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The map label for this gene is selB [H]

Identifier: 218550319

GI number: 218550319

Start: 3081311

End: 3083278

Strand: Reverse

Name: selB [H]

Synonym: EFER_3011

Alternate gene names: 218550319

Gene position: 3083278-3081311 (Counterclockwise)

Preceding gene: 218550320

Following gene: 218550318

Centisome position: 67.19

GC content: 50.76

Gene sequence:

>1968_bases
GTGAAGCTGTCAACAAAGCCCCTGGTATGTTTCGTTGGGGACAATAGTAAACACGCTTTCAGGAAGTTGATGGGGCCCGG
TGGCCCCTGCGGTCCTCAAAACCGTTGTCAGCTTATCGGCTGGGGCAGGTTCGACTCCTGCCGCTTCCGCCACACTTTTC
CTGAATCTGGAGAACATATCGTGTATGCGGTAACAGGAACAGCCGGACACGTGGATCATGGTAAATCCGCCCTTATTCAG
GCACTCACCGGAACACATCCTTCACATTTACCACAAGAGTTTGCTCGTGGTATGACGATTGAACTGGGATTTGCCTGTTT
ACGTAGCCCCGAAGGCGATGAAATTGGCATGATTGACGTACCCGGTCACGAACGCTTTTTGCGCAATATGCTGAGTAGTC
TTTGGGGGTTAGATCTGGTGCTGTTTGTGGTGGCAGCCGATGAAGGCTGGTCGCCGCTCAGCGAAGAACATTTACGTGTG
ATTGCGGCTCTTGGTATTCGCCACATTATGGTGGCAATCAACAAGTGTGACCTGGCCGATGATTCGCGTCTGGCCGAGGT
TGAAGAAGAGATCCTGGAGCGTTTTTTGACGCACTGCGACATGCTGCCGGATATCTGGAGAGTTAGCGCAAAGAGCGGTG
AGGGCGTGGAAGAACTCCGCCAGGCACTAATTAAACAAATCCGTCAGCAAACACCGTCATCATCACTCGCCCCCGGACCG
CATTTATATATTGACCGTGTATTTACTGTTAATGGGATTGGCACCACTGTAACGGGCACATTGCGTGGAGATGGCGTAGA
GATTGGTGACGTTTTGCGTTTGTATCCGGGAAATGAACTGGTAAAAGTGAAATCGATTCAAAGTTACCATCTTCCGAGGG
AGCGCGCACAACCGTGTAGCAGAGTGGCGATGAGCTTTCGTCAACTCAAAAAAGATAAAGTCGCGCGAGGAGATTGCCTG
GCAAGACCGGACGCCGGGGTGATGATCAGCCGCGAATGGATCGTACAGCTTCCCGCTGGAATTAGCGGCATGAAAAAACA
GTGTGAACTGGAAGTGGCGCTAGGGACTTCTTATGCTCAAGGGCGTTGCTATTTGCTCGGTGATGGGCGATTGGCGCGCT
TACAACTTTCCCGTGCGCTGCCGGTTTTTTGGGGACAGACAATATTGCTGATGATGCCCGGAGGTAGCCGGATGGTCAGC
GCCGGGCGTGTGGTATGGGCAGGAGCGCTTAGTCGCGAGCAGAGACCAAAATTGATTGCAACGCTTATTGGCTCAGAGAA
CACCGAACTACCGCAACTGAGAAAACAGGTTCAGTTGGCAGTAAATGGATATGTGGAATCTGATGGTAAACCTGCACCGT
CAAAGTGCCATGCGTTGCAGAGCTGGTGGCTGGCGGAAGACTACTATCAACAGTGTTTGACGCGGTGTAACCATATTTTT
ATGCAGGCGACATCGGCCCTGAATATGGAGGAGTTGGCTGCCCGTAGTGGCATAAGTATTGTTATTTTACGTGAACTGGT
AGAACAACAATGCCTGAACCAGAAGTGGCAACAAACAACCGAAGGCATCAGTGTATTCGGTGCCAGTTTTGGTCATCTTA
GCCAGGATTTACAAAAATTATTGGCTGAAATTCAATCAGTCGGGCAACTTTGCTTTTCTGCCACTCAACATGATCGACCT
TTACTGACACAGCAACTGCGTGCACTTGTTGAGAGAAAATGTATCGTGCCGATGGATGACAAAATGTTTATCACCAGGGA
ACACTACCAGACACTCCTGGATACGCTTTTTAGTGCATGCCAGGTGGGGGATTTGCTTTCAATAGCCGATGTCCGGGAGC
GAACTGGCCTTGCACGTAAGCAGCTAATTCCTCTGCTTAATCGCATGGAAAGAGACGGCTGGGTACGAAGGGAAGGCGAT
TTGCGCCGTGTGAAGAAAGCGCTGAGTTGTGCGGTGGAAAGTGGGTAA

Upstream 100 bases:

>100_bases
GCACTGACGCGCTATCGAAGTTTTTCTGCCGCATCACGTGCCGGGAAATGGCGTGAAGCTGAGCTGCAAGATTTTCAGCT
CATTGATTTGAATTTGTTGC

Downstream 100 bases:

>100_bases
CGGGGGAAAAGAGGGGAAGCTATATTCTCTCGCTATTTTATCGCCACTTTGTTGCCATTCGTACAAAAAAAGCCACTCGA
TCGAGTGGCTTAATTATTTG

Product: Selenocysteine-specific elongation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MKLSTKPLVCFVGDNSKHAFRKLMGPGGPCGPQNRCQLIGWGRFDSCRFRHTFPESGEHIVYAVTGTAGHVDHGKSALIQ
ALTGTHPSHLPQEFARGMTIELGFACLRSPEGDEIGMIDVPGHERFLRNMLSSLWGLDLVLFVVAADEGWSPLSEEHLRV
IAALGIRHIMVAINKCDLADDSRLAEVEEEILERFLTHCDMLPDIWRVSAKSGEGVEELRQALIKQIRQQTPSSSLAPGP
HLYIDRVFTVNGIGTTVTGTLRGDGVEIGDVLRLYPGNELVKVKSIQSYHLPRERAQPCSRVAMSFRQLKKDKVARGDCL
ARPDAGVMISREWIVQLPAGISGMKKQCELEVALGTSYAQGRCYLLGDGRLARLQLSRALPVFWGQTILLMMPGGSRMVS
AGRVVWAGALSREQRPKLIATLIGSENTELPQLRKQVQLAVNGYVESDGKPAPSKCHALQSWWLAEDYYQQCLTRCNHIF
MQATSALNMEELAARSGISIVILRELVEQQCLNQKWQQTTEGISVFGASFGHLSQDLQKLLAEIQSVGQLCFSATQHDRP
LLTQQLRALVERKCIVPMDDKMFITREHYQTLLDTLFSACQVGDLLSIADVRERTGLARKQLIPLLNRMERDGWVRREGD
LRRVKKALSCAVESG

Sequences:

>Translated_655_residues
MKLSTKPLVCFVGDNSKHAFRKLMGPGGPCGPQNRCQLIGWGRFDSCRFRHTFPESGEHIVYAVTGTAGHVDHGKSALIQ
ALTGTHPSHLPQEFARGMTIELGFACLRSPEGDEIGMIDVPGHERFLRNMLSSLWGLDLVLFVVAADEGWSPLSEEHLRV
IAALGIRHIMVAINKCDLADDSRLAEVEEEILERFLTHCDMLPDIWRVSAKSGEGVEELRQALIKQIRQQTPSSSLAPGP
HLYIDRVFTVNGIGTTVTGTLRGDGVEIGDVLRLYPGNELVKVKSIQSYHLPRERAQPCSRVAMSFRQLKKDKVARGDCL
ARPDAGVMISREWIVQLPAGISGMKKQCELEVALGTSYAQGRCYLLGDGRLARLQLSRALPVFWGQTILLMMPGGSRMVS
AGRVVWAGALSREQRPKLIATLIGSENTELPQLRKQVQLAVNGYVESDGKPAPSKCHALQSWWLAEDYYQQCLTRCNHIF
MQATSALNMEELAARSGISIVILRELVEQQCLNQKWQQTTEGISVFGASFGHLSQDLQKLLAEIQSVGQLCFSATQHDRP
LLTQQLRALVERKCIVPMDDKMFITREHYQTLLDTLFSACQVGDLLSIADVRERTGLARKQLIPLLNRMERDGWVRREGD
LRRVKKALSCAVESG
>Mature_655_residues
MKLSTKPLVCFVGDNSKHAFRKLMGPGGPCGPQNRCQLIGWGRFDSCRFRHTFPESGEHIVYAVTGTAGHVDHGKSALIQ
ALTGTHPSHLPQEFARGMTIELGFACLRSPEGDEIGMIDVPGHERFLRNMLSSLWGLDLVLFVVAADEGWSPLSEEHLRV
IAALGIRHIMVAINKCDLADDSRLAEVEEEILERFLTHCDMLPDIWRVSAKSGEGVEELRQALIKQIRQQTPSSSLAPGP
HLYIDRVFTVNGIGTTVTGTLRGDGVEIGDVLRLYPGNELVKVKSIQSYHLPRERAQPCSRVAMSFRQLKKDKVARGDCL
ARPDAGVMISREWIVQLPAGISGMKKQCELEVALGTSYAQGRCYLLGDGRLARLQLSRALPVFWGQTILLMMPGGSRMVS
AGRVVWAGALSREQRPKLIATLIGSENTELPQLRKQVQLAVNGYVESDGKPAPSKCHALQSWWLAEDYYQQCLTRCNHIF
MQATSALNMEELAARSGISIVILRELVEQQCLNQKWQQTTEGISVFGASFGHLSQDLQKLLAEIQSVGQLCFSATQHDRP
LLTQQLRALVERKCIVPMDDKMFITREHYQTLLDTLFSACQVGDLLSIADVRERTGLARKQLIPLLNRMERDGWVRREGD
LRRVKKALSCAVESG

