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The map label for this gene is aaeR [H]

Identifier: 218550527

GI number: 218550527

Start: 3304964

End: 3305893

Strand: Direct

Name: aaeR [H]

Synonym: EFER_3221

Alternate gene names: 218550527

Gene position: 3304964-3305893 (Clockwise)

Preceding gene: 218550522

Following gene: 218550536

Centisome position: 72.02

GC content: 50.32

Gene sequence:

>930_bases
ATGGAAAGACTAAAACGCATGTCGGTGTTCGCCAAAGTTGTTGAATTTGGCTCTTTTACTGCCGCCGCCAGACAGCTACA
GATGAGTGTTTCCTCCATCAGTCAAACTGTCTCTAAACTGGAAGATGAGTTGCAGGTTAAGCTGTTGAATCGCAGTACGC
GTAGTATCGGGCTGACTGAAGCGGGTCGAATTTACTATCAGGGTTGCCGCAGGATGCTACATGAAGTTCGTGATGTTCAT
GAGCAACTTTACGCCTTTAACAACACCCCTATTGGTACACTACGGATCGGCTGTTCTTCAACTATGGCGCAAAATGTTCT
CGCCGGACTAACCGCCAAATTATTAAAAGAGTACCCCGGTTTAACCGTAAATCTGGTGACCGGCATTCCGGCTCCTGATC
TGATCGCTGATGGTCTGGATGTGGTGATTCGTGTCGGTGCCTTGCAAGACTCAAGCCTGTTTTCACGTCGCCTTGGCGCG
ATGCCGATGGTGGTTTGCGCCGCTAAAAGCTATCTCAGCCAGTATGGCATACCAGAAAAACCTGCCGACCTTAGCAGCCA
TTCATGGCTTGAATACAGTGTGCGACCGGATAACGAATTTGAGCTGATCGCCCCGGAAGGGATCTCTACACGGTTGATCC
CACAAGGGCGGTTTGTCACCAACGATCCCATGACTCTGGTACGCTGGCTGACAGCAGGCGCAGGGATCGCATATGTTCCA
CTGATGTGGGTGATCAATGAGATCAACCGTGGAGAACTGGAGATCTTGCTGCCACGTTATCAGTCGGACCCGCGCCCGGT
TTATGCCCTGTACACTGAAAAGGATAAAATGCCTCTGAAGGTGCAGGTGGTGATTAACTCATTGACGGATTACTTTGTCG
AGGTGGCAAAACTGTTCCAGGAGATGCACGGGCGAGGAAAAGAGAAGTAA

Upstream 100 bases:

>100_bases
AGAACGACATAGCTGTTAATTGATAATTAATATATTAGCGTAACTGTTATGCTGTTATCTATATAATGTGATCTAAATCA
CTTTTAAGCCAGAGTGAATA

Downstream 100 bases:

>100_bases
TTAACTATCAGCACTCATGTCACATCTGGTGGCGACCTGTGCCTGATACGACGCTGACGTCGTATCAGGCCTGCACAGAT
TACGCTGTACCACCAACCGT

Product: DNA-binding transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MERLKRMSVFAKVVEFGSFTAAARQLQMSVSSISQTVSKLEDELQVKLLNRSTRSIGLTEAGRIYYQGCRRMLHEVRDVH
EQLYAFNNTPIGTLRIGCSSTMAQNVLAGLTAKLLKEYPGLTVNLVTGIPAPDLIADGLDVVIRVGALQDSSLFSRRLGA
MPMVVCAAKSYLSQYGIPEKPADLSSHSWLEYSVRPDNEFELIAPEGISTRLIPQGRFVTNDPMTLVRWLTAGAGIAYVP
LMWVINEINRGELEILLPRYQSDPRPVYALYTEKDKMPLKVQVVINSLTDYFVEVAKLFQEMHGRGKEK

Sequences:

>Translated_309_residues
MERLKRMSVFAKVVEFGSFTAAARQLQMSVSSISQTVSKLEDELQVKLLNRSTRSIGLTEAGRIYYQGCRRMLHEVRDVH
EQLYAFNNTPIGTLRIGCSSTMAQNVLAGLTAKLLKEYPGLTVNLVTGIPAPDLIADGLDVVIRVGALQDSSLFSRRLGA
MPMVVCAAKSYLSQYGIPEKPADLSSHSWLEYSVRPDNEFELIAPEGISTRLIPQGRFVTNDPMTLVRWLTAGAGIAYVP
LMWVINEINRGELEILLPRYQSDPRPVYALYTEKDKMPLKVQVVINSLTDYFVEVAKLFQEMHGRGKEK
>Mature_309_residues
MERLKRMSVFAKVVEFGSFTAAARQLQMSVSSISQTVSKLEDELQVKLLNRSTRSIGLTEAGRIYYQGCRRMLHEVRDVH
EQLYAFNNTPIGTLRIGCSSTMAQNVLAGLTAKLLKEYPGLTVNLVTGIPAPDLIADGLDVVIRVGALQDSSLFSRRLGA
MPMVVCAAKSYLSQYGIPEKPADLSSHSWLEYSVRPDNEFELIAPEGISTRLIPQGRFVTNDPMTLVRWLTAGAGIAYVP
LMWVINEINRGELEILLPRYQSDPRPVYALYTEKDKMPLKVQVVINSLTDYFVEVAKLFQEMHGRGKEK

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=309, Percent_Identity=98.0582524271845, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI145693193, Length=299, Percent_Identity=30.1003344481605, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1786401, Length=288, Percent_Identity=32.2916666666667, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787128, Length=270, Percent_Identity=28.1481481481481, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI87081978, Length=303, Percent_Identity=29.7029702970297, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787589, Length=274, Percent_Identity=28.4671532846715, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1789440, Length=290, Percent_Identity=27.2413793103448, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI157672245, Length=121, Percent_Identity=33.8842975206612, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788481, Length=146, Percent_Identity=30.8219178082192, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1789173, Length=250, Percent_Identity=25.6, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787601, Length=126, Percent_Identity=24.6031746031746, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082024, Length=161, Percent_Identity=29.8136645962733, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788706, Length=145, Percent_Identity=28.2758620689655, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788297, Length=123, Percent_Identity=30.0813008130081, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786508, Length=147, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34559; Mature: 34559

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLKRMSVFAKVVEFGSFTAAARQLQMSVSSISQTVSKLEDELQVKLLNRSTRSIGLTE
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCH
AGRIYYQGCRRMLHEVRDVHEQLYAFNNTPIGTLRIGCSSTMAQNVLAGLTAKLLKEYPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCC
LTVNLVTGIPAPDLIADGLDVVIRVGALQDSSLFSRRLGAMPMVVCAAKSYLSQYGIPEK
CEEEEEECCCCHHHHHCCHHHHEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
PADLSSHSWLEYSVRPDNEFELIAPEGISTRLIPQGRFVTNDPMTLVRWLTAGAGIAYVP
CCCCCCCCEEEEEECCCCCEEEECCCCCCEEECCCCCEECCCHHHHHHHHHHCCCHHHHH
LMWVINEINRGELEILLPRYQSDPRPVYALYTEKDKMPLKVQVVINSLTDYFVEVAKLFQ
HHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHH
EMHGRGKEK
HHHCCCCCC
>Mature Secondary Structure
MERLKRMSVFAKVVEFGSFTAAARQLQMSVSSISQTVSKLEDELQVKLLNRSTRSIGLTE
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCH
AGRIYYQGCRRMLHEVRDVHEQLYAFNNTPIGTLRIGCSSTMAQNVLAGLTAKLLKEYPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCC
LTVNLVTGIPAPDLIADGLDVVIRVGALQDSSLFSRRLGAMPMVVCAAKSYLSQYGIPEK
CEEEEEECCCCHHHHHCCHHHHEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
PADLSSHSWLEYSVRPDNEFELIAPEGISTRLIPQGRFVTNDPMTLVRWLTAGAGIAYVP
CCCCCCCCEEEEEECCCCCEEEECCCCCCEEECCCCCEECCCHHHHHHHHHHCCCHHHHH
LMWVINEINRGELEILLPRYQSDPRPVYALYTEKDKMPLKVQVVINSLTDYFVEVAKLFQ
HHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHH
EMHGRGKEK
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]