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The map label for this gene is fabF [H]

Identifier: 218550752

GI number: 218550752

Start: 3528520

End: 3529698

Strand: Direct

Name: fabF [H]

Synonym: EFER_3463

Alternate gene names: 218550752

Gene position: 3528520-3529698 (Clockwise)

Preceding gene: 218550751

Following gene: 218550753

Centisome position: 76.9

GC content: 60.22

Gene sequence:

>1179_bases
GTGACTGATATGATTTATATTTCCGCCGTCGGCATGATCAACGCCCTGGGAAATAACCTTGATGAGATCGCAGCCAACCT
GACTCGTGGTTCCGCTCCCGGCATGCGCCCACGCGCAGGCTGGTTGCAGGGGCATCCGCAGACGGTCCTGGCTGGCGTGG
ATGGCGAGCTTCCGCTTATCCCGGAAAAATTCGCTGCGCACCGCTCGCGCAACAATCAGGTCCTGCTGGCGGCGCTGGCG
CAGATCCAGCCGCAGGTTGATGACGCTATCGCGAAATATGGCCGCGAGCGCATCGCGATTGTGCTTGGCACCAGCACCTC
CGGCCTGCATGAAGGTGACACGCACGTTAACCTGCGCACCCACGGGCAGCCAAGCACCACATGGCACTATGCACAACAAG
AACTCGGCGATCCGTCGCGTTTTCTCAGCCACTGGCTGGCGCTCGACGGCCCGGCATATACCCTTTCAACCGCCTGCTCT
TCCAGCGCCAGAGCGATGATCAGCGGGCGCAGGCTTATCGAAGCGGGGCTGGTCGATGCTGCCATTGTGGGTGGCGCAGA
CACCCTGAGCCGGATGCCGATTAACGGTTTTCACAGTCTCGAATCGCTGTCGCCAACCTTATGTCAGCCGTTCGGCCGTG
ACCGTGCGGGCATCACCATTGGCGAAGGCGCGGGGCTAATGCTGCTGACCCGTGAACCGCAGCCCATCGCGTTGCTGGGC
GTTGGTGAATCGAGCGACGCTTACCATATTTCGGCCCCGCATCCGCAGGGCGAAGGGGCAATCCGCGCTATTAACCAGGC
GCTGACCGATGCGCAGCTTACGCCAGATGACGTCGGCTATATCAACCTGCACGGCACCGCCACACAACTCAACGATCAGA
TTGAATCAATAGTGGTTAACGCCCTGTTTGGCGAACGCGTACCGTGCAGCTCCACCAAACATTTGACCGGACACACGCTG
GGCGCGGCGGGCATTACCGAGGCGGCAATCAGTATGTTGATCTTACAGCGTGATTTACCGCTGCCCGCTCAGGACTTCAG
CCTGTCGCCACGCGATCCCACGCTACCACCGTGCGGCATTATCGAAAAACCACAGCCGCTGGCACGTCCGGTGATCCTGT
CCAATTCTTTCGCCTTTGGCGGCAATAACGCCAGCATTCTGCTCGGGAGGGTTTCGTGA

Upstream 100 bases:

>100_bases
CTGGTCACGGAAATCACTTATTTGAATCGCAAAGGAAAACGCGTGCCAATCAGCATTGAGCAGCATGTCTTTAAATACCA
CATCACCATTCAATACTTAG

Downstream 100 bases:

>100_bases
GCCACTATTTATCACCCGGCGCTTATCTGCCCCACGATGCGCCCATGTTGCTGCTGGAAGAAGTGGTGAGCGTCAGCGAT
GACAGCGCCGTGTGCCGCGT

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTDMIYISAVGMINALGNNLDEIAANLTRGSAPGMRPRAGWLQGHPQTVLAGVDGELPLIPEKFAAHRSRNNQVLLAALA
QIQPQVDDAIAKYGRERIAIVLGTSTSGLHEGDTHVNLRTHGQPSTTWHYAQQELGDPSRFLSHWLALDGPAYTLSTACS
SSARAMISGRRLIEAGLVDAAIVGGADTLSRMPINGFHSLESLSPTLCQPFGRDRAGITIGEGAGLMLLTREPQPIALLG
VGESSDAYHISAPHPQGEGAIRAINQALTDAQLTPDDVGYINLHGTATQLNDQIESIVVNALFGERVPCSSTKHLTGHTL
GAAGITEAAISMLILQRDLPLPAQDFSLSPRDPTLPPCGIIEKPQPLARPVILSNSFAFGGNNASILLGRVS

Sequences:

