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The map label for this gene is hemX [H]

Identifier: 218550975

GI number: 218550975

Start: 3794155

End: 3795330

Strand: Direct

Name: hemX [H]

Synonym: EFER_3702

Alternate gene names: 218550975

Gene position: 3794155-3795330 (Clockwise)

Preceding gene: 218550974

Following gene: 218550976

Centisome position: 82.68

GC content: 51.19

Gene sequence:

>1176_bases
ATGACGGAACAAGAAAAATCCTCCGCCGTGGTTGAAGAAACCAGGGAGAACGTGGATACCCCACCACAGCCAGTAGTTGC
TGAGAAAAAAAGTAAAAACAGTACCGCGCTGGTCCTGAGTGCTGTGGCTATTGCCATTGCACTGGCGGCAGGCGTTGGGC
TTTATGGCTGGGGTAAACAGCAGTCTGTTAATCAAACTGCCACCAGCGAAGCACTGGCTTTGCAGGTTACAGCGTTACAA
AAAGCGCAGGAAAGCCAAAAGGCAGAACTGGAAGGTATCATCAAACAGCAAGCAGTTCAGCTGGCGCAGGCGACTCAACA
GCAACAAGTGCTGGAAAAACAGTTGGCTGAAGTTCAGCAAAAAGTGGCCACTATTTCTGGTAGCGATGCGAAAACCTGGC
TGCTGGCGCAAGCAGATTTTCTCGTCAAACTCGCCGGGCGGAAATTGTGGAGTGATCAGGATGCCACAACTGCCGCAGCA
CTGCTTAAAAGCGCAGACGCCAGCCTGGCCGATATGAATGATCCAAGTTTGATCGCTGCTCGCCGTGCGATTACTGATGA
TATCGCCAGCCTCTCTGCCGTTGAACAGGTGGACTATGATGGCATCATCCTCAAACTGAATCAGCTGTCTAATCAGGTAG
ATAACTTACGTCTCGCAGATAAAGACCCTGATGGTTCGCCAATGGACTCGGACGATAGTGAGCTTTCCAGTTCCATTAGC
GAATGGCGCATTAACCTGCAAAAAAGCTGGCAAAACTTTATGGACAGCTTTATTACCATTCGTCGCCGTGATGACACAGC
TGTACCTCTGCTCGCGCCAAATCAAGATATCTATTTGCGTGAAAATATTCGTTCTCGCCTGCTGGTTGCCGCACAGGCCG
TACCACGTCATCAGGAAGAAACCTACCGCCAGGCGCTGGAGAATGTCTCCACCTGGGTGCGGGCGTATTACGATACTGAT
GACGCTACCACCAAAGCGTTCCTTGATGAGGTGGATCAGTTAAGTCAGCAGAATATCTCAATGGATGTGCCGGAAACCCT
GCAAAGCCAGGCAATTCTGGAAAAACTGATGCAAACGCGCGTACGTAACCTGCTGGCACAACCTGCTGCTCCAGCAACGG
AACCGACTCCTGCTCCACAAGTCGATACTCCGGCAGCTGCGCCGCAAGGAGAATAA

Upstream 100 bases:

>100_bases
TGCCCAGGAACTGGGTTGGCAAGACATTCAGATCGCTGATAACGCCGACAACGATGCGCTACTACGCGCATTACAATAAC
TCTCATAATGGGAAGCCATA

Downstream 100 bases:

>100_bases
CCATGTTAAAAGTGTTATTGCTCTTTGTGTTGCTGATTGCGGGGATCGTGGTCGGCCCGATGATTGCCGGGCATCAGGGT
TATGTACTGATCCAGACCGA

Product: uroporphyrinogen III C-methyltransferase

Products: NA

Alternate protein names: Urogen-III methylase; ORF X [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTEQEKSSAVVEETRENVDTPPQPVVAEKKSKNSTALVLSAVAIAIALAAGVGLYGWGKQQSVNQTATSEALALQVTALQ
KAQESQKAELEGIIKQQAVQLAQATQQQQVLEKQLAEVQQKVATISGSDAKTWLLAQADFLVKLAGRKLWSDQDATTAAA
LLKSADASLADMNDPSLIAARRAITDDIASLSAVEQVDYDGIILKLNQLSNQVDNLRLADKDPDGSPMDSDDSELSSSIS
EWRINLQKSWQNFMDSFITIRRRDDTAVPLLAPNQDIYLRENIRSRLLVAAQAVPRHQEETYRQALENVSTWVRAYYDTD
DATTKAFLDEVDQLSQQNISMDVPETLQSQAILEKLMQTRVRNLLAQPAAPATEPTPAPQVDTPAAAPQGE

