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The map label for this gene is citT [C]

Identifier: 218551372

GI number: 218551372

Start: 4255134

End: 4256639

Strand: Direct

Name: citT [C]

Synonym: EFER_4153

Alternate gene names: 218551372

Gene position: 4255134-4256639 (Clockwise)

Preceding gene: 218551371

Following gene: 218551373

Centisome position: 92.73

GC content: 50.6

Gene sequence:

>1506_bases
GTGAATATGTCATCAATATCCCATGACGCGTCACAAAAGCGTCGAATTATCCCTAATCCCGGCCTGTGGTTGGCGATCAT
TGCCGGAATTATTATTACCCTTCTGCCACTGGGCGATACATTGCCCGTCGCCGGACAAAATATGATCGCCATTCTGGTGT
TTGCCATTATTGTCTGGATCAGCGAAGCGATGGATTACACCGCCAGTGCAATTGTTATTTCCGCACTGATTATCTTTATG
GTTGGTTTTGCCCCGGATATGAATCACCCGGACACGATCCTTGGCACCGCGAAAGCGCTGAAAATGACTCTGTCGGGTTT
TTCTAATTCTGCTCTGGCGCTGGTGGCAGCAGCAATGTTTATCGCGGCGGCAATGACCATTACCGGGCTGGATAAACGCA
TTGCGCTATTTACTATGTCGAAAATAGGTGCCAGCAGCCGTAGCATTATTATCGGTGCCATTGTGGTGACCATCGTCCTG
AGTCTGGTCGTACCCAGTGCCACTGCCCGTACGGCTTGCGTGGTGCCGATTATGATGGGCGTCATTGCGGCATTTAAGGT
GGATAAACATTCACGTTTAGCGGCGTCAATGATGATTGTTATCGCCCAGGCGACCAGTATCTGGAACGTTGGTATTCAAA
CATCGGCGGCGCAAAACCTGCTTTCTATCGGTTTTATCAATAAAACTTTCGGCGCCGGGCATTCTGTCAGCTGGCTTGAC
TGGCTGTTAGCGGGCGCGCCCTGGAGCCTCACCATGTCGGTGATCCTCTATTTCCTCGCACGTAAATTGTTGCCGCCAGA
AACGGAAGCTGTTGAAGGGGGGAGCGATGCCATTAAAAAAGCACTCGCAGAGTTAGGACCAACCACCGGTAAAGAAAAAC
GCTTGATCGGTATTTCGCTGTTGTTACTGCTCTTTTGGTCTACTGGCGGAAAATTACACAGTATTGATACCACCTCTGTC
ACCCTTGCCGGACTGGCGATTATGTTGCTGCCTGGCATCGGTGTAATGAGCTGGAAAGAGGTCGAAAAACGTGTGCAGTG
GGGCACGTTGCTGATGTTTGGTATTGGTATCAGTCTGGGGTCCACGCTGCTTGATACACAGGCAGCTTCATGGATGGCGA
ACTATGTGGTGAAAGGTTTTGGTCTCGACGGCTTGCCATCATTAGCCATCTTCGCGATTCTCGCGGCTTTCTTGATCATC
ATCCATCTGGGCTTTGCCAGCGCTACTGCATTAACTGCTGCTTTGCTGCCTATCCTGATTAGTCTGTTAAGCAGCCTGCC
GCCAGAACTCGGTGTTAACCCGGTCGGCATGACCATTTTGCTGGCCTTCAGTGTCAGTTTTGGCTTCATTCTGCCAATTA
ACGCGCCACAAAATATGGTGTGTATGGGTACAGATACCTTCACGCCACGCCAGTTTACTCGTGTGGGACTGTACCTGACA
GTGATCGGCTACCTGCTATTACTGCTGTTTGCCGCCACATGGTGGAAGATCCTGGGACTGATGTGA

Upstream 100 bases:

>100_bases
GATAAATAGTTAAATCATTAAATAACAAAGCATTATTAAAAAATTAAAGATGGCATAGCTCCTGCAATAGCCAGGCAGGT
TTTTTATTTTTCACAATGAG

Downstream 100 bases:

>100_bases
GGAAACCAACGATGTCATTACAAATTGCGGTAGAAAAAGTGCGTTGGTTGACGGCCGGATTGCTGGAACTTAATGGCTGC
GATGCTGATATCGCTCAGGA

Product: transporter membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MNMSSISHDASQKRRIIPNPGLWLAIIAGIIITLLPLGDTLPVAGQNMIAILVFAIIVWISEAMDYTASAIVISALIIFM
VGFAPDMNHPDTILGTAKALKMTLSGFSNSALALVAAAMFIAAAMTITGLDKRIALFTMSKIGASSRSIIIGAIVVTIVL
SLVVPSATARTACVVPIMMGVIAAFKVDKHSRLAASMMIVIAQATSIWNVGIQTSAAQNLLSIGFINKTFGAGHSVSWLD
WLLAGAPWSLTMSVILYFLARKLLPPETEAVEGGSDAIKKALAELGPTTGKEKRLIGISLLLLLFWSTGGKLHSIDTTSV
TLAGLAIMLLPGIGVMSWKEVEKRVQWGTLLMFGIGISLGSTLLDTQAASWMANYVVKGFGLDGLPSLAIFAILAAFLII
IHLGFASATALTAALLPILISLLSSLPPELGVNPVGMTILLAFSVSFGFILPINAPQNMVCMGTDTFTPRQFTRVGLYLT
VIGYLLLLLFAATWWKILGLM

