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The map label for this gene is mutL [H]

Identifier: 218551440

GI number: 218551440

Start: 4330744

End: 4332591

Strand: Direct

Name: mutL [H]

Synonym: EFER_4223

Alternate gene names: 218551440

Gene position: 4330744-4332591 (Clockwise)

Preceding gene: 218551439

Following gene: 218551441

Centisome position: 94.38

GC content: 55.36

Gene sequence:

>1848_bases
ATGCCAATTCAGGTCTTACCGCCACAACTGGCGAACCAGATTGCCGCAGGTGAGGTGGTCGAGCGACCTGCGTCGGTAGT
CAAAGAACTGGTGGAAAACAGCCTCGATGCGGGTGCGACGCGTATTGATATTGATATCGAACGCGGTGGGGCGAAACTTA
TCCGCATTCGTGATAACGGCTGCGGTATCAAAAAAGATGAACTGGCGCTGGCGCTGGCGCGTCATGCTACCAGTAAAATC
GCCTCTCTGGACGATCTCGAAGCTATTATCAGCCTGGGGTTCCGCGGTGAGGCGCTGGCGAGTATCAGTTCAGTTTCCCG
TCTGACGCTCACTTCGCGCACCGTAGATCAGCAGGAAGCCTGGCAGGCATATGCCGAAGGGCGCGATATGGACGTGACGG
TTAAACCGGCGGCGCATCCGGTGGGAACGACGCTGGAAGTGCTGGATCTGTTCTACAACACCCCGGCGCGGCGGAAATTC
CTGCGTACCGAGAAAACCGAATTTAACCATATTGATGAAATCATCCGCCGCATTGCGCTGGCGCGTTTCGACGTCACTAT
AAACCTGTCGCATAACGGAAAAATTGTGCGTCAGTATCGTGCAGTGCCGGAAGGCGGGCAAAAAGAACGGCGTTTAGGCG
CGATTTGCGGCACCGCTTTTCTCGAACATGCGCTGGCGATTGAATGGCAGCACGGCGATCTCACGCTGCGCGGTTGGGTG
GCAGATCCAAACCATACCACGCCCACACTGGCAGAAATTCAGTATTGCTACGTGAATGGTCGCATGATGCGCGATCGCCT
GATCAATCATGCGATCCGTCAGGCCTGCGAAAACAAACTGGGGGCCGATCAGCAACCGGCATTTGTGTTGTATCTGGAGA
TCGACCCACATCAAGTGGACGTCAACGTGCACCCCGCCAAACACGAAGTGCGTTTCCATCAGTCGCGTCTGGTGCACGAC
TTTATCTATCAGGGCGTGCTGAGTGTGCTACAACAACAGCTGGAAACGCCGCTGCCACTGGACGATGAACCTCAACCTGC
ACCGCGCACCATTCCGGAGAACCGCGTGGCCGCCGGGCGTAATCATTTTGCTGAACCGGCAGTTCGTGAACCGGTAGCTC
CCCGCTACTCTCCTGCGCCCGCCTCTGGTGGTCGTCCAGCAGCTTCCTGGCCGAATGCGCAGCCAGGCTACCAGAAACAG
CAAGGTGAAGTGTATCGCCAGCTTTTGCAAACGCCTGCGCCGATGCAAAAACCAAAAGCACCTGAACCGCAGGAGCCAGC
GCTTGCGGCGAATAGTCAGAGTTTTGGTCGGGTACTGACTATCGTCCATTCCGACTGTGCGTTGCTGGAGCGCGACGGCA
ACATTTCACTTTTAGCCCTGCCAGTGGCAGAACGTTGGCTGCGTCAGGCGCAGTTGACGCCGGGTGAAACGCCAGTTTGC
GCCCAGCCGTTGCTTATTCCGTTGCGGCTAAAAGTTTCTGGCGAAGAAAAATCGGCATTAGAAAAAGCGCAGTCTGCCCT
GGCGGAATTGGGTATTGATTTCCAGTCCGATGCACAGTATGTGACCATCAGGGCCGTGCCTTTACCCTTACGCCAACAAA
ATTTACAAATCTTGATTCCTGAACTGATAGGCTACCTGGCGAAGCAGTCCGTATTCGAACCTGGCAATATTGCGCAGTGG
ATTGCACGAAATCTGATGAGCGAACATGCGCAGTGGTCAATGGCACAGGCCATCACCCTGCTGGCGGACGTGGAACGGTT
ATGTCCGCAACTTGTGAAAACGCCGCCGGGTGGTCTGTTACAATCTGTTGATTTACATCCGGCGATAAAAGCCCTGAAAG
ATGAGTGA

Upstream 100 bases:

>100_bases
CCTTGCGCATCCGATGCAATCTGCGCCGCAGGGGGCAACGGCACAAACGGCCAGCACGGTGACGACGCCAGATCGCACGC
TGCCAAACTAAGGATTATTG

Downstream 100 bases:

