Click here to switch to the map view.

The map label for this gene is ilvY [H]

Identifier: 218551000

GI number: 218551000

Start: 3825020

End: 3825994

Strand: Direct

Name: ilvY [H]

Synonym: EFER_3729

Alternate gene names: 218551000

Gene position: 3825020-3825994 (Clockwise)

Preceding gene: 218550998

Following gene: 218551007

Centisome position: 83.36

GC content: 55.9

Gene sequence:

>975_bases
ATGACAGGAAATTTATTGCGGAAATTGATATATTCACAACGTCACATTGCAATTTTTGCAACGTCAACATTGAGGGCTGC
GCCATTGGATTTACGCGATCTGAAAACCTTCCTGCATCTGGCGGAAAGCCGCCATTTTGGCCGTAGTGCGCGGGCGATGC
ACGTTAGTCCATCCACGCTCTCACGGCAGATTCAGCGCCTGGAAGAAGATCTCGGTCAGCCGCTGTTTGTGCGCGATAAC
CGCACGGTAACGCTGACCGAAGCGGGCGAAGAACTGCGCGTTTTCGCCCAGCAAACACTGTTGCAGTATCAGCAGCTGCG
CCACACCATCGACCAGCAAGGGCCGTCCCTCTCTGGCGAATTACATATCTTCTGCTCGGTGACCGCTGCCTACAGCCATC
TACCGCCGATTCTGGATCGCTTCCGCGCGGAACACCCGTCGGTGGAGATTAAACTCACTACTGGTGATGCGGCGGACGCA
ATGGAAAAAGTTGTAACGGGGGAAGCGGATCTGGCGATTGCCGGGAAGCCGGAGACGCTGCCAGGTGCGGTGGCATTTTC
GATGCTGGAGAATCTGGCGGTGGTGCTGATCGCGCCAGCCTTACCGTGCCCGGTGCGTAATCAGGTTTCGGTAGAGAAGC
CGGACTGGTCTACAGTGCCGTTTATCATGGCCGATCAGGGACCGGTACGCCGCCGCATTGAACTGTGGTTCCGACGCAAC
AAAATCAGCAACCCGATGATTTACGCCACAGTCGGTGGGCATGAAGCGATGGTATCGATGGTGGCGCTCGGCTGCGGCGT
GGCCTTGTTGCCAGAAGTGGTGCTGGAAAACAGCCCGGAACCGGTGCGTAACCGCGTGATGATTCTGGAGCGTAGCGATG
AGAAAACGCCGTTTGAACTGGGCGTGTGTGCACAAAAAAAGCGGCTGCATGAGCCGCTGATTGAGGCTTTCTGGAAGATT
TTACCGAACCATTAA

Upstream 100 bases:

>100_bases
TGGCGCAGGTTCAGTGTATTGAAGTAGTTAGCCATGGTGATTCCTCGTGATGTTGTGCTTCTTATTGTTCGGTTCGCGTT
TGCGAGATTGAATTCACTAT

Downstream 100 bases:

>100_bases
CCCGCCAAAAAGAACCTGAACGCCGGGTTATTGGTTTCGTCGTGGCAATCGTAGCCCAGCTCATTCAGCCGGGTTTCGAA
ATCCGGTTCATGATCGCCAA

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTGNLLRKLIYSQRHIAIFATSTLRAAPLDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDN
RTVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADA
MEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRN
KISNPMIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKI
LPNH

Sequences:

>Translated_324_residues
MTGNLLRKLIYSQRHIAIFATSTLRAAPLDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDN
RTVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADA
MEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRN
KISNPMIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKI
LPNH
>Mature_323_residues
TGNLLRKLIYSQRHIAIFATSTLRAAPLDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNR
TVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAM
EKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRNK
ISNPMIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKIL
PNH

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=296, Percent_Identity=99.6621621621622, Blast_Score=609, Evalue=1e-176,
Organism=Escherichia coli, GI1790399, Length=261, Percent_Identity=29.5019157088123, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=29.2682926829268, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI157672245, Length=182, Percent_Identity=32.4175824175824, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788887, Length=253, Percent_Identity=28.4584980237154, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI145693105, Length=167, Percent_Identity=29.3413173652695, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787806, Length=256, Percent_Identity=24.21875, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=26.8292682926829, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367136, Length=249, Percent_Identity=26.9076305220884, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787601, Length=148, Percent_Identity=28.3783783783784, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788481, Length=249, Percent_Identity=24.8995983935743, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790262, Length=299, Percent_Identity=25.0836120401338, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788296, Length=225, Percent_Identity=29.3333333333333, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788748, Length=303, Percent_Identity=25.0825082508251, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787530, Length=249, Percent_Identity=22.8915662650602, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788706, Length=143, Percent_Identity=31.4685314685315, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789440, Length=176, Percent_Identity=26.7045454545455, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48994962, Length=82, Percent_Identity=37.8048780487805, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787589, Length=194, Percent_Identity=29.3814432989691, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI145693193, Length=123, Percent_Identity=34.1463414634146, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36184; Mature: 36053

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGNLLRKLIYSQRHIAIFATSTLRAAPLDLRDLKTFLHLAESRHFGRSARAMHVSPSTL
CCHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHH
SRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGE
HHHHHHHHHHCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETL
EEEEEEEHHHHHCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCEEECCCCCCC
PGAVAFSMLENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRN
HHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHC
KISNPMIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFEL
CCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHH
GVCAQKKRLHEPLIEAFWKILPNH
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TGNLLRKLIYSQRHIAIFATSTLRAAPLDLRDLKTFLHLAESRHFGRSARAMHVSPSTL
CHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHH
SRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGE
HHHHHHHHHHCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETL
EEEEEEEHHHHHCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCEEECCCCCCC
PGAVAFSMLENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRN
HHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHC
KISNPMIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFEL
CCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHH
GVCAQKKRLHEPLIEAFWKILPNH
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]