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=286, Percent_Identity=30.4195804195804, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI54607086, Length=354, Percent_Identity=27.1186440677966, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI2367247, Length=356, Percent_Identity=33.4269662921348, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1790412, Length=285, Percent_Identity=28.7719298245614, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1789737, Length=285, Percent_Identity=28.7719298245614, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1789108, Length=258, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556456, Length=289, Percent_Identity=28.0276816608997, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17506081, Length=241, Percent_Identity=27.3858921161826, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI25141371, Length=297, Percent_Identity=28.2828282828283, Blast_Score=83, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324761, Length=305, Percent_Identity=27.5409836065574, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320863, Length=279, Percent_Identity=26.5232974910394, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI281363316, Length=284, Percent_Identity=30.6338028169014, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI17864358, Length=284, Percent_Identity=30.6338028169014, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI19922690, Length=335, Percent_Identity=29.2537313432836, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI19921738, Length=287, Percent_Identity=30.6620209059233, Blast_Score=98, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015189
- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09105 SelB-wing_1; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 72833; Mature: 72833

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSTKPLVCFVGDNSKHAFRKLMGPGGPCGPQNRCQLIGWGRFDSCRFRHTFPESGEHI
CCCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCEECCCCCCCCEE
VYAVTGTAGHVDHGKSALIQALTGTHPSHLPQEFARGMTIELGFACLRSPEGDEIGMIDV
EEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCEEEECHHHHCCCCCCCEEEEEC
PGHERFLRNMLSSLWGLDLVLFVVAADEGWSPLSEEHLRVIAALGIRHIMVAINKCDLAD
CCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DSRLAEVEEEILERFLTHCDMLPDIWRVSAKSGEGVEELRQALIKQIRQQTPSSSLAPGP
CHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
HLYIDRVFTVNGIGTTVTGTLRGDGVEIGDVLRLYPGNELVKVKSIQSYHLPRERAQPCS
CEEEEEEEEEECCCEEEEEEECCCCCCCCCEEEECCCCCEEEEECHHHHCCCHHHCCHHH
RVAMSFRQLKKDKVARGDCLARPDAGVMISREWIVQLPAGISGMKKQCELEVALGTSYAQ
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHEECCCCCCCCCHHCEEEEEECCCCCC
GRCYLLGDGRLARLQLSRALPVFWGQTILLMMPGGSRMVSAGRVVWAGALSREQRPKLIA
CEEEEEECCCEEEEEHHHCCCHHCCCEEEEEECCCCCEECCCCEEEEHHHCCCCCCHHHH
TLIGSENTELPQLRKQVQLAVNGYVESDGKPAPSKCHALQSWWLAEDYYQQCLTRCNHIF
HHHCCCCCCHHHHHHHHHHHHHCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQATSALNMEELAARSGISIVILRELVEQQCLNQKWQQTTEGISVFGASFGHLSQDLQKL
HHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAEIQSVGQLCFSATQHDRPLLTQQLRALVERKCIVPMDDKMFITREHYQTLLDTLFSAC
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
QVGDLLSIADVRERTGLARKQLIPLLNRMERDGWVRREGDLRRVKKALSCAVESG
HHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLSTKPLVCFVGDNSKHAFRKLMGPGGPCGPQNRCQLIGWGRFDSCRFRHTFPESGEHI
CCCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCEECCCCCCCCEE
VYAVTGTAGHVDHGKSALIQALTGTHPSHLPQEFARGMTIELGFACLRSPEGDEIGMIDV
EEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCEEEECHHHHCCCCCCCEEEEEC
PGHERFLRNMLSSLWGLDLVLFVVAADEGWSPLSEEHLRVIAALGIRHIMVAINKCDLAD
CCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DSRLAEVEEEILERFLTHCDMLPDIWRVSAKSGEGVEELRQALIKQIRQQTPSSSLAPGP
CHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
HLYIDRVFTVNGIGTTVTGTLRGDGVEIGDVLRLYPGNELVKVKSIQSYHLPRERAQPCS
CEEEEEEEEEECCCEEEEEEECCCCCCCCCEEEECCCCCEEEEECHHHHCCCHHHCCHHH
RVAMSFRQLKKDKVARGDCLARPDAGVMISREWIVQLPAGISGMKKQCELEVALGTSYAQ
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHEECCCCCCCCCHHCEEEEEECCCCCC
GRCYLLGDGRLARLQLSRALPVFWGQTILLMMPGGSRMVSAGRVVWAGALSREQRPKLIA
CEEEEEECCCEEEEEHHHCCCHHCCCEEEEEECCCCCEECCCCEEEEHHHCCCCCCHHHH
TLIGSENTELPQLRKQVQLAVNGYVESDGKPAPSKCHALQSWWLAEDYYQQCLTRCNHIF
HHHCCCCCCHHHHHHHHHHHHHCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQATSALNMEELAARSGISIVILRELVEQQCLNQKWQQTTEGISVFGASFGHLSQDLQKL
HHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAEIQSVGQLCFSATQHDRPLLTQQLRALVERKCIVPMDDKMFITREHYQTLLDTLFSAC
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
QVGDLLSIADVRERTGLARKQLIPLLNRMERDGWVRREGDLRRVKKALSCAVESG
HHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8893853 [H]