>100_bases
TATCAGTAAGGCGAGCCTGCCTAAGGCGATTTTTTTGATGGGGCCGACGGCCTCCGGTAAAACGGCGTTAGCCATTGAGC
TGCGTAAAATTTTACCAGTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKI
ASLDDLEAIISLGFRGEALASISSVSRLTLTSRTVDQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKF
LRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEHALAIEWQHGDLTLRGWV
ADPNHTTPTLAEIQYCYVNGRMMRDRLINHAIRQACENKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHD
FIYQGVLSVLQQQLETPLPLDDEPQPAPRTIPENRVAAGRNHFAEPAVREPVAPRYSPAPASGGRPAASWPNAQPGYQKQ
QGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLALPVAERWLRQAQLTPGETPVC
AQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQYVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQW
IARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE

Sequences:

>Translated_615_residues
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKI
ASLDDLEAIISLGFRGEALASISSVSRLTLTSRTVDQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKF
LRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEHALAIEWQHGDLTLRGWV
ADPNHTTPTLAEIQYCYVNGRMMRDRLINHAIRQACENKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHD
FIYQGVLSVLQQQLETPLPLDDEPQPAPRTIPENRVAAGRNHFAEPAVREPVAPRYSPAPASGGRPAASWPNAQPGYQKQ
QGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLALPVAERWLRQAQLTPGETPVC
AQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQYVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQW
IARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE
>Mature_614_residues
PIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKIA
SLDDLEAIISLGFRGEALASISSVSRLTLTSRTVDQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFL
RTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEHALAIEWQHGDLTLRGWVA
DPNHTTPTLAEIQYCYVNGRMMRDRLINHAIRQACENKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDF
IYQGVLSVLQQQLETPLPLDDEPQPAPRTIPENRVAAGRNHFAEPAVREPVAPRYSPAPASGGRPAASWPNAQPGYQKQQ
GEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLALPVAERWLRQAQLTPGETPVCA
QPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQYVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQWI
ARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=339, Percent_Identity=35.9882005899705, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI4505911, Length=318, Percent_Identity=31.4465408805031, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI189458898, Length=350, Percent_Identity=30.5714285714286, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI189458896, Length=316, Percent_Identity=30.0632911392405, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI4505913, Length=333, Percent_Identity=27.027027027027, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI310128478, Length=333, Percent_Identity=27.027027027027, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI263191589, Length=245, Percent_Identity=31.0204081632653, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI91992162, Length=362, Percent_Identity=24.585635359116, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI91992160, Length=362, Percent_Identity=24.585635359116, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=23.3898305084746, Blast_Score=88, Evalue=3e-17,
Organism=Escherichia coli, GI1790612, Length=615, Percent_Identity=97.3983739837398, Blast_Score=1223, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71991825, Length=324, Percent_Identity=37.037037037037, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=26.453488372093, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=343, Percent_Identity=34.9854227405248, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=361, Percent_Identity=29.0858725761773, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325093, Length=489, Percent_Identity=21.881390593047, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=215, Percent_Identity=30.2325581395349, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17136968, Length=363, Percent_Identity=33.6088154269972, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI17136970, Length=359, Percent_Identity=27.2980501392758, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67976; Mature: 67844

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
CGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTVDQQEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEHHHCCCHHHH
WQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIAL
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHH
ARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEHALAIEWQHGDLTLRGWV
HHEEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEE
ADPNHTTPTLAEIQYCYVNGRMMRDRLINHAIRQACENKLGADQQPAFVLYLEIDPHQVD
CCCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEE
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRTIPENRVAAGR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCC
NHFAEPAVREPVAPRYSPAPASGGRPAASWPNAQPGYQKQQGEVYRQLLQTPAPMQKPKA
CCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
PEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLALPVAERWLRQAQLTPGETPVC
CCCCCCCCCCCCCCHHHEEEEHCCCHHEEECCCCEEEEEEHHHHHHHHHHCCCCCCCCCC
AQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQYVTIRAVPLPLRQQNLQILIP
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEHH
ELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QSVDLHPAIKALKDE
HCCCCCHHHHHHCCC
>Mature Secondary Structure 
PIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
CGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTVDQQEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEHHHCCCHHHH
WQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIAL
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHH
ARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEHALAIEWQHGDLTLRGWV
HHEEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEE
ADPNHTTPTLAEIQYCYVNGRMMRDRLINHAIRQACENKLGADQQPAFVLYLEIDPHQVD
CCCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEE
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRTIPENRVAAGR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCC
NHFAEPAVREPVAPRYSPAPASGGRPAASWPNAQPGYQKQQGEVYRQLLQTPAPMQKPKA
CCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
PEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLALPVAERWLRQAQLTPGETPVC
CCCCCCCCCCCCCCHHHEEEEHCCCHHEEECCCCEEEEEEHHHHHHHHHHCCCCCCCCCC
AQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQYVTIRAVPLPLRQQNLQILIP
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEHH
ELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QSVDLHPAIKALKDE
HCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA