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The map label for this gene is ldh [H]

Identifier: 218551373

GI number: 218551373

Start: 4256513

End: 4257724

Strand: Direct

Name: ldh [H]

Synonym: EFER_4154

Alternate gene names: 218551373

Gene position: 4256513-4257724 (Clockwise)

Preceding gene: 218551372

Following gene: 218551376

Centisome position: 92.76

GC content: 52.56

Gene sequence:

>1212_bases
GTGTATGGGTACAGATACCTTCACGCCACGCCAGTTTACTCGTGTGGGACTGTACCTGACAGTGATCGGCTACCTGCTAT
TACTGCTGTTTGCCGCCACATGGTGGAAGATCCTGGGACTGATGTGAGGAAACCAACGATGTCATTACAAATTGCGGTAG
AAAAAGTGCGTTGGTTGACGGCCGGATTGCTGGAACTTAATGGCTGCGATGCTGATATCGCTCAGGATGTGGCAGAACAT
ATGATTGAAGCTGAACGTTATGGCTTTGCCAGCCACGGCGTCACGCTGCTACCGAAATATCTGGAAAATATCGCTCGTGG
CGATGTAACCGCGAATGCCCGCCCGGAATGCTTAACAAGTGAAGGTAATTTACAACGTTTTCATGCCCACAATGGCTTTG
GTCAACACGCCGGAAAAGTGGCGGTAAATGCTGCCATCGAACAAGCAAAACACCGCGGTTTTTGCCTGTTAACGTTGTGC
CATGCGCATCATTTAGGGCGTATGGGGCATTACGGGCAAATGGTTGCTGATCAAGGCCTGGCGATGCTGGCCATGAGTAA
CGTCACCGGGCGTCCGGCACTGGTCGCGCCCTGGGGCGGTGCGGAACCGCGTATGACCACTAACCCTTTCTGCTTTGCCT
GGCCGTTCAGTGATGGGCGTCCGCCGATTCTGGTTGATTTTGCCACCAGTAGCATGGCGCTAAATAAAGCACGGGTAATG
TCGTCCACCGGGAAGCAGGCCGCGCCGGGACAATTGATCGATGCACAGGGGAATCCAAGCAATGATCCTGGGGTGTTATT
CAGCAATCCTCCAGGGGCGTTACTGCCATTTGGTGAGCATAAAGGATTTGGCCTGGCACTGATGATTGAAATGATGGCGG
GGATCTTATCTGGTGGTGACACGATCGCCGAAGATCATCAGGCGGATGGATCTGCGCATAATCATCTTTTTGCGTTGGTC
ATCGATCCTGATCAATTCACCGATCTGGCAGGGGAGAAAGGGCTGTTCTTTGCGAATTATCTGTTAGCCACGCAGCCTCA
ACCTGGCGGCAATCCGGTGATTTACCCCGGTATGCCAGAAGCTGCCAACCGGGAACGCAATGCGAAGATGATTACGATCC
CGGTGTCATTCTGGTCCTGGGTAGTTGAACATTACGCCCGCAAAGGTATCGATTTGGGGTTACATCCTCAGGAATCAGCA
TTAGCTGGATGA

Upstream 100 bases:

>100_bases
CGCCAGAACTCGGTGTTAACCCGGTCGGCATGACCATTTTGCTGGCCTTCAGTGTCAGTTTTGGCTTCATTCTGCCAATT
AACGCGCCACAAAATATGGT

Downstream 100 bases:

>100_bases
TTCTGGTCGATAAACTTGCGGTTGAATCTGATGTTTGTTGAGTTTGTCATATAAAGTCTTGCGCGGCAGCTGTAATAGCC
GCGCTGTCAAACTGACCTGG

Product: malate/L-lactate dehydrogenases

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MYGYRYLHATPVYSCGTVPDSDRLPAITAVCRHMVEDPGTDVRKPTMSLQIAVEKVRWLTAGLLELNGCDADIAQDVAEH
MIEAERYGFASHGVTLLPKYLENIARGDVTANARPECLTSEGNLQRFHAHNGFGQHAGKVAVNAAIEQAKHRGFCLLTLC
HAHHLGRMGHYGQMVADQGLAMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFATSSMALNKARVM
SSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALMIEMMAGILSGGDTIAEDHQADGSAHNHLFALV
IDPDQFTDLAGEKGLFFANYLLATQPQPGGNPVIYPGMPEAANRERNAKMITIPVSFWSWVVEHYARKGIDLGLHPQESA
LAG

Sequences:

>Translated_403_residues
MYGYRYLHATPVYSCGTVPDSDRLPAITAVCRHMVEDPGTDVRKPTMSLQIAVEKVRWLTAGLLELNGCDADIAQDVAEH
MIEAERYGFASHGVTLLPKYLENIARGDVTANARPECLTSEGNLQRFHAHNGFGQHAGKVAVNAAIEQAKHRGFCLLTLC
HAHHLGRMGHYGQMVADQGLAMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFATSSMALNKARVM
SSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALMIEMMAGILSGGDTIAEDHQADGSAHNHLFALV
IDPDQFTDLAGEKGLFFANYLLATQPQPGGNPVIYPGMPEAANRERNAKMITIPVSFWSWVVEHYARKGIDLGLHPQESA
LAG
>Mature_403_residues
MYGYRYLHATPVYSCGTVPDSDRLPAITAVCRHMVEDPGTDVRKPTMSLQIAVEKVRWLTAGLLELNGCDADIAQDVAEH
MIEAERYGFASHGVTLLPKYLENIARGDVTANARPECLTSEGNLQRFHAHNGFGQHAGKVAVNAAIEQAKHRGFCLLTLC
HAHHLGRMGHYGQMVADQGLAMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFATSSMALNKARVM
SSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALMIEMMAGILSGGDTIAEDHQADGSAHNHLFALV
IDPDQFTDLAGEKGLFFANYLLATQPQPGGNPVIYPGMPEAANRERNAKMITIPVSFWSWVVEHYARKGIDLGLHPQESA
LAG

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=316, Percent_Identity=33.2278481012658, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1790000, Length=338, Percent_Identity=27.5147928994083, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786727, Length=344, Percent_Identity=28.4883720930233, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17507179, Length=325, Percent_Identity=26.4615384615385, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17536633, Length=298, Percent_Identity=22.8187919463087, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45553211, Length=298, Percent_Identity=26.8456375838926, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667912, Length=298, Percent_Identity=26.8456375838926, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667908, Length=298, Percent_Identity=26.8456375838926, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667904, Length=298, Percent_Identity=26.8456375838926, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24658010, Length=359, Percent_Identity=22.5626740947075, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648360, Length=296, Percent_Identity=22.2972972972973, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 43371; Mature: 43371

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGYRYLHATPVYSCGTVPDSDRLPAITAVCRHMVEDPGTDVRKPTMSLQIAVEKVRWLT
CCCEEEEECCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AGLLELNGCDADIAQDVAEHMIEAERYGFASHGVTLLPKYLENIARGDVTANARPECLTS
HHHHEECCCCHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHCCCCCCCCCCCEECC
EGNLQRFHAHNGFGQHAGKVAVNAAIEQAKHRGFCLLTLCHAHHLGRMGHYGQMVADQGL
CCCEEEEECCCCCCHHCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHCCCCHHHHHHHCCE
AMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFATSSMALNKARVM
EEEEECCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHH
SSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALMIEMMAGILSGGD
HCCCCCCCCCCEEECCCCCCCCCCEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCC
TIAEDHQADGSAHNHLFALVIDPDQFTDLAGEKGLFFANYLLATQPQPGGNPVIYPGMPE
CHHHCCCCCCCCCCEEEEEEECCHHHHHHCCCCCEEEEEEEEEECCCCCCCEEEECCCCC
AANRERNAKMITIPVSFWSWVVEHYARKGIDLGLHPQESALAG
CCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MYGYRYLHATPVYSCGTVPDSDRLPAITAVCRHMVEDPGTDVRKPTMSLQIAVEKVRWLT
CCCEEEEECCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AGLLELNGCDADIAQDVAEHMIEAERYGFASHGVTLLPKYLENIARGDVTANARPECLTS
HHHHEECCCCHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHCCCCCCCCCCCEECC
EGNLQRFHAHNGFGQHAGKVAVNAAIEQAKHRGFCLLTLCHAHHLGRMGHYGQMVADQGL
CCCEEEEECCCCCCHHCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHCCCCHHHHHHHCCE
AMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFATSSMALNKARVM
EEEEECCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHH
SSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALMIEMMAGILSGGD
HCCCCCCCCCCEEECCCCCCCCCCEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCC
TIAEDHQADGSAHNHLFALVIDPDQFTDLAGEKGLFFANYLLATQPQPGGNPVIYPGMPE
CHHHCCCCCCCCCCEEEEEEECCHHHHHHCCCCCEEEEEEEEEECCCCCCCEEEECCCCC
AANRERNAKMITIPVSFWSWVVEHYARKGIDLGLHPQESALAG
CCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8405966 [H]