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The map label for this gene is yiaY [H]

Identifier: 218551114

GI number: 218551114

Start: 3964526

End: 3965722

Strand: Direct

Name: yiaY [H]

Synonym: EFER_3870

Alternate gene names: 218551114

Gene position: 3964526-3965722 (Clockwise)

Preceding gene: 218551113

Following gene: 218551115

Centisome position: 86.4

GC content: 51.13

Gene sequence:

>1197_bases
GTGGGAAACGCCGTCGGAAAGATGGATTTGAACTTAAGGAGAGTCATTATGAGTTTTATGTTGGCATTACCGAAAATTAG
CCTGCATGGTGCTGGGGCAATTGGCGATATGGTAAATCTGGTTGCAAATAAACAGTGGGGAAAAGCACTGATCGTTACCG
ATGGGCAACTGGTTAAGTTGGGATTACTGGACAGCCTGTTTGCCGCACTGGATCAACACGAAATGTCTTATCACTTATTT
GATGAGGTATTTCCTAACCCCACCGAAGAACTGGTGCAAAAAGGCTACGCTGCATTTCAGGATGCCGCATGTGACTACAT
TATTGCTTTCGGTGGCGGTAGCCCAATTGATACTGCAAAAGCCGTAAAAATCCTTACCGCTAATCCCGCGCCTTCTACGG
CGTACTCTGGTGTGGGTAAAGTGACAAACCCCGGCGTACCGCTGGTGGCAATCAATACGACTGCCGGAACAGCTGCTGAG
ATGACCAGCAATGCAGTGATCATCGACACCGCGCGGCAGGTAAAAGAGGTCATTATTGACCCGAATATCATTCCAGATAT
TGCGGTGGATGATGCCAGTGTAATGCTGGAGATCCCGGCCTCTGTTACCGCCGCCACGGGTATGGATGCACTGACTCACG
CAGTTGAAGCCTATGTTTCTGTTGGTGCACATCCATTAACCGACGCTAACGCACTGGAAGCTATCCGTTTGATTACGCTG
TGGCTGCCAAAAGCGGTAGATGATGGTCATAATCTGGAAGCCCGTGAACAAATGGCATTCGCCCAGTACCTGGCAGGTAT
GGCATTTAACAGTGCGGGTCTGGGCCTTGTTCACGCACTGGCGCATCAGCCTGGCGCTACCCACAACCTGCCACATGGTG
TGTGCAATGCTATCTTGTTGCCAGTTATTGAAAACTTTAACCGTCCAAATGCCATCGCACGCTTTGCCCGCATTGCTCAG
GCGATGGGTGTCGATACGCGTGATATGAGTGACGAAGCGGCAAGCATTGAAGCAATTAACGCTATCCGCGCATTAAGCCA
TCGCGTGGGTATTCCGGCAGGATTCAGCCAACTTGGCATCACCAAAGAAGATATTGAAGGCTGGTTAGATAAAGCCCTGG
CTGACCCGTGCGCGCCATGTAACCCGCGTACCGCCAGCCGCGACGAGGTGCGCGAGCTGTATCTGGAGGCATTATGA

Upstream 100 bases:

>100_bases
CCATTACCCGCGAAGAGCTGATTGCACTCGGTGAGCGTTTTGGCGTTACGCCACTGGCCAGTGCGCTGGCACTTTAATAT
CCCGACAGATATCCGGCGGT

Downstream 100 bases:

>100_bases
TCCGTAAGGCATTTGTGATGCAGGTTAACCCCGATGCTCACGAAGAGTATCAGCATCGGCATAATCCTATCTGGCCAGAA
CTGGAAGTGGTGTTGAAATC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MGNAVGKMDLNLRRVIMSFMLALPKISLHGAGAIGDMVNLVANKQWGKALIVTDGQLVKLGLLDSLFAALDQHEMSYHLF
DEVFPNPTEELVQKGYAAFQDAACDYIIAFGGGSPIDTAKAVKILTANPAPSTAYSGVGKVTNPGVPLVAINTTAGTAAE
MTSNAVIIDTARQVKEVIIDPNIIPDIAVDDASVMLEIPASVTAATGMDALTHAVEAYVSVGAHPLTDANALEAIRLITL
WLPKAVDDGHNLEAREQMAFAQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIENFNRPNAIARFARIAQ
AMGVDTRDMSDEAASIEAINAIRALSHRVGIPAGFSQLGITKEDIEGWLDKALADPCAPCNPRTASRDEVRELYLEAL

Sequences:

