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The map label for this gene is yicE [H]

Identifier: 218551182

GI number: 218551182

Start: 4046474

End: 4047865

Strand: Direct

Name: yicE [H]

Synonym: EFER_3947

Alternate gene names: 218551182

Gene position: 4046474-4047865 (Clockwise)

Preceding gene: 218551179

Following gene: 218551183

Centisome position: 88.18

GC content: 53.52

Gene sequence:

>1392_bases
ATGTCTGTTTCCACCCTCGAGTCAGAAAATGCGCAACCGATTGCGCAGACTCAAAGCAGCGAGTTGATTTACCGTCTTGA
AGATCGTCCGCCGCTTCCTCAAACCCTGTTTGCCGCCTGCCAGCATCTGCTGGCGATGTTCGTTGCGGTGATCACGCCAG
CGCTATTAATCTGCCAGGCGCTGGGTTTACCGGCACAAGACACACAACACATTATTAGTATGTCGCTGTTTGCCTCCGGT
GTGGCGTCGATTATTCAAATTAAGGCCTGGGGCCCGGTTGGCTCCGGGCTGTTGTCTATTCAGGGCACCAGCTTCAACTT
TGTTGCCCCTCTGATTATGGGCGGTACGGCGCTTAAGACCGGTGGTGCTGATGTTCCTACCATGATGGCGGCTTTGTTCG
GCACGTTGATGCTGGCAAGTTGCACCGAGATGGTGATCTCCCGCGTTCTGCATCTGGCGCGCCGCATTATTACGCCGCTG
GTTTCTGGCGTTGTGGTGATGATTATCGGCCTGTCGCTAATTCAGGTTGGGTTAACGTCCATTGGCGGCGGTTACGCAGC
CATGAGCGATAACACCTTCGGCGCACCGAAAAATCTGCTGCTGGCAGGCGTGGTCTTAGCCTTAATTATCCTGCTTAACC
GTCAGCGCAACCCCTACTTACGCGTGGCCTCACTGGTGATTGCGATGGCGGCCGGATATGCGCTGGCATGGTTTATGGGC
ATGTTGCCAGAAAGCAACGAACCGATGACGCAAGAGCTGATTATGGTGCCAACGCCGCTCTATTACGGTCTTGGCATTGA
ATGGAGCCTGCTGCTGCCACTGATGCTGGTCTTTATGATCACCTCTCTGGAAACTATTGGCGATATCACGGCGACCTCTG
ACGTTTCGGAACAGCCTGTTTCTGGTCCGCTATACATGAAACGTCTGAAAGGCGGCGTGCTGGCGAATGGTCTGAACTCA
TTTGTGTCGGCGGTATTTAACACCTTCCCGAACTCCTGTTTTGGACAAAACAATGGTGTGATTCAGTTAACAGGTGTTGC
CAGCCGTTATGTTGGTTTTGTTGTGGCGCTGATGTTGATTTTGCTCGGCCTGTTCCCGGCAGTAAGTGGATTTGTGCAAC
ATATTCCTGAACCTGTGCTGGGCGGCGCGACGCTGGTAATGTTTGGTACTATCGCAGCATCAGGTGTGCGTATTGTCTCC
CGTGAGCCGCTAAACCGCCGGGCAATTCTGATTATTGCTCTGTCTCTGGCGGTCGGTCTGGGTGTTTCTCAGCAGCCACT
GATTTTGCAGTTTGCTCCTGACTGGCTGAAAAACCTGCTCTCCTCCGGGATCGCCGCAGGCGGTATTACTGCCATTGCGC
TGAACCTGATTTTCCCGCCGGAAAAACAGTAA

Upstream 100 bases:

>100_bases
ATTTATTGCATTTAAATATTTAGCGTAATCACTGGCAAACGTTTGCTTTTGGTCTATGGTCAGCTAAAATGCCCTCTTTG
CTACCACGGGATTGTTTTCG

Downstream 100 bases:

>100_bases
ATTCCTTGCGGCGGTAAGATATTTCTACCGCCGCAGTCATCCTCTTTCACTATTCCCGCCTTGAGGAATGCGCACAAATC
GTGCATAACTCCCTTATGTT

Product: transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSVSTLESENAQPIAQTQSSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASG
VASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPL
VSGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMG
MLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNS
FVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLILLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVS
REPLNRRAILIIALSLAVGLGVSQQPLILQFAPDWLKNLLSSGIAAGGITAIALNLIFPPEKQ

Sequences:

>Translated_463_residues
MSVSTLESENAQPIAQTQSSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASG
VASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPL
VSGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMG
MLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNS
FVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLILLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVS
REPLNRRAILIIALSLAVGLGVSQQPLILQFAPDWLKNLLSSGIAAGGITAIALNLIFPPEKQ
>Mature_462_residues
SVSTLESENAQPIAQTQSSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASGV
ASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLV
SGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMGM
LPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNSF
VSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLILLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSR
EPLNRRAILIIALSLAVGLGVSQQPLILQFAPDWLKNLLSSGIAAGGITAIALNLIFPPEKQ

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=516, Percent_Identity=23.062015503876, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI40316845, Length=516, Percent_Identity=23.062015503876, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790087, Length=463, Percent_Identity=98.9200863930886, Blast_Score=908, Evalue=0.0,
Organism=Escherichia coli, GI87082178, Length=443, Percent_Identity=45.1467268623025, Blast_Score=348, Evalue=6e-97,
Organism=Escherichia coli, GI87082181, Length=460, Percent_Identity=28.695652173913, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1788843, Length=444, Percent_Identity=26.1261261261261, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI87081818, Length=418, Percent_Identity=24.1626794258373, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17558856, Length=472, Percent_Identity=24.364406779661, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 48828; Mature: 48697

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSTLESENAQPIAQTQSSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQA
CCCCCCCCCCCCCHHHCCCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKT
HCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCCCC
GGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLVSGVVVMIIGLSLIQVGLTS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMG
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPV
HCCCCCCCHHHHHEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
LLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLAVGL
HHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHC
GVSQQPLILQFAPDWLKNLLSSGIAAGGITAIALNLIFPPEKQ
CCCCCCEEEEECHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SVSTLESENAQPIAQTQSSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQA
CCCCCCCCCCCCHHHCCCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKT
HCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCCCC
GGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLVSGVVVMIIGLSLIQVGLTS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMG
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPV
HCCCCCCCHHHHHEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
LLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLAVGL
HHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHC
GVSQQPLILQFAPDWLKNLLSSGIAAGGITAIALNLIFPPEKQ
CCCCCCEEEEECHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]