Click here to switch to the map view.

The map label for this gene is menA [H]

Identifier: 218551086

GI number: 218551086

Start: 3939549

End: 3940475

Strand: Direct

Name: menA [H]

Synonym: EFER_3842

Alternate gene names: 218551086

Gene position: 3939549-3940475 (Clockwise)

Preceding gene: 218551085

Following gene: 218551087

Centisome position: 85.85

GC content: 52.0

Gene sequence:

>927_bases
ATGACTGAACAACAAATTAGCCGAACTCAGGCGTGGCTGGAAAGTTTACGACCTAAAACCCTCCCCCTCGCCTTTGCTGC
AATTATCGTCGGGACGGCGCTGGCATGGTGGCAAGGTCACTTCGATCCGCTGGTCGCCCTCCTGGCACTGATTACCGCCG
GACTGCTGCAAATTCTCTCTAACCTCGCCAATGATTACGGCGATGCGGTAAAAGGCAGCGATAAACCTGACCGCATTGGA
CCACTGCGCGGCATGCAAAAAGGTGTGATTACCCAGCAAGAGATGAAACGGGCGCTGATCATCACTGTCGTTCTGATTTG
CCTCTCCGGGCTGGCACTGGTTGCAGTGGCATGTCATACACTCGCCGATTTTGTTGGTTTCCTGATTTTGGGTGGGCTTT
CAATTATTGCCGCGATCACCTACACCGTAGGCAATCGTCCATATGGATATATTGGCCTCGGTGATATTTCTGTCCTGATT
TTCTTTGGCTGGCTAAGTGTGATGGGAAGCTGGTATTTGCAGGCGCACACTCTGATTCCGGCGCTGATCCTTCCGGCGAC
GGCGTGTGGGTTGTTAGCAACAGCGGTACTGAATATTAATAACCTGCGCGATATCAATAGCGACCGGGAGAATGGCAAAA
ACACGCTGGTGGTGCGTTTAGGGGAAGTGAACGCACGTCGTTACCATGCTTGTCTGCTGATGGGCTCGCTGGTGTGTCTG
GCACTGTTTAATCTGATCTCTTTACATAGCGTTTGGGGCTGGCTGTTCCTGTTGGCGACACCGCTGCTGGTGAAACAGGC
GCGCTATGTCATGCGCGAAATGGAACCTGCCGCGATGCGCCCAATGCTGGAACGCACAGTAAAAGGGGCATTATTGACTA
ACCTTTTGTTTGTTTTAGGGATTATCTTAAGCCAGTGGTTGGCATAA

Upstream 100 bases:

>100_bases
GGCAGATGAAGATCTGAGCCGTTTTATCCTATAATCGCGTTCAATCATTTTCATCATTGTTTGATGGGGCTGAAAGGCCC
CATTTTTATTGGCGCGTATT

Downstream 100 bases:

>100_bases
CTGACAAATATCAATTAACAATTGATGATTTTGCCAACAACCCACATAGCGCGATATACTGAAAATTCTCGCAGCAACTG
AATGTTAAGCCTATGAAATA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTEQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGHFDPLVALLALITAGLLQILSNLANDYGDAVKGSDKPDRIG
PLRGMQKGVITQQEMKRALIITVVLICLSGLALVAVACHTLADFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVLI
FFGWLSVMGSWYLQAHTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGEVNARRYHACLLMGSLVCL
ALFNLISLHSVWGWLFLLATPLLVKQARYVMREMEPAAMRPMLERTVKGALLTNLLFVLGIILSQWLA

Sequences:

>Translated_308_residues
MTEQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGHFDPLVALLALITAGLLQILSNLANDYGDAVKGSDKPDRIG
PLRGMQKGVITQQEMKRALIITVVLICLSGLALVAVACHTLADFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVLI
FFGWLSVMGSWYLQAHTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGEVNARRYHACLLMGSLVCL
ALFNLISLHSVWGWLFLLATPLLVKQARYVMREMEPAAMRPMLERTVKGALLTNLLFVLGIILSQWLA
>Mature_307_residues
TEQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGHFDPLVALLALITAGLLQILSNLANDYGDAVKGSDKPDRIGP
LRGMQKGVITQQEMKRALIITVVLICLSGLALVAVACHTLADFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVLIF
FGWLSVMGSWYLQAHTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGEVNARRYHACLLMGSLVCLA
LFNLISLHSVWGWLFLLATPLLVKQARYVMREMEPAAMRPMLERTVKGALLTNLLFVLGIILSQWLA

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=308, Percent_Identity=30.5194805194805, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1790365, Length=308, Percent_Identity=97.4025974025974, Blast_Score=605, Evalue=1e-174,
Organism=Drosophila melanogaster, GI17737429, Length=309, Percent_Identity=26.8608414239482, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33585; Mature: 33453

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGHFDPLVALLALITAGLLQILS
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
NLANDYGDAVKGSDKPDRIGPLRGMQKGVITQQEMKRALIITVVLICLSGLALVAVACHT
HHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LADFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVLIFFGWLSVMGSWYLQAHTLIP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGEVNARRYHACLLMGSLVCL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
ALFNLISLHSVWGWLFLLATPLLVKQARYVMREMEPAAMRPMLERTVKGALLTNLLFVLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
IILSQWLA
HHHHHHCC
>Mature Secondary Structure 
TEQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGHFDPLVALLALITAGLLQILS
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
NLANDYGDAVKGSDKPDRIGPLRGMQKGVITQQEMKRALIITVVLICLSGLALVAVACHT
HHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LADFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVLIFFGWLSVMGSWYLQAHTLIP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGEVNARRYHACLLMGSLVCL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
ALFNLISLHSVWGWLFLLATPLLVKQARYVMREMEPAAMRPMLERTVKGALLTNLLFVLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
IILSQWLA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]