Sequences:

>Translated_501_residues
MNMSSISHDASQKRRIIPNPGLWLAIIAGIIITLLPLGDTLPVAGQNMIAILVFAIIVWISEAMDYTASAIVISALIIFM
VGFAPDMNHPDTILGTAKALKMTLSGFSNSALALVAAAMFIAAAMTITGLDKRIALFTMSKIGASSRSIIIGAIVVTIVL
SLVVPSATARTACVVPIMMGVIAAFKVDKHSRLAASMMIVIAQATSIWNVGIQTSAAQNLLSIGFINKTFGAGHSVSWLD
WLLAGAPWSLTMSVILYFLARKLLPPETEAVEGGSDAIKKALAELGPTTGKEKRLIGISLLLLLFWSTGGKLHSIDTTSV
TLAGLAIMLLPGIGVMSWKEVEKRVQWGTLLMFGIGISLGSTLLDTQAASWMANYVVKGFGLDGLPSLAIFAILAAFLII
IHLGFASATALTAALLPILISLLSSLPPELGVNPVGMTILLAFSVSFGFILPINAPQNMVCMGTDTFTPRQFTRVGLYLT
VIGYLLLLLFAATWWKILGLM
>Mature_501_residues
MNMSSISHDASQKRRIIPNPGLWLAIIAGIIITLLPLGDTLPVAGQNMIAILVFAIIVWISEAMDYTASAIVISALIIFM
VGFAPDMNHPDTILGTAKALKMTLSGFSNSALALVAAAMFIAAAMTITGLDKRIALFTMSKIGASSRSIIIGAIVVTIVL
SLVVPSATARTACVVPIMMGVIAAFKVDKHSRLAASMMIVIAQATSIWNVGIQTSAAQNLLSIGFINKTFGAGHSVSWLD
WLLAGAPWSLTMSVILYFLARKLLPPETEAVEGGSDAIKKALAELGPTTGKEKRLIGISLLLLLFWSTGGKLHSIDTTSV
TLAGLAIMLLPGIGVMSWKEVEKRVQWGTLLMFGIGISLGSTLLDTQAASWMANYVVKGFGLDGLPSLAIFAILAAFLII
IHLGFASATALTAALLPILISLLSSLPPELGVNPVGMTILLAFSVSFGFILPINAPQNMVCMGTDTFTPRQFTRVGLYLT
VIGYLLLLLFAATWWKILGLM

Specific function: Responsible For The Uptake Of Citrate In Exchange To The Efflux Of Succinate. Has A Relatively Broad Specificity For C(4)- Dicarboxylates And Tricarboxylates. [C]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. SODIT1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI29171306, Length=461, Percent_Identity=22.9934924078091, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI4506979, Length=547, Percent_Identity=22.3034734917733, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI301069349, Length=520, Percent_Identity=21.3461538461538, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1786829, Length=481, Percent_Identity=27.4428274428274, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1786986, Length=411, Percent_Identity=30.9002433090024, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789444, Length=423, Percent_Identity=28.6052009456265, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI32564681, Length=458, Percent_Identity=22.2707423580786, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71988385, Length=536, Percent_Identity=22.7611940298507, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32565804, Length=458, Percent_Identity=22.4890829694323, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 53039; Mature: 53039

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNMSSISHDASQKRRIIPNPGLWLAIIAGIIITLLPLGDTLPVAGQNMIAILVFAIIVWI
CCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
SEAMDYTASAIVISALIIFMVGFAPDMNHPDTILGTAKALKMTLSGFSNSALALVAAAMF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IAAAMTITGLDKRIALFTMSKIGASSRSIIIGAIVVTIVLSLVVPSATARTACVVPIMMG
HHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
VIAAFKVDKHSRLAASMMIVIAQATSIWNVGIQTSAAQNLLSIGFINKTFGAGHSVSWLD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHCCCCCCHHHHH
WLLAGAPWSLTMSVILYFLARKLLPPETEAVEGGSDAIKKALAELGPTTGKEKRLIGISL
HHHHCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHH
LLLLFWSTGGKLHSIDTTSVTLAGLAIMLLPGIGVMSWKEVEKRVQWGTLLMFGIGISLG
HHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
STLLDTQAASWMANYVVKGFGLDGLPSLAIFAILAAFLIIIHLGFASATALTAALLPILI
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLLSSLPPELGVNPVGMTILLAFSVSFGFILPINAPQNMVCMGTDTFTPRQFTRVGLYLT
HHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCCHHHHHHHHHHH
VIGYLLLLLFAATWWKILGLM
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8405966 [H]