>Translated_392_residues
MTDMIYISAVGMINALGNNLDEIAANLTRGSAPGMRPRAGWLQGHPQTVLAGVDGELPLIPEKFAAHRSRNNQVLLAALA
QIQPQVDDAIAKYGRERIAIVLGTSTSGLHEGDTHVNLRTHGQPSTTWHYAQQELGDPSRFLSHWLALDGPAYTLSTACS
SSARAMISGRRLIEAGLVDAAIVGGADTLSRMPINGFHSLESLSPTLCQPFGRDRAGITIGEGAGLMLLTREPQPIALLG
VGESSDAYHISAPHPQGEGAIRAINQALTDAQLTPDDVGYINLHGTATQLNDQIESIVVNALFGERVPCSSTKHLTGHTL
GAAGITEAAISMLILQRDLPLPAQDFSLSPRDPTLPPCGIIEKPQPLARPVILSNSFAFGGNNASILLGRVS
>Mature_391_residues
TDMIYISAVGMINALGNNLDEIAANLTRGSAPGMRPRAGWLQGHPQTVLAGVDGELPLIPEKFAAHRSRNNQVLLAALAQ
IQPQVDDAIAKYGRERIAIVLGTSTSGLHEGDTHVNLRTHGQPSTTWHYAQQELGDPSRFLSHWLALDGPAYTLSTACSS
SARAMISGRRLIEAGLVDAAIVGGADTLSRMPINGFHSLESLSPTLCQPFGRDRAGITIGEGAGLMLLTREPQPIALLGV
GESSDAYHISAPHPQGEGAIRAINQALTDAQLTPDDVGYINLHGTATQLNDQIESIVVNALFGERVPCSSTKHLTGHTLG
AAGITEAAISMLILQRDLPLPAQDFSLSPRDPTLPPCGIIEKPQPLARPVILSNSFAFGGNNASILLGRVS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=296, Percent_Identity=35.1351351351351, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=41.2162162162162, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI41872631, Length=261, Percent_Identity=31.0344827586207, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1787337, Length=268, Percent_Identity=34.3283582089552, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788663, Length=262, Percent_Identity=29.0076335877863, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=27.9236276849642, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=32.183908045977, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI212642053, Length=265, Percent_Identity=27.9245283018868, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17550940, Length=260, Percent_Identity=24.2307692307692, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=264, Percent_Identity=34.0909090909091, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24644341, Length=264, Percent_Identity=34.469696969697, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI221330659, Length=263, Percent_Identity=27.3764258555133, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19920632, Length=263, Percent_Identity=27.3764258555133, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24581345, Length=400, Percent_Identity=22.75, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 41413; Mature: 41281

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMIYISAVGMINALGNNLDEIAANLTRGSAPGMRPRAGWLQGHPQTVLAGVDGELPLI
CCCEEEEEHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCC
PEKFAAHRSRNNQVLLAALAQIQPQVDDAIAKYGRERIAIVLGTSTSGLHEGDTHVNLRT
CHHHHHHHCCCCEEEEEEHHHHCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEEE
HGQPSTTWHYAQQELGDPSRFLSHWLALDGPAYTLSTACSSSARAMISGRRLIEAGLVDA
CCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEHHHHCHHHHHHHHCCHHHHHCCHHH
AIVGGADTLSRMPINGFHSLESLSPTLCQPFGRDRAGITIGEGAGLMLLTREPQPIALLG
EEECCHHHHHCCCCCHHHHHHHCCHHHHHCCCCCCCCEEEECCCCEEEEECCCCCEEEEE
VGESSDAYHISAPHPQGEGAIRAINQALTDAQLTPDDVGYINLHGTATQLNDQIESIVVN
ECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
ALFGERVPCSSTKHLTGHTLGAAGITEAAISMLILQRDLPLPAQDFSLSPRDPTLPPCGI
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
IEKPQPLARPVILSNSFAFGGNNASILLGRVS
CCCCCHHCCCEEEECCEEECCCCCEEEEEECC
>Mature Secondary Structure 
TDMIYISAVGMINALGNNLDEIAANLTRGSAPGMRPRAGWLQGHPQTVLAGVDGELPLI
CCEEEEEHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCC
PEKFAAHRSRNNQVLLAALAQIQPQVDDAIAKYGRERIAIVLGTSTSGLHEGDTHVNLRT
CHHHHHHHCCCCEEEEEEHHHHCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEEE
HGQPSTTWHYAQQELGDPSRFLSHWLALDGPAYTLSTACSSSARAMISGRRLIEAGLVDA
CCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEHHHHCHHHHHHHHCCHHHHHCCHHH
AIVGGADTLSRMPINGFHSLESLSPTLCQPFGRDRAGITIGEGAGLMLLTREPQPIALLG
EEECCHHHHHCCCCCHHHHHHHCCHHHHHCCCCCCCCEEEECCCCEEEEECCCCCEEEEE
VGESSDAYHISAPHPQGEGAIRAINQALTDAQLTPDDVGYINLHGTATQLNDQIESIVVN
ECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
ALFGERVPCSSTKHLTGHTLGAAGITEAAISMLILQRDLPLPAQDFSLSPRDPTLPPCGI
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
IEKPQPLARPVILSNSFAFGGNNASILLGRVS
CCCCCHHCCCEEEECCEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]