSKQPGVYDLLTDAFAQVKGQDRHFDRAVRRFQQLL
RKPSEEQGREITLQLFILGCGAQMLRHASPPIAENWCQLMLGHRRGVRISEQVQNDLLLRATGGVCL

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=287, Percent_Identity=28.2229965156794, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI226958412, Length=271, Percent_Identity=24.7232472324723, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI226958414, Length=271, Percent_Identity=24.7232472324723, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI7656849, Length=266, Percent_Identity=27.0676691729323, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI4501859, Length=252, Percent_Identity=24.2063492063492, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI187960098, Length=279, Percent_Identity=25.4480286738351, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4557231, Length=279, Percent_Identity=25.4480286738351, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI21361497, Length=265, Percent_Identity=25.2830188679245, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI87082384, Length=541, Percent_Identity=87.2458410351202, Blast_Score=996, Evalue=0.0,
Organism=Escherichia coli, GI1786223, Length=329, Percent_Identity=25.8358662613982, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081958, Length=258, Percent_Identity=26.7441860465116, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=516, Percent_Identity=31.7829457364341, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI86563383, Length=516, Percent_Identity=31.7829457364341, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17538396, Length=272, Percent_Identity=30.1470588235294, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=266, Percent_Identity=23.6842105263158, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17506239, Length=270, Percent_Identity=23.3333333333333, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71985184, Length=354, Percent_Identity=22.8813559322034, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17551932, Length=307, Percent_Identity=25.7328990228013, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17505929, Length=298, Percent_Identity=26.1744966442953, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356377, Length=312, Percent_Identity=25.6410256410256, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21355753, Length=287, Percent_Identity=28.9198606271777, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281363737, Length=290, Percent_Identity=24.4827586206897, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646207, Length=276, Percent_Identity=25, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24666513, Length=266, Percent_Identity=22.1804511278195, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 61462; Mature: 61462

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEGDIVHWQTHTIFNQPAPLNNSNLYLSDSALCEAVNREGAAWDNELLASIGQQLGTAE
CCCCCEEEEEEHHHCCCCCCCCCCCEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHH
SLELGRLANIYPPELLRYDAQGRRLDDVRFHPAWHLLMQGLCANRVHNLAWEEDARVGSF
HHCCCCCCCCCCHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
VVRAARFIIHAQVEAGTLCPITMTFAATPLLLELLPAPFQDWKTPLLSDRYDSHLLPGGQ
HHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCHHCCCCCCCCCCCCC
KRGLLIGMGMTEKQGGSDVLSNTTQAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTKGG
CCCEEEECCCCCCCCCCHHHHCCHHHHHCCCCCEEEEEEEEEEECCCCCCEEEEEECCCC
LSCFFLPRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLVGNEGEGVRYILKM
EEEEEEHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEHHCCCEEECCCCCCEEEEEEC
GGMTRFDCALGSHAMMRRAFSLAIYHAHQRQVFGKPLIEQPLMRNVLCRMALQLEGQTSL
CCCCEEHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHH
LFRLARAWDRRTDEKEVLWARLFTPAAKFAVCKAGIPFVAEAMEVLGGIGYCEDSELPRL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHH
YREMPVNSIWEGSGNIMCLDVLRVLSKQPGVYDLLTDAFAQVKGQDRHFDRAVRRFQQLL
HHHCCCCCEECCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RKPSEEQGREITLQLFILGCGAQMLRHASPPIAENWCQLMLGHRRGVRISEQVQNDLLLR
HCCCCCCCCEEEEEEEEECCCHHHHHCCCCCHHHHHHHHHHCCCCCCEEHHHHHCCEEEE
ATGGVCL
ECCCCCC
>Mature Secondary Structure
MMEGDIVHWQTHTIFNQPAPLNNSNLYLSDSALCEAVNREGAAWDNELLASIGQQLGTAE
CCCCCEEEEEEHHHCCCCCCCCCCCEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHH
SLELGRLANIYPPELLRYDAQGRRLDDVRFHPAWHLLMQGLCANRVHNLAWEEDARVGSF
HHCCCCCCCCCCHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
VVRAARFIIHAQVEAGTLCPITMTFAATPLLLELLPAPFQDWKTPLLSDRYDSHLLPGGQ
HHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCHHCCCCCCCCCCCCC
KRGLLIGMGMTEKQGGSDVLSNTTQAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTKGG
CCCEEEECCCCCCCCCCHHHHCCHHHHHCCCCCEEEEEEEEEEECCCCCCEEEEEECCCC
LSCFFLPRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLVGNEGEGVRYILKM
EEEEEEHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEHHCCCEEECCCCCCEEEEEEC
GGMTRFDCALGSHAMMRRAFSLAIYHAHQRQVFGKPLIEQPLMRNVLCRMALQLEGQTSL
CCCCEEHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHH
LFRLARAWDRRTDEKEVLWARLFTPAAKFAVCKAGIPFVAEAMEVLGGIGYCEDSELPRL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHH
YREMPVNSIWEGSGNIMCLDVLRVLSKQPGVYDLLTDAFAQVKGQDRHFDRAVRRFQQLL
HHHCCCCCEECCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RKPSEEQGREITLQLFILGCGAQMLRHASPPIAENWCQLMLGHRRGVRISEQVQNDLLLR
HCCCCCCCCEEEEEEEEECCCHHHHHCCCCCHHHHHHHHHHCCCCCCEEHHHHHCCEEEE
ATGGVCL
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]