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The map label for this gene is aceB [H]

Identifier: 218551291

GI number: 218551291

Start: 4168275

End: 4169876

Strand: Direct

Name: aceB [H]

Synonym: EFER_4067

Alternate gene names: 218551291

Gene position: 4168275-4169876 (Clockwise)

Preceding gene: 218551290

Following gene: 218551292

Centisome position: 90.84

GC content: 50.94

Gene sequence:

>1602_bases
ATGAATCAACAGGCAACAACAACCGAAGAATTAACCTTTACCATGCCATTCGGTGAGCAGGAGAAGCATATTCTTACTTC
TGATGCTGTAGCATTTCTCACTGAACTGGTGACACGTTTTACACCTCAGCGGAATAAATTACTGGCGGCGCGCATTCAGC
AGCAGCAAGATATTGATAACGGAACGTTGCCTGATTTTATTTCGGAAACAGCTTCCATTCGTGATACAGACTGGAAAATT
CGTGGTATTCCTGCGGACTTAGAAGATCGTCGGGTAGAGATTACCGGACCCGTAGAGCGCAAGATGGTGATCAACGCACT
GAACGCCAATGTGAAAGTCTTTATGGCCGATTTCGAAGATTCACTGGCCCCGGACTGGAACAAAGTGATCGACGGGCAAA
TTAACCTGCGCGATGCGGTTAATGGCACCATCAGTTACACCAATGAAGCAGGTAAAATTTACCAGCTCAAGCCCAATCCA
GCGGTTTTGATTTGTCGGGTACGCGGTCTGCACTTGCCGGAAAAACATGTCACCTGGCGTGGTGAGGCAATCCCCGGTAG
CTTGTTTGATTTTGCGCTCTATTTCTTCCACAACTATCAGGCTCTGTTGGCAAAGGGCAGCGGTCCCTATTTCTATTTGC
CGAAAACCCAGTCCTGGCAGGAGGCTGCCTGGTGGCGCGAAGTCTTCAGCTATGCAGAAGATCGCTTTAATCTGCCGCGC
GGTACCATCAAGGCGACGTTGCTGATTGAAACGCTGCCCGCCGTGTTCCAGATGGACGAAATCCTTCACGCGCTGCGTGA
CCATATTGTTGGTCTGAACTGCGGTCGTTGGGATTACATCTTCAGCTATATCAAAACGTTGAAAAACTATCCCGATCGCG
TCCTGCCAGACAGACAGGCAGTGACGATGGATAAACCATTCCTGAATGCTTACTCACGCCTGTTGATTAAAACCTGCCAT
AAACGTGGTGCTTTTGCGATGGGCGGCATGGCGGCGTTTATTCCGAGCAAAGATGAAGAGCGCAATAACCAGGTGCTCAA
CAAAGTAAAAGCGGATAAAGCGCTGGAAGCCAATAACGGTCACGATGGCACATGGATCGCTCACCCAGGCCTTGCGGATA
CGGCAATGGCGGTATTCAACGACATTCTCGGCTCCCGTAAAAATCAGCTTGAAGTGATGCGCGAACAAGACGCGCCGATT
ACTGCCGATCAGCTGCTGGCACCTTGTGATGGTGAACGCACCGAAGAAGGTATGCGCGCCAACATTCGCGTGGCTGTGCA
GTACATCGAAGCATGGATCTCCGGCAACGGCTGCGTGCCGATTTATGGCCTGATGGAAGATGCGGCGACGGCTGAAATTT
CCCGTACCTCCATCTGGCAGTGGATCCATCACCAAAAAACGTTGAGTAATGGCAAACCGGTGACCAAAGCCTTGTTCCGC
CAGATGCTGGGCGAAGAGATGAAAGTCATTGCCAGCGAACTGGGCGAAGAACGTTTCTCCCAGGGGCGTTTTGACGATGC
CGCACGCTTGATGGAACAGATCACCACTTCCGATGAGTTAATTGATTTCCTGACCCTGCCAGGCTACCGCCTGTTAGCGT
AA

Upstream 100 bases:

>100_bases
CAATTTAATTGAGTAGTCTTAGTCGTGCTGAACGAAAAGCGCACAACGATCCTTCGTTCACATTTGGGATGCAGCAGGAT
CAAAGACGAGGGCTTACTCA

Downstream 100 bases:

>100_bases
ACCACCACATAACTATGGAGCATCTGCACATGAAAACCCGTACACAACAAATTGAAGAATTACAGAAAGAGTGGACTCAA
CCGCGTTGGGAAGGCATTAC

Product: malate synthase

Products: NA

Alternate protein names: MSA [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MNQQATTTEELTFTMPFGEQEKHILTSDAVAFLTELVTRFTPQRNKLLAARIQQQQDIDNGTLPDFISETASIRDTDWKI
RGIPADLEDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPDWNKVIDGQINLRDAVNGTISYTNEAGKIYQLKPNP
AVLICRVRGLHLPEKHVTWRGEAIPGSLFDFALYFFHNYQALLAKGSGPYFYLPKTQSWQEAAWWREVFSYAEDRFNLPR
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNYPDRVLPDRQAVTMDKPFLNAYSRLLIKTCH
KRGAFAMGGMAAFIPSKDEERNNQVLNKVKADKALEANNGHDGTWIAHPGLADTAMAVFNDILGSRKNQLEVMREQDAPI
TADQLLAPCDGERTEEGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKTLSNGKPVTKALFR
QMLGEEMKVIASELGEERFSQGRFDDAARLMEQITTSDELIDFLTLPGYRLLA