>Translated_398_residues
MGNAVGKMDLNLRRVIMSFMLALPKISLHGAGAIGDMVNLVANKQWGKALIVTDGQLVKLGLLDSLFAALDQHEMSYHLF
DEVFPNPTEELVQKGYAAFQDAACDYIIAFGGGSPIDTAKAVKILTANPAPSTAYSGVGKVTNPGVPLVAINTTAGTAAE
MTSNAVIIDTARQVKEVIIDPNIIPDIAVDDASVMLEIPASVTAATGMDALTHAVEAYVSVGAHPLTDANALEAIRLITL
WLPKAVDDGHNLEAREQMAFAQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIENFNRPNAIARFARIAQ
AMGVDTRDMSDEAASIEAINAIRALSHRVGIPAGFSQLGITKEDIEGWLDKALADPCAPCNPRTASRDEVRELYLEAL
>Mature_397_residues
GNAVGKMDLNLRRVIMSFMLALPKISLHGAGAIGDMVNLVANKQWGKALIVTDGQLVKLGLLDSLFAALDQHEMSYHLFD
EVFPNPTEELVQKGYAAFQDAACDYIIAFGGGSPIDTAKAVKILTANPAPSTAYSGVGKVTNPGVPLVAINTTAGTAAEM
TSNAVIIDTARQVKEVIIDPNIIPDIAVDDASVMLEIPASVTAATGMDALTHAVEAYVSVGAHPLTDANALEAIRLITLW
LPKAVDDGHNLEAREQMAFAQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILLPVIENFNRPNAIARFARIAQA
MGVDTRDMSDEAASIEAINAIRALSHRVGIPAGFSQLGITKEDIEGWLDKALADPCAPCNPRTASRDEVRELYLEAL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=405, Percent_Identity=26.9135802469136, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI48994951, Length=376, Percent_Identity=46.0106382978723, Blast_Score=340, Evalue=7e-95,
Organism=Escherichia coli, GI1789163, Length=381, Percent_Identity=42.7821522309711, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI87082107, Length=388, Percent_Identity=40.2061855670103, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI1787493, Length=406, Percent_Identity=32.512315270936, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1789386, Length=363, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=411, Percent_Identity=28.2238442822384, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6321181, Length=381, Percent_Identity=39.8950131233596, Blast_Score=285, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24657991, Length=402, Percent_Identity=27.6119402985075, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 42084; Mature: 41953

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNAVGKMDLNLRRVIMSFMLALPKISLHGAGAIGDMVNLVANKQWGKALIVTDGQLVKL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCEEEH
GLLDSLFAALDQHEMSYHLFDEVFPNPTEELVQKGYAAFQDAACDYIIAFGGGSPIDTAK
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHH
AVKILTANPAPSTAYSGVGKVTNPGVPLVAINTTAGTAAEMTSNAVIIDTARQVKEVIID
EEEEEECCCCCCHHHCCCCCCCCCCCCEEEEECCCCCHHHHCCCEEEEECHHHHHHHHCC
PNIIPDIAVDDASVMLEIPASVTAATGMDALTHAVEAYVSVGAHPLTDANALEAIRLITL
CCCCCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
WLPKAVDDGHNLEAREQMAFAQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
PVIENFNRPNAIARFARIAQAMGVDTRDMSDEAASIEAINAIRALSHRVGIPAGFSQLGI
HHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
TKEDIEGWLDKALADPCAPCNPRTASRDEVRELYLEAL
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
GNAVGKMDLNLRRVIMSFMLALPKISLHGAGAIGDMVNLVANKQWGKALIVTDGQLVKL
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCEEEH
GLLDSLFAALDQHEMSYHLFDEVFPNPTEELVQKGYAAFQDAACDYIIAFGGGSPIDTAK
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHH
AVKILTANPAPSTAYSGVGKVTNPGVPLVAINTTAGTAAEMTSNAVIIDTARQVKEVIID
EEEEEECCCCCCHHHCCCCCCCCCCCCEEEEECCCCCHHHHCCCEEEEECHHHHHHHHCC
PNIIPDIAVDDASVMLEIPASVTAATGMDALTHAVEAYVSVGAHPLTDANALEAIRLITL
CCCCCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
WLPKAVDDGHNLEAREQMAFAQYLAGMAFNSAGLGLVHALAHQPGATHNLPHGVCNAILL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
PVIENFNRPNAIARFARIAQAMGVDTRDMSDEAASIEAINAIRALSHRVGIPAGFSQLGI
HHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
TKEDIEGWLDKALADPCAPCNPRTASRDEVRELYLEAL
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]