Click here to switch to the map view.

The map label for this gene is yjcE [H]

Identifier: 218551385

GI number: 218551385

Start: 4269991

End: 4271637

Strand: Direct

Name: yjcE [H]

Synonym: EFER_4166

Alternate gene names: 218551385

Gene position: 4269991-4271637 (Clockwise)

Preceding gene: 218551384

Following gene: 218551387

Centisome position: 93.05

GC content: 52.34

Gene sequence:

>1647_bases
ATGGAAATTTTCTTTACCATACTCATCATGACCCTTGTGGTCTCGCTGTCCGGGGTGGTCACACGTGTACTGCCCTTCCA
GGTCCCCCTTCCATTAATGCAAATTGCCATTGGTGCGCTACTGGCGTGGCCAACGTTTGGCCTGCATGTGGAGTTCGATC
CCGAACTTTTCCTGGTGTTATTTATCCCGCCACTGCTGTTTGCTGATGGCTGGAAAACACCAACCAGAGAGTTTCTGGAA
CACGGGCGAGAGATATTTGGCCTGGCACTTGCGCTGGTACTGGTCACTGTGGTCGGTATCGGTTTTCTCATCTACTGGGT
GGTGCCGGGGATCCCGTTGATTCCAGCCTTTGCCCTGGCAGCGGTACTTTCTCCTACTGATGCGGTCGCTCTTTCGGGGA
TTGTCGGTGAAGGGCGTATCCCGAAAAAAATCATGGGCATTTTGCAGGGCGAAGCGTTGATGAATGACGCCTCTGGTCTG
GTGTCATTGAAATTTGCTGTTGCGGTGGCGATGGGCACAATGGTGTTTACTGTTGGTGGTGCCACCGTTGAGTTTCTTAA
AGTCGCCATTGGCGGCATTCTTGCGGGCTTTGTGGTGAGCTGGTTGTATGGGCGTTCACTGCGCTTCCTGAGCCGCTGGG
GTGGTGATGAGCCGGCAACGCAAATAGTATTGCTGTTCTTGCTGCCGTTTGCCTCTTACCTGATTGCAGAACATATTGGT
GTTTCTGGCATTTTGGCTGCGGTCGCCGCCGGGATGACGATTACTCGCTCTGGAGTAATGCGCCGGGCGCCGTTGGCAAT
GCGATTGCGTGCTAACAGTACCTGGGCGATGCTGGAGTTTGTCTTTAACGGCATGGTGTTCCTGCTGTTAGGGCTGCAAT
TGCCAGGAATTATGGAAACCTCACTGATTGCTGCAGAGGCCGATCCCAACGTCGAAGTCTGGATGTTGTTTATGGATATC
GTCCTGATTTATGTCGCTCTAATGCTGGTGCGTTTTGGCTGGCTGTGGACGATGAAAAAACTCAGCAAGCGCTTCCTGAA
GAAGAAACCGATGGAGTTTGGTTCGTGGAGTACGCGCGAAATCCTGATCGCTTCTTTTGCCGGCGTGCGTGGGGCGATTA
CCCTTGCGGGTGTGCTCTCAATACCGCTGTTATTGCCGGATGGCAATGTCTTCCCGGCACGCTACGAACTGGTGTTTCTT
GCGGCGGGTGTCATCCTCTTCTCGTTGTTTGTCGGCGTGGTGATGTTACCGATCCTGTTGCAACATATTGAAGTTGCTGA
TCACTCACAGCAACTGAAAGAAGAGCGTATCGCCCGCGCAGCGACTGCAGAAGTCGCAATTGTTGCGATCCAGAAAATGG
AAGAACGTCTGGCGGCAGATACCGAGGAGAACATTGATACGCAGCTACTTACGGAAGTGAGTTCGCGTGTTATTGGTAAC
CTGCGGCGTCGTGCTGATGGGCGAAACAATGTAGAAACGTCGTTACAGGAGGAAAACCTTGAGCGCCGTTTCCGCCTGGC
CGCATTACGCTCTGAACGAGCTGAACTTTACCATTTGCGCGCCACACGTGAGATCAGTAATGAGACGCTGCAAAAGCTGT
TGCACGATTTGGATTTGCTGGAAGCGTTATTGATAGAGAATCAATAA

Upstream 100 bases:

>100_bases
TCTGCGCACATCGCGGGAGCTTTTGCGATATTCTGAAAACGCGAGAAATCAGGCATAACGCCTTTCTCTGATCATAAGAA
ACATTGCAAACAGGGAACGC

Downstream 100 bases:

