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The map label for this gene is ubiB [H]

Identifier: 218550919

GI number: 218550919

Start: 3732936

End: 3734576

Strand: Reverse

Name: ubiB [H]

Synonym: EFER_3645

Alternate gene names: 218550919

Gene position: 3734576-3732936 (Counterclockwise)

Preceding gene: 218550920

Following gene: 218550918

Centisome position: 81.39

GC content: 50.03

Gene sequence:

>1641_bases
ATGACGCCAGGTGAAGTACGGCGCCTATATTTCATCATTCGCACTTTTTTAAGCTACGGACTTGATGAACTGATCCCTAA
AATGCGTATCACCCTGCCGTTACGGCTATGGCGATACTCATTATTCTGGATGCCGAATCGGCATAAAGACAAACCATTAG
GTGAGCGACTACGACTGGCTCTACAAGAACTGGGGCCGGTGTGGATTAAGTTCGGGCAGATGTTATCTACCCGCCGCGAC
CTGTTCCCGCCACATATTGCCGATCAACTGGCGTTATTGCAGGACAAAGTTGCGCCATTTGATGGCAGACTGGCGAAGCA
ACAGATTGAAGCAGCAATGGGCGGCCTGCCGGTGGAAGCCTGGTTTGATGATTTTGATATTAAGCCGCTGGCTTCGGCTT
CTATTGCCCAGGTTCATACTGCACGGCTGAAATCGAATGGCAAAGAGGTGGTAATTAAAGTCATCCGCCCGGATATTTTG
CCGGTCATTAAAGCAGACCTGAAACTTATCTACCGTCTGGCTCGTTGGGTACCGCGTTTGCTGCCGGATGGTCGTCGTCT
ACGCCCAACCGAAGTGGTGCGCGAGTACGAAAAAACGTTGATCGACGAACTGAATTTGCTGCGGGAATCTGCCAACGCCA
TTCAGCTTCGGCGCAATTTTGAAGACAGCCCGATGCTCTACATCCCGGAAGTTTACCCTGACTATTGCAGTGAAGGGATG
ATGGTGATGGAGCGTATTTACGGCATTCCGGTTTCTGATGTCGCGGCGCTGGAGAAAAACGGCACCAACATGAAATTGCT
GGCGGAACGCGGCGTGCAGGTGTTCTTCACTCAGGTCTTTCGCGACAGCTTTTTCCATGCCGATATGCATCCTGGCAACA
TCTTCGTAAGCTATGAACACCCGGAAAACCCAAAATATATCGGCATTGATTGCGGGATTGTCGGCTCGCTAAACAAAGAA
GATAAACGCTATCTGGCAGAAAACTTTATCGCCTTCTTTAATCGCGACTATCGCAAAGTGGCAGAGCTACACGTCGATTC
TGGCTGGGTGCCGCCAGATACCAATGTTGAAGAGTTCGAATTTGCCATTCGTACGGTCTGTGAACCTATCTTTGAGAAAC
CGCTGGCCGAAATTTCGTTTGGACATGTGCTGTTAAATCTGTTTAATACGGCGCGTCGCTTCAATATGGAAGTGCAGCCG
CAATTGGTGTTACTCCAGAAAACCTTGCTCTATATCGAAGGGGTAGGCCGCCAGCTTTATCCGCAGCTCGATTTATGGAA
AACGGCGAAGCCCTTCCTGGAGTCGTGGATTAAAGATCAGGTCGGTATTCCTGCGCTGGTGAGAGCATTAAAGGAAAAAG
CACCGTTCTGGGTCGAAAAAATGCCAGAACTGCCTGAACTGGTTTACGACAGTTTGCGCCAGGGCAAGTATTTGCAGCAC
AGTGTTGATAAGATTGCGCGCGAGTTACAGTCCAATCATGTGCGTCAGGGGCAATCTCGCTATTTATTAGGGATTGGCGC
GACTTTAGTATTAAGTGGCACATTTTTGCTGGTTAGCCGACCTGAATGGGGCCTGATGCCCGGCTGGTTAATGGCAGCTG
GTCTGGTCGCATGGTTTGTCGGTTGGCGCAAAACACGCTGA

Upstream 100 bases:

>100_bases
CGCCAGGTCCACTTGAAGTAGCCTGGTTTGCGGAAGAAACGGCAGCCGTTGAACGTGCCGTGGATTCCCTGACCAAACGG
CTGGAAAAACTGGAGGTTAA

Downstream 100 bases:

