Click here to switch to the map view.

The map label for this gene is sucD [H]

Identifier: 218551371

GI number: 218551371

Start: 4254056

End: 4254928

Strand: Direct

Name: sucD [H]

Synonym: EFER_4152

Alternate gene names: 218551371

Gene position: 4254056-4254928 (Clockwise)

Preceding gene: 218551370

Following gene: 218551372

Centisome position: 92.71

GC content: 50.97

Gene sequence:

>873_bases
ATGAGCGTTTTGATCAACAAACACACGCGGGTACTGGTGCAGGGCATTACTGGCAAAAACGGCACATTTCATACAGAGCA
GGCTATTGCGTATGGTACTCAGATTGTCGGTGGAGTGACGCCTGGCAAGGGCGGGCAACTGCATCTGGATCGCCCGGTTT
TTGATTCAATGAAAGAAGCGATGCGACAAACTGAGGCTGATGCCAGCGTAATTTATGTGCCTGCGCCGTTTGTGCTGGAT
TCTGTCGTTGAGGCTATTGAGTCTGGCGTCAAATTGATTGTGGTGATTACCGAAGGTGTGCCAACACTGGATATGGTGAA
AGTTCGTCGGTTGCTTGACTGCCACCCGGATGTGCGGCTGATTGGGCCAAACTGCCCAGGAATCATCACACCGGGCGAGT
GCAAAATCGGCATTATGCCGGGAGAAATCCACCGCCCAGGGCGTATTGGGATTGTTTCCCGCTCCGGTACATTAACCTAC
GAAGCTGTAGCGCAAACCACGGCGCTGGGACTTGGGCAATCCACCTGTATTGGTATTGGCGGCGATCCGGTTCCGGGGAC
TAACTTTATTGATGCGCTGCGTTTATTCGAAAATGATCCGCAAACAGACGCGGTAATTATGATCGGTGAAATTGGTGGTA
ATGCGGAAGAGCGCGCTGCAGAATTTATTCGCCATGAAATGAATAAAACGGTCGTAGGTTATATTGCCGGTGTTACTGCA
CCAAAAGGAAAACGCATGGGGCACGCCGGAGCCATTATTTCTGGCGGTAGCGGCAGTGCGGAGGATAAATTCCGTGCGTT
CGATAAAGCAGGCATGGCATGGACAAGAAACCCGGCGTTACTTGGCGAAACATTATGGAATGTCATTAAGTAA

Upstream 100 bases:

>100_bases
GCGGTTACTGGCAGAAAGTGGCCTGACGGTGGAAGCCGTCGATTCTCTGGATGATGCCGCGAAACGCATCATTGCGTTAC
TGAATTAACAGGAGGTTAAG

Downstream 100 bases:

>100_bases
TCCATAAATCTATCTCAAGGGAGCATATCGCTCCCTTTTTTTATCTGTGTGGTAAGGGAATCATCTTTTAATAATTGTGC
GGAAAACCGCGCATAAAATA

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSVLINKHTRVLVQGITGKNGTFHTEQAIAYGTQIVGGVTPGKGGQLHLDRPVFDSMKEAMRQTEADASVIYVPAPFVLD
SVVEAIESGVKLIVVITEGVPTLDMVKVRRLLDCHPDVRLIGPNCPGIITPGECKIGIMPGEIHRPGRIGIVSRSGTLTY
EAVAQTTALGLGQSTCIGIGGDPVPGTNFIDALRLFENDPQTDAVIMIGEIGGNAEERAAEFIRHEMNKTVVGYIAGVTA
PKGKRMGHAGAIISGGSGSAEDKFRAFDKAGMAWTRNPALLGETLWNVIK

Sequences:

>Translated_290_residues
MSVLINKHTRVLVQGITGKNGTFHTEQAIAYGTQIVGGVTPGKGGQLHLDRPVFDSMKEAMRQTEADASVIYVPAPFVLD
SVVEAIESGVKLIVVITEGVPTLDMVKVRRLLDCHPDVRLIGPNCPGIITPGECKIGIMPGEIHRPGRIGIVSRSGTLTY
EAVAQTTALGLGQSTCIGIGGDPVPGTNFIDALRLFENDPQTDAVIMIGEIGGNAEERAAEFIRHEMNKTVVGYIAGVTA
PKGKRMGHAGAIISGGSGSAEDKFRAFDKAGMAWTRNPALLGETLWNVIK
>Mature_289_residues
SVLINKHTRVLVQGITGKNGTFHTEQAIAYGTQIVGGVTPGKGGQLHLDRPVFDSMKEAMRQTEADASVIYVPAPFVLDS
VVEAIESGVKLIVVITEGVPTLDMVKVRRLLDCHPDVRLIGPNCPGIITPGECKIGIMPGEIHRPGRIGIVSRSGTLTYE
AVAQTTALGLGQSTCIGIGGDPVPGTNFIDALRLFENDPQTDAVIMIGEIGGNAEERAAEFIRHEMNKTVVGYIAGVTAP
KGKRMGHAGAIISGGSGSAEDKFRAFDKAGMAWTRNPALLGETLWNVIK

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=289, Percent_Identity=60.2076124567474, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI38569423, Length=314, Percent_Identity=28.0254777070064, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI38569421, Length=314, Percent_Identity=28.0254777070064, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1786949, Length=290, Percent_Identity=66.8965517241379, Blast_Score=408, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17553126, Length=292, Percent_Identity=57.5342465753425, Blast_Score=314, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI17550194, Length=288, Percent_Identity=56.5972222222222, Blast_Score=307, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI17557344, Length=247, Percent_Identity=32.3886639676113, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17551266, Length=227, Percent_Identity=33.0396475770925, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324716, Length=295, Percent_Identity=49.4915254237288, Blast_Score=278, Evalue=9e-76,
Organism=Drosophila melanogaster, GI21356559, Length=286, Percent_Identity=58.7412587412587, Blast_Score=351, Evalue=3e-97,
Organism=Drosophila melanogaster, GI28574296, Length=291, Percent_Identity=58.0756013745705, Blast_Score=309, Evalue=1e-84,
Organism=Drosophila melanogaster, GI281363477, Length=251, Percent_Identity=27.4900398406374, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281363475, Length=251, Percent_Identity=27.4900398406374, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281363473, Length=251, Percent_Identity=27.4900398406374, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30705; Mature: 30574

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLINKHTRVLVQGITGKNGTFHTEQAIAYGTQIVGGVTPGKGGQLHLDRPVFDSMKEA
CCEEECCCEEEEEEECCCCCCCEEHHHHHHHCCHHCCCCCCCCCCEEEECCHHHHHHHHH
MRQTEADASVIYVPAPFVLDSVVEAIESGVKLIVVITEGVPTLDMVKVRRLLDCHPDVRL
HHHCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEE
IGPNCPGIITPGECKIGIMPGEIHRPGRIGIVSRSGTLTYEAVAQTTALGLGQSTCIGIG
ECCCCCCEECCCCEEEEECCCCCCCCCEEEEEECCCCEEHHHHHHHHHHCCCCCEEEECC
GDPVPGTNFIDALRLFENDPQTDAVIMIGEIGGNAEERAAEFIRHEMNKTVVGYIAGVTA
CCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEEEEEECCC
PKGKRMGHAGAIISGGSGSAEDKFRAFDKAGMAWTRNPALLGETLWNVIK
CCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SVLINKHTRVLVQGITGKNGTFHTEQAIAYGTQIVGGVTPGKGGQLHLDRPVFDSMKEA
CEEECCCEEEEEEECCCCCCCEEHHHHHHHCCHHCCCCCCCCCCEEEECCHHHHHHHHH
MRQTEADASVIYVPAPFVLDSVVEAIESGVKLIVVITEGVPTLDMVKVRRLLDCHPDVRL
HHHCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEE
IGPNCPGIITPGECKIGIMPGEIHRPGRIGIVSRSGTLTYEAVAQTTALGLGQSTCIGIG
ECCCCCCEECCCCEEEEECCCCCCCCCEEEEEECCCCEEHHHHHHHHHHCCCCCEEEECC
GDPVPGTNFIDALRLFENDPQTDAVIMIGEIGGNAEERAAEFIRHEMNKTVVGYIAGVTA
CCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEEEEEECCC
PKGKRMGHAGAIISGGSGSAEDKFRAFDKAGMAWTRNPALLGETLWNVIK
CCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]