>100_bases
ATTTAATCTGCCGGAATGGGCGTTAATACGCCCTCCGGCATTTTTAATCAGTAGGTGGTGAGATTAGTTCTTCTTCACAA
ATTCAGATTTCAACTTCATC

Product: cation/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MEIFFTILIMTLVVSLSGVVTRVLPFQVPLPLMQIAIGALLAWPTFGLHVEFDPELFLVLFIPPLLFADGWKTPTREFLE
HGREIFGLALALVLVTVVGIGFLIYWVVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGL
VSLKFAVAVAMGTMVFTVGGATVEFLKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
VSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGIMETSLIAAEADPNVEVWMLFMDI
VLIYVALMLVRFGWLWTMKKLSKRFLKKKPMEFGSWSTREILIASFAGVRGAITLAGVLSIPLLLPDGNVFPARYELVFL
AAGVILFSLFVGVVMLPILLQHIEVADHSQQLKEERIARAATAEVAIVAIQKMEERLAADTEENIDTQLLTEVSSRVIGN
LRRRADGRNNVETSLQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLLEALLIENQ

Sequences:

>Translated_548_residues
MEIFFTILIMTLVVSLSGVVTRVLPFQVPLPLMQIAIGALLAWPTFGLHVEFDPELFLVLFIPPLLFADGWKTPTREFLE
HGREIFGLALALVLVTVVGIGFLIYWVVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGL
VSLKFAVAVAMGTMVFTVGGATVEFLKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
VSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGIMETSLIAAEADPNVEVWMLFMDI
VLIYVALMLVRFGWLWTMKKLSKRFLKKKPMEFGSWSTREILIASFAGVRGAITLAGVLSIPLLLPDGNVFPARYELVFL
AAGVILFSLFVGVVMLPILLQHIEVADHSQQLKEERIARAATAEVAIVAIQKMEERLAADTEENIDTQLLTEVSSRVIGN
LRRRADGRNNVETSLQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLLEALLIENQ
>Mature_548_residues
MEIFFTILIMTLVVSLSGVVTRVLPFQVPLPLMQIAIGALLAWPTFGLHVEFDPELFLVLFIPPLLFADGWKTPTREFLE
HGREIFGLALALVLVTVVGIGFLIYWVVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGL
VSLKFAVAVAMGTMVFTVGGATVEFLKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
VSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGIMETSLIAAEADPNVEVWMLFMDI
VLIYVALMLVRFGWLWTMKKLSKRFLKKKPMEFGSWSTREILIASFAGVRGAITLAGVLSIPLLLPDGNVFPARYELVFL
AAGVILFSLFVGVVMLPILLQHIEVADHSQQLKEERIARAATAEVAIVAIQKMEERLAADTEENIDTQLLTEVSSRVIGN
LRRRADGRNNVETSLQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLLEALLIENQ

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=462, Percent_Identity=25.7575757575758, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI148727259, Length=458, Percent_Identity=23.3624454148472, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI27734935, Length=340, Percent_Identity=22.9411764705882, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI194239733, Length=503, Percent_Identity=23.8568588469185, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI14211919, Length=259, Percent_Identity=25.4826254826255, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI41872703, Length=501, Percent_Identity=21.9560878243513, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI294997330, Length=269, Percent_Identity=22.6765799256506, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI5454070, Length=292, Percent_Identity=21.9178082191781, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI110227626, Length=269, Percent_Identity=22.6765799256506, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790501, Length=549, Percent_Identity=96.1748633879781, Blast_Score=1028, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71980847, Length=401, Percent_Identity=25.1870324189526, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25150332, Length=383, Percent_Identity=23.2375979112272, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71990932, Length=405, Percent_Identity=23.4567901234568, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71990924, Length=405, Percent_Identity=23.2098765432099, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71999821, Length=399, Percent_Identity=22.0551378446115, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71999819, Length=399, Percent_Identity=22.0551378446115, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71999817, Length=399, Percent_Identity=22.0551378446115, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992107, Length=254, Percent_Identity=20.8661417322835, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992101, Length=254, Percent_Identity=20.8661417322835, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=370, Percent_Identity=22.4324324324324, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281364513, Length=447, Percent_Identity=21.2527964205817, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI221473222, Length=447, Percent_Identity=21.2527964205817, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221510734, Length=403, Percent_Identity=23.3250620347395, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221473215, Length=449, Percent_Identity=21.1581291759465, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221510738, Length=403, Percent_Identity=23.3250620347395, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221473212, Length=461, Percent_Identity=20.6073752711497, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221510732, Length=403, Percent_Identity=23.3250620347395, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221510736, Length=403, Percent_Identity=23.3250620347395, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI221510740, Length=403, Percent_Identity=23.3250620347395, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24585580, Length=403, Percent_Identity=23.3250620347395, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24585578, Length=403, Percent_Identity=23.3250620347395, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 60314; Mature: 60314

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCC
>Mature Secondary Structure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HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]