Sequences:

>Translated_391_residues
MTEQEKSSAVVEETRENVDTPPQPVVAEKKSKNSTALVLSAVAIAIALAAGVGLYGWGKQQSVNQTATSEALALQVTALQ
KAQESQKAELEGIIKQQAVQLAQATQQQQVLEKQLAEVQQKVATISGSDAKTWLLAQADFLVKLAGRKLWSDQDATTAAA
LLKSADASLADMNDPSLIAARRAITDDIASLSAVEQVDYDGIILKLNQLSNQVDNLRLADKDPDGSPMDSDDSELSSSIS
EWRINLQKSWQNFMDSFITIRRRDDTAVPLLAPNQDIYLRENIRSRLLVAAQAVPRHQEETYRQALENVSTWVRAYYDTD
DATTKAFLDEVDQLSQQNISMDVPETLQSQAILEKLMQTRVRNLLAQPAAPATEPTPAPQVDTPAAAPQGE
>Mature_390_residues
TEQEKSSAVVEETRENVDTPPQPVVAEKKSKNSTALVLSAVAIAIALAAGVGLYGWGKQQSVNQTATSEALALQVTALQK
AQESQKAELEGIIKQQAVQLAQATQQQQVLEKQLAEVQQKVATISGSDAKTWLLAQADFLVKLAGRKLWSDQDATTAAAL
LKSADASLADMNDPSLIAARRAITDDIASLSAVEQVDYDGIILKLNQLSNQVDNLRLADKDPDGSPMDSDDSELSSSISE
WRINLQKSWQNFMDSFITIRRRDDTAVPLLAPNQDIYLRENIRSRLLVAAQAVPRHQEETYRQALENVSTWVRAYYDTDD
ATTKAFLDEVDQLSQQNISMDVPETLQSQAILEKLMQTRVRNLLAQPAAPATEPTPAPQVDTPAAAPQGE

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790235, Length=393, Percent_Identity=90.3307888040712, Blast_Score=677, Evalue=0.0,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 42703; Mature: 42572

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQEKSSAVVEETRENVDTPPQPVVAEKKSKNSTALVLSAVAIAIALAAGVGLYGWGKQ
CCCCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
QSVNQTATSEALALQVTALQKAQESQKAELEGIIKQQAVQLAQATQQQQVLEKQLAEVQQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVATISGSDAKTWLLAQADFLVKLAGRKLWSDQDATTAAALLKSADASLADMNDPSLIAA
HHHHCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHCCCCCHHHHH
RRAITDDIASLSAVEQVDYDGIILKLNQLSNQVDNLRLADKDPDGSPMDSDDSELSSSIS
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHH
EWRINLQKSWQNFMDSFITIRRRDDTAVPLLAPNQDIYLRENIRSRLLVAAQAVPRHQEE
HHHHHHHHHHHHHHHHHHEEECCCCCCCCEECCCCCEEEHHHHHHHHHHHHHHCCCHHHH
TYRQALENVSTWVRAYYDTDDATTKAFLDEVDQLSQQNISMDVPETLQSQAILEKLMQTR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
VRNLLAQPAAPATEPTPAPQVDTPAAAPQGE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEQEKSSAVVEETRENVDTPPQPVVAEKKSKNSTALVLSAVAIAIALAAGVGLYGWGKQ
CCCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
QSVNQTATSEALALQVTALQKAQESQKAELEGIIKQQAVQLAQATQQQQVLEKQLAEVQQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVATISGSDAKTWLLAQADFLVKLAGRKLWSDQDATTAAALLKSADASLADMNDPSLIAA
HHHHCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHCCCCCHHHHH
RRAITDDIASLSAVEQVDYDGIILKLNQLSNQVDNLRLADKDPDGSPMDSDDSELSSSIS
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHH
EWRINLQKSWQNFMDSFITIRRRDDTAVPLLAPNQDIYLRENIRSRLLVAAQAVPRHQEE
HHHHHHHHHHHHHHHHHHEEECCCCCCCCEECCCCCEEEHHHHHHHHHHHHHHCCCHHHH
TYRQALENVSTWVRAYYDTDDATTKAFLDEVDQLSQQNISMDVPETLQSQAILEKLMQTR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
VRNLLAQPAAPATEPTPAPQVDTPAAAPQGE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062586; 3054815; 1379743; 9278503; 9298646 [H]