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The map label for this gene is fucA [C]

Identifier: 218550120

GI number: 218550120

Start: 2874428

End: 2875159

Strand: Reverse

Name: fucA [C]

Synonym: EFER_2808

Alternate gene names: 218550120

Gene position: 2875159-2874428 (Counterclockwise)

Preceding gene: 218550121

Following gene: 218550119

Centisome position: 62.66

GC content: 48.5

Gene sequence:

>732_bases
ATGGGAATATCAATTGAAGAGCAGATCCGTGTCGATCTGGCCGTAACCTTCCGCATAATTGCCCATCTTGGGATGCACGA
AGCTGTCGCTAATCATTTCAGCGCGGCAATTTCTGACGACGGAAAGACGTTTCTGCTGAATCCTAAGTGGAAACATTTTT
CCCGGATTCGTGCCAGCGACTTGCTGTTGTTAGATGCTGATGATGAAGCTAATGCCCACCGTGAAGATGTCGATGCCACG
GCATGGGCGATTCATGGGCAGATTCATCAACGTCTGCCAGCAGCACGTGTCGTGCTGCATCTTCATCCGGTCTATACCAC
CAGCGTTGCGTGTCTGGAGACACCGCATATTCCTGCAATCGATCAAAATACGGCACGTTATTTTAATCGTATGGCAATAG
ATACCTTATATGGTGGAATGGCAGACACAACGGCAGAAGGTGCCCGACTGGCAGGATTACTGGGAGAAAAACGGCGCTTG
CTGATGGGTAACCACGGCGTGTTAGTTACTGGTATTTCAGTAGGGGAAGCATTTGATGATATCTGGACGCTTGAGCGTGC
TTGTCAGATATTTGTTACTGCTATGTCCTGTGGACAGCCACTGAAAATCCTGCCGGATGAAGTCGCAGAAAAAACGGCCC
GTGACTGGGAGAAGATCGTTGATTTTTCCCGTCAGCATTTTGCTGAAATGAAGCAACTGATGATTGAAGCAGATCCGTCA
GTGCTTGATTAA

Upstream 100 bases:

>100_bases
AGCGCCACGCCGGAATATGCCGCTTTGCTGAAGAAATATAACTTCACCCCGCCAACTGCGGAAGATCTCAACACTCTGAT
GCCAAAAGCGGAATAAATGA

Downstream 100 bases:

>100_bases
CATGTTATGTCAGATGCAAGAGATTGGGCATCTTGCGGATGGCTGCTATCATAAAGCGACTTGAAATATCGTGAGGATTC
GCTTTGAGCGCAGGACGCTT

Product: hypothetical protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MGISIEEQIRVDLAVTFRIIAHLGMHEAVANHFSAAISDDGKTFLLNPKWKHFSRIRASDLLLLDADDEANAHREDVDAT
AWAIHGQIHQRLPAARVVLHLHPVYTTSVACLETPHIPAIDQNTARYFNRMAIDTLYGGMADTTAEGARLAGLLGEKRRL
LMGNHGVLVTGISVGEAFDDIWTLERACQIFVTAMSCGQPLKILPDEVAEKTARDWEKIVDFSRQHFAEMKQLMIEADPS
VLD

Sequences:

>Translated_243_residues
MGISIEEQIRVDLAVTFRIIAHLGMHEAVANHFSAAISDDGKTFLLNPKWKHFSRIRASDLLLLDADDEANAHREDVDAT
AWAIHGQIHQRLPAARVVLHLHPVYTTSVACLETPHIPAIDQNTARYFNRMAIDTLYGGMADTTAEGARLAGLLGEKRRL
LMGNHGVLVTGISVGEAFDDIWTLERACQIFVTAMSCGQPLKILPDEVAEKTARDWEKIVDFSRQHFAEMKQLMIEADPS
VLD
>Mature_242_residues
GISIEEQIRVDLAVTFRIIAHLGMHEAVANHFSAAISDDGKTFLLNPKWKHFSRIRASDLLLLDADDEANAHREDVDATA
WAIHGQIHQRLPAARVVLHLHPVYTTSVACLETPHIPAIDQNTARYFNRMAIDTLYGGMADTTAEGARLAGLLGEKRRLL
MGNHGVLVTGISVGEAFDDIWTLERACQIFVTAMSCGQPLKILPDEVAEKTARDWEKIVDFSRQHFAEMKQLMIEADPSV
LD

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI89276787, Length=195, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI9257190, Length=195, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI297307160, Length=195, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI297307158, Length=197, Percent_Identity=27.9187817258883, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI9257192, Length=197, Percent_Identity=27.9187817258883, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI9951927, Length=195, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI62912453, Length=195, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI9943848, Length=195, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115533216, Length=197, Percent_Identity=24.8730964467005, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 27017; Mature: 26886

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGISIEEQIRVDLAVTFRIIAHLGMHEAVANHFSAAISDDGKTFLLNPKWKHFSRIRASD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCC
LLLLDADDEANAHREDVDATAWAIHGQIHQRLPAARVVLHLHPVYTTSVACLETPHIPAI
EEEEECCCCCCCCHHCCCHHHHHHHHHHHHHCCHHEEHEEECCHHHHHHHEEECCCCCCC
DQNTARYFNRMAIDTLYGGMADTTAEGARLAGLLGEKRRLLMGNHGVLVTGISVGEAFDD
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEECCCCEEEEECCHHHHHHH
IWTLERACQIFVTAMSCGQPLKILPDEVAEKTARDWEKIVDFSRQHFAEMKQLMIEADPS
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VLD
CCC
>Mature Secondary Structure 
GISIEEQIRVDLAVTFRIIAHLGMHEAVANHFSAAISDDGKTFLLNPKWKHFSRIRASD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCC
LLLLDADDEANAHREDVDATAWAIHGQIHQRLPAARVVLHLHPVYTTSVACLETPHIPAI
EEEEECCCCCCCCHHCCCHHHHHHHHHHHHHCCHHEEHEEECCHHHHHHHEEECCCCCCC
DQNTARYFNRMAIDTLYGGMADTTAEGARLAGLLGEKRRLLMGNHGVLVTGISVGEAFDD
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEECCCCEEEEECCHHHHHHH
IWTLERACQIFVTAMSCGQPLKILPDEVAEKTARDWEKIVDFSRQHFAEMKQLMIEADPS
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VLD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]