Sequences:

>Translated_533_residues
MNQQATTTEELTFTMPFGEQEKHILTSDAVAFLTELVTRFTPQRNKLLAARIQQQQDIDNGTLPDFISETASIRDTDWKI
RGIPADLEDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPDWNKVIDGQINLRDAVNGTISYTNEAGKIYQLKPNP
AVLICRVRGLHLPEKHVTWRGEAIPGSLFDFALYFFHNYQALLAKGSGPYFYLPKTQSWQEAAWWREVFSYAEDRFNLPR
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNYPDRVLPDRQAVTMDKPFLNAYSRLLIKTCH
KRGAFAMGGMAAFIPSKDEERNNQVLNKVKADKALEANNGHDGTWIAHPGLADTAMAVFNDILGSRKNQLEVMREQDAPI
TADQLLAPCDGERTEEGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKTLSNGKPVTKALFR
QMLGEEMKVIASELGEERFSQGRFDDAARLMEQITTSDELIDFLTLPGYRLLA
>Mature_533_residues
MNQQATTTEELTFTMPFGEQEKHILTSDAVAFLTELVTRFTPQRNKLLAARIQQQQDIDNGTLPDFISETASIRDTDWKI
RGIPADLEDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPDWNKVIDGQINLRDAVNGTISYTNEAGKIYQLKPNP
AVLICRVRGLHLPEKHVTWRGEAIPGSLFDFALYFFHNYQALLAKGSGPYFYLPKTQSWQEAAWWREVFSYAEDRFNLPR
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNYPDRVLPDRQAVTMDKPFLNAYSRLLIKTCH
KRGAFAMGGMAAFIPSKDEERNNQVLNKVKADKALEANNGHDGTWIAHPGLADTAMAVFNDILGSRKNQLEVMREQDAPI
TADQLLAPCDGERTEEGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKTLSNGKPVTKALFR
QMLGEEMKVIASELGEERFSQGRFDDAARLMEQITTSDELIDFLTLPGYRLLA

Specific function: Glyoxylate bypass; second step. [C]

COG id: COG2225

COG function: function code C; Malate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790444, Length=533, Percent_Identity=97.1857410881801, Blast_Score=1083, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17561814, Length=528, Percent_Identity=50.7575757575758, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI71982926, Length=422, Percent_Identity=53.3175355450237, Blast_Score=420, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6322222, Length=514, Percent_Identity=47.2762645914397, Blast_Score=440, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6324212, Length=524, Percent_Identity=45.9923664122137, Blast_Score=437, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011076
- InterPro:   IPR006252
- InterPro:   IPR001465
- InterPro:   IPR019830 [H]

Pfam domain/function: PF01274 Malate_synthase [H]

EC number: =2.3.3.9 [H]

Molecular weight: Translated: 60364; Mature: 60364

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00510 MALATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQQATTTEELTFTMPFGEQEKHILTSDAVAFLTELVTRFTPQRNKLLAARIQQQQDIDN
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
GTLPDFISETASIRDTDWKIRGIPADLEDRRVEITGPVERKMVINALNANVKVFMADFED
CCCCHHHHHHCCCCCCCEEEECCCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCC
SLAPDWNKVIDGQINLRDAVNGTISYTNEAGKIYQLKPNPAVLICRVRGLHLPEKHVTWR
CCCCCHHHHCCCCEEEHHHCCCEEEEECCCCEEEEECCCCEEEEEEECCCCCCCHHCCCC
GEAIPGSLFDFALYFFHNYQALLAKGSGPYFYLPKTQSWQEAAWWREVFSYAEDRFNLPR
CCCCCCHHHHHHHHHHHCCHHEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNYPDRVLPDRQA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCE
VTMDKPFLNAYSRLLIKTCHKRGAFAMGGMAAFIPSKDEERNNQVLNKVKADKALEANNG
EECCCHHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCC
HDGTWIAHPGLADTAMAVFNDILGSRKNQLEVMREQDAPITADQLLAPCDGERTEEGMRA
CCCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCC
NIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKTLSNGKPVTKALFR
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QMLGEEMKVIASELGEERFSQGRFDDAARLMEQITTSDELIDFLTLPGYRLLA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MNQQATTTEELTFTMPFGEQEKHILTSDAVAFLTELVTRFTPQRNKLLAARIQQQQDIDN
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
GTLPDFISETASIRDTDWKIRGIPADLEDRRVEITGPVERKMVINALNANVKVFMADFED
CCCCHHHHHHCCCCCCCEEEECCCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCC
SLAPDWNKVIDGQINLRDAVNGTISYTNEAGKIYQLKPNPAVLICRVRGLHLPEKHVTWR
CCCCCHHHHCCCCEEEHHHCCCEEEEECCCCEEEEECCCCEEEEEEECCCCCCCHHCCCC
GEAIPGSLFDFALYFFHNYQALLAKGSGPYFYLPKTQSWQEAAWWREVFSYAEDRFNLPR
CCCCCCHHHHHHHHHHHCCHHEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNYPDRVLPDRQA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCE
VTMDKPFLNAYSRLLIKTCHKRGAFAMGGMAAFIPSKDEERNNQVLNKVKADKALEANNG
EECCCHHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCC
HDGTWIAHPGLADTAMAVFNDILGSRKNQLEVMREQDAPITADQLLAPCDGERTEEGMRA
CCCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCC
NIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKTLSNGKPVTKALFR
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QMLGEEMKVIASELGEERFSQGRFDDAARLMEQITTSDELIDFLTLPGYRLLA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3050899; 3060852; 8265357; 9278503 [H]