>100_bases
TTTTTTCATCGCTCAAGGCGGGCCGTGTAACGTATAATGCGGCTTTATTAATTCATCATCTACCACAGAGGAACATGTAT
GGGTGGTATCAGTATTTGGC

Product: ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKPLGERLRLALQELGPVWIKFGQMLSTRRD
LFPPHIADQLALLQDKVAPFDGRLAKQQIEAAMGGLPVEAWFDDFDIKPLASASIAQVHTARLKSNGKEVVIKVIRPDIL
PVIKADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGM
MVMERIYGIPVSDVAALEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPENPKYIGIDCGIVGSLNKE
DKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQP
QLVLLQKTLLYIEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRALKEKAPFWVEKMPELPELVYDSLRQGKYLQH
SVDKIARELQSNHVRQGQSRYLLGIGATLVLSGTFLLVSRPEWGLMPGWLMAAGLVAWFVGWRKTR

Sequences:

>Translated_546_residues
MTPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKPLGERLRLALQELGPVWIKFGQMLSTRRD
LFPPHIADQLALLQDKVAPFDGRLAKQQIEAAMGGLPVEAWFDDFDIKPLASASIAQVHTARLKSNGKEVVIKVIRPDIL
PVIKADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGM
MVMERIYGIPVSDVAALEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPENPKYIGIDCGIVGSLNKE
DKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQP
QLVLLQKTLLYIEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRALKEKAPFWVEKMPELPELVYDSLRQGKYLQH
SVDKIARELQSNHVRQGQSRYLLGIGATLVLSGTFLLVSRPEWGLMPGWLMAAGLVAWFVGWRKTR
>Mature_545_residues
TPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKPLGERLRLALQELGPVWIKFGQMLSTRRDL
FPPHIADQLALLQDKVAPFDGRLAKQQIEAAMGGLPVEAWFDDFDIKPLASASIAQVHTARLKSNGKEVVIKVIRPDILP
VIKADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGMM
VMERIYGIPVSDVAALEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPENPKYIGIDCGIVGSLNKED
KRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQ
LVLLQKTLLYIEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRALKEKAPFWVEKMPELPELVYDSLRQGKYLQHS
VDKIARELQSNHVRQGQSRYLLGIGATLVLSGTFLLVSRPEWGLMPGWLMAAGLVAWFVGWRKTR

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=272, Percent_Identity=28.6764705882353, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI40254938, Length=256, Percent_Identity=28.515625, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI32261307, Length=320, Percent_Identity=24.0625, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI217035081, Length=223, Percent_Identity=28.6995515695067, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI34147522, Length=213, Percent_Identity=28.169014084507, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI2367309, Length=546, Percent_Identity=98.5347985347985, Blast_Score=1104, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559152, Length=285, Percent_Identity=27.0175438596491, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI32565180, Length=306, Percent_Identity=26.4705882352941, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6325148, Length=441, Percent_Identity=23.5827664399093, Blast_Score=129, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6323282, Length=297, Percent_Identity=24.2424242424242, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321319, Length=201, Percent_Identity=27.8606965174129, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24662575, Length=246, Percent_Identity=32.1138211382114, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI22024280, Length=253, Percent_Identity=31.2252964426877, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63148; Mature: 63016

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKPLGERLRLA
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHH
LQELGPVWIKFGQMLSTRRDLFPPHIADQLALLQDKVAPFDGRLAKQQIEAAMGGLPVEA
HHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
WFDDFDIKPLASASIAQVHTARLKSNGKEVVIKVIRPDILPVIKADLKLIYRLARWVPRL
HCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHH
LPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHH
MVMERIYGIPVSDVAALEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEH
HHHHHHHCCCHHHHHHHHCCCCCEEHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
PENPKYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFE
CCCCCEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
FAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYIEGVGRQLY
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHC
PQLDLWKTAKPFLESWIKDQVGIPALVRALKEKAPFWVEKMPELPELVYDSLRQGKYLQH
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCHHHHH
SVDKIARELQSNHVRQGQSRYLLGIGATLVLSGTFLLVSRPEWGLMPGWLMAAGLVAWFV
HHHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHH
GWRKTR
HHHCCC
>Mature Secondary Structure 
TPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKPLGERLRLA
CCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHH
LQELGPVWIKFGQMLSTRRDLFPPHIADQLALLQDKVAPFDGRLAKQQIEAAMGGLPVEA
HHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
WFDDFDIKPLASASIAQVHTARLKSNGKEVVIKVIRPDILPVIKADLKLIYRLARWVPRL
HCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHH
LPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHH
MVMERIYGIPVSDVAALEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEH
HHHHHHHCCCHHHHHHHHCCCCCEEHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
PENPKYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFE
CCCCCEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
FAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYIEGVGRQLY
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHC
PQLDLWKTAKPFLESWIKDQVGIPALVRALKEKAPFWVEKMPELPELVYDSLRQGKYLQH
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCHHHHH
SVDKIARELQSNHVRQGQSRYLLGIGATLVLSGTFLLVSRPEWGLMPGWLMAAGLVAWFV
HHHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHH
GWRKTR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA