Click here to switch to the map view.

The map label for this gene is emrD [H]

Identifier: 218551205

GI number: 218551205

Start: 4074065

End: 4075249

Strand: Direct

Name: emrD [H]

Synonym: EFER_3970

Alternate gene names: 218551205

Gene position: 4074065-4075249 (Clockwise)

Preceding gene: 218551197

Following gene: 218551207

Centisome position: 88.78

GC content: 52.07

Gene sequence:

>1185_bases
ATGAAAAGGCAAAGAAACGTCAATTTGCTATTGATGTTGATATTACTCGTAGCTGTCGGCCAGATGGCACAAACCATTTA
TATTCCAGCTATTGCCGATATGGCACGCGAACTGAATGTCCGTGAGGGTGCAGTTCAAAGTGTGATGGGTGCGTATCTGC
TGACTTATGGTATCTCACAGCTGTTTTATGGCCCCATTTCTGACCGGGTCGGTCGCCGCCCGGTGATCCTCATCGGAATG
TCCATTTTTATGCTGGCAACACTTCTAGCCGCCACGACTCATAGCCTGACGGTGCTGATTGCCGCCAGCGCGATGCAGGG
CATGGGAACCGGCGTCGGGGGAGTGATGGCGCGCACGCTACCGCGTGATTTATATGAACGGACACAACTGCGCCATGCCA
ATAGCTTGTTAAATATGGGGATTCTCGTAAGTCCATTATTGGCTCCCCTGATTGGTGGTGTGCTCGATACCCTATGGAAC
TGGCGTGCCTGTTATCTGTTTTTGCTGGTTTTATGTGCCGGCGTCACCTTTAGTATGGCCCGCTGGATGCCAGAAACACG
GCCCGCTGACGCACCGCGAACCAGTTTGATCACCAGCTATAAAACACTTTTTGGCAACGGGGGTTTTGACTGCTATCTGT
TGATGTTGATTGGCGGTCTGGCGGGGATTGCTGCCTTTGAAGCTTGCTCCGGCGTGCTCATGGGGGCGGTATTAGGACTC
AACAGCATGACGGTGAGTATTTTGTTTATCCTGCCAATCCCGGCTGCATTTTTCGGTGCATGGTTTGCCGGACGCCCAAA
TAAACGTTTCTCAACCTTAATGTGGCAATCTGCAATCTGTTGTTTGCTGGCAGGCCTTTTGATGTGGCTCCCTGCCTGGT
TTGGCATCATGAACATCTGGACACTTCTGACGCCTGCCGCGCTATTCTTTTTTGGGGCCGGGATGTTATTCCCACTGGCA
ACCAGTGGCGCAATGGAACCTTTTCCGTTCCTGGCCGGTACTGCAGGTGCATTGGTTGGCGGATTACAGAACATTGGCTC
TGGTGCACTCGCTTCGCTCTCCGCCATGTTGCCGCAAACCGATCAGGGAAGCCTTGGAATGTTAATGACACTGATGGGAG
TGTTGATTGTATTGTGCTGGCTTCCGTTAGCAGCTCGCATGTCACATCAGGGGCAAGCGGTTTAA

Upstream 100 bases:

>100_bases
CATATCTGGCTAACATTCATCAATGTGATAGATTCCTCTCCCGCATTTATGGGAATGCGTAGCGACTTATTCTGAATATT
TTTCTAAAAGCATCATCGAA

Downstream 100 bases:

>100_bases
TTCATTATAAGGTGGCCTTCGGGCTACCTTACCTGTTCTTTTAGCCAGGTAATAAATGCCTCAATTTTTGGCCACTGCCT
GCCCGGTAATGTGGTGATGT

Product: multidrug resistance protein D

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MKRQRNVNLLLMLILLVAVGQMAQTIYIPAIADMARELNVREGAVQSVMGAYLLTYGISQLFYGPISDRVGRRPVILIGM
SIFMLATLLAATTHSLTVLIAASAMQGMGTGVGGVMARTLPRDLYERTQLRHANSLLNMGILVSPLLAPLIGGVLDTLWN
WRACYLFLLVLCAGVTFSMARWMPETRPADAPRTSLITSYKTLFGNGGFDCYLLMLIGGLAGIAAFEACSGVLMGAVLGL
NSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSAICCLLAGLLMWLPAWFGIMNIWTLLTPAALFFFGAGMLFPLA
TSGAMEPFPFLAGTAGALVGGLQNIGSGALASLSAMLPQTDQGSLGMLMTLMGVLIVLCWLPLAARMSHQGQAV

Sequences:

>Translated_394_residues
MKRQRNVNLLLMLILLVAVGQMAQTIYIPAIADMARELNVREGAVQSVMGAYLLTYGISQLFYGPISDRVGRRPVILIGM
SIFMLATLLAATTHSLTVLIAASAMQGMGTGVGGVMARTLPRDLYERTQLRHANSLLNMGILVSPLLAPLIGGVLDTLWN
WRACYLFLLVLCAGVTFSMARWMPETRPADAPRTSLITSYKTLFGNGGFDCYLLMLIGGLAGIAAFEACSGVLMGAVLGL
NSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSAICCLLAGLLMWLPAWFGIMNIWTLLTPAALFFFGAGMLFPLA
TSGAMEPFPFLAGTAGALVGGLQNIGSGALASLSAMLPQTDQGSLGMLMTLMGVLIVLCWLPLAARMSHQGQAV
>Mature_394_residues
MKRQRNVNLLLMLILLVAVGQMAQTIYIPAIADMARELNVREGAVQSVMGAYLLTYGISQLFYGPISDRVGRRPVILIGM
SIFMLATLLAATTHSLTVLIAASAMQGMGTGVGGVMARTLPRDLYERTQLRHANSLLNMGILVSPLLAPLIGGVLDTLWN
WRACYLFLLVLCAGVTFSMARWMPETRPADAPRTSLITSYKTLFGNGGFDCYLLMLIGGLAGIAAFEACSGVLMGAVLGL
NSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSAICCLLAGLLMWLPAWFGIMNIWTLLTPAALFFFGAGMLFPLA
TSGAMEPFPFLAGTAGALVGGLQNIGSGALASLSAMLPQTDQGSLGMLMTLMGVLIVLCWLPLAARMSHQGQAV

Specific function: Multidrug resistance pump that participates in a low energy shock adaptative response [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI87082312, Length=394, Percent_Identity=93.1472081218274, Blast_Score=670, Evalue=0.0,
Organism=Escherichia coli, GI1788509, Length=364, Percent_Identity=24.7252747252747, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI48994889, Length=369, Percent_Identity=25.4742547425474, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790146, Length=347, Percent_Identity=26.8011527377522, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787065, Length=171, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790794, Length=200, Percent_Identity=25, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324264, Length=165, Percent_Identity=32.1212121212121, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42113; Mature: 42113

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
8.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
6.6 %Met     (Mature Protein)
8.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRQRNVNLLLMLILLVAVGQMAQTIYIPAIADMARELNVREGAVQSVMGAYLLTYGISQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LFYGPISDRVGRRPVILIGMSIFMLATLLAATTHSLTVLIAASAMQGMGTGVGGVMARTL
HHCCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
PRDLYERTQLRHANSLLNMGILVSPLLAPLIGGVLDTLWNWRACYLFLLVLCAGVTFSMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RWMPETRPADAPRTSLITSYKTLFGNGGFDCYLLMLIGGLAGIAAFEACSGVLMGAVLGL
HCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSAICCLLAGLLMWLPAWFGIMNIW
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLLTPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNIGSGALASLSAMLPQT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
DQGSLGMLMTLMGVLIVLCWLPLAARMSHQGQAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKRQRNVNLLLMLILLVAVGQMAQTIYIPAIADMARELNVREGAVQSVMGAYLLTYGISQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LFYGPISDRVGRRPVILIGMSIFMLATLLAATTHSLTVLIAASAMQGMGTGVGGVMARTL
HHCCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
PRDLYERTQLRHANSLLNMGILVSPLLAPLIGGVLDTLWNWRACYLFLLVLCAGVTFSMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RWMPETRPADAPRTSLITSYKTLFGNGGFDCYLLMLIGGLAGIAAFEACSGVLMGAVLGL
HCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSAICCLLAGLLMWLPAWFGIMNIW
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLLTPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNIGSGALASLSAMLPQT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
DQGSLGMLMTLMGVLIVLCWLPLAARMSHQGQAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8240355; 7686882; 9278503 [H]